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Pathol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.micinf.2004.03.002","article-title":"Protective role of ETA endothelin receptors during the acute phase of Trypanosoma cruzi infection in rats.","volume":"6","author":"ER Camargos","year":"2004","journal-title":"Microbes Infect"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0002-9149(01)01502-8","article-title":"High plasma immunoreactive endothelin levels in patients with Chagas&apos; cardiomyopathy.","volume":"87","author":"OA Salomone","year":"2001","journal-title":"Am J Cardiol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1128\/IAI.73.4.2496-2503.2005","article-title":"Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease.","volume":"73","author":"HB Tanowitz","year":"2005","journal-title":"Infect Immun"},{"key":"ref80","first-page":"1403","article-title":"Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy.","volume":"144","author":"ZA Andrade","year":"1994","journal-title":"Am J Path"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0166-6851(88)90076-X","article-title":"Alterations in intracellular calcium following infection of human endothelial cells with Trypanosoma cruzi.","volume":"29","author":"SA Morris","year":"1988","journal-title":"Molec Biochem Parasit"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1161\/01.CIR.82.6.1900","article-title":"Pathophysiological insights into the cardiomyopathy of Chagas&apos; disease.","volume":"82","author":"SA Morris","year":"1990","journal-title":"Circulation"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0014-4894(92)90140-6","article-title":"Trypanosoma cruzi: alteration of cAMP metabolism following infection of human endothelial cells.","volume":"74","author":"SA Morris","year":"1992","journal-title":"Exp Parasitol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4049\/jimmunol.148.1.239","article-title":"Coculture of human peripheral blood mononuclear cells with Trypanosoma cruzi leads to proliferation of lymphocytes and cytokine production.","volume":"184","author":"WC Van Voorhis","year":"1992","journal-title":"J Immunol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0167-5699(89)90270-3","article-title":"Cytokines as communication signals between leukocytes and endothelial cells.","volume":"10","author":"A Mantovani","year":"1989","journal-title":"Immunol Today"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1084\/jem.160.2.618","article-title":"Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.","volume":"160","author":"MP Bevilacqua","year":"1984","journal-title":"J Exp Med"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1084\/jem.163.6.1595","article-title":"Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.","volume":"163","author":"RL Nachman","year":"1986","journal-title":"J Exp Med"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1172\/JCI112266","article-title":"A neuraminidase from Trypanosoma cruzi removes sialic acid from the surface of mammalian myocardial and endothelial cells.","volume":"77","author":"P Libby","year":"1986","journal-title":"J Clin Invest"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/infdis\/171.2.493","article-title":"Trypanosoma cruzi induces endothelin release from endothelial cells.","volume":"171","author":"M Wittner","year":"1995","journal-title":"J Infect Dis"},{"key":"ref90","first-page":"94","article-title":"Tripanosomiasis cruzi; anarqu\u00eda angiotopogr\u00e1fica por descapilarizaci\u00f3n mesenquimorreactiva: cofactor patog\u00e9nico de la miocardiopatia cr\u00f3nica.","volume":"61","author":"ME J\u00f6rg","year":"1974","journal-title":"Pren M\u00e9d Argent"},{"key":"ref91","first-page":"81","article-title":"Coronariografia post mortem na cardite chag\u00e1sica cr\u00f4nica: correla\u00e7\u00e3o an\u00e1tomo-radiol\u00f3gica.","volume":"34","author":"CS Ferreira","year":"1980","journal-title":"Arq Bras Cardiol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/0002-9149(92)90505-S","article-title":"Myocardial perfusion abnormalities in chronic Chagas&apos; disease as detected by Thallium-201 scintigraphy.","volume":"69","author":"JA Marin-Neto","year":"1992","journal-title":"Am J Cardiol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0002-8703(85)90598-8","article-title":"Increased capacity of the coronary arteries in chronic Chagas&apos; heart disease: further support for the neurogenic pathogenesis concept.","volume":"109","author":"JS Oliveira","year":"1985","journal-title":"Am Heart J"},{"key":"ref94","first-page":"226","article-title":"Evaluacion de la performance cardiaca y perfusion miocardica con radiotrazadores en la cardiopatia chagasica cronica.","volume":"17","author":"R Castro","year":"1988","journal-title":"Rev Fed Argent Cardiol"},{"key":"ref95","first-page":"631","article-title":"Chagas&apos; heart disease in the USA: Thallium abnormalities mimic coronary artery disease.","volume":"84","author":"JM Hagar","year":"1991","journal-title":"Circulation"},{"key":"ref96","first-page":"187","article-title":"Valoraci\u00f3n del flujo mioc\u00e1rdico con Rb 86, en pacientes con cardiopatia chagasica, con insuficiencia coronaria y en controles normales. Parte 1: estudios basales.","volume":"27","author":"E Kuschnir","year":"1974","journal-title":"Arq Bras Cardiol"},{"key":"ref97","first-page":"721","article-title":"Valoraci\u00f3n del flujo mioc\u00e1rdico con Rb 86, en pacientes con cardiopatia chagasica, con insuficiencia coronaria y en controles normales. Parte 2: respuesta al ejercicio y la cardiotonificaci\u00f3n aguda.","volume":"27","author":"E Kuschnir","year":"1974","journal-title":"Arq Bras Cardiol"},{"key":"ref98","first-page":"362","article-title":"Myocardial perfusion disturbances detected by Tc-99m microspheres scintigraphy in Chagas&apos; patients with angiographically normal coronary arteries.","volume":"15","author":"JA Marin-Neto","year":"1994","journal-title":"Eur Heart J"},{"key":"ref99","first-page":"41","article-title":"Myocardial infarct without coronary obstruction associated with chronic Chagas cardiopathy.","volume":"33","author":"LG Vianna","year":"1979","journal-title":"Arq Bras Cardiol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0002-8703(95)90122-1","article-title":"Coronary vascular reactivity is abnormal in patients with Chagas&apos; disease.","volume":"129","author":"FW Torres","year":"1995","journal-title":"Am Heart J"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/0002-9149(88)90148-8","article-title":"Basement membrane thickening in cardiac myocytes and capillaries in chronic Chagas&apos; disease.","volume":"61","author":"VJ Ferrans","year":"1988","journal-title":"Am J Cardiol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00583587","article-title":"Hypertensive diabetic cardiomyopathy in the rat: ultrastructural features.","volume":"398","author":"SM Factor","year":"1983","journal-title":"Virchows Arch A Pathol Anat Histopatol"},{"key":"ref103","first-page":"383","article-title":"Severe arteriolar dilatation and ischemic lesions in chronic Chagas&apos; cardiopathy: a 3D confocal laser microscopic study.","volume":"31","author":"ML Higuchi","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/hrt.82.3.279","article-title":"Different microcirculatory and interstitial matrix patterns in idiopathic dilated cardiomyopathy and Chagas&apos; disease: a three dimensional confocal microscopy study.","volume":"82","author":"ML Higuchi","year":"1999","journal-title":"Heart"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0002-9149(00)01133-4","article-title":"Relation of regional sympathetic denervation and myocardial perfusion disturbance to wall motion impairment in Chagas&apos; cardiomyopathy.","volume":"86","author":"MV Sim\u00f5es","year":"2000","journal-title":"Am J Cardiol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijcard.2004.03.087","article-title":"Ventricular tachycardia in Chagas&apos; disease: a comparison of clinical, angiographic, electrophysiologic and myocardial perfusion disturbances between patients presenting with either sustained or nonsustained forms.","volume":"102","author":"AV Sarabanda","year":"2005","journal-title":"Int J Cardiol"},{"key":"ref107","first-page":"150","article-title":"Comparative connective tissue structure-function relationships in biologic pumps.","volume":"58","author":"SM Factor","year":"1988","journal-title":"Lab Invest"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/jmcc.1994.1036","article-title":"Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms.","volume":"26","author":"KT Weber","year":"1994","journal-title":"J Mol Cell Cardiol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/00004872-199816070-00018","article-title":"Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans.","volume":"16","author":"MA Rossi","year":"1998","journal-title":"J Hypertens"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/1054-8807(96)00005-1","article-title":"Pathogenesis of chronic Chagas&apos;myocarditis: an overview.","volume":"5","author":"MA Rossi","year":"1996","journal-title":"Cardiovasc Pathol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.170.3.655","article-title":"Tumor necrosis factor\/cachetin plays a key role in bleomycin-induced pneumopathy and fibrosis.","volume":"170","author":"PF Piguet","year":"1989","journal-title":"J Exp Med"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0167-5699(91)90107-5","article-title":"Fibrogenic cytokines: the role of immune mediators in the development of scar tissue.","volume":"12","author":"EJ Kovacs","year":"1991","journal-title":"Immunol Today"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1056\/NEJM199404213301607","article-title":"Immune mechanism of cardiac disease.","volume":"330","author":"LG Lange","year":"1994","journal-title":"New Engl J Med"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/S0006-291X(88)81021-0","article-title":"Fibroblast growth factors are present in adult cardiac myocytes in vivo.","volume":"157","author":"E Speir","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/384353a0","article-title":"Inhibition of myocardial endothelin pathway improves long-term survival in heart failure.","volume":"384","author":"S Sakai","year":"1996","journal-title":"Nature"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/art.1780340807","article-title":"Endothelin, an endothelial-dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic action.","volume":"34","author":"MB Kahaleh","year":"1991","journal-title":"Arthritis Rheum"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"27S","DOI":"10.1016\/S0002-9343(98)00208-3","article-title":"Evolution of angiotensin-converting enzyme inhibition in hypertension, heart failure, and vascular protection.","volume":"105","author":"WW Parmley","year":"1998","journal-title":"Am J Med"},{"key":"ref118","first-page":"417","article-title":"Treatment of mild and moderate cardiac failure with captopril. A multicenter study.","volume":"58","author":"M Batlouni","year":"1992","journal-title":"Arq Bras Cardiol"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/oxfordjournals.eurheartj.a060301","article-title":"Chagas cardiomyopathy and captopril.","volume":"13","author":"RR Roberti","year":"1992","journal-title":"Eur Heart J"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000176409","article-title":"Noinvasive predictors of mortality for patients with Chagas&apos; heart disease: a multivariate stepwise logistic regression study.","volume":"84","author":"RB Bestetti","year":"1994","journal-title":"Cardiology"},{"key":"ref121","first-page":"273","article-title":"Beneficial effects of enalapril on the diastolic ventricular function in Chagas myocardiopathy.","volume":"60","author":"FE Szajnbok","year":"1993","journal-title":"Arq Bras Cardiol"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijcard.2008.04.043","article-title":"The use of Levosimendan for myocardiopathy due to acute Chagas&apos; disease.","volume":"136","author":"R de March Ronsoni","year":"2009","journal-title":"Int J Cardiol"},{"key":"ref123","first-page":"59","article-title":"Alpha and beta-adrenergic blocking drugs.","author":"WH Frishman","year":"1997"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s00436-004-1080-1","article-title":"Effects of early and late verapamil administration on the development of cardiomyopathy in experimental chronic Trypanosoma cruzi (Brazil strain) infection.","volume":"92","author":"AP De Souza","year":"2004","journal-title":"Parasitol Res"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/S0020-7519(02)00136-4","article-title":"Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas&apos; disease.","volume":"32","author":"LA Jelicks","year":"2002","journal-title":"Int J Parasitol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T02:37:20Z","timestamp":1685759840000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000674"}},"subtitle":[],"editor":[{"given":"Simon","family":"Brooker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,8,31]]},"references-count":125,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,8,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000674","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,31]]}}}