{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:57:19Z","timestamp":1789757839726,"version":"4.0.1"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T00:00:00Z","timestamp":1320710400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001383","type":"journal-article","created":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T21:45:59Z","timestamp":1320788759000},"page":"e1383","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Induction of CD4+CD25+FOXP3+ Regulatory T Cells during Human Hookworm Infection Modulates Antigen-Mediated Lymphocyte Proliferation"],"prefix":"10.1371","volume":"5","author":[{"given":"Natasha Delaqua","family":"Ricci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline Ara\u00fajo","family":"Fi\u00faza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Lacerda","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Grossi Lopes","family":"Can\u00e7ado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique","family":"Gazzinelli-Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgillio Gandra","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Ferreira","family":"Matoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Rodrigues Cambraia de","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan Michael","family":"Geiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Correa-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Gazzinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella Castanheira","family":"Bartholomeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Toshio","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,11,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1196\/annals.1425.000","article-title":"Hookworm and poverty.","volume":"1136","author":"P Hotez","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1473-3099(06)70630-2","article-title":"Hookworm vaccines: past, present, and future.","volume":"6","author":"A Loukas","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0140-6736(06)68653-4","article-title":"Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm.","volume":"367","author":"J Bethony","year":"2006","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMra064142","article-title":"Control of neglected tropical diseases.","volume":"357","author":"PJ Hotez","year":"2007","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0020-7292(97)02865-8","article-title":"Effects of chronic parasitosis on women&apos;s health.","volume":"58","author":"R Santiso","year":"1997","journal-title":"Int J Gynaecol Obstet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/00006454-198908000-00009","article-title":"Hookworm disease in children.","volume":"8","author":"PJ Hotez","year":"1989","journal-title":"Pediatr Infect Dis J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0035-9203(92)90215-X","article-title":"Intestinal parasitic infections: a soluble public health problem.","volume":"86","author":"L Savioli","year":"1992","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1017\/S0031182000006491","article-title":"Malnutrition and parasitic helminth infections.","volume":"121","author":"LS Stephenson","year":"2000","journal-title":"Parasitology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection.","volume":"7","author":"RM Anthony","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.4049\/jimmunol.173.4.2699","article-title":"A secreted protein from the human hookworm necator americanus binds selectively to NK cells and induces IFN-gamma production.","volume":"173","author":"GC Hsieh","year":"2004","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-3024.2007.00950.x","article-title":"Stage-specific immune responses in human Necator americanus infection.","volume":"29","author":"SM Geiger","year":"2007","journal-title":"Parasite Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1128\/IAI.00094-08","article-title":"Role for nitric oxide in hookworm-associated immune suppression.","volume":"76","author":"B Dondji","year":"2008","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e399","DOI":"10.1371\/journal.pntd.0000399","article-title":"Necator americanus infection: a possible cause of altered dendritic cell differentiation and eosinophil profile in chronically infected individuals.","volume":"3","author":"RT Fujiwara","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jaci.2005.08.047","article-title":"Role of regulatory T cells in human diseases.","volume":"116","author":"TA Chatila","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e9623","DOI":"10.1371\/journal.pone.0009623","article-title":"Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites.","volume":"5","author":"LL Bueno","year":"2010","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nri2189","article-title":"Regulatory T cells and infection: a dangerous necessity.","volume":"7","author":"Y Belkaid","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1084\/jem.20101074","article-title":"Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-beta pathway.","volume":"207","author":"JR Grainger","year":"2010","journal-title":"J Exp Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.4049\/jimmunol.0901435","article-title":"Pronounced phenotype in activated regulatory T cells during a chronic helminth infection.","volume":"184","author":"LE Layland","year":"2010","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.4049\/jimmunol.0802767","article-title":"Regulatory T cells: a role in the control of helminth-driven intestinal pathology and worm survival.","volume":"182","author":"R D'Elia","year":"2009","journal-title":"J Immunol"},{"key":"ref20","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni.","volume":"14","author":"N Katz","year":"1972","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-3156.2008.02022.x","article-title":"Age patterns in undernutrition and helminth infection in a rural area of Brazil: associations with ascariasis and hookworm.","volume":"13","author":"A Jardim-Botelho","year":"2008","journal-title":"Trop Med Int Health"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2249.2004.02449.x","article-title":"Cellular responses and cytokine production in post-treatment hookworm patients from an endemic area in Brazil.","volume":"136","author":"SM Geiger","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1046-2023(02)00349-3","article-title":"Mapping T cell epitopes by flow cytometry.","volume":"29","author":"B Hoffmeister","year":"2003","journal-title":"Methods"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri821","article-title":"CD4+ CD25+ suppressor T cells: more questions than answers.","volume":"2","author":"EM Shevach","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1126\/science.1142331","article-title":"Emerging challenges in regulatory T cell function and biology.","volume":"317","author":"S Sakaguchi","year":"2007","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1084\/jem.20011347","article-title":"Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses.","volume":"196","author":"M Kursar","year":"2002","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ni1181","article-title":"Natural regulatory T cells in infectious disease.","volume":"6","author":"Y Belkaid","year":"2005","journal-title":"Nat Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/365797a0","article-title":"Immunological modulation and evasion by helminth parasites in human populations.","volume":"365","author":"RM Maizels","year":"1993","journal-title":"Nature"},{"key":"ref29","first-page":"723","article-title":"Cell interactions in the induction of tolerance: the role of thymic lymphocytes.","volume":"18","author":"RK Gershon","year":"1970","journal-title":"Immunology"},{"key":"ref30","first-page":"903","article-title":"Infectious immunological tolerance.","volume":"21","author":"RK Gershon","year":"1971","journal-title":"Immunology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S1286-4579(02)00014-X","article-title":"Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis).","volume":"4","author":"J Satoguina","year":"2002","journal-title":"Microbes Infect"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/eji.200939699","article-title":"Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum.","volume":"40","author":"LJ Wammes","year":"2010","journal-title":"Eur J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1128\/IAI.73.7.4034-4042.2005","article-title":"Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae.","volume":"73","author":"V Gillan","year":"2005","journal-title":"Infect Immun"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.4049\/jimmunol.176.9.5374","article-title":"Naturally occurring CD4+Foxp3+ regulatory T cells are an essential, IL-10-independent part of the immunoregulatory network in Schistosoma mansoni egg-induced inflammation.","volume":"176","author":"M Baumgart","year":"2006","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.4049\/jimmunol.176.10.5839","article-title":"Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population.","volume":"176","author":"JJ Taylor","year":"2006","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1084\/jem.20042572","article-title":"Suppression of allergic airway inflammation by helminth-induced regulatory T cells.","volume":"202","author":"MS Wilson","year":"2005","journal-title":"J Exp Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/eji.200838727","article-title":"Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection.","volume":"39","author":"MD Taylor","year":"2009","journal-title":"Eur J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.4049\/jimmunol.181.9.6456","article-title":"Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi.","volume":"181","author":"HJ McSorley","year":"2008","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/eji.200636751","article-title":"Expansion and activation of CD4(+)CD25(+) regulatory T cells in <italic>Heligmosomoides polygyrus<\/italic> infection.","volume":"37","author":"CA Finney","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.4049\/jimmunol.180.11.7305","article-title":"Regulatory CD4+CD25+Foxp3+ T cells selectively inhibit the spontaneous form of lymphopenia-induced proliferation of naive T cells.","volume":"180","author":"CJ Winstead","year":"2008","journal-title":"J Immunol"},{"key":"ref41","first-page":"311","article-title":"CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.","volume":"16","author":"RS McHugh","year":"2002","journal-title":"Immunity"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni759","article-title":"Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance.","volume":"3","author":"J Shimizu","year":"2002","journal-title":"Nat Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.188.10.1849","article-title":"Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells.","volume":"188","author":"W Chen","year":"1998","journal-title":"J Exp Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3.","volume":"299","author":"S Hori","year":"2003","journal-title":"Science"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.","volume":"4","author":"JD Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/eji.200738111","article-title":"The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function.","volume":"38","author":"EM Shevach","year":"2008","journal-title":"Eur J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000067596","article-title":"The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells.","volume":"129","author":"MK Levings","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1582-4934.2007.00084.x","article-title":"Immunosuppression induced by immature dendritic cells is mediated by TGF-beta\/IL-10 double-positive CD4+ regulatory T cells.","volume":"12","author":"N Cools","year":"2008","journal-title":"J Cell Mol Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/intimm\/dxh165","article-title":"Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells.","volume":"16","author":"H Yagi","year":"2004","journal-title":"Int Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/eji.200636933","article-title":"GITR\/GITRL: more than an effector T cell co-stimulatory system.","volume":"37","author":"G Nocentini","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nri1867","article-title":"The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?","volume":"6","author":"EM Shevach","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.imlet.2008.09.003","article-title":"In vivo expansion of CD4+Foxp3+ regulatory T cells mediated by GITR molecules.","volume":"121","author":"T Nishioka","year":"2008","journal-title":"Immunol Lett"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.0105-2896.2004.00191.x","article-title":"Helminth parasites\u2013masters of regulation.","volume":"201","author":"RM Maizels","year":"2004","journal-title":"Immunol Rev"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/35105024","article-title":"T-cell regulation by CD28 and CTLA-4.","volume":"1","author":"ML Alegre","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.182.2.459","article-title":"CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.","volume":"182","author":"MF Krummel","year":"1995","journal-title":"J Exp Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/1074-7613(94)90071-X","article-title":"CTLA-4 can function as a negative regulator of T cell activation.","volume":"1","author":"TL Walunas","year":"1994","journal-title":"Immunity"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/ni1003","article-title":"Modulation of tryptophan catabolism by regulatory T cells.","volume":"4","author":"F Fallarino","year":"2003","journal-title":"Nat Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.4049\/jimmunol.170.4.1930","article-title":"CTLA-4 in filarial infections: implications for a role in diminished T cell reactivity.","volume":"170","author":"C Steel","year":"2003","journal-title":"J Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.micinf.2008.09.003","article-title":"Early stage-specific immune responses in primary experimental human hookworm infection.","volume":"10","author":"SM Geiger","year":"2008","journal-title":"Microbes Infect"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"e1000543","DOI":"10.1371\/journal.ppat.1000543","article-title":"<italic>Plasmodium falciparum<\/italic>-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta.","volume":"5","author":"A Scholzen","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref61","article-title":"Hookworm products ameliorate DSS-induced colitis in BALB\/c mice.","author":"GG Cancado","journal-title":"Inflamm Bowel Dis"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/ibd.20633","article-title":"Helminths and the IBD hygiene hypothesis.","volume":"15","author":"JV Weinstock","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/ibd.20787","article-title":"Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice.","volume":"15","author":"NE Ruyssers","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.4049\/jimmunol.181.4.2414","article-title":"Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production.","volume":"181","author":"DE Elliott","year":"2008","journal-title":"J Immunol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 Cells.","volume":"27","author":"T Korn","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1365-3024.2010.01224.x","article-title":"The immunology of human hookworm infections.","volume":"32","author":"HJ McSorley","year":"2010","journal-title":"Parasite Immunol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-3024.2006.00821.x","article-title":"Comparative immunology of human and animal models of hookworm infection.","volume":"28","author":"RT Fujiwara","year":"2006","journal-title":"Parasite Immunol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1096\/fj.05-3936fje","article-title":"Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals.","volume":"19","author":"J Bethony","year":"2005","journal-title":"FASEB J"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1371\/journal.pntd.0000439","article-title":"The hookworm tissue inhibitor of metalloproteases (Ac-TMP-1) modifies dendritic cell function and induces generation of CD4 and CD8 suppressor T cells.","volume":"3","author":"C Cuellar","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"911","DOI":"10.4269\/ajtmh.2009.09-0237","article-title":"Immunologic profiles of persons recruited for a randomized, placebo-controlled clinical trial of hookworm infection.","volume":"81","author":"D Blount","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.femsim.2004.11.006","article-title":"Immunobiology of hookworm infection.","volume":"43","author":"A Loukas","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/1471-2164-11-307","article-title":"Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation.","volume":"11","author":"Z Wang","journal-title":"BMC Genomics"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"e684","DOI":"10.1371\/journal.pntd.0000684","article-title":"Massively parallel sequencing and analysis of the Necator americanus transcriptome.","volume":"4","author":"C Cantacessi","journal-title":"PLoS Negl Trop Dis"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T14:55:47Z","timestamp":1713106547000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001383"}},"subtitle":[],"editor":[{"given":"Maria","family":"Yazdanbakhsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,11,8]]},"references-count":73,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001383","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,8]]}}}