{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:07:39Z","timestamp":1773097659956,"version":"3.50.1"},"reference-count":93,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T00:00:00Z","timestamp":1337644800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001660","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T23:24:59Z","timestamp":1337729099000},"page":"e1660","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Salivary Gland Transcriptomes and Proteomes of Phlebotomus tobbi and Phlebotomus sergenti, Vectors of Leishmaniasis"],"prefix":"10.1371","volume":"6","author":[{"given":"Iva","family":"Rohou\u0161ov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreenath","family":"Subrahmanyam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u011bra","family":"Volfov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbing","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Volf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus G.","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan C.","family":"Jochim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.3344436","article-title":"Salivary-Gland Lysates from the Sand Fly Lutzomyia-Longipalpis Enhance Leishmania Infectivity.","volume":"239","author":"RG Titus","year":"1988","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.14411\/fp.2006.022","article-title":"Sand fly saliva: effects on host immune response and Leishmania transmission.","volume":"53","author":"I Rohousova","year":"2006","journal-title":"Folia Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1084\/jem.188.10.1941","article-title":"Development of a natural model of cutaneous leishmaniasis: Powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis.","volume":"188","author":"Y Belkaid","year":"1998","journal-title":"J Exp Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.290.5495.1351","article-title":"Protection against cutaneous Leishmaniasis resulting from bites of uninfected sand flies.","volume":"290","author":"S Kamhawi","year":"2000","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.4049\/jimmunol.167.9.5226","article-title":"Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L-major infection.","volume":"167","author":"RV Morris","year":"2001","journal-title":"J Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.194.3.331","article-title":"Toward a defined anti-Leishmania vaccine targeting vector antigens: Characterization of a protective salivary protein.","volume":"194","author":"JG Valenzuela","year":"2001","journal-title":"J Exp Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7845","DOI":"10.1073\/pnas.0712153105","article-title":"Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model.","volume":"105","author":"R Gomes","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1000441","DOI":"10.1371\/journal.ppat.1000441","article-title":"Sand Fly Salivary Proteins Induce Strong Cellular Immunity in a Natural Reservoir of Visceral Leishmaniasis with Adverse Consequences for Leishmania.","volume":"5","author":"N Collin","year":"2009","journal-title":"Plos Pathog"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"32383","DOI":"10.1074\/jbc.M111.268904","article-title":"Structure and function of a \u201cyellow\u201d protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection.","volume":"286","author":"X Xu","year":"2011","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.4269\/ajtmh.2000.62.740","article-title":"Human immune response to sand fly salivary gland antigens: A useful epidemiological marker?","volume":"62","author":"A Barral","year":"2000","journal-title":"Am J Trop Med Hyg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1086\/344733","article-title":"Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity.","volume":"186","author":"RB Gomes","year":"2002","journal-title":"J Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1017\/S003118200400681X","article-title":"Detection of species-specific antibody response of humans and mice bitten by sand flies.","volume":"130","author":"I Rohousova","year":"2005","journal-title":"Parasitology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1371\/journal.pntd.0000084","article-title":"Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva.","volume":"1","author":"TR de Moura","year":"2007","journal-title":"PLoS Negl Trop Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"825","DOI":"10.4269\/ajtmh.2010.10-0182","article-title":"Short report: Epidemiological study of the association between anti-Lutzomyia longipalpis saliva antibodies and development of delayed-type hypersensitivity to Leishmania antigen.","volume":"83","author":"DMC Aquino","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"801","DOI":"10.4269\/ajtmh.2010.09-0336","article-title":"Measurement of recent exposure to Phlebotomus argentipes, the vector of Indian visceral leishmaniasis, by using human antibody responses to sand fly saliva.","volume":"82","author":"MF Clements","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e638","DOI":"10.1371\/journal.pntd.0000638","article-title":"Discovery of Markers of Exposure Specific to Bites of Lutzomyia longipalpis, the Vector of Leishmania infantum chagasi in Latin America.","volume":"4","author":"C Teixeira","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1296","DOI":"10.1371\/journal.pntd.0001296","article-title":"Serological markers of sand fly exposure to evaluate insecticidal nets against visceral leishmaniasis in India and Nepal: a cluster-randomized trial.","volume":"5","author":"K Gidwani","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4269\/ajtmh.2011.10-0598","article-title":"Characterization of the Antibody Response to the Saliva of Phlebotomus papatasi in People Living in Endemic Areas of Cutaneous Leishmaniasis.","volume":"84","author":"S Marzouki","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1089\/vbz.2007.0214","article-title":"Kinetics of canine antibody response to saliva of the sand fly Lutzomyia longipalpis.","volume":"8","author":"J Hostomska","year":"2008","journal-title":"Vector Borne Zoonotic Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e649","DOI":"10.1371\/journal.pntd.0000649","article-title":"Using Recombinant Proteins from Lutzomyia longipalpis Saliva to Estimate Human Vector Exposure in Visceral Leishmaniasis Endemic Areas.","volume":"4","author":"AP Souza","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1344","DOI":"10.1371\/journal.pntd.0001344","article-title":"Canine antibody response to Phlebotomus perniciosus bites negatively correlates with the risk of Leishmania infantum transmission.","volume":"5","author":"M Vlkova","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0031182000007046","article-title":"Species-specific antigens in salivary glands of phlebotomine sandflies.","volume":"122","author":"P Volf","year":"2001","journal-title":"Parasitology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"15155","DOI":"10.1073\/pnas.96.26.15155","article-title":"Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly Lutzomyia longipalpis.","volume":"96","author":"R Charlab","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1242\/jeb.01185","article-title":"Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi.","volume":"207","author":"JG Valenzuela","year":"2004","journal-title":"J Exp Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2164-7-52","article-title":"Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis.","volume":"7","author":"JM Anderson","year":"2006","journal-title":"BMC Genomics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/1471-2164-7-226","article-title":"High degree of conservancy among secreted salivary gland proteins from two geographically distant Phlebotomus duboscqi sandflies populations (Mali and Kenya).","volume":"7","author":"H Kato","year":"2006","journal-title":"BMC Genomics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.vaccine.2005.07.085","article-title":"From transcriptome to immunome: Identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library.","volume":"24","author":"F Oliveira","year":"2006","journal-title":"Vaccine"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/1471-2164-10-282","article-title":"Analysis of salivary transcripts and antigens of the sand fly Phlebotomus arabicus.","volume":"10","author":"J Hostomska","year":"2009","journal-title":"BMC Genomics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0738-081X(99)00046-2","article-title":"The biology and control of phlebotomine sand flies.","volume":"17","author":"R Killick-Kendrick","year":"1999","journal-title":"Clin Dermatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1286-4579(03)00066-2","article-title":"Experimental transmission of Leishmania tropica to hamsters and mice by the bite of Phlebotomus sergenti.","volume":"5","author":"M Svobodova","year":"2003","journal-title":"Microbes Infect"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.3201\/eid1212.060497","article-title":"Distinct transmission cycles of Leishmania tropica in 2 adjacent foci, Northern Israel.","volume":"12","author":"M Svobodova","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ijpara.2008.06.016","article-title":"Cutaneous leishmaniasis caused by Leishmania infantum transmitted by Phlebotomus tobbi.","volume":"39","author":"M Svobodova","year":"2009","journal-title":"Int J Parasitol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-2583.2000.00168.x","article-title":"Phylogenetic relationships of phlebotomine sandflies inferred from small subunit nuclear ribosomal DNA.","volume":"9","author":"AM Aransay","year":"2000","journal-title":"Insect Mol Bio"},{"key":"ref34","first-page":"268","article-title":"Molecular detection of Leishmania infantum in naturally infected Phlebotomus perniciosus from Algarve region, Portugal.","volume":"46","author":"C Maia","year":"2009","journal-title":"J Vector Borne Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1948-7134.2011.00106.x","article-title":"Establishment and maintenance of sand fly colonies.","volume":"36","author":"P Volf","year":"2011","journal-title":"J Vector Ecol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/1471-2164-9-233","article-title":"Insight into the sialome of the castor bean tick, Ixodes ricinus.","volume":"9","author":"J Chmelar","year":"2008","journal-title":"BMC Genomics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/jcb.22409","article-title":"Protein alterations induced by long-term agonist treatment of HEK293 cells expressing thyrotropin-releasing hormone receptor and G(11)alpha protein.","volume":"109","author":"Z Drastichova","year":"2010","journal-title":"J Cell Biochem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/bioinformatics\/btp129","article-title":"dCAS: a desktop application for cDNA sequence annotation.","volume":"25","author":"YJ Guo","year":"2009","journal-title":"Bioinformatics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1101\/gr.9.9.868","article-title":"CAP3: A DNA sequence assembly program.","volume":"9","author":"XQ Huang","year":"1999","journal-title":"Genome Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1101\/gr.8.3.175","article-title":"Base-calling of automated sequencer traces using phred. I. Accuracy assessment.","volume":"8","author":"B Ewing","year":"1998","journal-title":"Genome Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1101\/gr.8.3.186","article-title":"Base-calling of automated sequencer traces using phred. II. Error probabilities.","volume":"8","author":"B Ewing","year":"1998","journal-title":"Genome Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool for the unification of biology.","volume":"25","author":"M Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-4-41","article-title":"The COG database: an updated version includes eukaryotes.","volume":"4","author":"RL Tatusov","year":"2003","journal-title":"BMC Bioinformatics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/nar\/28.1.263","article-title":"The Pfam protein families database.","volume":"28","author":"A Bateman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/nar\/28.1.231","article-title":"SMART: a web-based tool for the study of genetically mobile domains.","volume":"28","author":"J Schultz","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0.","volume":"340","author":"JD Bendtsen","year":"2004","journal-title":"J Mol Biol"},{"key":"ref48","article-title":"NetNGlyc 1.0 Server."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and clustal X version 2.0.","volume":"23","author":"MA Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/bioinformatics\/bti263","article-title":"ProtTest: selection of best-fit models of protein evolution.","volume":"21","author":"F Abascal","year":"2005","journal-title":"Bioinformatics"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/bioinformatics\/18.3.502","article-title":"TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing.","volume":"18","author":"HA Schmidt","year":"2002","journal-title":"Bioinformatics"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular evolutionary genetics analysis (MEGA) software version 4.0.","volume":"24","author":"K Tamura","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/S0965-1748(02)00109-1","article-title":"Salivary gland hyaluronidase in various species of phlebotomine sand flies (Diptera : Psychodidae).","volume":"32","author":"P Cerna","year":"2002","journal-title":"Insect Biochem Mol Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/abio.1997.2262","article-title":"A microtiter-based assay for hyaluronidase activity not requiring specialized reagents.","volume":"251","author":"GI Frost","year":"1997","journal-title":"Anal Biochem"},{"key":"ref55","first-page":"59","article-title":"From Sialomes to the Sialoverse: An Insight into Salivary Potion of Blood-Feeding Insects.","volume":"37","author":"JMC Ribeiro","year":"2009","journal-title":"Adv In Insect Phys"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ibmb.2010.08.002","article-title":"An insight into the sialome of blood-feeding Nematocera.","volume":"40","author":"JMC Ribeiro","year":"2010","journal-title":"Insect Biochem Mol Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2180-3-3","article-title":"New knowledge from old: In silico discovery of novel protein domains in Streptomyces coelicolor.","volume":"3","author":"C Yeats","year":"2003","journal-title":"BMC Microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/jmedent\/45.1.94","article-title":"An immunoglobulin binding protein (Antigen 5) of the stable fly (Diptera : Muscidae) salivary gland stimulates bovine immune responses.","volume":"45","author":"M Ameri","year":"2008","journal-title":"J Med Entomol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxicon.2009.06.038","article-title":"A horsefly saliva antigen 5-like protein containing RTS motif is an angiogenesis inhibitor.","volume":"55","author":"DY Ma","year":"2010","journal-title":"Toxicon"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1074\/mcp.M700497-MCP200","article-title":"Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands.","volume":"7","author":"XQ Xu","year":"2008","journal-title":"Mol Cell Proteomics"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.vetimm.2009.09.017","article-title":"Cloning of IgE-binding proteins from Simulium vittatum and their potential significance as allergens for equine insect bite hypersensitivity.","volume":"132","author":"A Schaffartzik","year":"2009","journal-title":"Vet Immunol Immunopathol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.vetimm.2010.04.012","article-title":"Cloning, production and characterization of antigen 5 like proteins from Simulium vittatum and Culicoides nubeculosus, the first cross-reactive allergen associated with equine insect bite hypersensitivity.","volume":"137","author":"A Schaffartzik","year":"2010","journal-title":"Vet Immunol Immunopathol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ibmb.2009.01.010","article-title":"Identification of a functional Antigen5-related allergen in the saliva of a blood feeding insect, the tsetse fly.","volume":"39","author":"G Caljon","year":"2009","journal-title":"Insect Biochem Mol Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0300-9629(86)90709-7","article-title":"Blood-Finding Strategy of A Capillary-Feeding Sandfly, Lutzomyia-Longipalpis.","volume":"83","author":"JMC Ribeiro","year":"1986","journal-title":"Comp Biochem Physiol A Comp Physiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0020-1790(89)90046-2","article-title":"Salivary apyrase activity of some Old World Phlebotomine sand flies.","volume":"19","author":"JMC Ribeiro","year":"1989","journal-title":"Insect Biochem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.jinsphys.2009.07.010","article-title":"Functional characterization of a salivary apyrase from the sand fly, Phlebotomus duboscqi, a vector of Leishmania major.","volume":"55","author":"R Hamasaki","year":"2009","journal-title":"J Insect Physiol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1242\/jeb.204.2.229","article-title":"The salivary apyrase of the blood-sucking sand fly Phlebotomus papatasi belongs to the novel Cimex family of apyrases.","volume":"204","author":"JG Valenzuela","year":"2001","journal-title":"J Exp Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11302-005-5300-7","article-title":"The calcium activated nucleotidases: A diverse family of soluble and membrane associated nucleotide hydrolyzing enzymes.","volume":"2","author":"TM Smith","year":"2006","journal-title":"Purinergic Signal"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.1021\/bi049565o","article-title":"Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): Identification of residues essential for enzyme activity and the Ca2+-induced conformational change.","volume":"43","author":"MY Yang","year":"2004","journal-title":"Biochemistry"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(04)00172-2","article-title":"Structure and protein design of a human platelet function inhibitor.","volume":"116","author":"JY Dai","year":"2004","journal-title":"Cell"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"105R","DOI":"10.1093\/glycob\/cwg112","article-title":"Devising a pathway for hyaluronan catabolism: are we there yet?","volume":"13","author":"R Stern","year":"2003","journal-title":"Glycobiology"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.1371\/journal.pntd.0000294","article-title":"Hyaluronidase of Bloodsucking Insects and Its Enhancing Effect on Leishmania Infection in Mice.","volume":"2","author":"V Volfova","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1603\/0022-2585-37.5.743","article-title":"Simulium vittatum (Diptera : Simuliidae) and Lutzomyia longipalpis (Diptera : Psychodidae) salivary gland hyaluronidase activity.","volume":"37","author":"JMC Ribeiro","year":"2000","journal-title":"J Med Entomol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1021\/cr050247k","article-title":"Hyaluronidases: Their genomics, structures, and mechanisms of action.","volume":"106","author":"R Stern","year":"2006","journal-title":"Chem Rev"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0969-2126(00)00511-6","article-title":"Crystal structure of hyaluronidase, a major allergen of bee venom.","volume":"8","author":"Z Markovic-Housley","year":"2000","journal-title":"Structure"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.vetimm.2007.10.011","article-title":"Identification of abundant proteins and potential allergens in Culicoides nubeculosus salivary glands.","volume":"122","author":"AD Wilson","year":"2008","journal-title":"Vet Immunol Immunopathol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1002\/eji.200737431","article-title":"Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis.","volume":"37","author":"V Vinhas","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1365-2583.2002.00319.x","article-title":"The D7 family of salivary proteins in blood sucking diptera.","volume":"11","author":"JG Valenzuela","year":"2002","journal-title":"Insect Mol Bio"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0166-6851(91)90010-4","article-title":"Isolation and Characterization of the Gene Expressing the Major Salivary-Gland Protein of the Female Mosquito, Aedes-Aegypti.","volume":"44","author":"AA James","year":"1991","journal-title":"Molecul Biochem Parasitol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00436-009-1470-5","article-title":"Differentially expressed genes between female and male adult Anopheles anthropophagus.","volume":"105","author":"YJ Geng","year":"2009","journal-title":"Parasitol Res"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1074\/jbc.M510359200","article-title":"Function and evolution of a mosquito salivary protein family.","volume":"281","author":"E Calvo","year":"2006","journal-title":"J Biol Chem"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ibmb.2007.02.002","article-title":"Identification and characterization of a new kallikrein-kinin system inhibitor from the salivary glands of the malaria vector mosquito Anopheles stephensi.","volume":"37","author":"H Isawa","year":"2007","journal-title":"Insect Biochem Mol Biol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"e1000547","DOI":"10.1371\/journal.pbio.1000547","article-title":"The Function and Three-Dimensional Structure of a Thromboxane A(2)\/Cysteinyl Leukotriene-Binding Protein from the Saliva of a Mosquito Vector of the Malaria Parasite.","volume":"8","author":"PH Alvarenga","year":"2010","journal-title":"Plos Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"e226","DOI":"10.1371\/journal.pntd.0000226","article-title":"Immunity to Distinct Sand Fly Salivary Proteins Primes the Anti-Leishmania Immune Response towards Protection or Exacerbation of Disease.","volume":"2","author":"F Oliveira","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00436-006-0307-8","article-title":"Antibodies from dogs with canine visceral leishmaniasis recognise two proteins from the saliva of Lutzomyia longipalpis.","volume":"100","author":"D Bahia","year":"2007","journal-title":"Parasitol Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2583.2004.00539.x","article-title":"Genetic variation in the sand fly salivary protein, SP-15, a potential vaccine candidate against Leishmania major.","volume":"14","author":"DEA Elnaiem","year":"2005","journal-title":"Insect Mol Bio"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1603\/ME10072","article-title":"Differential Expression of Salivary Gland Genes in the Female Sand Fly Phlebotomus papatasi (Diptera: Psychodidae).","volume":"47","author":"IV Coutinho-Abreu","year":"2010","journal-title":"J Med Entomol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s000180050229","article-title":"A family of major royal jelly proteins of the honeybee Apis mellifera L.","volume":"54","author":"J Schmitzova","year":"1998","journal-title":"Cell Mol Life Sci"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1002\/j.1460-2075.1986.tb04548.x","article-title":"On the Molecular Mechanism of Gypsy-Induced Mutations at the Yellow Locus of Drosophila-Melanogaster.","volume":"5","author":"PK Geyer","year":"1986","journal-title":"EMBO J"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/PL00006551","article-title":"The family of major royal jelly proteins and its evolution.","volume":"49","author":"S Albert","year":"1999","journal-title":"J Mol Evol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1471-2164-11-213","article-title":"An insight into the sialome of Glossina morsitans morsitans.","volume":"11","author":"J Alves-Silva","year":"2010","journal-title":"BMC Genomics"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0965-1748(01)00072-8","article-title":"Cloning and characterization of a dopachrome conversion enzyme from the yellow fever mosquito, Aedes aegypti.","volume":"31","author":"JK Johnson","year":"2001","journal-title":"Insect Biochem Mol Biol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1046\/j.1432-1033.2002.03349.x","article-title":"Characterization of the lectin from females of Phlebotomus duboscqi sand flies.","volume":"269","author":"P Volf","year":"2002","journal-title":"Eur J Biochem"}],"updated-by":[{"DOI":"10.1371\/annotation\/fb586825-2ad7-41a5-b7d6-aef0e65c5887","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T00:00:00Z","timestamp":1340323200000}}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T03:10:33Z","timestamp":1642302633000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001660"}},"subtitle":[],"editor":[{"given":"Cheng-Chen","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,22]]},"references-count":93,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001660","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,22]]}}}