{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:04:43Z","timestamp":1778699083455,"version":"3.51.4"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:00:00Z","timestamp":1276560000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0000712","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T20:24:42Z","timestamp":1276633482000},"page":"e712","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Immunity to Lutzomyia intermedia Saliva Modulates the Inflammatory Environment Induced by Leishmania braziliensis"],"prefix":"10.1371","volume":"4","author":[{"given":"Tatiana R.","family":"de Moura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiano","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele C.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia W.","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi F.","family":"Fukutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda O.","family":"Novais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel","family":"Barral-Netto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Brodskyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldina","family":"Barral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila I.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,6,15]]},"reference":[{"key":"ref1","year":"2010"},{"key":"ref2","first-page":"313","article-title":"New World Leishmaniasis;","author":"R Lainson","year":"2005"},{"key":"ref3","first-page":"291","article-title":"Ecologia das Leishmanioses: transmissores de leishmaniose tegumentar americana.","author":"EF Rangel","year":"2003"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.3344436","article-title":"Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity.","volume":"239","author":"RG Titus","year":"1988","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1084\/jem.188.10.1941","article-title":"Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis.","volume":"188","author":"Y Belkaid","year":"1998","journal-title":"J Exp Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"969","DOI":"10.4049\/jimmunol.165.2.969","article-title":"A natural model of Leishmania major infection reveals a prolonged \u201csilent\u201d phase of parasite amplification in the skin before the onset of lesion formation and immunity.","volume":"165","author":"Y Belkaid","year":"2000","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6704","DOI":"10.1073\/pnas.97.12.6704","article-title":"Delayed-type hypersensitivity to Phlebotomus papatasi sand fly bite: An adaptive response induced by the fly?","volume":"97","author":"Y Belkaid","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.micinf.2005.01.013","article-title":"Sand fly specificity of saliva-mediated protective immunity in Leishmania amazonensis-BALB\/c mouse model.","volume":"7","author":"M Thiakaki","year":"2005","journal-title":"Microbes Infect"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"7845","DOI":"10.1073\/pnas.0712153105","article-title":"Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model.","volume":"105","author":"R Gomes","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1371\/journal.pntd.0000084","article-title":"Enhanced Leishmania braziliensis Infection Following Pre-Exposure to Sandfly Saliva.","volume":"1","author":"TR de Moura","year":"2007","journal-title":"PLoS Negl Trop Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1017\/S003118200400681X","article-title":"Detection of species-specific antibody response of humans and mice bitten by sand flies.","volume":"130","author":"I Rohousova","year":"2005","journal-title":"Parasitology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4269\/ajtmh.2005.72.94","article-title":"Inflammatory cell infiltration and high antibody production in BALB\/c mice caused by natural exposure to Lutzomyia longipalpis bites.","volume":"72","author":"F Silva","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1128\/IAI.72.3.1298-1305.2004","article-title":"Lutzomyia longipalpis salivary gland homogenate impairs cytokine production and costimulatory molecule expression on human monocytes and dendritic cells.","volume":"72","author":"DJ Costa","year":"2004","journal-title":"Infect Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-3024.2003.00623.x","article-title":"Immunomodulatory effects of Maxadilan and Phlebotomus papatasi sand fly salivary gland lysates on human primary in vitro immune responses.","volume":"25","author":"KA Rogers","year":"2003","journal-title":"Parasite Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0001-706X(95)00112-R","article-title":"The chemotactic effect of Phlebotomus duboscqi (Diptera: Psychodidae) salivary gland lysates to murine monocytes.","volume":"60","author":"CO Anjili","year":"1995","journal-title":"Acta Trop"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/expr.1998.4272","article-title":"Salivary gland lysate from the sand fly Lutzomyia longipalpis suppresses the immune response of mice to sheep red blood cells in vivo and concanavalin A in vitro.","volume":"89","author":"RG Titus","year":"1998","journal-title":"Exp Parasitol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.vaccine.2005.07.085","article-title":"From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library.","volume":"24","author":"F Oliveira","year":"2006","journal-title":"Vaccine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2172-9-12","article-title":"Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva.","volume":"9","author":"MJ Menezes","year":"2008","journal-title":"BMC Immunol"},{"key":"ref19","first-page":"327","article-title":"Inflammation induced by bacterial cell wall fragments in the rat air pouch. Comparison of rat strains and measurement of arachidonic acid metabolites.","volume":"121","author":"S Yoshino","year":"1985","journal-title":"Am J Pathol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8346","DOI":"10.4049\/jimmunol.175.12.8346","article-title":"Saliva from Lutzomyia longipalpis induces CC chemokine ligand 2\/monocyte chemoattractant protein-1 expression and macrophage recruitment.","volume":"175","author":"CR Teixeira","year":"2005","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1128\/IAI.73.9.5827-5834.2005","article-title":"Toward a novel experimental model of infection to study American cutaneous leishmaniasis caused by Leishmania braziliensis.","volume":"73","author":"TR de Moura","year":"2005","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1086\/339260","article-title":"Leishmania-induced cellular recruitment during the early inflammatory response: modulation of proinflammatory mediators.","volume":"185","author":"C Matte","year":"2002","journal-title":"J Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nri933","article-title":"The immunology of susceptibility and resistance to Leishmania major in mice.","volume":"2","author":"D Sacks","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-3083.2007.01964.x","article-title":"Role of sand fly saliva in human and experimental leishmaniasis: current insights.","volume":"66","author":"BB Andrade","year":"2007","journal-title":"Scand J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.194.3.331","article-title":"Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein.","volume":"194","author":"JG Valenzuela","year":"2001","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.1159194","article-title":"In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies.","volume":"321","author":"NC Peters","year":"2008","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"898","DOI":"10.4049\/jimmunol.169.2.898","article-title":"Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major.","volume":"169","author":"E Aga","year":"2002","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.4049\/jimmunol.173.11.6521","article-title":"Cutting edge: neutrophil granulocyte serves as a vector for Leishmania entry into macrophages.","volume":"173","author":"G van Zandbergen","year":"2004","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1098\/rstb.1994.0097","article-title":"Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis.","volume":"345","author":"A Warburg","year":"1994","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/S0965-1748(02)00109-1","article-title":"Salivary gland hyaluronidase in various species of phlebotomine sand flies (Diptera: psychodidae).","volume":"32","author":"P Cerna","year":"2002","journal-title":"Insect Biochem Mol Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.1371\/journal.pntd.0000294","article-title":"Hyaluronidase of bloodsucking insects and its enhancing effect on leishmania infection in mice.","volume":"2","author":"V Volfova","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.2741\/2853","article-title":"The role of chemokines in neutrophil biology.","volume":"13","author":"Y Kobayashi","year":"2008","journal-title":"Front Biosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.4049\/jimmunol.154.11.6048","article-title":"Expression and biologic characterization of the murine chemokine KC.","volume":"154","author":"CR Bozic","year":"1995","journal-title":"J Immunol"},{"key":"ref35","article-title":"Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators.","author":"CA Reichel","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.4049\/jimmunol.157.8.3598","article-title":"Synthesis of the CC-chemokines MIP-1alpha, MIP-1beta, and RANTES is associated with a type 1 immune response.","volume":"157","author":"S Schrum","year":"1996","journal-title":"J Immunol"},{"key":"ref37","first-page":"577","article-title":"The role of lymphocytes in the neutrophil migration induced by ovalbumin in immunized rats.","volume":"84","author":"A Klein","year":"1995","journal-title":"Immunology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/sj.bjp.0704403","article-title":"Tumour necrosis factor-alpha and leukotriene B(4) mediate the neutrophil migration in immune inflammation.","volume":"134","author":"C Canetti","year":"2001","journal-title":"Br J Pharmacol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1189\/jlb.0404237","article-title":"MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4.","volume":"78","author":"CD Ramos","year":"2005","journal-title":"J Leukoc Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e1000555","DOI":"10.1371\/journal.ppat.1000555","article-title":"Proteophosophoglycans regurgitated by Leishmania-infected sand flies target the L-arginine metabolism of host macrophages to promote parasite survival.","volume":"5","author":"M Rogers","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1084\/jem.173.1.49","article-title":"A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva.","volume":"173","author":"J Samuelson","year":"1991","journal-title":"J Exp Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1128\/IAI.64.12.5442-5445.1996","article-title":"Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB\/c mice.","volume":"64","author":"HC Lima","year":"1996","journal-title":"Infect Immun"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1128\/IAI.59.5.1592-1598.1991","article-title":"Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice.","volume":"59","author":"CM Theodos","year":"1991","journal-title":"Infect Immun"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature02675","article-title":"Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG.","volume":"430","author":"ME Rogers","year":"2004","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4269\/ajtmh.2007.76.88","article-title":"Effect of Lutzomyia longipalpis salivary gland extracts on leukocyte migration induced by Leishmania major.","volume":"76","author":"MC Monteiro","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1128\/IAI.73.2.1191-1195.2005","article-title":"Distinct Leishmania braziliensis Isolates Induce Different Paces of Chemokine Expression Patterns.","volume":"73","author":"MJ Teixeira","year":"2005","journal-title":"Infect Immun"},{"key":"ref47","article-title":"CXCL10 production by human monocytes in response to Leishmania braziliensis infection.","author":"DA Vargas-Inchaustegui","year":"2009","journal-title":"Infect Immun"},{"key":"ref48","first-page":"143","article-title":"Blood-feeding arthropods: live syringes or invertebrate pharmacologists?","volume":"4","author":"JM Ribeiro","year":"1995","journal-title":"Infect Agents Dis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.290.5495.1351","article-title":"Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies.","volume":"290","author":"S Kamhawi","year":"2000","journal-title":"Science"},{"key":"ref50","article-title":"Neutrophils and Macrophages Cooperate in Host Resistance against Leishmania braziliensis Infection.","author":"FO Novais","year":"2009","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.4049\/jimmunol.168.7.3195","article-title":"IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking.","volume":"168","author":"JH Dufour","year":"2002","journal-title":"J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.4049\/jimmunol.166.2.1141","article-title":"The role of IL-10 in promoting disease progression in leishmaniasis.","volume":"166","author":"MM Kane","year":"2001","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1084\/jem.194.10.1497","article-title":"The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.","volume":"194","author":"Y Belkaid","year":"2001","journal-title":"J Exp Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s004300100084","article-title":"Chemokines, natural killer cells and granulocytes in the early course of Leishmania major infection in mice.","volume":"190","author":"K Muller","year":"2001","journal-title":"Med Microbiol Immunol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T16:29:50Z","timestamp":1711556990000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000712"}},"subtitle":[],"editor":[{"given":"Genevieve","family":"Milon","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,6,15]]},"references-count":54,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,6,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000712","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,15]]}}}