{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:28:14Z","timestamp":1792704494800,"version":"4.5.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T00:00:00Z","timestamp":1283212800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0000809","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T19:10:36Z","timestamp":1283281836000},"page":"e809","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":68,"title":["Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection"],"prefix":"10.1371","volume":"4","author":[{"given":"Jia-Li","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ying","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(07)61687-0","article-title":"Dengue.","volume":"370","author":"SB Halstead","year":"2007","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jcv.2007.04.024","article-title":"Apoptosis in tissues from fatal dengue shock syndrome.","volume":"40","author":"D Limonta","year":"2007","journal-title":"J Clin Virol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1574-695X.2008.00420.x","article-title":"Vascular endothelium: the battlefield of dengue viruses.","volume":"53","author":"A Basu","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref4","first-page":"953","article-title":"Dynamic changes in the monolayer permeability and rearrangement microfilaments in ECV304 cells after dengue virus infection (in Chinese).","volume":"21","author":"JL Wang","year":"2005","journal-title":"Chin J Zoonoses"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bbrc.2007.03.051","article-title":"Up-regulated expression of beta3 integrin induced by dengue virus serotype 2 infection associated with virus entry into human dermal microvascular endothelial cells.","volume":"356","author":"JL Zhang","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1128\/JVI.76.11.5588-5597.2002","article-title":"Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge.","volume":"76","author":"IK Bosch","year":"2002","journal-title":"J Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1099\/vir.0.19652-0","article-title":"IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers.","volume":"85","author":"D Talavera","year":"2004","journal-title":"J Gen Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1021\/pr900060g","article-title":"Alterations in actin cytoskeletal assembly and junctional protein complexes in human endothelial cells induced by dengue virus infection and mimicry of leukocyte transendothelial migration.","volume":"8","author":"R Kanlaya","year":"2009","journal-title":"J Proteome Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1126\/science.1118133","article-title":"Vesicle Formation at the Plasma Membrane and Trans-Golgi Network: The Same but Different.","volume":"313","author":"MA McNiven","year":"2006","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"8990","DOI":"10.1073\/pnas.0409099102","article-title":"Cytoskeletal rearrangements and cell extensions induced by the US3 kinase of an alphaherpesvirus are associated with enhanced spread.","volume":"102","author":"HW Favoreel","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.virol.2004.10.010","article-title":"Cooperativity of actin and microtubule elements during replication of respiratory syncytial virus.","volume":"331","author":"NL Kallewaard","year":"2005","journal-title":"Virology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/jmv.10495","article-title":"Actin filaments participate in West Nile (Sarafend) virus maturation process.","volume":"71","author":"JJ Chu","year":"2003","journal-title":"J Med Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1128\/JVI.72.4.2865-2870.1998","article-title":"Role of actin microfilaments in Black Creek Canal virus morphogenesis.","volume":"72","author":"EV Ravkov","year":"1998","journal-title":"J Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1128\/JVI.02210-06","article-title":"Rab 5 is required for the cellular entry of dengue and West Nile viruses.","volume":"81","author":"MN Krishnan","year":"2007","journal-title":"J Virol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1139\/W08-107","article-title":"Entry of dengue virus serotype 2 into ECV304 cells depends on clathrin-dependent endocytosis, but not on caveolae-dependent endocytosis.","volume":"55","author":"T Peng","year":"2009","journal-title":"Can J Microbiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1099\/vir.0.83357-0","article-title":"Functional entry of dengue virus into Aedes albopictus mosquito cells is dependent on clathrin-mediated endocytosis.","volume":"89","author":"EG Acosta","year":"2008","journal-title":"J Gen Virol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1423-0127-16-17","article-title":"Characterization of dengue virus entry into HepG2 cells.","volume":"16","author":"L Suksanpaisan","year":"2009","journal-title":"J Biomed Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/382177a0","article-title":"Regulation of receptor-mediated endocytosis by Rho and Rac.","volume":"382","author":"C Lamaze","year":"1996","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.1128\/JVI.78.13.7138-7147.2004","article-title":"Actin cytoskeletal reorganizations and coreceptor-mediated activation of rac during human immunodeficiency virus-induced cell fusion.","volume":"78","author":"SE Pontow","year":"2004","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1099\/vir.0.82231-0","article-title":"Early herpes simplex virus type 1 infection is dependent on regulated Rac1\/Cdc42 signalling in epithelial MDCKII cells.","volume":"87","author":"S Hoppe","year":"2006","journal-title":"J Gen Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chom.2007.07.003","article-title":"Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5.","volume":"2","author":"CB Coyne","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.bbamcr.2007.10.024","article-title":"Rac1 GTPase is activated by hepatitis B virus replication\u2014involvement of HBX.","volume":"1783","author":"TL Tan","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1099\/vir.0.014159-0","article-title":"Cross-talk between Rac1 and Cdc42 GTPases regulates formation of filopodia required for dengue virus type-2 entry into HMEC-1 cells.","volume":"90","author":"H Zamudio-Meza","year":"2009","journal-title":"J Gen Virol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1099\/0022-1317-67-12-2663","article-title":"Antigenic comparison of envelope protein E between Japanese encephalitis virus and some other flaviviruses using monoclonal antibodies.","volume":"67","author":"J Kimura-Kuroda","year":"1986","journal-title":"J Gen Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(92)90164-8","article-title":"The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.","volume":"70","author":"AJ Ridley","year":"1992","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"23296","DOI":"10.1074\/jbc.M700950200","article-title":"Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1.","volume":"282","author":"K Ieguchi","year":"2007","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1091\/mbc.E04-09-0774","article-title":"A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis.","volume":"16","author":"D Yarar","year":"2005","journal-title":"Mol Biol Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1128\/JVI.73.4.2650-2657.1999","article-title":"Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes\/macrophages by blockade of virus entry via a CD14-dependent mechanism.","volume":"73","author":"YC Chen","year":"1999","journal-title":"J Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/sj.embor.embor866","article-title":"Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses.","volume":"4","author":"E Navarro Sanchez","year":"2003","journal-title":"EMBO Rep"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.20021840","article-title":"DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells.","volume":"197","author":"B Tassaneetrithep","year":"2003","journal-title":"J Exp Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00705-003-0263-x","article-title":"Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2.","volume":"149","author":"S Jindadamrongwech","year":"2004","journal-title":"Arch Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"10543","DOI":"10.1128\/JVI.78.19.10543-10555.2004","article-title":"Infectious entry of West Nile virus occurs through a clathrin-mediated endocytic pathway.","volume":"78","author":"JJ Chu","year":"2004","journal-title":"J Virol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/s00705-008-0183-x","article-title":"Vimentin is required for dengue virus serotype 2 infection but microtubules are not necessary for this process.","volume":"153","author":"W Chen","year":"2008","journal-title":"Arch Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.embor.7400814","article-title":"Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproduction.","volume":"7","author":"N Luplerdlop","year":"2006","journal-title":"EMBO Rep"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1091\/mbc.11.1.287","article-title":"Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1.","volume":"11","author":"TS Jou","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1242\/jcs.114.6.1041","article-title":"Phosphoinositides in membrane traffic at the synapse.","volume":"114","author":"O Cremona","year":"2001","journal-title":"J Cell Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0960-9822(00)00778-8","article-title":"Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis.","volume":"10","author":"N Malecz","year":"2000","journal-title":"Curr Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0959-437X(98)80063-4","article-title":"Regulation of inositol lipid kinases by Rho and Rac.","volume":"8","author":"XD Ren","year":"1998","journal-title":"Curr Opin Genet Dev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nature00859","article-title":"Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.","volume":"418","author":"S Eden","year":"2002","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ncb0806-781","article-title":"Front and back by Rho and Rac.","volume":"8","author":"K Burridge","year":"2006","journal-title":"Nat Cell Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/ncb1226","article-title":"Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.","volume":"7","author":"X Chen","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity.","volume":"181","author":"DW Vaughn","year":"2000","journal-title":"J Infect Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1086\/528805","article-title":"Dengue and dengue hemorrhagic fever among adults: clinical outcomes related to viremia, serotypes, and antibody response.","volume":"197","author":"AO Guilarde","year":"2008","journal-title":"J Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"408","DOI":"10.4269\/ajtmh.1991.45.408","article-title":"Demonstration of yellow fever and dengue antigens in formalin-fixed paraffin-embedded human liver by immunohistochemical analysis.","volume":"45","author":"WC Hall","year":"1991","journal-title":"Am J Trop Med Hyg"},{"key":"ref45","first-page":"107","article-title":"Immunohistochemical characterization of a new monoclonal antibody reactive with dengue virus-infected cells in frozen tissue using immunoperoxidase technique.","volume":"14","author":"L Bhoopat","year":"1996","journal-title":"Asian Pac J Allergy Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1086\/383043","article-title":"Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization.","volume":"189","author":"K Jessie","year":"2004","journal-title":"J Infect Dis"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T18:34:40Z","timestamp":1636310080000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000809"}},"subtitle":[],"editor":[{"given":"Maria G.","family":"Guzman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,8,31]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,8,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000809","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,31]]}}}