{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:15:16Z","timestamp":1780618516740,"version":"3.54.1"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2011,6,7]],"date-time":"2011-06-07T00:00:00Z","timestamp":1307404800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001157","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:45:13Z","timestamp":1308339913000},"page":"e1157","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of Chronic Ascariasis and Trichuriasis on Cytokine Production and Gene Expression in Human Blood: A Cross-Sectional Study"],"prefix":"10.1371","volume":"5","author":[{"given":"Miguel","family":"Reina Ortiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Benitez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nely","family":"Broncano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha E.","family":"Chico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maritza","family":"Vaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Dougan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,6,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/S0140-6736(05)66433-1","article-title":"Extending the benefits of deworming for development.","volume":"365","author":"L Savioli","year":"2005","journal-title":"Lancet"},{"key":"ref2","first-page":"CD000371","article-title":"Deworming drugs for treating soil-transmitted intestinal worms in children: effects on growth and school performance.","volume":"4","author":"DC Taylor-Robinson","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1086\/315837","article-title":"Albendazole treatment of children with ascariasis enhances the vibriocidal antibody response to the live attenuated oral cholera vaccine CVD 103-HgR.","volume":"182","author":"PJ Cooper","year":"2000","journal-title":"J Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2249.2001.01446.x","article-title":"Effect of deworming on human T cell responses to mycobacterial antigens in helminth-exposed individuals before and after Bacille Calmette-Gu\u00e9rin (BCG) vaccination.","volume":"123","author":"D Elias","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1371\/journal.pntd.0000403","article-title":"Immunologic Responses to Vibrio cholerae in Patients Co-Infected with Intestinal Parasites in Bangladesh.","volume":"3","author":"JB Harris","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/mi.2009.14","article-title":"Mucosal immunology of geohelminth infections in humans.","volume":"2","author":"PJ Cooper","year":"2009","journal-title":"Mucosal Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nri2252","article-title":"Micromanagement of the immune system by microRNAs.","volume":"8","author":"HF Lodish","year":"2008","journal-title":"Nature Rev Immunol"},{"key":"ref8","article-title":"Diagnostic techniques for intestinal parasitic infections (IPI) applicable to primary health care (PHC) services","year":"1985"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1086\/315830","article-title":"Human infection with Ascaris lumbricoides is associated with a polarized cytokine response.","volume":"182","author":"PJ Cooper","year":"2000","journal-title":"J Infect Dis"},{"key":"ref10","article-title":"Statistical Methods in Medical Research. 4th ed","author":"P Armitage","year":"2001"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1086\/425014","article-title":"T helper cell type 2 responsiveness predicts future susceptibility to gastrointestinal nematodes in humans.","volume":"190","author":"JA Jackson","year":"2004","journal-title":"J Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/sim.4780090710","article-title":"More powerful procedures for multiple significance testing.","volume":"9","author":"Y Hochberg","year":"1990","journal-title":"Stat Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(00)03206-2","article-title":"Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10.","volume":"356","author":"AH van den Biggelaar","year":"2000","journal-title":"Lancet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1067\/mai.2003.1348","article-title":"Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics.","volume":"111","author":"PJ Cooper","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1164\/rccm.200603-331OC","article-title":"Asthma and current intestinal parasite infection: systematic review and meta-analysis.","volume":"174","author":"J Leonardi-Bee","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/infdis\/173.5.1277","article-title":"Elevations in granulocyte-macrophage colony-stimulating factor and interleukin-5 levels precede posttreatment eosinophilia in onchocerciasis.","volume":"173","author":"JB Hagan","year":"1996","journal-title":"J Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.4049\/jimmunol.150.12.5511","article-title":"Regulation of IL-5 in onchocerciasis. A critical role for IL-2.","volume":"150","author":"C Steel","year":"1993","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1289\/ehp.0800366","article-title":"Spontaneous cytokine production in children according to biological characteristics and environmental exposures.","volume":"117","author":"CA Figueiredo","year":"2009","journal-title":"Environ Health Perspect"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1128\/IAI.01228-09","article-title":"Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network.","volume":"78","author":"CA Figueiredo","year":"2010","journal-title":"Infect Immun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1172\/JCI116752","article-title":"Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.","volume":"92","author":"CL King","year":"1993","journal-title":"J Clin Invest"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-3024.1995.tb00906.x","article-title":"Immunoregulation in human lymphatic filariasis: the role of interleukin 10.","volume":"17","author":"S Mahanty","year":"1995","journal-title":"Parasite Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1128\/IAI.73.6.3385-3393.2005","article-title":"Diminished monocyte function in microfilaremic patients with lymphatic filariasis and its relationship to altered lymphoproliferative responses.","volume":"73","author":"B Sasisekhar","year":"2005","journal-title":"Infect Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/ACI.0b013e32831f44a6","article-title":"Interactions of parasites with allergy.","volume":"9","author":"PJ Cooper","year":"2009","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00281-003-0149-8","article-title":"Mechanisms of tolerance to inhalant allergens: the relevance of a modified Th2 response to allergens from domestic animals.","volume":"25","author":"TA Platts-Mills","year":"2004","journal-title":"Springer Semin Immunopathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nri2039","article-title":"Suppression of Th2-type allergic reactions by helminth infection.","volume":"7","author":"PG Fallon","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00062752-200701000-00003","article-title":"Regulation of neutrophil homeostasis.","volume":"14","author":"MJ Christopher","year":"2007","journal-title":"Curr Opin Hematol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1158\/1078-0432.CCR-08-1954","article-title":"Characterization and regulation of bv8 in human blood cells.","volume":"15","author":"C Zhong","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI19930","article-title":"Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis.","volume":"113","author":"SH Jia","year":"2004","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.exphem.2005.06.028","article-title":"CCL23\/myeloid progenitor inhibitory factor-1 inhibits production and release of polymorphonuclear leukocytes and monocytes from the bone marrow.","volume":"33","author":"CH Shih","year":"2005","journal-title":"Exp Hematol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-3024.2006.00892.x","article-title":"Early stages of Ascaris suum induce airway inflammation and hyperreactivity in a mouse model.","volume":"28","author":"CS Enobe","year":"2006","journal-title":"Parasite Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1863-2378.2008.01182.x","article-title":"Experimental infection with Toxocara cati in BALB\/c mice, migratory behaviour and pathological changes.","volume":"56","author":"N Cardillo","year":"2009","journal-title":"Zoonoses Public Health"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.4269\/ajtmh.1985.34.735","article-title":"Comparative toxicity of purified human eosinophil granule cationic proteins for schistosomula of Schistosoma mansoni.","volume":"34","author":"SJ Ackerman","year":"1985","journal-title":"Am J Trop Med Hyg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.micinf.2008.10.007","article-title":"Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host.","volume":"11","author":"T Zelante","year":"2009","journal-title":"Microbes Infect"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1084\/jem.185.7.1163","article-title":"Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors.","volume":"185","author":"VP Patel","year":"1997","journal-title":"J Exp Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ceb.2005.10.001","article-title":"Life in the balance: how BH3-only proteins induce apoptosis.","volume":"17","author":"SN Willis","year":"2005","journal-title":"Curr Opin Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.4049\/jimmunol.179.9.5999","article-title":"Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc.","volume":"179","author":"A De Luca","year":"2007","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1139253","article-title":"Requirement of bic\/microRNA-155 for normal immune function.","volume":"316","author":"A Rodriguez","year":"2007","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"28929","DOI":"10.1074\/jbc.M702633200","article-title":"A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection.","volume":"282","author":"XM Chen","year":"2007","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1086\/605443","article-title":"Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response.","volume":"200","author":"B Xiao","year":"2009","journal-title":"J Infect Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3324\/haematol.2009.020685","article-title":"Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA let-7d in erythroid cells.","volume":"95","author":"I Andolfo","year":"2010","journal-title":"Haematologica"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2353\/ajpath.2009.080731","article-title":"Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma.","volume":"174","author":"G Childs","year":"2009","journal-title":"Am J Path"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1164\/rccm.200911-1698OC","article-title":"Inhibition and role of Let-7d in idiopathic pulmonary fibrosis.","volume":"182","author":"KV Pandit","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1084\/jem.185.7.1163","article-title":"Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors.","volume":"185","author":"VP Patel","year":"1997","journal-title":"J Exp Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"18704","DOI":"10.1073\/pnas.0905063106","article-title":"Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease.","volume":"106","author":"J Mattes","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1128\/IAI.67.7.3444-3451.1999","article-title":"Development of antibody isotype responses to Schistosoma mansoni in an immunologically naive immigrant population: influence of infection duration, infection intensity, and host age.","volume":"67","author":"CW Naus","year":"1999","journal-title":"Infect Immun"},{"key":"ref46","first-page":"381","article-title":"IgG responses to antigens of Necator americanus: potential for use in large-scale epidemiological studies.","volume":"74","author":"DR Palmer","year":"1996","journal-title":"Bull World Health Organ"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.4049\/jimmunol.160.7.3555","article-title":"IgE versus IgG4 production can be differentially regulated by IL-10.","volume":"160","author":"P Jeannin","year":"1998","journal-title":"J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2249.2004.02449.x","article-title":"Cellular responses and cytokine production in post-treatment hookworm patients from an endemic area in Brazil.","volume":"136","author":"SM Geiger","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1086\/586717","article-title":"Intensity of intestinal infection with multiple worm species is related to regulatory cytokine output and immune hyporesponsiveness.","volume":"197","author":"JD Turner","year":"2008","journal-title":"J Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.4049\/jimmunol.0904067","article-title":"At homeostasis filarial infections have expanded adaptive T regulatory but not classical Th2 cells.","volume":"184","author":"S Metenou","year":"2010","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/infdis\/170.4.962","article-title":"Transient changes in cytokine profiles following ivermectin treatment of onchocerciasis.","volume":"170","author":"C Steel","year":"1994","journal-title":"J Infect Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/infdis\/173.3.769","article-title":"High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis.","volume":"173","author":"S Mahanty","year":"1996","journal-title":"J Infect Dis"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T12:33:31Z","timestamp":1686141211000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001157"}},"subtitle":[],"editor":[{"given":"Judd L.","family":"Walson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,6,7]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001157","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,7]]}}}