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This study examined whether therapeutic experiences originally created in the MindGym could maintain their efficacy when delivered via 360-degree recordings through virtual reality (VR) headsets. A randomized controlled trial (N=126) compared anxiety reduction, cognitive performance, and physiological responses across four conditions: MindGym and VR platforms, each delivering either breathwork or rain stimuli. Results demonstrated significant improvements across all conditions in cognitive performance (Trail Making Test RTACC, p.fdr&lt;.001; Architex Total Speed, p.fdr&lt;.001) and anxiety reduction (STAI, p.fdr&lt;.001). Breathwork conditions produced greater decreases in breath rate compared to rain stimuli (p.fdr=.002). Treatment responses were moderated by individual differences, with absorption (MODTAS) predicting both awe (p.fdr=.004) and ego dissolution (p.fdr=.015), while openness to experience interacted with stimuli type to influence anxiety reduction (p.fdr=.038). The anxiolytic effects originally generated in the MindGym maintained full efficacy when translated to VR delivery, with no significant differences in effectiveness or immersion between the original environment and its virtual reproduction. These findings establish the MindGym as a viable content creation platform for immersive, anxiety-reducing experiences that can be successfully adapted to more accessible delivery systems, while highlighting the potential for personalization based on individual differences. Future research should investigate the translation of more complex MindGym-generated experiences to expand accessible anxiety management tools.<\/jats:p>","DOI":"10.1371\/journal.pmen.0000269","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T17:23:21Z","timestamp":1741800201000},"page":"e0000269","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmen.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Contrasting cognitive, behavioral, and physiological responses to breathwork vs. naturalistic stimuli in reflective chamber and VR headset environments"],"prefix":"10.1371","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0230-5070","authenticated-orcid":true,"given":"Ninette","family":"Simonian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah Alan","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geena","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9286-4687","authenticated-orcid":true,"given":"Velu","family":"Kumaravel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-1584","authenticated-orcid":true,"given":"Taylor","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Schoeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicco","family":"Reggente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"issue":"1","key":"pmen.0000269.ref001","doi-asserted-by":"crossref","first-page":"17073","DOI":"10.1038\/s41598-022-21575-9","article-title":"Investigating the role of auditory and visual sensory inputs for inducing relaxation during virtual reality stimulation","volume":"12","author":"AC Naef","year":"2022","journal-title":"Sci Rep"},{"key":"pmen.0000269.ref002","doi-asserted-by":"crossref","DOI":"10.3389\/frvir.2022.893052","article-title":"Effects of immersion and navigation agency in virtual environments on emotions and behavioral intentions","volume":"3","author":"R Weller","year":"2022","journal-title":"Front Virtual Real"},{"issue":"1","key":"pmen.0000269.ref003","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/s41598-023-28070-9","article-title":"Daily exposure to virtual nature reduces symptoms of anxiety in college students","volume":"13","author":"MHEM Browning","year":"2023","journal-title":"Sci Rep"},{"key":"pmen.0000269.ref004"},{"key":"pmen.0000269.ref005"},{"key":"pmen.0000269.ref006","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-244X-14-128","article-title":"The prevalence and burden of subthreshold generalized anxiety disorder: a systematic review","volume":"14","author":"H Haller","year":"2014","journal-title":"BMC Psychiatry"},{"key":"pmen.0000269.ref007","unstructured":"National Institute of Mental Health (NIMH) - Transforming the understanding and treatment of mental illnesses [Internet]. 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