{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:01:26Z","timestamp":1791216086965,"version":"4.1.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T00:00:00Z","timestamp":1281398400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0000795","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T19:26:20Z","timestamp":1281468380000},"page":"e795","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":58,"title":["Comparison of Microscopy and Alamar Blue Reduction in a Larval Based Assay for Schistosome Drug Screening"],"prefix":"10.1371","volume":"4","author":[{"given":"Nuha R.","family":"Mansour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin D.","family":"Bickle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk.","volume":"6","author":"P Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1017\/S0031182009991600","article-title":"Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution.","volume":"136","author":"J Utzinger","year":"2009","journal-title":"Parasitology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1017\/S0031182009990400","article-title":"The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002\u20132008.","volume":"136","author":"A Fenwick","year":"2009","journal-title":"Parasitology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1046\/j.1365-3156.2001.00811.x","article-title":"Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence.","volume":"6","author":"B Gryseels","year":"2001","journal-title":"Trop Med Int Health"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00001432-200012000-00014","article-title":"Praziquantel: is there real resistance and are there alternatives?","volume":"13","author":"D Cioli","year":"2000","journal-title":"Curr Opin Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ijpara.2004.05.001","article-title":"Determination of ED50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates.","volume":"34","author":"D Cioli","year":"2004","journal-title":"Int J Parasitol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1517\/17460441.2.S1.S3","article-title":"The Concept Paper on the Helminth Drug Initiative. Onchocerciasis\/lymphatic filariais and schistosomiasis: opportunities and challenges for the discovery of new drugs\/diagnostics.","volume":"2","author":"A Hudson","year":"2007","journal-title":"Expert Opinion on Drug Discovery"},{"key":"ref8","first-page":"S53","article-title":"Schistosomes: challenges in compound screening Expert Opinion on Drug Discovery","volume":"2","author":"B Ramirez","year":"2007"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e478","DOI":"10.1371\/journal.pntd.0000478","article-title":"Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.","volume":"3","author":"MH Abdulla","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref10","first-page":"1","article-title":"In vitro and in vivo trematode models for chemotherapeutic studies.","volume":"137","author":"J Keiser","year":"2009","journal-title":"Parasitology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0001-706X(97)00079-X","article-title":"The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro.","volume":"68","author":"B Raz","year":"1997","journal-title":"Acta Trop"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.mimet.2008.05.026","article-title":"Rapid fluorescent assay for screening drugs on Leishmania amastigotes.","volume":"75","author":"O Shimony","year":"2008","journal-title":"J Microbiol Methods"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/0006-2952(91)90267-9","article-title":"Differential effects of oltipraz and its oxy-analogue on the viability of Schistosoma mansoni and the activity of glutathione S-transferase.","volume":"42","author":"B Nare","year":"1991","journal-title":"Biochem Pharmacol"},{"key":"ref14","first-page":"25","article-title":"Preliminary clinical trials with oxamniquine, a new antischistosomal agent.","volume":"15","author":"N Katz","year":"1973","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref15","first-page":"781","article-title":"Preliminary trials with praziquantel in human infections due to Schistosoma mansoni.","volume":"57","author":"N Katz","year":"1979","journal-title":"Bull World Health Organ"},{"key":"ref16","first-page":"617","article-title":"Preliminary results in human schistosomiasis with Ro 11-3128.","volume":"55","author":"AP Baard","year":"1979","journal-title":"S Afr Med J"},{"key":"ref17","first-page":"466","article-title":"Initial therapeutic trials of an antibilharzial agent, 35 972 R.P. in man.","volume":"72","author":"M Gentilini","year":"1979","journal-title":"Bull Soc Pathol Exot Filiales"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0035-9203(87)90210-0","article-title":"Parasitological evaluation of curative and subcurative doses of 9-acridanone-hydrazone drugs against Schistosoma mansoni in baboons, and observations on changes in serum levels of anti-egg antibodies detected by ELISA.","volume":"81","author":"RF Sturrock","year":"1987","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref19","first-page":"295","article-title":"Experimental trials of an artemisinin derivative in treatment of Schistosoma mansoni infected mice.","volume":"30","author":"SS Abdel Aziz","year":"2000","journal-title":"J Egypt Soc Parasitol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/S0140-6736(00)02114-0","article-title":"Oral artemether for prevention of Schistosoma mansoni infection: randomised controlled trial.","volume":"355","author":"J Utzinger","year":"2000","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"742","DOI":"10.2307\/3280663","article-title":"Characteristics of antischistosomal benzodiazepine binding sites in Schistosoma mansoni.","volume":"66","author":"JL Bennett","year":"1980","journal-title":"J Parasitol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1017\/S0022149X00005344","article-title":"Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. I. Demonstration of resistance to reinfection using a model system that involves perfusion of mice within three weeks of challenge.","volume":"52","author":"M Doenhoff","year":"1978","journal-title":"J Helminthol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2307\/3280632","article-title":"Cultivation of Schistosoma mansoni in vitro. I. Establishment of cultures from cercariae and development until pairing.","volume":"67","author":"PF Basch","year":"1981","journal-title":"J Parasitol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1017\/S0022149X0002664X","article-title":"Transformation of cercariae to schistosomula: a quantitative comparison of transformation techniques and of infectivity by different injection routes of the organisms produced.","volume":"50","author":"ER James","year":"1976","journal-title":"J Helminthol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0014-4894(82)90090-X","article-title":"Schistosoma mansoni: rapid isolation and purification of schistosomula of different developmental stages by centrifugation on discontinuous density gradients of Percoll.","volume":"53","author":"JK Lazdins","year":"1982","journal-title":"Exp Parasitol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:26:07Z","timestamp":1588965967000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000795"}},"subtitle":[],"editor":[{"given":"Roger K.","family":"Prichard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,8,10]]},"references-count":25,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,8,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000795","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,10]]}}}