{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:05:52Z","timestamp":1778627152338,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T00:00:00Z","timestamp":1338854400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001685","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T17:12:08Z","timestamp":1338916328000},"page":"e1685","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["Efficacy and Safety of Nitazoxanide, Albendazole, and Nitazoxanide-Albendazole against Trichuris trichiura Infection: A Randomized Controlled Trial"],"prefix":"10.1371","volume":"6","clinical-trial-number":[{"clinical-trial-number":"isrctn08336605","registry":"10.18810\/isrctn"}],"author":[{"given":"Benjamin","family":"Speich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaali M.","family":"Ame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said M.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Alles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Hattendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrg","family":"Utzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Albonico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0169-4758(97)01144-7","article-title":"The global burden of intestinal nematode infections\u2013fifty years on.","volume":"13","author":"MS Chan","year":"1997","journal-title":"Parasitol Today"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1371\/journal.pmed.0030102","article-title":"Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV\/AIDS, tuberculosis, and malaria.","volume":"3","author":"PJ Hotez","year":"2006","journal-title":"PLoS Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0140-6736(06)68653-4","article-title":"Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm.","volume":"367","author":"J Bethony","year":"2006","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1756-3305-5-81","article-title":"The global limits and population at risk of soil-transmitted helminth infections in 2010.","volume":"5","author":"RL Pullan","year":"2012","journal-title":"Parasites & vectors"},{"key":"ref5","first-page":"294","article-title":"Parasitic infections in Pemba Island school children.","volume":"74","author":"M Albonico","year":"1997","journal-title":"East Afr Med J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0140-6736(88)92483-X","article-title":"Hookworm control.","volume":"332","author":"KS Warren","year":"1988","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0065-308X(08)60151-7","article-title":"Control strategies for human intestinal nematode infections.","volume":"42","author":"M Albonico","year":"1999","journal-title":"Adv Parasitol"},{"key":"ref8","year":"2010"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.pt.2003.09.007","article-title":"Human gastrointestinal helminth infections: are they now neglected diseases?","volume":"19","author":"J Horton","year":"2003","journal-title":"Trends Parasitol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0065-308X(10)73008-6","article-title":"The drugs we have and the drugs we need against major helminth infections.","volume":"73","author":"J Keiser","year":"2010","journal-title":"Adv Parasitol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/inf.1982.14.issue-4.10","article-title":"Treatment of <italic>Trichuris trichiura<\/italic> infection with a single dose of oxantel pamoate.","volume":"14","author":"K Peldan","year":"1982","journal-title":"Scand J Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0035-9203(02)90352-4","article-title":"Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections.","volume":"96","author":"M Albonico","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0020-7519(91)90081-H","article-title":"Response of pre-adult and adult stages of <italic>Trichuris muris<\/italic> to common anthelmintics in mice.","volume":"21","author":"GR Rajasekariah","year":"1991","journal-title":"Int J Parasitol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1517\/14656566.7.7.953","article-title":"Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections.","volume":"7","author":"A Hemphill","year":"2006","journal-title":"Expert Opin Pharmacother"},{"key":"ref15","first-page":"28216","article-title":"New derivative of 2-benzamido-5-nitrothiols.","volume":"83","author":"JF Rossignol","year":"1975","journal-title":"Chemical Abstracts"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mimet.2011.08.009","article-title":"Exploration of novel <italic>in vitro<\/italic> assays to study drugs against <italic>Trichuris<\/italic> spp.","volume":"87","author":"A Silbereisen","year":"2012","journal-title":"J Microbiol Methods"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0011-393X(98)85006-6","article-title":"Nitazoxanide in the treatment of patients with intestinal protozoan and helminthic infections: a report on 546 patients in Egypt.","volume":"59","author":"H Abaza","year":"1998","journal-title":"Curr Ther Res Clin Exp"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0035-9203(97)90531-9","article-title":"Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico.","volume":"91","author":"R Romero Cabello","year":"1997","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0035-9203(02)90301-9","article-title":"Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru.","volume":"96","author":"JO Juan","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4269\/ajtmh.2003.68.384","article-title":"Epidemiology and control of intestinal parasites with nitazoxanide in children in Mexico.","volume":"68","author":"E Diaz","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.299.16.1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis.","volume":"299","author":"J Keiser","year":"2008","journal-title":"JAMA"},{"key":"ref22","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni.","volume":"14","author":"N Katz","year":"1972","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4269\/ajtmh.1968.17.382","article-title":"Evaluation of Kato thick-smear technique for quantitative diagnosis of helminth infections.","volume":"17","author":"LK Martin","year":"1968","journal-title":"Am J Trop Med Hyg"},{"key":"ref24","article-title":"Guidelines for the evaluation of soil-transmitted helminthiasis and schistosomiasis at community level: a guide for managers and control programs","author":"A Montresor","year":"1998"},{"key":"ref25","article-title":"Cochane Statistical Methods Group: chapter 16: special topics in statistics.","author":"JP Higgins","year":"2008"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1471-4922(01)02205-X","article-title":"Treatment of intestinal parasitic infections: a review of nitazoxanide.","volume":"18","author":"HM Gilles","year":"2002","journal-title":"Trends Parasitol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.pt.2007.08.015","article-title":"Recent progress in integrated neglected tropical disease control.","volume":"23","author":"P Hotez","year":"2007","journal-title":"Trends Parasitol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1036","DOI":"10.1371\/journal.pntd.0001036","article-title":"Diagnostic accuracy of Kato-Katz and FLOTAC for assessing anthelmintic drug efficacy.","volume":"5","author":"S Knopp","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0035-9203(94)90174-0","article-title":"A randomized controlled trial comparing mebendazole and albendazole against <italic>Ascaris<\/italic>, <italic>Trichuris<\/italic> and hookworm infections.","volume":"88","author":"M Albonico","year":"1994","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1086\/657310","article-title":"Albendazole and mebendazole administered alone or in combination with ivermectin against <italic>Trichuris trichiura<\/italic>: a randomized controlled trial.","volume":"51","author":"S Knopp","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.trstmh.2011.09.007","article-title":"The impact of baseline faecal egg counts on the efficacy of single-dose albendazole against <italic>Trichuris trichiura<\/italic>.","volume":"106","author":"B Levecke","year":"2012","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ijpddr.2012.02.004","article-title":"Nitazoxanide: <italic>in vitro<\/italic> and <italic>in vivo<\/italic> drug effects against <italic>Trichuris muris<\/italic> and <italic>Ancylostoma ceylanicum<\/italic>, alone or in combination.","volume":"2","author":"L Tritten","year":"2012","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.trstmh.2008.11.013","article-title":"A single FLOTAC is more sensitive than triplicate Kato-Katz for the diagnosis of low-intensity soil-transmitted helminth infections.","volume":"103","author":"S Knopp","year":"2009","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1017\/S0031182003004128","article-title":"The influence of sampling effort and the performance of the Kato-Katz technique in diagnosing <italic>Schistosoma mansoni<\/italic> and hookworm co-infections in rural C\u00f4te d&apos;Ivoire.","volume":"127","author":"M Booth","year":"2003","journal-title":"Parasitology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nprot.2009.235","article-title":"FLOTAC: new multivalent techniques for qualitative and quantitative copromicroscopic diagnosis of parasites in animals and humans.","volume":"5","author":"G Cringoli","year":"2010","journal-title":"Nat Protoc"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.trstmh.2007.09.009","article-title":"FLOTAC: a new sensitive technique for the diagnosis of hookworm infections in humans.","volume":"102","author":"J Utzinger","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1371\/journal.pntd.0000754","article-title":"Comparing diagnostic accuracy of Kato-Katz, Koga agar plate, ether-concentration, and FLOTAC for <italic>Schistosoma mansoni<\/italic> and soil-transmitted helminths.","volume":"4","author":"D Glinz","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"685","DOI":"10.4269\/ajtmh.2007.77.685","article-title":"Simultaneous detection and quantification of <italic>Ancylostoma duodenale<\/italic>, <italic>Necator americanus<\/italic>, and <italic>Oesophagostomum bifurcum<\/italic> in fecal samples using multiplex real-time PCR.","volume":"77","author":"JJ Verweij","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00228-003-0612-4","article-title":"Placebo effect and placebos: what are we talking about? Some conceptual and historical considerations.","volume":"59","author":"A Macedo","year":"2003","journal-title":"Eur J Clin Pharmacol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T07:24:46Z","timestamp":1561793086000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001685"}},"subtitle":[],"editor":[{"given":"Michael","family":"Cappello","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,5]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001685","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,5]]}}}