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Lymphoproliferative responses to trypanosomal antigens during acute and chronic experimental Chagas&apos; disease.","volume":"44","author":"F Kierszenbaum","year":"1981","journal-title":"Immunology"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev.immunol.23.021704.115728","article-title":"Marginal zone B cells.","volume":"23","author":"S Pillai","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000082100","article-title":"Marginal zone B cell physiology and disease.","volume":"8","author":"T Lopes-Carvalho","year":"2005","journal-title":"Curr Dir Autoimmun"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4049\/jimmunol.171.1.317","article-title":"<italic>Plasmodium chabaudi chabaudi<\/italic> infection in mice induces strong B cell responses and striking but temporary changes in splenic cell distribution.","volume":"171","author":"AH Achtman","year":"2003","journal-title":"J Immunol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4049\/jimmunol.0900068","article-title":"Generation of Protective T Cell-Independent Antiviral Antibody Responses in SCID Mice Reconstituted with Follicular or Marginal Zone B Cells.","volume":"183","author":"HM Guay","year":"2009","journal-title":"J Immunol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.4049\/jimmunol.174.9.5681","article-title":"Infection-induced marginal zone B cell production of <italic>Borrelia hermsii<\/italic>-specific antibody is impaired in the absence of CD1d.","volume":"174","author":"AA Belperron","year":"2005","journal-title":"J Immunol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ijc.2910530128","article-title":"Epstein-Barr virus (EBV) nuclear-antigen-2-induced up-regulation of CD21 and CD23 molecules is dependent on a permissive cellular context.","volume":"53","author":"M Cordier-Bussat","year":"1993","journal-title":"Int J Cancer"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1128\/JVI.00297-09","article-title":"Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent protein.","volume":"83","author":"CM Collins","year":"2009","journal-title":"J Virol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.coi.2009.07.006","article-title":"CD8+ T cells in <italic>Trypanosoma cruzi<\/italic> infection.","volume":"21","author":"AM Padilla","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.1128\/IAI.73.8.4934-4940.2005","article-title":"Type 1 immunity provides both optimal mucosal and systemic protection against a mucosally invasive, intracellular pathogen.","volume":"73","author":"DF Hoft","year":"2005","journal-title":"Infect Immun"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.coi.2007.06.003","article-title":"Immune system recognition of <italic>Trypanosoma cruzi<\/italic>.","volume":"19","author":"RL Tarleton","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.0105-2896.2004.00183.x","article-title":"Generation, specificity, and function of CD8+ T cells in <italic>Trypanosoma cruzi<\/italic> infection.","volume":"201","author":"D Martin","year":"2004","journal-title":"Immunol Rev"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0923-2494(91)90020-J","article-title":"Chagas&apos; disease: <italic>Trypanosoma cruzi<\/italic> vs. the host immune system.","volume":"142","author":"M Hontebeyrie-Joskowicz","year":"1991","journal-title":"Res Immunol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.4049\/jimmunol.142.11.4017","article-title":"Indiscriminate representation of VH-gene families in the murine B lymphocyte responses to <italic>Trypanosoma cruzi<\/italic>.","volume":"142","author":"P Minoprio","year":"1989","journal-title":"J Immunol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0165-2478(99)00172-8","article-title":"IL-12 and IFN-gamma production, and NK cell activity, in acute and chronic experimental <italic>Trypanosoma cruzi<\/italic> infections.","volume":"71","author":"MI Antunez","year":"2000","journal-title":"Immunol Lett"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.4049\/jimmunol.166.7.4596","article-title":"Antigen-specific Th1 but not Th2 cells provide protection from lethal <italic>Trypanosoma cruzi<\/italic> infection in mice.","volume":"166","author":"S Kumar","year":"2001","journal-title":"J Immunol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.micinf.2008.04.013","article-title":"Impaired <italic>Trypanosoma cruzi<\/italic>-specific IFN-gamma secretion by T cells bearing the BV9 T-cell receptor is associated with local IL-10 production in non-lymphoid tissues of chronically infected mice.","volume":"10","author":"J Vogt","year":"2008","journal-title":"Microbes Infect"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.4049\/jimmunol.167.6.3346","article-title":"IL-12-independent IFN-gamma production by T cells in experimental Chagas&apos; disease is mediated by IL-18.","volume":"167","author":"U Muller","year":"2001","journal-title":"J Immunol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"493","DOI":"10.4049\/jimmunol.172.1.493","article-title":"Galectin-3 Mediates IL-4-Induced Survival and Differentiation of B Cells: Functional Cross-Talk and Implications during <italic>Trypanosoma cruzi<\/italic>.","volume":"172","author":"EV Acosta-Rodriguez","year":"2004","journal-title":"Infection J Immunol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/PL00008577","article-title":"IL-4 reduces resistance of mice to <italic>Trypanosoma cruzi<\/italic> infection.","volume":"87","author":"K Hiyama","year":"2001","journal-title":"Parasitol Res"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/cimm.1996.0132","article-title":"Antigen-specific Il-4- and IL-10-secreting CD4+ lymphocytes increase in vivo susceptibility to <italic>Trypanosoma cruzi<\/italic> infection.","volume":"170","author":"LC Barbosa de Oliveira","year":"1996","journal-title":"Cell Immunol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1128\/IAI.00926-09","article-title":"Genetic immunization converts the <italic>Trypanosoma cruzi<\/italic> B-Cell mitogen proline racemase to an effective immunogen.","volume":"78","author":"MA Bryan","journal-title":"Infect Immun"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cytogfr.2007.01.007","article-title":"Cytokines and chemokines shaping the B-cell compartment.","volume":"18","author":"EV Acosta-Rodriguez","year":"2007","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0014-4894(81)90069-2","article-title":"<italic>Trypanosoma cruzi<\/italic>: role of different antibody classes in protection against infection in the mouse.","volume":"52","author":"HA Takehara","year":"1981","journal-title":"Exp Parasitol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1365-3024.1993.tb00603.x","article-title":"Host genetics and resistance to acute <italic>Trypanosoma cruzi<\/italic> infection in mice. I. Antibody isotype profiles.","volume":"15","author":"MR Powell","year":"1993","journal-title":"Parasite Immunol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1645\/GE-212R","article-title":"Challenge of <italic>Trypanosoma cruzi<\/italic> chronically infected mice with trypomastigotes activates the immune system and reduces subpatent parasitemia levels.","volume":"90","author":"CR Marinho","year":"2004","journal-title":"J Parasitol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1365-3024.2001.00418.x","article-title":"Increased immunoglobulin secretion by B lymphocytes from <italic>Trypanosoma cruzi<\/italic> infected mice after B lymphocytes-natural killer cell interaction.","volume":"23","author":"LB De Arruda Hinds","year":"2001","journal-title":"Parasite Immunol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1471-4906(01)02086-5","article-title":"Death-receptor contribution to the germinal-center reaction.","volume":"22","author":"M van Eijk","year":"2001","journal-title":"Trends Immunol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1586\/erv.09.56","article-title":"How do natural killer T cells help B cells?","volume":"8","author":"ML Lang","year":"2009","journal-title":"Expert Rev Vaccines"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.4049\/jimmunol.168.11.5778","article-title":"Treatment with alpha-galactosylceramide before <italic>Trypanosoma cruzi<\/italic> infection provides protection or induces failure to thrive.","volume":"168","author":"MS Duthie","year":"2002","journal-title":"J Immunol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2567.2006.02439.x","article-title":"During acute <italic>Trypanosoma cruzi<\/italic> infection highly susceptible mice deficient in natural killer cells are protected by a single alpha-galactosylceramide treatment.","volume":"119","author":"MS Duthie","year":"2006","journal-title":"Immunology"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"8339","DOI":"10.1073\/pnas.0801375105","article-title":"NK T cells provide lipid antigen-specific cognate help for B cells.","volume":"105","author":"EA Leadbetter","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/expr.1996.0109","article-title":"<italic>Trypanosoma cruzi<\/italic>:IL-10, TNF, IFN-[gamma], and IL-12 Regulate Innate and Acquired Immunity to Infection.","volume":"84","author":"IA Abrahamsohn","year":"1996","journal-title":"Experimental Parasitology"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0165-2478(01)00283-8","article-title":"Early IFN-gamma production is related to the presence of interleukin (IL)-18 and the absence of IL-13 in experimental <italic>Trypanosoma cruzi<\/italic> infections.","volume":"79","author":"MI Antunez","year":"2001","journal-title":"Immunol Lett"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-3083.1994.tb03339.x","article-title":"Endogenous IL-10 and IFN-gamma production controls thymic cell proliferation in mice acutely infected by <italic>Trypanosoma cruzi<\/italic>.","volume":"39","author":"MD Leite de Moraes","year":"1994","journal-title":"Scand J Immunol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1365-2249.2003.02022.x","article-title":"Differential CD86 and CD40 co-stimulatory molecules and cytokine expression pattern induced by <italic>Trypanosoma cruzi<\/italic> in APCs from resistant or susceptible mice.","volume":"131","author":"L Planelles","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0923-2494(91)90019-F","article-title":"Is TNF alpha involved in early susceptibility of <italic>Trypanosoma cruzi<\/italic>-infected C3H\/He mice?","volume":"142","author":"N Starobinas","year":"1991","journal-title":"Res Immunol"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.4049\/jimmunol.165.3.1520","article-title":"Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with <italic>Trypanosoma cruzi<\/italic>.","volume":"165","author":"RL Tarleton","year":"2000","journal-title":"J Immunol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1189\/jlb.0407214","article-title":"Polyclonal B cell activation in infections: infectious agents&apos; 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