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This study aimed to assess changes in sleep-specific and general patient-reported outcome measures (PROMs) in individuals prescribed cannabis-based medicinal products for insomnia and to assess the incidence of adverse events. A case series was analysed with patients diagnosed with primary insomnia from the UK Medical Cannabis Registry (UKMCR). The primary outcome examined changes in the Single-Item Sleep Quality Scale (SQS), Generalised Anxiety Disorder-7 (GAD-7), and EuroQol-5 Dimension-5 Level (EQ-5D-5L). Changes in PROMs were assessed from baseline to 1-, 3-, 6-, 12- and 18-months. Adverse events were classified according to the CTCAE version 4.0. The inclusion criteria were met by 124 participants. SQS scores showed improvement from baseline (2.66\u2009\u00b1\u20092.41) to 1- (5.67\u2009\u00b1\u20092.65; p\u2009&lt;\u20090.001), 3- (5.41\u2009\u00b1\u20092.69; p\u2009&lt;\u20090.001), 6- (4.80\u2009\u00b1\u20092.89; p\u2009&lt;\u20090.001), 12- (4.24\u2009\u00b1\u20093.01; p\u2009&lt;\u20090.001) and 18-months (3.81\u2009\u00b1\u20092.90; p\u2009&lt;\u20090.001). GAD-7 scores improved from baseline to 1-, 3-, 6-, 12- and 18-months (p\u2009&lt;\u20090.050). There were also improvements in EQ-5D-5L dimensions of usual activities, pain\/discomfort, anxiety\/depression, and index values (p\u2009&lt;\u20090.001). Eleven (8.87%) participants reported a total of 112 (90.32%) adverse events, but none were disabling or life-threatening. The study demonstrated improvements in subjective sleep quality and other captured PROMs in insomnia patients treated with cannabis-based medicinal products. Although the treatment was generally well-tolerated, randomised controlled trials are needed to confirm the effectiveness and safety of cannabis-based medicinal products.<\/jats:p>","DOI":"10.1371\/journal.pmen.0000390","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:25:52Z","timestamp":1756315552000},"page":"e0000390","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmen.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["UK Medical Cannabis Registry: A clinical outcomes analysis for insomnia"],"prefix":"10.1371","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3853-2586","authenticated-orcid":true,"given":"Arushika","family":"Aggarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Erridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Cowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1365-8682","authenticated-orcid":true,"given":"Madhur","family":"Varadpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evonne","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Coomber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Rucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Weatherall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-3924","authenticated-orcid":true,"given":"Mikael H.","family":"Sodergren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"pmen.0000390.ref001","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM-5)","author":"American Psychiatric Association","year":"2013","edition":"5"},{"key":"pmen.0000390.ref002","article-title":"Characteristics of insomnia in the United States: results of the 1991 National Sleep Foundation Survey. 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