{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:05:18Z","timestamp":1790661918273,"version":"4.1.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001519","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T22:01:03Z","timestamp":1330466463000},"page":"e1519","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Therapeutic DNA Vaccine Encoding Peptide P10 against Experimental Paracoccidioidomycosis"],"prefix":"10.1371","volume":"6","author":[{"given":"Glauce M. G.","family":"Rittner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n E.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre F.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Nosanchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos P.","family":"Taborda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz R.","family":"Travassos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"ref1","first-page":"109","article-title":"Epidemiology and paracoccidioidomycosis infection.","author":"B Wanke","year":"1994"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1590\/S0074-02762009000300019","article-title":"Mortality in Brazil of systemic mycosis as primary cause of death or in association with AIDS: a review from 1996 to 2006.","volume":"104","author":"M Prado","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11046-007-9065-0","article-title":"An overview of the immunopathology of human paracoccidioidomycosis.","volume":"165","author":"G Benard","year":"2008","journal-title":"Mycopathologia"},{"key":"ref4","first-page":"297","article-title":"Guidelines in paracoccidioidomycosis.","volume":"39","author":"MA Shikanai-Yasuda","year":"2006","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1128\/IAI.53.1.199-206.1986","article-title":"Exocellular components of <italic>Paracoccidioides brasiliensis<\/italic>: identification of a specific antigen.","volume":"53","author":"R Puccia","year":"1986","journal-title":"Infect Immun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1074\/jbc.271.8.4553","article-title":"Cloning, characterization, and epitope expression of the major diagnostic antigen of <italic>Paracoccidioides brasiliensis<\/italic>.","volume":"271","author":"PS Cisalpino","year":"1996","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/02681218980000531","article-title":"Identification of antigenic polypeptides of <italic>Paracoccidioides brasiliensis<\/italic> by immunoblotting.","volume":"27","author":"ZP Camargo","year":"1989","journal-title":"J Med Vet Mycol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/02681219480000111","article-title":"Nature of the reactive epitopes in <italic>Paracoccidioides brasiliensis<\/italic> polysaccharide antigen.","volume":"32","author":"EG Rodrigues","year":"1994","journal-title":"J Med Vet Mycol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/02681219680000261","article-title":"<italic>Paracoccidioides brasiliensis<\/italic>-gp43 used as paracoccidioidin.","volume":"34","author":"EC Saraiva","year":"1996","journal-title":"J Med Vet Mycol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/glycob\/6.5.507","article-title":"Structure of the N-linked oligosaccharide of the main diagnostic antigen of the pathogenic fungus <italic>Paracoccidioides brasiliensis<\/italic>.","volume":"6","author":"IC Almeida","year":"1996","journal-title":"Glycobiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1128\/IAI.66.2.786-793.1998","article-title":"Mapping of the T-cell epitope in the major 43-kilodalton glycoprotein of <italic>Paracoccidioides brasiliensis<\/italic> which induces a Th-1 response protective against fungal infection in BALB\/c mice.","volume":"66","author":"CP Taborda","year":"1998","journal-title":"Infect Immun"},{"key":"ref12","first-page":"279","article-title":"The gp43 from <italic>Paracoccidioides brasiliensis<\/italic>: A major diagnostic antigen and vaccine candidate.","author":"LR Travassos","year":"2004"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/S0002-9440(10)65053-5","article-title":"Interferon-gamma and tumor necrosis factor-alpha determine resistance to <italic>Paracoccidioides brasiliensis<\/italic> infection in mice.","volume":"156","author":"JT Souto","year":"2000","journal-title":"Am J Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1128\/IAI.66.2.800-806.1998","article-title":"Protective role of gamma interferon in experimental pulmonary paracoccidioidomycosis.","volume":"66","author":"LE Cano","year":"1998","journal-title":"Infect Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/mmy.38.2.177.182","article-title":"Effect of cytokines on antifungal activity of human polymorphonuclear leucocytes against yeast cells of <italic>Paracoccidioides brasiliensis<\/italic>.","volume":"38","author":"N Kurita","year":"2000","journal-title":"Med Mycol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1128\/JCM.38.11.3960-3966.2000","article-title":"Polymorphism in the gene coding for the immunodominant antigen gp43 from the pathogenic fungus <italic>Paracoccidioides brasiliensis<\/italic>.","volume":"38","author":"FV Morais","year":"2000","journal-title":"J Clin Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.0300-9475.2004.01359.x","article-title":"Synthesis and immunological activity of a branched peptide carrying the T-cell epitope of gp43, the major exocellular antigen of <italic>Paracoccidioides brasiliensis<\/italic>.","volume":"59","author":"CP Taborda","year":"2004","journal-title":"Scand J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF03402131","article-title":"In silico prediction of peptides binding to multiple HLA-DR molecules accurately identifies immunodominant epitopes from gp43 of <italic>Paracoccidioides brasiliensis<\/italic> frequently recognized in primary peripheral blood mononuclear cell responses from sensitized individuals.","volume":"9","author":"LK Iwai","year":"2003","journal-title":"Mol Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1128\/AAC.00220-06","article-title":"Peptide immunization as an adjuvant to chemotherapy in mice challenged intratracheally with virulent yeast cells of <italic>Paracoccidioides brasiliensis<\/italic>.","volume":"50","author":"AF Marques","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.micinf.2008.07.027","article-title":"Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of <italic>Paracoccidioides brasiliensis<\/italic>.","volume":"10","author":"AF Marques","year":"2008","journal-title":"Microb Infec"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1046\/j.1365-3083.2001.00937.x","article-title":"Immunostimulatory DNA from <italic>Paracoccidioides brasiliensis<\/italic> acts as T-helper 1 promoter in susceptible mice.","volume":"54","author":"MC Souza","year":"2001","journal-title":"Scand J Immunol."},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-3083.2005.01680.x","article-title":"Adjuvant effect of synthetic oligodeoxyribonucleotides (CpG-ODN) from the <italic>Paracoccidioides brasiliensis<\/italic> gp43 gene on the Th2-Th1 immunomodulation of experimental paracoccidioidomycosis.","volume":"62","author":"SR Almeida","year":"2005","journal-title":"Scand J Immunol"},{"key":"ref23","first-page":"151","article-title":"Immunogenetics in Paracoccidioidomycosis.","author":"VL Calich","year":"1994"},{"key":"ref24","first-page":"241","article-title":"Immunomodulation and immunoprotection in Fungal infections: humoral and cellular immune responses.","author":"LR Travassos","year":"2005"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1016\/S0264-410X(00)00074-8","article-title":"DNA-based vaccination against murine paracoccidioidomycosis using the gp43 gene from <italic>Paracoccidioides brasiliensis<\/italic>.","volume":"18","author":"AR Pinto","year":"2000","journal-title":"Vaccine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2174\/1566524054022530","article-title":"Protective antibodies and endemic dimorphic fungi.","volume":"5","author":"JD Nosanchuk","year":"2005","journal-title":"Curr Mol Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/clim.2002.5207","article-title":"Interleukin-12 protects mice against disseminated infection caused by <italic>Paracoccidioides brasiliensis<\/italic> but enhances pulmonary inflammation.","volume":"103","author":"C Arruda","year":"2002","journal-title":"Clin Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1473-3099(08)70016-1","article-title":"Fungal vaccines: real progress from real challenges.","volume":"8","author":"A Cassone","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1586\/14787210.6.2.251","article-title":"Treatment options for paracoccidioidomycosis and new strategies investigated.","volume":"6","author":"LR Travassos","year":"2008","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1016\/j.vaccine.2008.07.097","article-title":"Protective immunity induced by rPb27 of <italic>Paracoccidioides brasiliensis<\/italic>.","volume":"26","author":"BS Reis","year":"2008","journal-title":"Vaccin"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1128\/IAI.00753-07","article-title":"Vaccination with heat shock protein 60 induces a protective immune response against experimental <italic>Paracoccidioides brasiliensis<\/italic> pulmonary infection.","volume":"76","author":"ASR de Bastos","year":"2008","journal-title":"Infect Immun"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11046-009-9197-5","article-title":"Mice immunization with radioattenuated cells of <italic>Paracoccidioides brasiliensis<\/italic>: influence of the number of immunizations.","volume":"168","author":"EMN Martins","year":"2009","journal-title":"Mycopathologia"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.vaccine.2008.10.022","article-title":"DNAhsp65 vaccination induces protection in mice against <italic>Paracoccidioides brasiliensis<\/italic> infection.","volume":"27","author":"AM Ribeiro","year":"2009","journal-title":"Vaccine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1128\/IAI.01470-08","article-title":"<italic>Paracoccidioides brasiliensis<\/italic> vaccine formulations based on the gp 43-derived P10 sequence and the <italic>Salmonella enterica<\/italic> FliC flagellin.","volume":"77","author":"CJ Braga","year":"2009","journal-title":"Infect Immun"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T11:50:42Z","timestamp":1593777042000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001519"}},"subtitle":[],"editor":[{"given":"Jeffrey Michael","family":"Bethony","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,28]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001519","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,28]]}}}