{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:17:01Z","timestamp":1793888221491,"version":"4.8.0"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T00:00:00Z","timestamp":1327968000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001488","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T22:09:38Z","timestamp":1328047778000},"page":"e1488","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":87,"title":["Melioidosis Vaccines: A Systematic Review and Appraisal of the Potential to Exploit Biodefense Vaccines for Public Health Purposes"],"prefix":"10.1371","volume":"6","author":[{"given":"Sharon J.","family":"Peacock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Direk","family":"Limmathurotsakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoel","family":"Lubell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin C. K. W.","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P. J.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Titball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00001432-200204000-00005","article-title":"Melioidosis.","volume":"15","author":"DAB Dance","year":"2002","journal-title":"Curr Opin Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.clinthera.2010.07.020","article-title":"Progress toward development of vaccines against melioidosis: A review.","volume":"32","author":"M Sarkar-Tyson","year":"2010","journal-title":"Clin Ther"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0035-9203(08)70002-6","article-title":"The global distribution of <italic>Burkholderia pseudomallei<\/italic> and melioidosis: an update.","volume":"102","author":"BJ Currie","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/bmb\/ldr007","article-title":"Melioidosis: a clinical overview.","volume":"99","author":"D Limmathurotsakul","year":"2011","journal-title":"Br Med Bull"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4269\/ajtmh.2010.10-0038","article-title":"Increasing incidence of human melioidosis in Northeast Thailand.","volume":"82","author":"D Limmathurotsakul","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0001-706X(99)00060-1","article-title":"The epidemiology of melioidosis in Australia and Papua New Guinea.","volume":"74","author":"BJ Currie","year":"2000","journal-title":"Acta Trop"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1586\/14787210.4.3.445","article-title":"Management of melioidosis.","volume":"4","author":"V Wuthiekanun","year":"2006","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e900","DOI":"10.1371\/journal.pntd.0000900","article-title":"The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study.","volume":"4","author":"BJ Currie","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1017\/S0266462306051051","article-title":"Use of quality-adjusted life years for the estimation of effectiveness of health care: A systematic literature review.","volume":"22","author":"P Rasanen","year":"2006","journal-title":"Int J Technol Assess Health Care"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1590\/S1020-49892002000800017","article-title":"Macroeconomics and health: Investing in health for economic development","author":"J Sachs","year":"2002"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"903","DOI":"10.2165\/10899580-000000000-00000","article-title":"Cost effectiveness in low- and middle-income countries: a review of the debates surrounding decision rules.","volume":"27","author":"SD Shillcutt","year":"2009","journal-title":"Pharmacoeconomics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1365-3156.2004.01328.x","article-title":"Melioidosis epidemiology and risk factors from a prospective whole-population study in northern Australia.","volume":"9","author":"BJ Currie","year":"2004","journal-title":"Trop Med Int Health"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/CMR.18.2.383-416.2005","article-title":"Melioidosis: epidemiology, pathophysiology, and management.","volume":"18","author":"AC Cheng","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/ije\/23.5.1082","article-title":"The epidemiology of melioidosis in Ubon Ratchatani, northeast Thailand.","volume":"23","author":"Y Suputtamongkol","year":"1994","journal-title":"Int J Epidemiol"},{"key":"ref15","first-page":"425","article-title":"The 1990\u20131991 outbreak of melioidosis in the Northern Territory of Australia: epidemiology and environmental studies.","volume":"24","author":"A Merianos","year":"1993","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/infdis\/124.6.598","article-title":"The <italic>pseudomallei<\/italic> group: a review.","volume":"124","author":"C Howe","year":"1971","journal-title":"J Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/S0035-9203(08)70008-7","article-title":"Melioidosis and Aboriginal seasons in northern Australia.","volume":"102","author":"AC Cheng","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.3201\/eid0912.020750","article-title":"Intensity of rainfall and severity of melioidosis, Australia.","volume":"9","author":"BJ Currie","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"ref19","first-page":"56","article-title":"<italic>Burkholderia pseudomallei<\/italic> traced to water treatment plant in Australia.","volume":"6","author":"TJ Inglis","year":"2000","journal-title":"Emerg Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4269\/ajtmh.2001.65.177","article-title":"A cluster of melioidosis cases from an endemic region is clonal and is linked to the water supply using molecular typing of Burkholderia pseudomallei isolates.","volume":"65","author":"BJ Currie","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1371\/journal.pntd.0000182","article-title":"Genetic diversity and microevolution of <italic>Burkholderia pseudomallei<\/italic> in the environment.","volume":"2","author":"N Chantratita","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1017\/S0950268804002663","article-title":"Preliminary report on the northern Australian melioidosis environmental surveillance project.","volume":"132","author":"TJ Inglis","year":"2004","journal-title":"Epidemiol Infect"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1099\/0022-1317-51-7-539","article-title":"Characterisation of an acapsular mutant of <italic>Burkholderia pseudomallei<\/italic> identified by signature tagged mutagenesis.","volume":"51","author":"T Atkins","year":"2002","journal-title":"J Med Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.1128\/IAI.70.9.5290-5294.2002","article-title":"A mutant of <italic>Burkholderia pseudomallei<\/italic>, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis.","volume":"70","author":"T Atkins","year":"2002","journal-title":"Infect Immun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1086\/508217","article-title":"A live experimental vaccine against <italic>Burkholderia pseudomallei<\/italic> elicits CD4+ T cell-mediated immunity, priming T cells specific for 2 type III secretion system proteins.","volume":"194","author":"A Haque","year":"2006","journal-title":"J Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1099\/mic.0.27146-0","article-title":"Attenuated virulence and protective efficacy of a <italic>Burkholderia pseudomallei<\/italic> bsa type III secretion mutant in murine models of melioidosis.","volume":"150","author":"MP Stevens","year":"2004","journal-title":"Microbiology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"8178","DOI":"10.1128\/JB.01006-06","article-title":"Global map of growth-regulated gene expression in <italic>Burkholderia pseudomallei<\/italic>, the causative agent of melioidosis.","volume":"188","author":"F Rodrigues","year":"2006","journal-title":"J Bacteriol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1128\/IAI.01240-06","article-title":"Development of signature-tagged mutagenesis in <italic>Burkholderia pseudomallei<\/italic> to identify genes important in survival and pathogenesis.","volume":"75","author":"J Cuccui","year":"2007","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1016\/S0035-9203(08)70022-1","article-title":"Induction of protective immunity against <italic>Burkholderia pseudomallei<\/italic> using attenuated mutants with defects in the intracellular life cycle.","volume":"102","author":"K Breitbach","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref30","first-page":"123","article-title":"Construction and characterization of an unmarked aroC deletion mutant of <italic>Burkholderia pseudomallei<\/italic> strain A2.","volume":"40","author":"T Srilunchang","year":"2009","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.micinf.2005.04.013","article-title":"A model of immunity to <italic>Burkholderia pseudomallei<\/italic>: unique responses following immunization and acute lethal infection.","volume":"7","author":"GC Ulett","year":"2005","journal-title":"Microbes Infect"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1128\/IAI.05044-11","article-title":"The <italic>Burkholderia pseudomallei<\/italic> Delta asd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in mice.","volume":"79","author":"MH Norris","year":"2011","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/infdis\/jir301","article-title":"Combining vaccination and postexposure CpG therapy provides optimal protection against lethal sepsis in a biodefense model of human melioidosis.","volume":"204","author":"A Easton","year":"2011","journal-title":"The Journal of infectious diseases"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1016\/j.jcpa.2009.10.021","article-title":"Evaluation of the persistence of vaccine-induced protection with human vaccines.","volume":"142","author":"E Vidor","year":"2010","journal-title":"J Comp Pathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/eji.201040923","article-title":"Persistence of cell-mediated immunity three decades after vaccination with the live vaccine strain of <italic>Francisella tularensis<\/italic>.","volume":"41","author":"K Eneslatt","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.amjmed.2008.08.019","article-title":"Immunity from smallpox vaccine persists for decades: a longitudinal study.","volume":"121","author":"DD Taub","year":"2008","journal-title":"Am J Med"},{"key":"ref37","first-page":"576","article-title":"Still protected against smallpox? Estimation of the duration of vaccine-induced immunity against smallpox.","volume":"17","author":"H Nishiura","year":"2006","journal-title":"Epidemiology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1128\/JCM.43.2.970-972.2005","article-title":"Cutaneous melioidosis in a man who was taken as a prisoner of war by the Japanese during World War II.","volume":"43","author":"V Ngauy","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0140-6736(67)90335-2","article-title":"A seven-year field trial of two typhoid vaccines in Guyana.","volume":"2","author":"MT Ashcroft","year":"1967","journal-title":"Lancet"},{"key":"ref40","first-page":"321","article-title":"A controlled field trial and laboratory study of five typhoid vaccines in the USSR.","volume":"34","author":"LB Hejfec","year":"1966","journal-title":"Bull World Health Organ"},{"key":"ref41","first-page":"105","article-title":"Protection studies using whole cells and partially purified toxic material (PPTM) of <italic>Pseudomonas pseudomallei<\/italic>.","volume":"15","author":"CE Razak","year":"1986","journal-title":"Malays Appl Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/sj.icb.7100084","article-title":"Development of protective immunity in a murine model of melioidosis is influenced by the source of <italic>Burkholderia pseudomallei<\/italic> antigens.","volume":"85","author":"JL Barnes","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1099\/jmm.0.47043-0","article-title":"Polysaccharides and virulence of <italic>Burkholderia pseudomallei<\/italic>.","volume":"56","author":"M Sarkar-Tyson","year":"2007","journal-title":"J Med Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1016\/j.vaccine.2009.05.040","article-title":"Protective efficacy of heat-inactivated <italic>B. thailandensis<\/italic>, <italic>B. mallei<\/italic> or <italic>B. pseudomallei<\/italic> against experimental melioidosis and glanders.","volume":"27","author":"M Sarkar-Tyson","year":"2009","journal-title":"Vaccine"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"5304","DOI":"10.1016\/j.vaccine.2011.05.009","article-title":"Mucosal immunization with liposome-nucleic acid adjuvants generates effective humoral and cellular immunity.","volume":"29","author":"A Henderson","year":"2011","journal-title":"Vaccine"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1128\/IAI.00834-06","article-title":"Expression of the lipopolysaccharide-modifying enzymes PagP and PagL modulates the endotoxic activity of <italic>Bordetella pertussis<\/italic>.","volume":"74","author":"J Geurtsen","year":"2006","journal-title":"Infect Immun"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1046\/j.1365-2249.2000.01386.x","article-title":"Kinetic studies of the production of nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) in macrophages stimulated with <italic>Burkholderia pseudomallei<\/italic> endotoxin.","volume":"122","author":"P Utaisincharoen","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-2172-9-46","article-title":"Activation of Toll-like receptors by <italic>Burkholderia pseudomallei<\/italic>.","volume":"9","author":"TE West","year":"2008","journal-title":"BMC Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1574-6968.1996.tb08086.x","article-title":"Biological activities of lipopolysaccharide of <italic>Burkholderia (Pseudomonas) pseudomallei<\/italic>.","volume":"137","author":"M Matsuura","year":"1996","journal-title":"FEMS Microbiol Lett"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1128\/CVI.00389-09","article-title":"Serum bactericidal antibody response 1 year after meningococcal polysaccharide vaccination of patients with common variable immunodeficiency.","volume":"17","author":"N Rezaei","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.vaccine.2011.01.025","article-title":"Antibody levels and immune memory 23 years after primary plasma-derived hepatitis B vaccination: results of a randomized placebo-controlled trial cohort from China where endemicity is high.","volume":"29","author":"Q Wu","year":"2011","journal-title":"Vaccine"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1056\/NEJMoa066092","article-title":"Duration of humoral immunity to common viral and vaccine antigens.","volume":"357","author":"IJ Amanna","year":"2007","journal-title":"N Engl J Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1099\/jmm.0.45766-0","article-title":"Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis.","volume":"53","author":"M Nelson","year":"2004","journal-title":"J Med Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1128\/IAI.00404-07","article-title":"Identification of a LolC homologue in <italic>Burkholderia pseudomallei<\/italic>, a novel protective antigen for melioidosis.","volume":"75","author":"DN Harland","year":"2007","journal-title":"Infect Immun"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1574-695X.2007.00345.x","article-title":"Evaluating <italic>Burkholderia pseudomallei<\/italic> Bip proteins as vaccines and Bip antibodies as detection agents.","volume":"52","author":"C Druar","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e6496","DOI":"10.1371\/journal.pone.0006496","article-title":"Immunogenic <italic>Burkholderia pseudomallei<\/italic> outer membrane proteins as potential candidate vaccine targets.","volume":"4","author":"Y Hara","year":"2009","journal-title":"PLoS One"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1016\/j.vaccine.2010.05.022","article-title":"Immunization with the recombinant <italic>Burkholderia pseudomallei<\/italic> outer membrane protein Omp85 induces protective immunity in mice.","volume":"28","author":"YC Su","year":"2010","journal-title":"Vaccine"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.1016\/j.vaccine.2007.08.045","article-title":"Analysis of peptide mimotopes of <italic>Burkholderia pseudomallei<\/italic> exopolysaccharide.","volume":"25","author":"JB Legutki","year":"2007","journal-title":"Vaccine"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1128\/IAI.01218-10","article-title":"The cluster 1 type VI secretion system is a major virulence determinant in <italic>Burkholderia pseudomallei<\/italic>.","volume":"79","author":"MN Burtnick","year":"2011","journal-title":"Infect Immun"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"7551","DOI":"10.1016\/j.vaccine.2010.08.058","article-title":"Lipopolysaccharide from <italic>Burkholderia thailandensis<\/italic> E264 provides protection in a murine model of melioidosis.","volume":"28","author":"SA Ngugi","year":"2010","journal-title":"Vaccine"},{"key":"ref61","article-title":"A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary <italic>Burkholderia pseudomallei<\/italic> infection.","author":"W Nieves","year":"2011","journal-title":"Vaccine"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4269\/ajtmh.2006.74.348","article-title":"Lipopolysaccharide heterogeneity among <italic>Burkholderia pseudomallei<\/italic> from different geographic and clinical origins.","volume":"74","author":"N Anuntagool","year":"2006","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.vaccine.2005.08.069","article-title":"Immunogenicity and anti-<italic>Burkholderia pseudomallei<\/italic> activity in Balb\/c mice immunized with plasmid DNA encoding flagellin.","volume":"24","author":"YS Chen","year":"2006","journal-title":"Vaccine"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1128\/IAI.74.3.1699-1705.2006","article-title":"CpG-modified plasmid DNA encoding flagellin improves immunogenicity and provides protection against <italic>Burkholderia pseudomallei<\/italic> infection in BALB\/c mice.","volume":"74","author":"YS Chen","year":"2006","journal-title":"Infect Immun"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-065X.2010.00980.x","article-title":"DNA vaccines: an historical perspective and view to the future.","volume":"239","author":"MA Liu","year":"1111","journal-title":"Immunol Rev"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"5945","DOI":"10.1128\/IAI.73.9.5945-5951.2005","article-title":"Humoral and cell-mediated adaptive immune responses are required for protection against <italic>Burkholderia pseudomallei<\/italic> challenge and bacterial clearance postinfection.","volume":"73","author":"GD Healey","year":"2005","journal-title":"Infect Immun"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1128\/IAI.74.3.1706-1711.2006","article-title":"Protection against heterologous <italic>Burkholderia pseudomallei<\/italic> strains by dendritic cell immunization.","volume":"74","author":"SJ Elvin","year":"2006","journal-title":"Infect Immun"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2174\/156652409788970689","article-title":"Clinical considerations in developing dendritic cell vaccine based immunotherapy protocols in cancer.","volume":"9","author":"V Murthy","year":"2009","journal-title":"Curr Mol Med"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1016\/j.vaccine.2011.07.043","article-title":"Challenges in dendritic cells-based therapeutic vaccination in HIV-1 infection Workshop in dendritic cell-based vaccine clinical trials in HIV-1.","volume":"29","author":"F Garcia","year":"2011","journal-title":"Vaccine"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/mpat.1997.0179","article-title":"BALB\/c and C57BI\/6 mice infected with virulent <italic>Burkholderia pseudomallei<\/italic> provide contrasting animal models for the acute and chronic forms of human melioidosis.","volume":"24","author":"A Leakey","year":"1998","journal-title":"Microb Pathog"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ajpath.2011.03.031","article-title":"Low-dose exposure of C57BL\/6 mice to <italic>Burkholderia pseudomallei<\/italic> mimics chronic human melioidosis.","volume":"179","author":"L Conejero","year":"2011","journal-title":"Am J Pathol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3201\/eid1104.041051","article-title":"Route of infection in melioidosis.","volume":"11","author":"JL Barnes","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.4269\/ajtmh.2010.10-0306","article-title":"Pathogenicity of high-dose enteral inoculation of <italic>Burkholderia pseudomallei<\/italic> to mice.","volume":"83","author":"TE West","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1128\/IAI.64.7.2824-2828.1996","article-title":"Structural and immunological characterization of <italic>Burkholderia pseudomallei<\/italic> O-polysaccharide-flagellin protein conjugates.","volume":"64","author":"PJ Brett","year":"1996","journal-title":"Infect Immun"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1128\/IAI.61.10.4045-4050.1993","article-title":"Interaction of insulin with <italic>Pseudomonas pseudomallei<\/italic>.","volume":"61","author":"DE Woods","year":"1993","journal-title":"Infect Immun"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1574-695X.2010.00767.x","article-title":"Impact of streptozotocin-induced diabetes on functional responses of dendritic cells and macrophages towards <italic>Burkholderia pseudomallei<\/italic>.","volume":"61","author":"NL Williams","year":"2011","journal-title":"FEMS Immunol Med Microbiol"}],"updated-by":[{"DOI":"10.1371\/annotation\/20664ec9-17e4-4ba6-8c65-481a70a5c4ad","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000}}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T14:28:32Z","timestamp":1593613712000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001488"}},"subtitle":[],"editor":[{"given":"Bart J.","family":"Currie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,31]]},"references-count":76,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001488","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/20664ec9-17e4-4ba6-8c65-481a70a5c4ad","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,31]]}}}