{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:16:52Z","timestamp":1792001812448,"version":"4.4.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001641","type":"journal-article","created":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T16:55:27Z","timestamp":1335891327000},"page":"e1641","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":134,"title":["Diabetes with Hypertension as Risk Factors for Adult Dengue Hemorrhagic Fever in a Predominantly Dengue Serotype 2 Epidemic: A Case Control Study"],"prefix":"10.1371","volume":"6","author":[{"given":"Junxiong","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agus","family":"Salim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin L.","family":"Hibberd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Seng","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Sin","family":"Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Lye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"ref1","article-title":"First WHO report on neglected tropical diseases: working to overcome the global impact of neglected tropical diseases.","year":"2010"},{"key":"ref2","article-title":"Dengue haemorrhagic fever: diagnosis, treatment, prevention and control. Second edition.","year":"1997"},{"key":"ref3","article-title":"Dengue: Guidelines for diagnosis, treatment, prevention and control.","year":"2009"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3201\/eid1206.051210","article-title":"Dengue prevention and 35 years of vector control in Singapore.","volume":"12","author":"EE Ooi","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0065-3527(03)60010-2","article-title":"Immunology and immunopathogenesis of dengue disease.","volume":"60","author":"AL Rothman","year":"2003","journal-title":"Adv Virus Res"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri3014","article-title":"Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms.","volume":"11","author":"AL Rothman","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref7","first-page":"67","article-title":"Markers of dengue disease severity.","volume":"338","author":"A Srikiatkhachorn","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4269\/ajtmh.1990.42.179","article-title":"Dengue hemorrhagic fever in Cuba, 1981: a retrospective sero-epidemiologic study.","volume":"42","author":"MG Guzm\u00e1n","year":"1990","journal-title":"Am J Trop Med Hyg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4269\/ajtmh.1997.56.566","article-title":"Risk factors in dengue shock syndrome.","volume":"56","author":"S Thein","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0140-6736(99)04015-5","article-title":"Failure of secondary infection with American genotype dengue 2 to cause dengue hemorrhagic fever.","volume":"354","author":"DM Watts","year":"1999","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4269\/ajtmh.1988.38.172","article-title":"A prospective study of dengue infections in Bangkok.","volume":"38","author":"DF Burke","year":"1988","journal-title":"Am J Trop Med Hyg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0035-9203(84)90286-4","article-title":"Dengue hemorrhagic fever in Cuba. II. Clinical investigations.","volume":"78","author":"MG Guzm\u00e1n","year":"1984","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S1201-9712(02)90072-X","article-title":"Effect of age on outcome of secondary dengue 2 infections.","volume":"6","author":"MG Guzm\u00e1n","year":"2002","journal-title":"Int J Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1201-9712(03)90057-9","article-title":"Effect of increasing age on the trend of dengue and dengue hemorrhagic fever in Singapore.","volume":"7","author":"EE Ooi","year":"2003","journal-title":"Int J Infect Dis"},{"issue":"2","key":"ref15","first-page":"121","article-title":"Clinical characteristics of dengue and dengue hemorrhagic fever in a medical center of southern Taiwan during the 2002 epidemic.","volume":"39","author":"MS Lee","year":"2006","journal-title":"J Microbiol Immunol Infect"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"e699","DOI":"10.1371\/journal.pntd.0000699","article-title":"Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study.","volume":"4","author":"MAA Figueiredo","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0035-9203(87)90041-1","article-title":"Why dengue haemorrhagic fever in Cuba? 1. Individual risk factors for dengue haemorrhagic fever\/dengue shock syndrome (DHF\/DSS).","volume":"81","author":"J Bravo","year":"1987","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0035-9203(99)90008-1","article-title":"Dengue epidemic in the State of Rio Grande do Norte, Brazil, in 1997.","volume":"93","author":"RV Cunha","year":"1999","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ijid.2004.07.012","article-title":"Classical dengue hemorrhagic fever resulting from two dengue infections spaced 20 years or more apart: Havana, Dengue 3 epidemic, 2001\u20132002.","volume":"9","author":"D Gonz\u00e1lez","year":"2005","journal-title":"Int J Infect Dis"},{"issue":"5","key":"ref20","first-page":"846","article-title":"Dengue virus surveillance for early warning, Singapore.","volume":"16","author":"KS Lee","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1086\/501358","article-title":"The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infection.","volume":"42","author":"SD Blacksell","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1128\/CDLI.8.6.1150-1155.2001","article-title":"Use of recombinant envelope proteins for serological diagnosis of dengue virus infection in an immunochromatographic assay.","volume":"8","author":"AJ Cuzzubbo","year":"2001","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.trstmh.2005.05.015","article-title":"The performance of RT-PCR compared with a rapid serological assay for acute dengue fever in a diagnostic laboratory.","volume":"100","author":"TM Barkham","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"e617","DOI":"10.1371\/journal.pntd.0000617","article-title":"Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006.","volume":"2;4","author":"JR Fried","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jcv.2007.12.017","article-title":"Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults.","volume":"42","author":"VJ Lee","year":"2008","journal-title":"J Clin Virol"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4269\/ajtmh.2011.10-0476","article-title":"Epidemiological factors associated with dengue shock syndrome and mortality in hospitalized dengue patients in Ho Chi Minh City, Vietnam.","volume":"84","author":"KL Anders","year":"2011","journal-title":"Am J Trop Med Hyg"},{"issue":"9257","key":"ref27","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(00)04137-4","article-title":"Dengue seroepidemiology in Singapore.","volume":"357","author":"EE Ooi","year":"2001","journal-title":"Lancet"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1016\/j.ijid.2009.06.026","article-title":"The benign nature of acute dengue infection in hospitalized older adults in Singapore.","volume":"14","author":"DC Lye","year":"2010","journal-title":"Int J Infect Dis"},{"key":"ref29","article-title":"Preventing chronic diseases: a vital investment: WHO global report.","year":"2005"},{"key":"ref30","article-title":"Global status report on noncommunicable disease.","year":"2010"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0140-6736(10)61414-6","article-title":"Raising the priority of preventing chronic diseases: a political process.","volume":"376","author":"R Geneau","year":"2010","journal-title":"Lancet"},{"issue":"21","key":"ref32","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1001\/jama.289.21.JOC30885","article-title":"Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area.","volume":"289","author":"CM Booth","year":"2003","journal-title":"JAMA"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2334-10-50","article-title":"A comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan.","volume":"10","author":"EH Lau","year":"2010","journal-title":"BMC Infect Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1056\/NEJMoa0906695","article-title":"Hospitalized patients with 2009 H1N1 influenza in the United States.","volume":"361","author":"S Jain","year":"2009","journal-title":"N Engl J Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S1473-3099(09)70282-8","article-title":"Tuberculosis and diabetes mellitus: Convergence of two epidemics.","volume":"9","author":"KE Dooley","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"634","DOI":"10.4269\/ajtmh.2009.80.634","article-title":"Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis.","volume":"80","author":"KE Dooley","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/hep.21239","article-title":"Impact of obesity on treatment of chronic hepatitis C.","volume":"43","author":"MR Charlton","year":"2006","journal-title":"Hepatology"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1086\/431594","article-title":"Evaluating diabetes mellitus as a risk factor for community-acquired infections.","volume":"41","author":"AL Jackson","year":"2005","journal-title":"Clin Infect Dis"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1086\/431587","article-title":"Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus.","volume":"41","author":"LM Muller","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1056\/NEJM198610093151502","article-title":"Acquired defect in interleukin-2 production in patients with type I diabetes mellitus.","volume":"315","author":"WA Kaye","year":"1986","journal-title":"N Engl J Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1574-695X.1999.tb01397.x","article-title":"Immune dysfunction in patients with diabetes mellitus (DM).","volume":"26","author":"SE Geerlings","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.amjmed.2004.02.042","article-title":"Insulin resistance and the endothelium.","volume":"117","author":"WA Hsueh","year":"2004","journal-title":"Am J Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1023\/B:REMD.0000032407.88070.0a","article-title":"Endothelial dysfunction, inflammation and diabetes.","volume":"5","author":"P Dandona","year":"2004","journal-title":"Rev Endocr Metab Dis"},{"issue":"8","key":"ref44","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.humimm.2011.03.027","article-title":"Differential expression of antimicrobial peptides in active and latent tuberculosis and its relationship with diabetes mellitus.","volume":"72","author":"I Gonzalez-Curiel","year":"2011","journal-title":"Hum Immunol"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"990","DOI":"10.4269\/ajtmh.2008.78.990","article-title":"Influence of the dengue serotype, previous dengue Infection, and plasma viral load on clinical presentation and outcome during a dengue-2 and dengue-4 co-epidemic.","volume":"78","author":"L Thomas","year":"2008","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/CMR.11.3.480","article-title":"Dengue and dengue hemorrhagic fever.","volume":"11","author":"DJ Gubler","year":"1998","journal-title":"Clin Microbiol Rev"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T20:08:28Z","timestamp":1594066108000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001641"}},"subtitle":[],"editor":[{"given":"Scott B.","family":"Halstead","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,1]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001641","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.720295227.793513005","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,1]]}}}