{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:14:36Z","timestamp":1791332076742,"version":"4.3.1"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T00:00:00Z","timestamp":1274745600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0000718","type":"journal-article","created":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T22:39:14Z","timestamp":1274827154000},"page":"e718","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":103,"title":["\u201cManifesto\u201d for Advancing the Control and Elimination of Neglected Tropical Diseases"],"prefix":"10.1371","volume":"4","author":[{"given":"Peter J.","family":"Hotez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Pecoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,5,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMra064142","article-title":"Control of neglected tropical diseases.","volume":"357","author":"PJ Hotez","year":"2007","journal-title":"N Engl J Med"},{"key":"ref2","article-title":"Forgotten People, Forgotten Diseases: the Neglected Tropical Diseases and their Impact on Global Health and Development.","volume":"218","author":"PJ Hotez","year":"2008","journal-title":"ASM Press"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/S0140-6736(09)60233-6","article-title":"Rescuing the bottom billion through control of neglected tropical diseases.","volume":"373","author":"PJ Hotez","year":"2009","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e559","DOI":"10.1371\/journal.pntd.0000559","article-title":"Empowering women and improving female reproductive health through control of neglected tropical diseases.","volume":"3","author":"PJ Hotez","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref5","author":"M Moran","year":"2009"},{"key":"ref6","article-title":"The Millennium Development Goals Report.","year":"2009"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1016\/j.vaccine.2006.05.008","article-title":"The antipoverty vaccines.","volume":"24","author":"PJ Hotez","year":"2006","journal-title":"Vaccine"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.biologicals.2009.02.008","article-title":"Neglected tropical disease vaccines.","volume":"37","author":"PJ Hotez","year":"2009","journal-title":"Biologicals"},{"key":"ref9","article-title":"Investing in health research and development. Document 10. TDR\/Gen\/96.1","year":"1996"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/S0140-6736(06)68672-8","article-title":"Global framework on essential health R&amp;D.","volume":"367","author":"P Chirac","year":"2006","journal-title":"Lancet"},{"key":"ref11"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/clpt.2009.16","article-title":"Mass drug administration and integrated control for the world&apos;s high-prevalence neglected tropical diseases.","volume":"85","author":"PJ Hotez","year":"2009","journal-title":"Clin Pharmacol Therap"},{"key":"ref13","first-page":"333","article-title":"Global programme to eliminate lymphatic filariasis.","volume":"83","year":"2008","journal-title":"Wkly Epidemiol Rec"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e497","DOI":"10.1371\/journal.pntd.0000497","article-title":"Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: First evidence from studies in Mali and Senegal.","volume":"3","author":"L Diawara","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.ophtha.2009.04.041","article-title":"Complete local elimination of infectious trachoma from severely affected communities after six biannual mass azithromycin distributions.","volume":"116","author":"JB Biebesheimer","year":"2009","journal-title":"Ophthalmology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e336","DOI":"10.1371\/journal.pmed.0020336","article-title":"\u201cRapid impact\u201d interventions: How a policy of integrated control for Africa&apos;s neglected tropical diseases could benefit the poor.","volume":"2","author":"DH Molyneux","year":"2005","journal-title":"PLoS Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1371\/journal.pmed.0030102","article-title":"Incorporating a rapid impact package for neglected tropical diseases with programs for HIV\/AIDS, tuberculosis and malaria, a comprehensive pro-poor health policy and strategy for the developing world.","volume":"3","author":"PJ Hotez","year":"2006","journal-title":"PLoS Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e341","DOI":"10.1371\/journal.pmed.0020341","article-title":"The global campaign to eliminate leprosy.","volume":"2","author":"A Rinaldi","year":"2005","journal-title":"PLoS Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4269\/ajtmh.2008.79.474","article-title":"Dracunculiasis eradication: neglected no longer.","volume":"79","author":"DR Hopkins","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4269\/ajtmh.2005.72.67","article-title":"Elimination of dengue by community programs using Mesocycyclops (Copepoda) against Aedes aegypti in central Vietham.","volume":"72","author":"SN Vu","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/S0140-6736(08)60836-3","article-title":"Trachoma.","volume":"37","author":"HR Wright","year":"2008","journal-title":"Lancet"},{"key":"ref22","first-page":"437","article-title":"Control of human African trypanosomiasis: back to square one (French).","volume":"61","author":"J Jannin","year":"2001","journal-title":"Med Trop (Mars)"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0140-6736(09)61117-X","article-title":"Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial.","volume":"374","author":"G Priotto","year":"2009","journal-title":"Lancet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1590\/S0074-02762009000900007","article-title":"Elimination of Chagas disease transmission: perspectives.","volume":"104","author":"JC Dias","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e488","DOI":"10.1371\/journal.pntd.0000488","article-title":"Feasibility, drug safety, and effectiveness of etiological treatment programs for chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Medecins Sans Frontieres.","volume":"3","author":"O Yun","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref26","first-page":"105","article-title":"Can visceral leishmaniasis be eliminated from Asia?","volume":"45","author":"JA Narain","year":"2008","journal-title":"J Vector Borne Dis"},{"key":"ref27","first-page":"255","article-title":"Insect vectors of Leishmania: distribution, physiology and their control.","volume":"45","author":"U Sharma","year":"2008","journal-title":"J Vector Borne Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/CMR.19.1.111-126.2006","article-title":"Drug Resistance in Leishmaniasis.","volume":"19","author":"SL Croft","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e211","DOI":"10.1371\/journal.pmed.0020211","article-title":"Visceral Leishmaniasis: new health tools are needed.","volume":"2","author":"A Hailu","year":"2005","journal-title":"PLoS Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3748\/wjg.14.666","article-title":"Opisthorchias viverrini: the carcinogenic human liver fluke.","volume":"14","author":"N Kaewpitoon","year":"2008","journal-title":"World J Gastroenterol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.clindermatol.2008.09.021","article-title":"Buruli ulcer.","volume":"27","author":"F Portaels","year":"2009","journal-title":"Clin Dermatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/S0140-6736(09)60919-3","article-title":"An assessment of interactions between global health initiatives and country health systems.","volume":"373","year":"2009","journal-title":"Lancet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1017\/S1462399409001252","article-title":"Trypanocidal drugs: mechanisms, resistance and new targets.","volume":"11","author":"SR Wilkinson","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.1112181","article-title":"Comparative genomics of trypanosomatid parasitic protozoa.","volume":"309","author":"NM El-Sayed","year":"2005","journal-title":"Science"},{"key":"ref35","article-title":"The TDR Targets Database."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1365-3156.1996.tb00084.x","article-title":"Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436.","volume":"1","author":"FW Jennings","year":"1996","journal-title":"Trop Med Int Health"},{"key":"ref37","article-title":"Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches.","author":"JA Urbina","year":"2009"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1590\/S0074-02762009000900034","article-title":"Two approaches to discovering and developing new drugs for Chagas disease.","volume":"104","author":"JH McKerrow","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1517\/14728210903153862","article-title":"Developments in the treatment of visceral leishmaniasis.","volume":"14","author":"ML Den Boer","year":"2009","journal-title":"Expert Opin Emerg Drugs"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1590\/S0074-02762009000900036","article-title":"Perspectives of vaccination in Chagas disease revisited.","volume":"104","author":"EP Camargo","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pt.2005.03.006","article-title":"Second-generation vaccines against leishmaniasis.","volume":"21","author":"RN Coler","year":"2005","journal-title":"Trends Parasitol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1586\/14760584.4.5.657","article-title":"Vaccine prospects for amebiasis.","volume":"4","author":"OA Chaudhry","year":"2005","journal-title":"Expert Rev Vaccines"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00430-009-0109-6","article-title":"Buruli ulcer disease: prospects for a vaccine.","volume":"198","author":"K Huygen","year":"2009","journal-title":"Med Microbiol Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"7125","DOI":"10.1016\/j.vaccine.2009.09.054","article-title":"Protective effect of the combination BCG vaccination and rifampicin prophylaxis in leprosy prevention.","volume":"27","author":"RP Schuring","year":"2009","journal-title":"Vaccine"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S1473-3099(09)70254-3","article-title":"Progress towards a dengue vaccine.","volume":"9","author":"DP Webster","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"ref46","first-page":"129","article-title":"Dengue vaccine candidates in development.","volume":"338","author":"AP Durbin","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.299.16.1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis.","volume":"299","author":"J Keiser","year":"2008","journal-title":"JAMA"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature06722","article-title":"A new class of anthelmintics effective against drug-resistant nematodes.","volume":"452","author":"R Kaminsky","year":"2008","journal-title":"Nature"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e499","DOI":"10.1371\/journal.pntd.0000499","article-title":"The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist.","volume":"3","author":"Y Hu","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e614","DOI":"10.1371\/journal.pntd.0000614","article-title":"Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice.","volume":"4","author":"Y Hu","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1473-3099(06)70630-2","article-title":"Hookworm vaccines: past, present, and future.","volume":"6","author":"A Loukas","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nm1737","article-title":"Identification of oxadiazoles as new drug leads for the control of schistosomiasis.","volume":"14","author":"AA Sayed","year":"2008","journal-title":"Nat Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e478","DOI":"10.1371\/journal.pntd.0000478","article-title":"Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.","volume":"3","author":"MH Abdulla","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke Schistosoma mansoni.","volume":"460","author":"M Berriman","year":"2009","journal-title":"Nature"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1128\/CMR.00046-07","article-title":"Current status of vaccines for schistosomiasis.","volume":"21","author":"DP McManus","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1017\/S0031182009991600","article-title":"Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution.","volume":"136","author":"J Utzinger","year":"2009","journal-title":"Parasitology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/sj.eye.6701962","article-title":"Ivermectin and onchocerciasis: is it all solved?","volume":"19","author":"AD Hopkins","year":"2005","journal-title":"Eye (Lond)"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/QCO.0b013e328315cde7","article-title":"Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis.","volume":"21","author":"A Hoerauf","year":"2008","journal-title":"Curr Opin Infect Dis"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nbt0806-919","article-title":"Partnering for better microbial diagnostics.","volume":"24","author":"MD Perkins","year":"2006","journal-title":"Nat Biotechnol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1377\/hlthaff.28.6.1760","article-title":"A business plan to help the \u2018global South\u2019 in its fight against neglected diseases.","volume":"28","author":"SE Frew","year":"2009","journal-title":"Health Aff (Millwood)"},{"key":"ref61","article-title":"The George Institute for International Health.","journal-title":"Registering New Drugs: The African Context"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0140-6736(07)61301-4","article-title":"Neglected diseases, civil conflicts, and the right to health.","volume":"370","author":"C Beyrer","year":"2007","journal-title":"Lancet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e606","DOI":"10.1371\/journal.pntd.0000606","article-title":"Neglected Infections of Poverty among the Indigenous Peoples of the Arctic.","volume":"4","author":"PJ Hotez","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1377\/hlthaff.28.6.1720","article-title":"Neglected diseases amid wealth in the United States and Europe.","volume":"28","author":"P Hotez","year":"2009","journal-title":"Health Aff (Millwood)"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1371\/journal.pntd.0000071","article-title":"Eliminating lymphatic filariasis, onchocerciasis, and schistosomiasis from the Americas: breaking a historical legacy of slavery.","volume":"1","author":"PJ Lammie","year":"2007","journal-title":"PLoS Negl Trop Dis"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.1371\/journal.pntd.0000256","article-title":"Neglected infections of poverty in the United States of America.","volume":"2","author":"PJ Hotez","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref67","article-title":"Gandhi&apos;s hookworms.","author":"PJ Hotez","year":"2010"},{"key":"ref68","first-page":"424","article-title":"The Life of Mahatma Gandhi. HarperCollins.","volume":"43","author":"L Fischer","year":"1997","journal-title":"Part II"},{"key":"ref69","article-title":"The bottom billion: Why the poorest countries are failing and what can be done about it","author":"P Collier","year":"2007"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"e346","DOI":"10.1371\/journal.pntd.0000346","article-title":"Waging peace through neglected tropical disease control: a U.S. foreign policy for the bottom billion.","volume":"3","author":"PJ Hotez","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref71","article-title":"Sleeping Sickness.","year":"2005"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1365-3156.2003.01192.x","article-title":"Research for control: the onchocerciasis experience.","volume":"9","author":"JHF Remme","year":"2004","journal-title":"Trop Med Int Health"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1179\/000349802125000664","article-title":"Monitoring community-directed treatment programmes for sustainability: lessons from the African Programme for Onchocerciasis Control (APOC).","volume":"96","author":"UV Amazigo","year":"2002","journal-title":"Ann Trop Med Parasitol"},{"key":"ref74","article-title":"Community directed interventions for priority health problems in Africa: results of a multi-country study","year":"2009"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1586\/14787210.3.6.841","article-title":"Government action needed to step up research and development for the world&apos;s most neglected diseases.","volume":"3","author":"B Pecoul","year":"2005","journal-title":"Expert Rev Anti Infect Ther"}],"updated-by":[{"DOI":"10.1371\/annotation\/53d95072-6329-412d-a5e4-c1a00acd1934","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T00:00:00Z","timestamp":1274832000000}}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T13:01:43Z","timestamp":1559134903000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,25]]},"references-count":75,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,5,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000718","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/53d95072-6329-412d-a5e4-c1a00acd1934","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,25]]}}}