{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:33:33Z","timestamp":1784601213877,"version":"3.55.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T00:00:00Z","timestamp":1216166400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0000262","type":"journal-article","created":{"date-parts":[[2008,7,15]],"date-time":"2008-07-15T21:11:53Z","timestamp":1216156313000},"page":"e262","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":77,"title":["Proteomic Analysis of Skin Invasion by Blood Fluke Larvae"],"prefix":"10.1371","volume":"2","author":[{"given":"Elizabeth","family":"Hansell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Braschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin F.","family":"Medzihradszky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Sajid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moumita","family":"Debnath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ingram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"McKerrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1600-0625.1996.tb00117.x","article-title":"Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers.","volume":"5","author":"PM Elias","year":"1996","journal-title":"Exp Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0968-4328(01)00019-1","article-title":"Ultrastructure of the Schistosoma mansoni cercaria.","volume":"33","author":"CH Dorsey","year":"2002","journal-title":"Micron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0065-308X(08)60388-7","article-title":"Schistosoma mansoni: cercaria to schistosomule.","volume":"12","author":"MA Stirewalt","year":"1974","journal-title":"Adv Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00925346","article-title":"Characterization of chemical stimuli for the penetration of Schistosoma mansoni cercariae. I. Effective substances, host specificity.","volume":"66","author":"W Haas","year":"1982","journal-title":"Z Parasitenkd"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.2307\/3284366","article-title":"Schistosoma mansoni cercariae: stimulation of acetabular gland secretion is adapted to the chemical composition of mammalian skin.","volume":"83","author":"W Haas","year":"1997","journal-title":"J Parasitol"},{"key":"ref6","first-page":"195","article-title":"Degradation of extracellular matrix by larvae of Schistosoma mansoni. I. Degradation by cercariae as a model for initial parasite invasion of host.","volume":"49","author":"JH McKerrow","year":"1983","journal-title":"Lab Invest"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-4894(72)90112-9","article-title":"Schistosoma mansoni: stimulatory effect of rat skin lipid fractions on cercarial penetration behavior.","volume":"31","author":"FG Austin","year":"1972","journal-title":"Exp Parasitol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.pt.2004.03.003","article-title":"Schistosomes in the skin: a balance between immune priming and regulation.","volume":"20","author":"AP Mountford","year":"2004","journal-title":"Trends Parasitol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3181\/00379727-197-43233","article-title":"Recent insights into the structure and function of a larval proteinase involved in host infection by a multicellular parasite.","volume":"197","author":"JH McKerrow","year":"1991","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1471-4922(03)00143-0","article-title":"Invasion by schistosome cercariae: studies with human skin explants.","volume":"19","author":"PJ Whitfield","year":"2003","journal-title":"Trends Parasitol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1074\/mcp.M500313-MCP200","article-title":"Identification of novel proteases and immunomodulators in the secretions of schistosome cercariae that facilitate host entry.","volume":"5","author":"RS Curwen","year":"2006","journal-title":"Mol Cell Proteomics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1074\/mcp.M500097-MCP200","article-title":"Proteomic analysis of Schistosoma mansoni cercarial secretions.","volume":"4","author":"GM Knudsen","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"24618","DOI":"10.1074\/jbc.M202364200","article-title":"Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes.","volume":"277","author":"JP Salter","year":"2002","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"38667","DOI":"10.1074\/jbc.M006997200","article-title":"Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease.","volume":"275","author":"JP Salter","year":"2000","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/S0167-7799(01)01795-4","article-title":"Matching peptide mass spectra to EST and genomic DNA databases.","volume":"19","author":"JS Choudhary","year":"2001","journal-title":"Trends Biotechnol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S0031182096008001","article-title":"Schistosoma japonicum: immunolocalization of paramyosin during development.","volume":"114 ( Pt 1)","author":"GN Gobert","year":"1997","journal-title":"Parasitology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1128\/IAI.71.11.6402-6410.2003","article-title":"Inhibition of the complement membrane attack complex by Schistosoma mansoni paramyosin.","volume":"71","author":"J Deng","year":"2003","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0166-6851(00)00209-7","article-title":"Cloning and expression of a gene encoding SM16, an anti-inflammatory protein from Schistosoma mansoni.","volume":"108","author":"KVN Rao","year":"2000","journal-title":"Molecular and Biochemical Parasitology"},{"key":"ref19","first-page":"15","article-title":"Characterization of Sm20.8, a member of a family of schistosome tegumental antigens.","volume":"96","author":"MM Mohamed","year":"1998","journal-title":"Mol Biochem Parasitol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0166-6851(92)90218-9","article-title":"Cloning of a 21.7-kDa vaccine-dominant antigen gene of Schistosoma mansoni reveals an EF hand-like motif.","volume":"50","author":"P Francis","year":"1992","journal-title":"Mol Biochem Parasitol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/expr.1995.1038","article-title":"Schistosoma mansoni: cloning the gene encoding glutathione peroxidase.","volume":"80","author":"H Mei","year":"1995","journal-title":"Exp Parasitol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1471-2164-9-89","article-title":"Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family.","volume":"9","author":"IW Chalmers","year":"2008","journal-title":"BMC Genomics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0166-6851(89)90008-X","article-title":"Rapid changes in the expression of a gene encoding a calcium-binding protein in Schistosoma mansoni.","volume":"34","author":"D Ram","year":"1989","journal-title":"Mol Biochem Parasitol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1002\/pmic.200600938","article-title":"Suction blister fluid as potential body fluid for biomarker proteins.","volume":"7","author":"J Kool","year":"2007","journal-title":"Proteomics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1074\/jbc.M504670200","article-title":"Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L.","volume":"281","author":"D Baechle","year":"2006","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"9700","DOI":"10.1021\/bi960920n","article-title":"The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure.","volume":"35","author":"D Wen","year":"1996","journal-title":"Biochemistry"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1172\/JCI200214211","article-title":"Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor.","volume":"109","author":"ED Han","year":"2002","journal-title":"J Clin Invest"},{"key":"ref28","first-page":"1","article-title":"Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules.","volume":"53","author":"PJ Koch","year":"1990","journal-title":"Eur J Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/mas.20037","article-title":"Prospective highlights of functional skin proteomics.","volume":"24","author":"CM Huang","year":"2005","journal-title":"Mass Spectrom Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.0022-202X.2004.23501.x","article-title":"Proteome Analysis of Skin Distinguishes Acute Guttate from Chronic Plaque Psoriasis.","volume":"124","author":"LM Carlen","year":"2005","journal-title":"J Invest Dermatol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1016\/S0021-9258(19)83680-3","article-title":"Purification and characterization of an elastinolytic proteinase secreted by cercariae of Schistosoma mansoni.","volume":"260","author":"JH McKerrow","year":"1985","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-3024.2005.00789.x","article-title":"Modulation of the host's immune response by schistosome larvae.","volume":"27","author":"SJ Jenkins","year":"2005","journal-title":"Parasite Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1006\/expr.1997.4178","article-title":"ICAM-1 and iNOS expression increased in the skin of mice after vaccination with gamma-irradiated cercariae of Schistosoma mansoni.","volume":"86","author":"K Ramaswamy","year":"1997","journal-title":"Exp Parasitol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1128\/IAI.67.7.3403-3409.1999","article-title":"Schistosoma mansoni activates host microvascular endothelial cells to acquire an anti-inflammatory phenotype.","volume":"67","author":"F Trottein","year":"1999","journal-title":"Infect Immun"},{"key":"ref35","first-page":"567","article-title":"Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions.","volume":"45","author":"A Aslam","year":"2008","journal-title":"Molelcular Immonology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2307\/3279310","article-title":"Schistosoma mansoni: Calcium content of cercariae and its effects on protease activity in vitro.","volume":"61","author":"MH Dresden","year":"1975","journal-title":"The Journal of Parasitology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0166-6851(90)90094-3","article-title":"Molecular cloning and tissue distribution of a 26-kilodalton Schistosoma mansoni glutathione S-transferase.","volume":"41","author":"F Trottein","year":"1990","journal-title":"Mol Biochem Parasitol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1645\/0022-3395(2000)086[0908:MAECOS]2.0.CO;2","article-title":"Molecular and enzymatic characterization of Schistosoma mansoni thioredoxin peroxidase.","volume":"86","author":"MA Kwatia","year":"2000","journal-title":"J Parasitol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"806","DOI":"10.4049\/jimmunol.157.2.806","article-title":"Calpain is the target antigen of a Th1 clone that transfers protective immunity against Schistosoma mansoni.","volume":"157","author":"D Jankovic","year":"1996","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"15085","DOI":"10.1016\/S0021-9258(18)98590-X","article-title":"Characterization of cDNA clones encoding a novel calcium-activated neutral proteinase from Schistosoma mansoni.","volume":"Aug 15;266(23)","author":"K Andresen","year":"1991","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jcp.20058","article-title":"Apoptosis induced by interferon-alpha and antagonized by EGF is regulated by caspase-3-mediated cleavage of gelsolin in human epidermoid cancer cells.","volume":"201","author":"M Boccellino","year":"2004","journal-title":"J Cell Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"34329","DOI":"10.1074\/jbc.M201344200","article-title":"Skin-stage schistosomula of Schistosoma mansoni produce an apoptosis-inducing factor that can cause apoptosis of T cells.","volume":"277","author":"L Chen","year":"2002","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0169-4758(89)90218-4","article-title":"Complement and parasitic trematodes.","volume":"5","author":"Z Fishelson","year":"1989","journal-title":"Parasitol Today"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0014-4894(80)90029-6","article-title":"Schistosoma mansoni: activation of the alternative pathway of human complement by schistosomula.","volume":"50","author":"W Dias Da Silva","year":"1980","journal-title":"Exp Parasitol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1590\/S0074-02762006000900032","article-title":"Proteomic analysis of the schistosome tegument and its surface membranes.","volume":"101","author":"S Braschi","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1128\/IAI.51.1.181-186.1986","article-title":"Cercarial glycocalyx of Schistosoma mansoni activates human complement.","volume":"51","author":"JC Samuelson","year":"1986","journal-title":"Infect Immun"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:38:34Z","timestamp":1684474714000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000262"}},"subtitle":[],"editor":[{"given":"Malcolm K.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,7,16]]},"references-count":46,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2008,7,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000262","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,16]]}}}