{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T21:57:34Z","timestamp":1768427854413,"version":"3.49.0"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T00:00:00Z","timestamp":1288051200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0000855","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T19:30:41Z","timestamp":1288121441000},"page":"e855","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":82,"title":["Paromomycin for the Treatment of Visceral Leishmaniasis in Sudan: A Randomized, Open-Label, Dose-Finding Study"],"prefix":"10.1371","volume":"4","clinical-trial-number":[{"clinical-trial-number":"nct00255567","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Ahmed M.","family":"Musa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brima","family":"Younis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Fadlalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Royce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manica","family":"Balasegaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Wasunna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asrat","family":"Hailu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tansy","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Omollo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Mudawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Kokwaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"El-Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eltahir","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,10,26]]},"reference":[{"key":"ref1","first-page":"417","article-title":"Leishmaniasis. Public health aspects and control.","volume":"14","author":"P Desjeux","year":"1996","journal-title":"Clin Dermatol"},{"key":"ref2","article-title":"Leishmaniasis.","year":"2009"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/CMR.19.1.111-126.2006","article-title":"Drug resistance in leishmaniasis.","volume":"19","author":"SL Croft","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0035-9203(03)80043-3","article-title":"Sodium stibogluconate cardiotoxicity and safety of generics.","volume":"97","author":"S Rijal","year":"2003","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/00034983.1998.11813313","article-title":"Do the diminishing efficacy and increasing toxicity of sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar, India, justify its continued use as a first-line drug? An observational study of 80 cases.","volume":"92","author":"CP Thakur","year":"1998","journal-title":"Ann Trop Med Parasitol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1056\/NEJMoa066536","article-title":"Injectable paromomycin for Visceral leishmaniasis in India.","volume":"356","author":"S Sundar","year":"2007","journal-title":"N Engl J Med"},{"key":"ref7","article-title":"Geographical Variation in the Response of Visceral Leishmaniasis to Paromomycin in East Africa: a Multicentre, Open-label, Randomized Trial.","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/bmj.316.7139.1200","article-title":"Randomised controlled trial of aminosidine (paromomycin) v sodium stibogluconate for treating visceral leishmaniasis in North Bihar, India.","volume":"316","author":"TK Jha","year":"1998","journal-title":"BMJ"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0035-9203(00)90131-7","article-title":"Treatment of visceral leishmaniasis with injectable paromomycin (aminosidine). An open-label randomized phase-II clinical study.","volume":"94","author":"CP Thakur","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref10","article-title":"Guidelines for Hearing Aids and Services for Developing Countries.","year":"2004"},{"key":"ref11","article-title":"Basic Laboratory Methods in Medical Parasitology","year":"1991"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4269\/ajtmh.1983.32.475","article-title":"Quantification of amastigates of <italic>Leishmania donovani<\/italic> in smears of splenic aspirates from patients with visceral leishmaniasis.","volume":"32","author":"JD Chulay","year":"1983","journal-title":"Am J Trop Med Hyg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0196-0709(86)80040-0","article-title":"Aminoglycoside ototoxicity.","volume":"7","author":"GJ Matz","year":"1986","journal-title":"Am J Otolaryngol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1128\/AAC.41.5.982","article-title":"Pharmacokinetics of intramuscularly administered aminosidine in healthy subjects.","volume":"41","author":"TP Kanyok","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"ref15","year":"2005"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"781","DOI":"10.7326\/0003-4819-141-10-200411160-00009","article-title":"Better reporting of harms in randomized trials: an extension of the CONSORT statement.","volume":"141","author":"JPA Ioannidis","year":"2004","journal-title":"Ann Intern Med"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0000855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T22:20:36Z","timestamp":1559773236000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0000855"}},"subtitle":[],"editor":[{"given":"Diana N. J.","family":"Lockwood","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,10,26]]},"references-count":16,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2010,10,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0000855","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,26]]}}}