{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:52:19Z","timestamp":1775026339729,"version":"3.50.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T00:00:00Z","timestamp":1328572800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001511","type":"journal-article","created":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T22:02:05Z","timestamp":1328652125000},"page":"e1511","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":53,"title":["Early Clinical Manifestations Associated with Death from Visceral Leishmaniasis"],"prefix":"10.1371","volume":"6","author":[{"given":"Valdelaine Etelvina Miranda","family":"de Ara\u00fajo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena Franco","family":"Morais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilka Afonso","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rabello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00e2ngela","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,2,7]]},"reference":[{"key":"ref1","article-title":"The global burden of disease: 2004 update.","author":"WHO","year":"2008"},{"key":"ref2","article-title":"First WHO report on neglected tropical diseases: working to overcome the global impact of neglected tropical diseases.","author":"WHO","year":"2010"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e584","DOI":"10.1371\/journal.pntd.0000584","article-title":"Control of visceral leishmaniasis in latin america-a systematic review.","volume":"4","author":"GA Romero","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s15010-003-3139-9","article-title":"Prognostic factors for death from visceral leishmaniasis in Teresina, Brazil.","volume":"31","author":"GL Werneck","year":"2003","journal-title":"Infection"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/CMR.10.2.298","article-title":"Leishmania and human immunodeficiency virus coinfection: the first 10 years.","volume":"10","author":"J Alvar","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1371\/journal.pntd.0000313","article-title":"Complexities of assessing the disease burden attributable to leishmaniasis.","volume":"2","author":"C Bern","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s004300100085","article-title":"Worldwide increasing risk factors for leishmaniasis.","volume":"190","author":"P Desjeux","year":"2001","journal-title":"Med Microbiol Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1590\/S0037-86822006000500005","article-title":"[Emergent outbreak of visceral leishmaniasis in Mato Grosso do Sul State].","volume":"39","author":"AL Oliveira","year":"2006","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref9","first-page":"249","article-title":"[Leishmaniasis urbanization and low diagnosis capacity in the Metropolitan Region of Belo Horizonte].","volume":"34","author":"ZM Profeta da Luz","year":"2001","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/0035-9203(94)90393-X","article-title":"An urban outbreak of visceral leishmaniasis in Natal, Brazil.","volume":"88","author":"SM Jeronimo","year":"1994","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3201\/eid0202.960213","article-title":"The reemergence of visceral leishmaniasis in Brazil.","volume":"2","author":"JR Arias","year":"1996","journal-title":"Emerg Infect Dis"},{"key":"ref12","article-title":"Guia de vigil\u00e2ncia epidemiol\u00f3gica. 7<sup>a<\/sup> edition. Bras\u00edlia.","year":"2009"},{"key":"ref13","article-title":"Casos confirmados de Leishmaniose Visceral, Brasil, Grandes Regi\u00f5es e Unidades Federadas. 1990 a 2009.","year":"2010"},{"key":"ref14","article-title":"Letalidade por Leishmaniose Visceral. Brasil, Grandes Regi\u00f5es e Unidades Federadas, 2000 a 2009.","year":"2010"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1590\/S1020-49892003000300006","article-title":"Epidemiological aspects of human and canine visceral leishmaniasis in Venezuela.","volume":"13","author":"O Zerpa","year":"2003","journal-title":"Rev Panam Salud Publica"},{"key":"ref16","first-page":"931","article-title":"[Analysis of visceral leishmaniasis reports by the capture-recapture method].","volume":"41","author":"AN Maia-Elkhoury","year":"2007","journal-title":"Rev Saude Publica"},{"key":"ref17","article-title":"Manual de vigil\u00e2ncia e controle da leishmaniose visceral, 1th ed. Secretaria de Vigil\u00e2ncia em Sa\u00fade.","author":"Brasil","year":"2006"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4269\/ajtmh.1996.55.125","article-title":"The logic of visceral leishmaniasis control.","volume":"55","author":"C Dye","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"ref19","article-title":"Leishmaniose visceral grave: normas e condutas. Secretaria de Vigil\u00e2ncia em Sa\u00fade.","author":"Brasil","year":"2006"},{"key":"ref20","article-title":"Urban parasitology:visceral leishmaniasis inBrazil.","author":"MO Harway","year":"2011","journal-title":"Trends in Parasitology"},{"key":"ref21","article-title":"Censo Demogr\u00e1fico 2010.","author":"Brasil","year":"2000"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.1997.03550060067038","article-title":"Prognostic factors in meningococcal disease: development of a beside predictive model an scoring system.","volume":"278","author":"N Barquet","year":"1997","journal-title":"JAMA"},{"key":"ref23","article-title":"Epidemiology: beyond the basis","author":"M Szklo","year":"2007"},{"key":"ref24","first-page":"188","article-title":"[Mortality due to visceral leishmaniasis: clinical and laboratory characteristics].","volume":"43","author":"JM Oliveira","year":"2010","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1590\/S0037-86822010000400010","article-title":"Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study.","volume":"43","author":"CHN Costa","year":"2010","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e877","DOI":"10.1371\/journal.pntd.0000877","article-title":"Risk factors for death in children with visceral leishmaniasis.","volume":"4","author":"MJAQ Sampaio","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"664","DOI":"10.7326\/0003-4819-124-7-199604010-00007","article-title":"Epidemic visceral leishmaniasis in southern Sudan: treatment of severely debilitated patients under wartime conditions and with limited resources.","volume":"124","author":"J Seaman","year":"1996","journal-title":"Ann Intern Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1086\/381203","article-title":"Conflict and kala-azar: determinants of adverse outcomes of kala-azar among patients in southern Sudan.","volume":"38","author":"S Collin","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-3156.2010.02694.x","article-title":"Risk factors for relapse of visceral leishmaniasis in Georgia.","volume":"16","author":"M Kajaia","year":"2011","journal-title":"Tropical Medicine and International Health"},{"key":"ref30","first-page":"535","article-title":"[Visceral leishmaniasis in children: prognostic factors].","volume":"81","author":"MS Abdelmoula","year":"2003","journal-title":"Tunis Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1590\/S0036-46651987000300003","article-title":"Histopathological patterns of the liver involvement in visceral leishmaniasis.","volume":"29","author":"MI Duarte","year":"1987","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref32","first-page":"409","article-title":"Acute hepatitis as a presenting manifestation of kala azar.","volume":"10","author":"JA Hervas","year":"1991","journal-title":"Pediatr Infect Dis J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1365-3156.2009.02305.x","article-title":"Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda.","volume":"14","author":"Y Mueller","year":"2009","journal-title":"Trop Med Int Health"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1093\/infdis\/162.6.1354","article-title":"Bacterial infections in patients with visceral leishmaniasis.","volume":"162","author":"TM Andrade","year":"1990","journal-title":"J Infect Dis"},{"key":"ref35","first-page":"47","article-title":"[Study of intravascular coagulation activation markers in patients with visceral leishmaniasis].","author":"ML Lomtadze","year":"2005","journal-title":"Georgian Med News"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.thromres.2004.06.028","article-title":"The impact of the inflammatory response on coagulation.","volume":"114","author":"C Esmon","year":"2004","journal-title":"Thromb Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e1153","DOI":"10.1371\/journal.pntd.0001153","article-title":"Predictors of Visceral Leishmaniasis Relapse in HIV Infected Patients: A Systematic Review.","volume":"5","author":"GF Cota","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1128\/CMR.00061-07","article-title":"The relationship between leishmaniasis and AIDS: the second 10 years.","volume":"21","author":"J Alvar","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.0022-202x.2001.00038.x","article-title":"Leishmaniasis as an emerging infection.","volume":"6","author":"CM Choi","year":"2001","journal-title":"J Investig Dermatol Symp Proc"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00002030-199801000-00004","article-title":"Impact of opportunistic disease on survival in patients with HIV infection.","volume":"12","author":"GJ Chaisson RE","year":"1998","journal-title":"AIDS"},{"key":"ref41","first-page":"357","article-title":"Leishmania\/HIV co-infections in the second decade.","volume":"123","author":"I Cruz","year":"2006","journal-title":"Indian J Med Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/003655498750002268","article-title":"Live and killed human immunodeficiency virus type-1 increases the intracellular growth of Leishmania donovani in monocyte-derived cells.","volume":"30","author":"AH Wolday D","year":"1998","journal-title":"Scand J Infect Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1590\/S0100-55022007000200002","article-title":"Avalia\u00e7\u00e3o dos Prontu\u00e1rios M\u00e9dicos de Hospitais de Ensino do Brasil.","volume":"29","author":"FG Silva","year":"2007","journal-title":"Revista Brasileita de Educa\u00e7\u00e3o M\u00e9dica"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T21:58:39Z","timestamp":1593640719000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001511"}},"subtitle":[],"editor":[{"given":"Richard","family":"Reithinger","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,7]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001511","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,7]]}}}