{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:06:32Z","timestamp":1771632392716,"version":"3.50.1"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T00:00:00Z","timestamp":1243900800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0000449","type":"journal-article","created":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T22:16:18Z","timestamp":1243894578000},"page":"e449","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["SmCL3, a Gastrodermal Cysteine Protease of the Human Blood Fluke Schistosoma mansoni"],"prefix":"10.1371","volume":"3","author":[{"given":"Jan","family":"Dvo\u0159\u00e1k","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan T.","family":"Mashiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Sajid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Braschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melaine","family":"Delcroix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric L.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson H.","family":"McKerrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Bahgat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Hansell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia C.","family":"Babbitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Craik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"McKerrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor R.","family":"Caffrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2009,6,2]]},"reference":[{"key":"ref1","article-title":"Handbook of Proteolytic Enzymes. 2nd edition","author":"AJ Barrett","year":"2004"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(01)00438-8","article-title":"Cysteine proteases of parasitic organisms.","volume":"120","author":"M Sajid","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1146\/annurev.pathol.1.110304.100151","article-title":"Proteases in parasitic diseases.","volume":"1","author":"JH McKerrow","year":"2006","journal-title":"Annu Rev Pathol"},{"key":"ref4","first-page":"348","article-title":"Proteases in Trematode biology.","author":"JP Dalton","year":"2006"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk.","volume":"6","author":"P Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0166-6851(00)00351-0","article-title":"Proteolysis of human hemoglobin by schistosome cathepsin D.","volume":"112","author":"PJ Brindley","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.pt.2004.03.004","article-title":"Blood \u2018n\u2019 guts: an update on schistosome digestive peptidases.","volume":"20","author":"CR Caffrey","year":"2004","journal-title":"Trends Parasitol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"39316","DOI":"10.1074\/jbc.M607128200","article-title":"A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite.","volume":"281","author":"M Delcroix","year":"2006","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ijpara.2004.01.008","article-title":"Leucine aminopeptidase of the human blood flukes, <italic>Schistosoma mansoni<\/italic> and <italic>Schistosoma japonicum<\/italic>.","volume":"34","author":"E McCarthy","year":"2004","journal-title":"Int J Parasitol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1128\/AAC.42.9.2254","article-title":"Antimalarial synergy of cysteine and aspartic protease inhibitors.","volume":"42","author":"A Semenov","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"35950","DOI":"10.1074\/jbc.M405842200","article-title":"A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.","volume":"279","author":"AL Williamson","year":"2004","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1756-3305-1-7","article-title":"Profiling of proteolytic enzymes in the gut of the tick <italic>Ixodes ricinus<\/italic> reveals an evolutionarily conserved network of aspartic and cysteine peptidases.","volume":"1","author":"D Sojka","year":"2008","journal-title":"Parasit Vectors"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0264-410X(01)00345-0","article-title":"DNA vaccination with asparaginyl endopeptidase (Sm32) from the parasite Schistosoma mansoni: anti-fecundity effect induced in mice.","volume":"20","author":"K Chlichlia","year":"2001","journal-title":"Vaccine"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1128\/CMR.00046-07","article-title":"Current status of vaccines for schistosomiasis.","volume":"21","author":"DP McManus","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0166-6851(96)02703-X","article-title":"Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo.","volume":"81","author":"MM Wasilewski","year":"1996","journal-title":"Mol Biochem Parasitol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1371\/journal.pmed.0040014","article-title":"Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor.","volume":"4","author":"MH Abdulla","year":"2007","journal-title":"PLoS Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s004360050060","article-title":"Circulating antigens in schistosomiasis: detection of 31\/32-kDa proteins in sera from patients infected with <italic>Schistosoma japonicum<\/italic>, <italic>S. mansoni<\/italic>, <italic>S. haematobium<\/italic>, or <italic>S. intercalatum<\/italic>.","volume":"82","author":"YL Li","year":"1996","journal-title":"Parasitol Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ng1237","article-title":"Transcriptome analysis of the acoelomate human parasite <italic>Schistosoma mansoni<\/italic>.","volume":"35","author":"S Verjovski-Almeida","year":"2003","journal-title":"Nat Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks.","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4269\/ajtmh.1967.16.483","article-title":"An improved perfusion technique for recovering adult schistosomes from laboratory animals.","volume":"16","author":"RH Duvall","year":"1967","journal-title":"Am J Trop Med Hyg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2307\/3280632","article-title":"Cultivation of <italic>Schistosoma mansoni in vitro<\/italic>: I. Establishment of cultures from cercariae and development until pairing.","volume":"67","author":"PF Basch","year":"1981","journal-title":"J Parasitol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0014-4894(74)90005-8","article-title":"<italic>Schistosoma mansoni<\/italic>: simplified method for the production of schistosomules.","volume":"35","author":"DG Colley","year":"1974","journal-title":"Exp Parasitol"},{"key":"ref23","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers.","author":"S Rozen","year":"2000"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/oxfordjournals.molbev.a026393","article-title":"Phylogenies inferred from mitochondrial gene orders\u2014a cautionary tale from the parasitic flatworms.","volume":"17","author":"TH Le","year":"2000","journal-title":"Mol Biol Evol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0.","volume":"340","author":"JD Bendtsen","year":"2004","journal-title":"J Mol Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-6851(02)00022-1","article-title":"SmCB2, a novel tegumental cathepsin B from adult <italic>Schistosoma mansoni<\/italic>.","volume":"121","author":"CR Caffrey","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijpara.2005.02.018","article-title":"Multiple cathepsin B isoforms in schistosomula of <italic>Trichobilharzia regenti<\/italic>: identification, characterisation and putative role in migration and nutrition.","volume":"35","author":"J Dvo\u0159\u00e1k","year":"2005","journal-title":"Int J Parasitol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S1074-5521(00)00014-4","article-title":"Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools.","volume":"7","author":"D Greenbaum","year":"2000","journal-title":"Chem Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0166-6851(03)00194-4","article-title":"Functional expression and characterization of <italic>Schistosoma mansoni<\/italic> cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase.","volume":"131","author":"M Sajid","year":"2003","journal-title":"Mol Biochem Parasitol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1021\/bi00534a031","article-title":"Determination of the rate constant of enzyme modification by measuring the substrate reaction in the presence of the modifier.","volume":"21","author":"WX Tian","year":"1982","journal-title":"Biochemistry"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1021\/jm00017a002","article-title":"Vinyl sulfones as mechanism-based cysteine protease inhibitors.","volume":"38","author":"JT Palmer","year":"1995","journal-title":"J Med Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1084\/jem.188.4.725","article-title":"Cysteine protease inhibitors cure an experimental <italic>Trypanosoma cruzi<\/italic> infection.","volume":"188","author":"JC Engel","year":"1998","journal-title":"J Exp Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0076-6879(95)48007-2","article-title":"Theoretical and practical aspects of proteinase inhibition kinetics.","volume":"248","author":"JG Beith","year":"1995","journal-title":"Methods Enzymol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"12824","DOI":"10.1074\/jbc.M513331200","article-title":"Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.","volume":"281","author":"Y Choe","year":"2006","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ijpara.2006.12.020","article-title":"IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick <italic>Ixodes ricinus<\/italic>.","volume":"37","author":"D Sojka","year":"2007","journal-title":"Int J Parasitol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biochi.2007.08.013","article-title":"Differential use of protease families for invasion by schistosome cercariae.","volume":"90","author":"J Dvo\u0159\u00e1k","year":"2008","journal-title":"Biochimie"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1111\/j.1742-4658.2005.04945.x","article-title":"Protein database searches using compositionally adjusted substitution matrices.","volume":"272","author":"SF Altschul","year":"2005","journal-title":"FEBS J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/prot.10613","article-title":"A hierarchical approach to all-atom protein loop prediction.","volume":"55","author":"MP Jacobson","year":"2004","journal-title":"Proteins"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis.","volume":"25","author":"EF Pettersen","year":"2004","journal-title":"J Comput Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/jmbi.1999.3091","article-title":"Protein secondary structure prediction based on position-specific scoring matrices.","volume":"292","author":"DT Jones","year":"1999","journal-title":"J Mol Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1093\/bioinformatics\/btm098","article-title":"UniRef: comprehensive and non-redundant UniProt reference clusters.","volume":"23","author":"BE Suzek","year":"2007","journal-title":"Bioinformatics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/bioinformatics\/btl158","article-title":"Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.","volume":"22","author":"W Li","year":"2006","journal-title":"Bioinformatics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e4345","DOI":"10.1371\/journal.pone.0004345","article-title":"Using sequence similarity networks for visualization of relationships across diverse protein superfamilies.","volume":"4","author":"HJ Atkinson","year":"2009","journal-title":"PLoS ONE"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cub.2004.08.038","article-title":"The real \u2018kingdoms\u2019 of eukaryotes.","volume":"14","author":"AG Simpson","year":"2004","journal-title":"Curr Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1128\/IAI.67.1.368-374.1999","article-title":"Recombinant expression and localization of <italic>Schistosoma mansoni<\/italic> cathepsin L1 support its role in the degradation of host hemoglobin.","volume":"67","author":"CP Brady","year":"1999","journal-title":"Infect Immun"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/elps.11501401163","article-title":"The focusing positions of polypeptides in immobilized pH gradients can be predicted from their amino acid sequences.","volume":"14","author":"B Bjellqvist","year":"1993","journal-title":"Electrophoresis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/abbi.2000.1905","article-title":"Molecular modeling and substrate specificity of discrete cruzipain-like and cathepsin L-like cysteine proteinases of the human blood fluke <italic>Schistosoma mansoni<\/italic>.","volume":"380","author":"CP Brady","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1371\/journal.ppat.0020029","article-title":"New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of <italic>Schistosoma japonicum<\/italic>.","volume":"2","author":"F Liu","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pt.2008.11.002","article-title":"The enigmatic asparaginyl endopeptidase of helminth parasites.","volume":"25","author":"JP Dalton","year":"2009","journal-title":"Trends Parasitol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1046\/j.1432-1327.1999.00950.x","article-title":"Atlantic salmon (<italic>Salmo salar<\/italic> L.) skin contains a novel kininogen and another cysteine proteinase inhibitor.","volume":"26","author":"A Ylonen","year":"1999","journal-title":"Eur J Biochem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0166-6851(98)00164-9","article-title":"The propeptide of <italic>Fasciola hepatica<\/italic> cathepsin L is a potent and selective inhibitor of the mature enzyme.","volume":"98","author":"L Roche","year":"1999","journal-title":"Mol Biochem Parasitol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1073\/pnas.90.7.3063","article-title":"Two distinct gene subfamilies within the family of cysteine protease genes.","volume":"90","author":"KM Karrer","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"10838","DOI":"10.1074\/jbc.270.18.10838","article-title":"Processing of the papain precursor. The ionization state of a conserved amino acid motif within the Pro region participates in the regulation of intramolecular processing.","volume":"270","author":"T Vernet","year":"1995","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0020-7519(03)00168-1","article-title":"The uptake of Texas Red-BSA in the excretory system of schistosomes and its colocalisation with ER60 promoter-induced GFP in transiently transformed adult males.","volume":"33","author":"V Wippersteg","year":"2003","journal-title":"Int J Parasitol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1645\/0022-3395(2001)087[0237:GAIOTS]2.0.CO;2","article-title":"Gut-associated immunolocalization of the <italic>Schistosoma mansoni<\/italic> cysteine proteases, SmCL1 and SmCL2.","volume":"87","author":"BJ Bogitsh","year":"2001","journal-title":"J Parasitol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0167-4838(99)00263-0","article-title":"Lysosomal cysteine proteases: more than scavengers.","volume":"1477","author":"B Turk","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1074\/mcp.M700560-MCP200","article-title":"Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen <italic>Fasciola hepatica<\/italic>: expansion of a repertoire of virulence-associated factors.","volume":"7","author":"MW Robinson","year":"2008","journal-title":"Mol Cell Proteomics"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.molbiopara.2008.05.001","article-title":"Identification and characterization of a cathepsin L-like cysteine protease from <italic>Gnathostoma spinigerum<\/italic>.","volume":"160","author":"N Kongkerd","year":"2008","journal-title":"Mol Biochem Parasitol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1094\/MPMI.2003.16.12.1077","article-title":"A set of genes differentially expressed between avirulent and virulent <italic>Meloidogyne incognita<\/italic> near-isogenic lines encode secreted proteins.","volume":"16","author":"C Neveu","year":"2003","journal-title":"Mol Plant Microbe Interact"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0014-4894(86)90148-7","article-title":"<italic>Schistosoma mansoni<\/italic>: proteinase activity of \u201chemoglobinase\u201d from the digestive tract of adult worms.","volume":"61","author":"CL Chappell","year":"1986","journal-title":"Exp Parasitol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1074\/jbc.M708521200","article-title":"Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, <italic>Fasciola hepatica<\/italic>.","volume":"283","author":"CM Stack","year":"2008","journal-title":"J Biol Chem"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.biochi.2008.04.020","article-title":"A distinctive repertoire of cathepsins is expressed by juvenile invasive <italic>Fasciola hepatica<\/italic>.","volume":"90","author":"M Cancela","year":"2008","journal-title":"Biochimie"},{"key":"ref64","first-page":"95","article-title":"An active zymogen: unravelling the mystery of tissue-type plasminogen activator.","volume":"379","author":"MT Stubbs","year":"1998","journal-title":"Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"30606","DOI":"10.1074\/jbc.M803041200","article-title":"Activation mechanism of recombinant Der p 3 allergen zymogen: contribution of cysteine protease Der p 1 and effect of propeptide glycosylation.","volume":"283","author":"ME Dumez","year":"2008","journal-title":"J Biol Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0166-6851(95)00092-F","article-title":"Sequence, characterization and localization of a cysteine proteinase cathepsin L in <italic>Schistosoma mansoni<\/italic>.","volume":"73","author":"A Michel","year":"1995","journal-title":"Mol Biochem Parasitol"},{"key":"ref67","first-page":"1439","article-title":"The human cathepsin F gene\u2014a fusion product between an ancestral cathepsin and cystatin gene.","volume":"380","author":"T Wex","year":"1999","journal-title":"Biol Chem"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0969-2126(98)00007-0","article-title":"Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function.","volume":"6","author":"G Guncar","year":"1998","journal-title":"Structure"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0065-308X(08)60243-2","article-title":"Proteinases and associated genes of parasitic helminths.","volume":"43","author":"J Tort","year":"1999","journal-title":"Adv Parasitol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/expr.2001.4634","article-title":"<italic>Paragonimus westermani<\/italic>: cloning of a cathepsin F-like cysteine proteinase from the adult worm.","volume":"98","author":"H Park","year":"2001","journal-title":"Exp Parasitol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0031182003004335","article-title":"A cathepsin F of adult <italic>Clonorchis sinensis<\/italic> and its phylogenetic conservation in trematodes.","volume":"128","author":"TH Kang","year":"2004","journal-title":"Parasitology"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T01:34:32Z","timestamp":1589852072000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000449"}},"subtitle":[],"editor":[{"given":"John Pius","family":"Dalton","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,6,2]]},"references-count":71,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,6,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000449","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,2]]}}}