{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:10:42Z","timestamp":1793862642702,"version":"4.6.1"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2010,4,27]],"date-time":"2010-04-27T00:00:00Z","timestamp":1272326400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0000672","type":"journal-article","created":{"date-parts":[[2010,4,27]],"date-time":"2010-04-27T20:51:37Z","timestamp":1272401497000},"page":"e672","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":125,"title":["A Non Mouse-Adapted Dengue Virus Strain as a New Model of Severe Dengue Infection in AG129 Mice"],"prefix":"10.1371","volume":"4","author":[{"given":"Grace K.","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jowin K. W.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Trasti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Schul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Yip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0966-842X(01)02288-0","article-title":"Epidemic dengue\/dengue hemorrhagic fever as a public health, social and economic problem in the 21<sup>st<\/sup> century.","volume":"10","author":"DJ Gubler","year":"2002","journal-title":"Trends Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cppeds.2009.01.001","article-title":"Mosquito-borne diseases.","volume":"39","author":"MA Tolle","year":"2009","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(07)61687-0","article-title":"Dengue.","volume":"370","author":"SB Halstead","year":"2007","journal-title":"Lancet"},{"key":"ref4","first-page":"4113","article-title":"Vaccine","volume":"26","year":"2008","journal-title":"Vaccine"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.00035-09","article-title":"Dengue virus pathogenesis: an integrated view.","volume":"22","author":"BEE Martina","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/vim.2006.19.127","article-title":"Autoimmune pathogenesis in dengue virus infection.","volume":"19","author":"CF Lin","year":"2006","journal-title":"Viral Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3181\/0805-RM-147","article-title":"Proteomic analysis of endothelial cell autoantigens recognized by anti-dengue virus nonstructural protein 1 antibodies.","volume":"234","author":"HJ Cheng","year":"2009","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.bbrc.2007.08.137","article-title":"Secreted complement regulatory protein clusterin interacts with dengue virus nonstructural protein 1.","volume":"362","author":"T Kurosu","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1574-695X.2006.00058.x","article-title":"Dengue and dengue hemorrhagic fever: implications of host genetics.","volume":"47","author":"UC Chaturvedi","year":"2006","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e304","DOI":"10.1371\/journal.pntd.0000304","article-title":"Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome.","volume":"2","author":"NT Lan","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1399-0039.2004.00304.x","article-title":"TNF-alpha-308A allele, a possible severity risk factor of hemorrhagic manifestation in dengue fever patients.","volume":"64","author":"MT Fern\u00e1ndez-Mestre","year":"2004","journal-title":"Tissue Antigens"},{"key":"ref12","first-page":"266","article-title":"Molecular evolution, distribution and genetic relationship among the dengue 2 viruses isolated from different clinical severity.","volume":"31","author":"BD Pandey","year":"2000","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1128\/JVI.73.6.4738-4747.1999","article-title":"Dengue virus structural differences that correlate with pathogenesis.","volume":"73","author":"KC Leitmeyer","year":"1999","journal-title":"J Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/QCO.0b013e328329ae32","article-title":"Pathogenesis and prevention of dengue virus infection: state-of-the-art.","volume":"22","author":"GK Tan","year":"2009","journal-title":"Curr Opin Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.antiviral.2008.06.010","article-title":"Mouse models of dengue virus infection and disease.","volume":"80","author":"LE Yauch","year":"2008","journal-title":"Antiviral Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/infdis\/128.1.7","article-title":"Studies on the pathogenesis of dengue infection in monkeys. I. Clinical laboratory responses to primary infection.","volume":"128","author":"SB Halstead","year":"1973","journal-title":"J Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4269\/ajtmh.1978.27.590","article-title":"Experimental infection of chimpanzees with dengue viruses.","volume":"27","author":"WF Scherer","year":"1978","journal-title":"Am J Trop Med Hyg"},{"key":"ref18","article-title":"Dengue virus induced hemorrhage in a nonhuman primate model.","author":"N Onlamoon","year":"2009"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1086\/503372","article-title":"Protection of rhesus monkeys against dengue virus challenge after tetravalent live attenuated dengue virus vaccination.","volume":"193","author":"W Sun","year":"2006","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1128\/JVI.79.9.5516-5528.2005","article-title":"Recombinant, live attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeys.","volume":"79","author":"JE Blaney Jr","year":"2005","journal-title":"J Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.101.2634.640","article-title":"Production of immunity to dengue with virus modified by propagation in mice.","volume":"101","author":"AB Sabin","year":"1945","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/oxfordjournals.aje.a120981","article-title":"Pathogenesis of type 1 dengue virus infection in suckling, weanling and adult mice. 1. The relation of virus replication to interferon and antibody formation.","volume":"89","author":"GA Cole","year":"1969","journal-title":"Am J Epidemiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"468","DOI":"10.4269\/ajtmh.1995.52.468","article-title":"Evaluation of the severe combined immunodeficient (SCID) mouse as an animal model for dengue viral infection.","volume":"52","author":"SJ Wu","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"9729","DOI":"10.1128\/JVI.72.12.9729-9737.1998","article-title":"Study of dengue virus infection in SCID mice engrafted with human K562 cells.","volume":"72","author":"YL Lin","year":"1998","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/viro.1999.9887","article-title":"Development of a novel mouse model for dengue virus infection.","volume":"263","author":"J An","year":"1999","journal-title":"Virology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/viro.2002.1528","article-title":"Genetic basis of attenuation of dengue virus type 4 small plaque mutants with restricted replication in suckling mice and in SCID mice transplanted with human liver cells.","volume":"300","author":"JE Blaney Jr","year":"2002","journal-title":"Virology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"13797","DOI":"10.1128\/JVI.79.21.13797-13799.2005","article-title":"Dengue fever in humanized NOD\/SCID mice.","volume":"79","author":"DA Bente","year":"2005","journal-title":"J Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1099\/0022-1317-52-1-71","article-title":"Inoculation of dengue virus into nude mice.","volume":"52","author":"H Hotta","year":"1981","journal-title":"J Gen Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1128\/JVI.78.6.2701-2710.2004","article-title":"Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity is less critical.","volume":"78","author":"S Shresta","year":"2004","journal-title":"J Virol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1128\/JVI.00062-06","article-title":"Murine model for dengue virus-induced lethal disease with increased vascular permeability.","volume":"80","author":"S Shresta","year":"2006","journal-title":"J Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/JVI.73.1.783-786.1999","article-title":"New mouse model for dengue virus vaccine testing.","volume":"73","author":"AJ Johnson","year":"1999","journal-title":"J Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1086\/511310","article-title":"A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs.","volume":"195","author":"W Schul","year":"2007","journal-title":"J Infect Dis"},{"key":"ref33","first-page":"E12","article-title":"A mouse model for studying dengue virus pathogenesis and immune response.","volume":"1171","author":"KL Williams","year":"2009","journal-title":"Immunology and pathogenesis of viral hemorrhagic fevers: Ann NY Acad Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"954","DOI":"10.4269\/ajtmh.1969.18.954","article-title":"Dengue and chikungunya virus infection in man in Thailand, 1962-1964. I. Observations on hospitalized patients with hemorrhagic fever.","volume":"18","author":"S Nimmannitya","year":"1969","journal-title":"Am J Trop Med Hyg"},{"key":"ref35","first-page":"293","article-title":"Observations related to pathogenesis of dengue hemorrhagic fever. III. Virologic studies of fatal disease.","volume":"42","author":"A Nisalak","year":"1970","journal-title":"Yale J Biol Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.vaccine.2007.12.047","article-title":"Induction of neutralizing antibodies against dengue virus type 2 upon mucosal administration of a recombinant <italic>Lactococcus lactis<\/italic> strain expressing envelope domain III antigen.","volume":"26","author":"AC Sim","year":"2008","journal-title":"Vaccine"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/01.shk.0000093540.78705.71","article-title":"Organ-specific extravasation of albumin-bound Evans blue during nonresuscitated hemorrhagic shock in rats.","volume":"20","author":"J Schumacher","year":"2003","journal-title":"Shock"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrmicro1690","article-title":"Prospects for a dengue virus vaccine.","volume":"5","author":"SS Whitehead","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1574-695X.2008.00420.x","article-title":"Vascular endothelium: the battlefield of dengue viruses.","volume":"53","author":"A Basu","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1574-695X.2000.tb01474.x","article-title":"Cytokine cascade in Dengue haemorrhagic fever: implications for pathogenesis.","volume":"28","author":"UC Chaturvedi","year":"2000","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jcv.2009.04.004","article-title":"Early clinical and biological features of severe clinical manifestations of dengue in Vietnamese adults.","volume":"45","author":"PT Binh","year":"2009","journal-title":"J Clin Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1371\/journal.pntd.0000196","article-title":"Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness.","volume":"2","author":"L Tanner","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1128\/JVI.02575-06","article-title":"Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage.","volume":"81","author":"HC Chen","year":"2007","journal-title":"J Virol"},{"key":"ref44","first-page":"E42","article-title":"Dengue hemorrhage in a mouse model.","volume":"1171","author":"BA Wu-Hsieh","year":"2009","journal-title":"Immunology and pathogenesis of viral hemorrhagic fevers: Ann NY Acad Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"8638","DOI":"10.1128\/JVI.00581-09","article-title":"Humanized mice show clinical signs of dengue fever according to infecting virus genotype.","volume":"83","author":"J Mota","year":"2009","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"793","DOI":"10.4269\/ajtmh.1993.48.793","article-title":"Unusual neurologic manifestations occurring during dengue fever infection.","volume":"48","author":"O Patey","year":"1993","journal-title":"Am J Trop Med Hyg"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4269\/ajtmh.1996.54.256","article-title":"Dengue encephalitis: a true entity?","volume":"54","author":"LC Lum","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"ref48","first-page":"57","article-title":"Systemic vascular leakage associated with dengue infections-the clinical perspective.","volume":"338","author":"DT Trung","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1365-2249.1993.tb05901.x","article-title":"Combination of low concentrations of cytokines and acute agonists synergize in increasing the permeability of endothelial monolayers.","volume":"91","author":"HL Beynon","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.4049\/jimmunol.0800672","article-title":"Deletion of the C-terminal region of dengue virus nonstructural protein 1 (NS1) abolishes anti-NS1-mediated platelet dysfunction and bleeding tendency.","volume":"183","author":"MC Chen","year":"2009","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.molimm.2009.08.033","article-title":"Anti-dengue virus non-structural protein 1 antibodies recognize protein disulfide isomerise on platelets and inhibit platelet aggregation.","volume":"47","author":"HJ Cheng","year":"2009","journal-title":"Mol Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"841","DOI":"10.4269\/ajtmh.2009.80.841","article-title":"Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages.","volume":"80","author":"S Honda","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref53","first-page":"E24","article-title":"A re-evaluation of the mechanisms leading to dengue hemorrhagic fever.","volume":"1171","author":"S Noisakran","year":"2009","journal-title":"Immunology and pathogenesis of viral hemorrhagic fevers: Ann NY Acad Sci"}],"updated-by":[{"DOI":"10.1371\/annotation\/03774b36-c453-404a-b295-7b91bfd9cebd","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T00:00:00Z","timestamp":1288137600000}}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T02:10:05Z","timestamp":1591236605000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000672"}},"subtitle":[],"editor":[{"given":"Eva","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,4,27]]},"references-count":53,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,4,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000672","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/03774b36-c453-404a-b295-7b91bfd9cebd","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,27]]}}}