{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:18:42Z","timestamp":1778537922988,"version":"3.51.4"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T00:00:00Z","timestamp":1221004800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0000293","type":"journal-article","created":{"date-parts":[[2008,9,9]],"date-time":"2008-09-09T20:27:25Z","timestamp":1220992045000},"page":"e293","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["Impact of Long-Term Treatment with Ivermectin on the Prevalence and Intensity of Soil-Transmitted Helminth Infections"],"prefix":"10.1371","volume":"2","author":[{"given":"Ana Lucia","family":"Moncayo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maritza","family":"Vaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Erazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Oviedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Quinzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Padilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Chico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Lovato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio L.","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2008,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/bmj.327.7412.431","article-title":"Helminthic infections.","volume":"327","author":"S Awasthi","year":"2003","journal-title":"Bmj"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0065-308X(05)62007-6","article-title":"Global epidemiology, ecology and control of soil-transmitted helminth infections.","volume":"62","author":"S Brooker","year":"2006","journal-title":"Adv Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0001-706X(03)00035-4","article-title":"Impact of mass chemotherapy on the morbidity due to soil-transmitted nematodes.","volume":"86","author":"NR de Silva","year":"2003","journal-title":"Acta Trop"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1017\/S0031182000006491","article-title":"Malnutrition and parasitic helminth infections.","volume":"121","author":"LS Stephenson","year":"2000","journal-title":"Parasitology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1046\/j.1365-3156.2001.00820.x","article-title":"Drug-based helminth control in Western Pacific countries: a general perspective.","volume":"6","author":"C Urbani","year":"2001","journal-title":"Trop Med Int Health"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0035-9203(02)90316-0","article-title":"Schistosomiasis and soil-transmitted helminth infections: forging control efforts.","volume":"96","author":"L Savioli","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref7","article-title":"Essential Medicines: WHO model list","year":"2007"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/QCO.0b013e328010774c","article-title":"Ivermectin: uses and impact 20 years on.","volume":"19","author":"LM Fox","year":"2006","journal-title":"Curr Opin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.pt.2005.08.014","article-title":"Ivermectin 20 years on: maturation of a wonder drug.","volume":"21","author":"TG Geary","year":"2005","journal-title":"Trends Parasitol"},{"key":"ref10","first-page":"35","article-title":"A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp.","volume":"81","author":"VY Belizario","year":"2003","journal-title":"Bull World Health Organ"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4269\/ajtmh.1999.60.479","article-title":"Assessment of combined ivermectin and albendazole for treatment of intestinal helminth and Wuchereria bancrofti infections in Haitian schoolchildren.","volume":"60","author":"MJ Beach","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4269\/ajtmh.1996.55.477","article-title":"A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children.","volume":"55","author":"H Marti","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4269\/ajtmh.1989.40.304","article-title":"Ivermectin for human strongyloidiasis and other intestinal helminths.","volume":"40","author":"C Naquira","year":"1989","journal-title":"Am J Trop Med Hyg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/infdis\/159.6.1151","article-title":"The efficacy of ivermectin in the chemotherapy of gastrointestinal helminthiasis in humans.","volume":"159","author":"DO Freedman","year":"1989","journal-title":"J Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1741-7015-5-9","article-title":"Impact of long-term treatment of onchocerciasis with ivermectin in Ecuador: potential for elimination of infection.","volume":"5","author":"JC Vieira","year":"2007","journal-title":"BMC Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.1128\/IAI.67.11.5951-5957.1999","article-title":"Human onchocerciasis and tetanus vaccination: impact on the postvaccination antitetanus antibody response.","volume":"67","author":"PJ Cooper","year":"1999","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1590\/S0037-86821993000300007","article-title":"Intestinal helminthiases in Ecuador: the relationship between prevalence, genetic, and socioeconomic factors.","volume":"26","author":"PJ Cooper","year":"1993","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2466-6-24","article-title":"Risk factors for asthma and allergy associated with urban migration: background and methodology of a cross-sectional study in Afro-Ecuadorian school children in Northeastern Ecuador (Esmeraldas-SCAALA Study).","volume":"6","author":"PJ Cooper","year":"2006","journal-title":"BMC Pulm Med"},{"key":"ref19","article-title":"Diagnostic techniques for intestinal parasitic infections (IPI) appicable to primary health care (PHC) services","year":"1985"},{"key":"ref20","first-page":"251","article-title":"Negative Binomial Regression","author":"J Hilbe","year":"2007"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1017\/S0031182000052288","article-title":"Community control of helminth infections of man by mass and selective chemotherapy.","volume":"90(Pt 4)","author":"RM Anderson","year":"1985","journal-title":"Parasitology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0035-9203(90)90399-Y","article-title":"Control of geohelminths by delivery of targeted chemotherapy through schools.","volume":"84","author":"DA Bundy","year":"1990","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/0035-9203(95)90101-9","article-title":"Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area.","volume":"89","author":"M Albonico","year":"1995","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.299.16.1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis.","volume":"299","author":"J Keiser","year":"2008","journal-title":"Jama"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.trstmh.2007.03.006","article-title":"Efficacy and safety of drug combinations in the treatment of schistosomiasis, soil-transmitted helminthiasis, lymphatic filariasis and onchocerciasis.","volume":"101","author":"A Olsen","year":"2007","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0035-9203(91)90241-P","article-title":"The impact of three-monthly age-targetted chemotherapy on Ascaris lumbricoides infection.","volume":"85","author":"H Thein","year":"1991","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0001-706X(01)00168-1","article-title":"Effective control of hookworm infection in school children from Dhofar, Sultanate of Oman: a four-year experience with albendazole mass chemotherapy.","volume":"80","author":"MA Idris","year":"2001","journal-title":"Acta Trop"},{"key":"ref28","first-page":"563","article-title":"Selective mass treatment with ivermectin to control intestinal helminthiases and parasitic skin diseases in a severely affected population.","volume":"82","author":"J Heukelbach","year":"2004","journal-title":"Bull World Health Organ"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0035-9203(91)90037-Y","article-title":"A field study of the effect of ivermectin on intestinal helminths in man.","volume":"85","author":"JA Whitworth","year":"1991","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1017\/S0950268804003024","article-title":"Spatial analysis of the distribution of intestinal nematode infections in Uganda.","volume":"132","author":"S Brooker","year":"2004","journal-title":"Epidemiol Infect"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/00034983.2001.11813651","article-title":"Follow-up of Ascaris lumbricoides and Trichuris trichiura infections in children living in a community treated with ivermectin at 3-monthly intervals.","volume":"95","author":"S Ranque","year":"2001","journal-title":"Ann Trop Med Parasitol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4269\/ajtmh.1993.48.652","article-title":"Concurrent parasitic infections in onchocerciasis and the occurrence of adverse reactions after ivermectin treatment.","volume":"48","author":"FL Njoo","year":"1993","journal-title":"Am J Trop Med Hyg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1017\/S0022149X00014334","article-title":"Effect of ivermectin on infection with gastro-intestinal nematodes in Sierra Leone.","volume":"68","author":"JM Behnke","year":"1994","journal-title":"J Helminthol"},{"key":"ref34","first-page":"7","article-title":"Effect of ivermectin (Mectizan) on intestinal nematodes.","volume":"32","author":"S Taticheff","year":"1994","journal-title":"Ethiop Med J"},{"key":"ref35","first-page":"70","article-title":"Impact of ivermectin mass distribution for onchocerciasis control on <italic>Ascaris lumbricoides<\/italic> among schoolchildren in Rungwe and Kyela Distrits, southwest Tanzania.","volume":"8","author":"B Maegga","year":"2006","journal-title":"Tanzania Helath Research Bulletin"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2307\/3271720","article-title":"The egg production of <italic>Ascaris lumbricoides<\/italic>.","volume":"14","author":"H Brown","year":"1927","journal-title":"J Parasitology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/S0140-6736(07)61638-9","article-title":"Effect of city-wide sanitation programme on reduction in rate of childhood diarrhoea in northeast Brazil: assessment by two cohort studies.","volume":"370","author":"ML Barreto","year":"2007","journal-title":"Lancet"},{"key":"ref38","first-page":"542","article-title":"Avalia\u00e7\u00e3o do Impacto Epidemiol\u00f3gico do Programa de Saneamento Ambiental da Ba\u00eda de Todos os Santos","author":"ML Barreto","year":"2006"},{"key":"ref39","first-page":"343","article-title":"Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar.","volume":"81","author":"M Albonico","year":"2003","journal-title":"Bull World Health Organ"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0001-706X(97)00106-X","article-title":"Failure of pyrantel in treatment of human hookworm infections (Ancylostoma duodenale) in the Kimberley region of north west Australia.","volume":"68","author":"JA Reynoldson","year":"1997","journal-title":"Acta Trop"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1128\/CMR.13.2.207-222.2000","article-title":"Drug resistance in human helminths: current situation and lessons from livestock.","volume":"13","author":"S Geerts","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/00034983.1999.11813449","article-title":"Efficacy of albendazole and its combinations with ivermectin or diethylcarbamazine (DEC) in the treatment of Trichuris trichiura infections in Sri Lanka.","volume":"93","author":"MM Ismail","year":"1999","journal-title":"Ann Trop Med Parasitol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:20:34Z","timestamp":1588969234000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000293"}},"subtitle":[],"editor":[{"given":"Jeffrey","family":"Bethony","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2008,9,10]]},"references-count":42,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2008,9,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000293","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,10]]}}}