{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:26:03Z","timestamp":1791296763306,"version":"4.1.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2009,11,3]],"date-time":"2009-11-03T00:00:00Z","timestamp":1257206400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0000540","type":"journal-article","created":{"date-parts":[[2009,11,2]],"date-time":"2009-11-02T21:48:22Z","timestamp":1257198502000},"page":"e540","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen"],"prefix":"10.1371","volume":"3","author":[{"given":"Elizabeth R.","family":"Sharlow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Close","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongying","family":"Shun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Leimgruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Mustata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wipf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O'Neil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Gr\u00f6gl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Magill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Lazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,11,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1517\/14656566.8.16.2689","article-title":"Cutaneous leishmaniasis: therapeutic strategies and future directions.","volume":"8","author":"M Ameen","year":"2007","journal-title":"Expert Opin Pharmacother"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/jac\/dkh058","article-title":"Treatment of cutaneous leishmaniasis among travelers.","volume":"53","author":"J Blum","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1590\/S0074-02762007000500001","article-title":"The leishmaniasis\u2013survival and expansion in a changing world. A mini-review.","volume":"102","author":"J Shaw","year":"2007","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1610-0387.2008.06809.x","article-title":"Leishmaniasis.","volume":"9","author":"H Neuber","year":"2008","journal-title":"J Dtsch Dermatol Ges"},{"key":"ref5","first-page":"399","article-title":"Leishmaniasis emergence and climate change.","volume":"27","author":"PD Ready","year":"2008","journal-title":"Rev Sci Tech"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/bmj.321.7264.801","article-title":"Leishmaniasis.","volume":"321","author":"LJ Roberts","year":"2000","journal-title":"BMJ"},{"key":"ref7","first-page":"536","article-title":"CMAJ","volume":"167","year":"2002","journal-title":"CMAJ"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1001\/jama.292.11.1294-a","article-title":"Leishmaniasis epidemic.","volume":"292","author":"J Stephenson","year":"2004","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.1371\/journal.pntd.0000256","article-title":"Neglected infections of poverty in the United States of America.","volume":"2","author":"P Hotez","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1111\/j.1537-2995.2006.00941.x","article-title":"<italic>Leishmania<\/italic>: risk to the blood supply.","volume":"46","author":"LJ Cardo","year":"2006","journal-title":"Transfusion"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.pt.2006.09.004","article-title":"Leishmaniasis and poverty.","volume":"22","author":"J Alvar","year":"2006","journal-title":"Trends Parasitol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.pt.2006.06.004","article-title":"Reconsidering the underestimated burden caused by neglected tropical diseases.","volume":"22","author":"D Engels","year":"2006","journal-title":"Trends Parasitol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1371\/journal.pntd.0000313","article-title":"Complexities of assessing the disease burden attributable to leishmaniasis.","volume":"2","author":"C Bern","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1172\/JCI33945","article-title":"Kinetoplastids: related protozoan pathogens, different diseases.","volume":"118","author":"R Stuart","year":"2008","journal-title":"J Clin Invest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/S0140-6736(09)60233-6","article-title":"Rescuing the bottom billion through control of neglected tropical diseases.","volume":"373","author":"PJ Hotez","year":"2009","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10156-004-0348-9","article-title":"Challenges and new discoveries in the treatment of leishmaniasis.","volume":"10","author":"S Singh","year":"2004","journal-title":"J Infect Chemother"},{"key":"ref17","first-page":"163","article-title":"Recent advances in antileishmanial drug development.","volume":"6","author":"AJ Davis","year":"2005","journal-title":"Curr Opin Invest Drugs"},{"key":"ref18","first-page":"399","article-title":"Current scenario of drug development for leishmaniasis.","volume":"123","author":"SL Croft","year":"2006","journal-title":"Ind J Med Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1365-2958.2008.06314.x","article-title":"Role of hexosamine biosynthesis in <italic>Leishmania<\/italic> growth and virulence.","volume":"69","author":"T Naderer","year":"2008","journal-title":"Mol Micro"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3949\/ccjm.72.2.93","article-title":"Nonhealing skin lesions in a sailor and a journalist returing from Iraq.","volume":"72","author":"EP Lesho","year":"2005","journal-title":"Cleve Clin J Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4269\/ajtmh.1992.46.296","article-title":"Recommendations for treating leishmaniasis with sodium stibogluconate (Pentostam) and review of pertinent clinical studies.","volume":"46","author":"BL Herwaldt","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/clinids\/10.3.560","article-title":"Chemotherapy for leishmaniasis: biochemical mechanisms, clinical efficacy, and future strategies.","volume":"10","author":"JD Berman","year":"1988","journal-title":"Rev Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1159\/000251981","article-title":"Treatment of cutaneous leishmaniasis with trimethoprim-sulfamethoxazole combination.","volume":"146","author":"E Kandil","year":"1973","journal-title":"Dermatologica"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0035-9203(79)90161-5","article-title":"Nifurtimox in the treatment of South American leishmaniasis.","volume":"73","author":"PD Marsden","year":"1979","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-4362.1982.tb00517.x","article-title":"Rifampicin treatment of cutaneous leishmaniasis.","volume":"21","author":"Z Even-Paz","year":"1982","journal-title":"Int J Dermatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1365-4362.1988.tb01274.x","article-title":"Combination therapy (monomycine and methyluracil) in leishmaniasis cutis.","volume":"27","author":"MZ Hossain","year":"1988","journal-title":"Int J Dermatol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5070\/D334C3G2QM","article-title":"Doxycycline for the treatment of cutaneous leishmaniasis.","volume":"14","author":"A Masmoudi","year":"2008","journal-title":"Dermatol Online J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.1371\/journal.pntd.0000249","article-title":"Tamoxifen is effective in the treatment of <italic>Leishmania amazonensis<\/italic> infections in mice.","volume":"2","author":"DC Miguel","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jac\/dkn509","article-title":"Tamoxifen as a potential antileishmanial agent: efficacy in the treatment of <italic>Leishmania braziliensis<\/italic> and <italic>Leishmania chagasi<\/italic> infections.","volume":"63","author":"DC Miguel","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.1112680","article-title":"The genome of the kinetoplastid parasite, <italic>Leishmania major<\/italic>.","volume":"309","author":"AC Ivens","year":"2005","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbapap.2005.08.018","article-title":"Protein kinases as drug targets in trypanosomes and <italic>Leishmania<\/italic>.","volume":"1754","author":"C Naula","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ng2053","article-title":"Comparative genomic analysis of three <italic>Leishmania<\/italic> species that cause diverse human disease.","volume":"39","author":"CS Peacock","year":"2007","journal-title":"Nat Gen"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.pt.2003.09.008","article-title":"Leishmaniasis\u2013current chemotherapy and recent advances in the search for novel drugs.","volume":"19","author":"SL Croft","year":"2003","journal-title":"Trends Parasitol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrd2201","article-title":"Drugs for bad bugs: confronting the challenges of antibacterial discovery.","volume":"6","author":"DJ Payne","year":"2006","journal-title":"Nat Rev Drug Disc"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmc.2006.01.007","article-title":"Indazole <italic>N<\/italic>- oxide derivatives as antiprotozoal agents: synthesis, biological evaluation and mechanism of action studies.","volume":"14","author":"A Gerpe","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejmech.2006.07.013","article-title":"High selective leishmanicidal activity of 3-hydroxy-2-methylene-3-(4- bromophenyl)propanenitrile and analogous compounds.","volume":"42","author":"R de Souza","year":"2007","journal-title":"Eur J Med Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nchembio.2007.17","article-title":"High-throughput screening assays for the identification of chemical probes.","volume":"3","author":"J Inglese","year":"2007","journal-title":"Nat Chem Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/nprot.2007.155","article-title":"Development and optimization of high-throughput <italic>in vitro<\/italic> protein phosphatase screening assays.","volume":"2","author":"MB Tierno","year":"2007","journal-title":"Nat Protocol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nprot.2008.111","article-title":"Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high throughput screening assays for low- molecular-weight compound libraries.","volume":"3","author":"ER Sharlow","year":"2008","journal-title":"Nat Protoc"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1128\/AAC.41.4.818","article-title":"An axenic amastigote system for drug screening.","volume":"41","author":"HL Callahan","year":"1997","journal-title":"Antimicrob Agents Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0924-8579(99)00133-8","article-title":"A comparison of the activities of three amphotericin B lipid formulations against experimental visceral and cutaneous leishmaniasis.","volume":"13","author":"V Yardley","year":"2000","journal-title":"Int J Antimicrob Agents"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1128\/AAC.45.1.288-292.2001","article-title":"Antileishmanial activities of aphodicolin and its semisynthetic derivatives.","volume":"45","author":"O Kayser","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1383-5769(99)00020-3","article-title":"A simple colorimetric method to screen drug cytotoxicity against <italic>Leishmania<\/italic> using the dye Alamar blue.","volume":"48","author":"D Mikus","year":"2000","journal-title":"Parasitol Int"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.resmic.2004.01.001","article-title":"<italic>In vitro<\/italic> assays for evaluation of drug activity against <italic>Leishmania<\/italic> spp.","volume":"155","author":"L Fumarola","year":"2004","journal-title":"Res Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4269\/ajtmh.2005.72.600","article-title":"Colorimetric assay for screening compounds against <italic>Leishmania<\/italic> amastigotes grown in macrophages.","volume":"72","author":"FS Buckner","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/00034983.1992.11812698","article-title":"Axenic cultivation of amastigotes of <italic>Leishmania donovani<\/italic> and <italic>Leishmania major<\/italic> and their infectivity.","volume":"86","author":"NT Al-Bashir","year":"1992","journal-title":"Ann Trop Med Parasitol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0169-4758(93)90181-E","article-title":"Axenic culture of <italic>Leishmania<\/italic> amastigotes.","volume":"9","author":"PA Bates","year":"1993","journal-title":"Parasitol Today"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1471-4922(00)01811-0","article-title":"<italic>In vitro<\/italic> cultivation and characterization of axenic amastigotes of <italic>Leishmania<\/italic>.","volume":"17","author":"N Gupta","year":"2001","journal-title":"Trends Parasitol"},{"key":"ref49","first-page":"6","article-title":"Characterization of <italic>in vitro<\/italic> cultivated amastigote like of <italic>Leishmania major<\/italic>: a substitution for <italic>in vivo<\/italic> studies.","volume":"3","author":"P Habibi","year":"2008","journal-title":"Iran J Parasitol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A simple statistical parameter for use in evaluation and validation of high throughput screening assays.","volume":"4","author":"JH Zhang","year":"1999","journal-title":"J Biomol Screen"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1109\/T-C.1973.223640","article-title":"Clustering Using a Similarity Measure Based on Shared Near Neighbors.","volume":"C-22","author":"RA Jarvis","year":"1973","journal-title":"IEEE Trans Comput"},{"key":"ref52"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2174\/1389557033487601","article-title":"Fragmental methods in the analysis of biological activities of diverse compound sets.","volume":"3","author":"P Japertas","year":"2003","journal-title":"Mini Rev Med Chem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2307\/3280796","article-title":"A monophasic liquid medium (GD-NRC) for the cultivation of <italic>Leishmania donovani<\/italic>.","volume":"67","author":"GH Al-Khateeb","year":"1981","journal-title":"J Parasitol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1128\/AAC.41.5.972","article-title":"Axenically cultured amastigote forms as an <italic>in vitro<\/italic> model for investigation of antileishmanial agents.","volume":"41","author":"D Sereno","year":"1997","journal-title":"Antimicrob Agent Chemotherapy"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"947","DOI":"10.4269\/ajtmh.1983.32.947","article-title":"Activity of oral drugs against <italic>Leishmania tropica<\/italic> in human macrophages <italic>in vitro<\/italic>.","volume":"32","author":"JD Berman","year":"1983","journal-title":"Am J Trop Med Hyg"},{"key":"ref57","first-page":"207","article-title":"Efficacy of ivermectin on the infectivity of <italic>Leishmania major<\/italic> promastigotes.","volume":"28","author":"KA Rasheid","year":"1998","journal-title":"J Egypt Soc Parasitol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4269\/ajtmh.1995.52.166","article-title":"A randomized, double-blind, clinical trial of topical clotrimazole versus miconazole for treatment of cutaneous leishmaniasis in the eastern province of Saudi Arabia.","volume":"52","author":"EB Larbi","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"ref59","first-page":"15","article-title":"The effects of clofazimine, niclosamide and amphotericin B, on electron transport of <italic>Leishmania donovani<\/italic> promastigotes.","volume":"112","author":"G Datta","year":"2000","journal-title":"Ind J Med Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/S0960-894X(01)00528-5","article-title":"Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.","volume":"11","author":"K Chibale","year":"2001","journal-title":"Bioorg Med Chem Lett"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1128\/AAC.21.6.887","article-title":"<italic>In vitro<\/italic> effects of mycophenolic acid and allopurinol against <italic>Leishmania tropica<\/italic> in human macrophages.","volume":"21","author":"JD Berman","year":"1982","journal-title":"Antimicrob Agents Chemother"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/AAC.34.5.918","article-title":"Berberine derivatives as antileishmanial drugs.","volume":"34","author":"JL Vennerstrom","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/0006-291X(90)92109-D","article-title":"Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis.","volume":"170","author":"T Mukherjee","year":"1990","journal-title":"Biochem Biophys Res Comm"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1128\/AAC.40.3.684","article-title":"Activity and mode of action of acridine compounds against <italic>Leishmania donovani<\/italic>.","volume":"40","author":"CM Mesa-Valle","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"7553","DOI":"10.1016\/j.bmc.2007.09.007","article-title":"Synthesis and <italic>in vitro<\/italic> evaluation of leishmanicidal and trypanocidal activities of N-quinoli-8-yl-arylsulfonamides.","volume":"15","author":"LE da Silva","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1124\/mi.8.2.1","article-title":"Rear-view mirrors and crystal balls: a brief reflection on drug discovery.","volume":"8","author":"JS Lazo","year":"2008","journal-title":"Mol Interv"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1128\/AAC.50.2.474-479.2006","article-title":"Novel Compounds Active against <italic>Leishmania major<\/italic>.","volume":"50","author":"S St. George","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1128\/IAI.68.1.288-293.2000","article-title":"Roles of Endogeneous Gamma Interferon and Macrophage Microbicidal Mechanism in Host Response to Chemotherapy in Experimental Visceral Leishmaniasis.","volume":"68","author":"HW Murray","year":"2000","journal-title":"Infect Immun"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1590\/S0074-02762001000100010","article-title":"Immunochemotherapy in American Cutaneous Leishmaniasis: Immunological aspects before and after treatment.","volume":"96","author":"VPCP Toledo","year":"2001","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1210\/rp.57.1.19","article-title":"Steroidogenic factor 1: an essential mediator of endocrine development.","volume":"57","author":"KL Parker","year":"2002","journal-title":"Recent Prog Horm Res"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"6895","DOI":"10.1158\/0008-5472.CAN-06-0358","article-title":"Polo-like kinase 1: target and regulator of anaphase-promoting complex\/cyclosome-dependent proteolysis.","volume":"66","author":"F Eckerdt","year":"2006","journal-title":"Cancer Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tips.2006.04.003","article-title":"PKD at the crossroads of DAG and PKC signaling.","volume":"27","author":"QJ Wang","year":"2006","journal-title":"Trends Pharm Sci"},{"key":"ref73","first-page":"1255","article-title":"Pentamidine is an inhibitor of PRL phosphatases with anticancer activity.","volume":"1","author":"MK Pathak","year":"2002","journal-title":"Mol Cancer Ther"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/S0021-9258(19)77930-7","article-title":"Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.","volume":"263","author":"CR Loomis","year":"1988","journal-title":"J Biol Chem"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.1046\/j.1432-1033.2002.03287.x","article-title":"A functionally conserved member of the FTZ-F1 nuclear receptor family from <italic>Schistosoma mansoni<\/italic>.","volume":"269","author":"RL de Mendonca","year":"2002","journal-title":"Eur J Biochem"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1471-2164-6-127","article-title":"Comparative analysis of the kinomes of three pathogenic trypanosomatids: <italic>Leishmania major<\/italic>, <italic>Trypanosoma brucei<\/italic> and <italic>Trypanosoma cruzi<\/italic>.","volume":"6","author":"M Parsons","year":"2005","journal-title":"BMC Genomics"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1186\/1471-2164-8-434","article-title":"The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains.","volume":"8","author":"R Brenchley","year":"2007","journal-title":"BMC Genomics"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T07:34:47Z","timestamp":1634110487000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000540"}},"subtitle":[],"editor":[{"given":"Elodie","family":"Ghedin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,11,3]]},"references-count":77,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,11,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000540","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,3]]}}}