{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:39:56Z","timestamp":1790861996166,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:00:00Z","timestamp":1339459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001696","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T17:12:36Z","timestamp":1339521156000},"page":"e1696","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":59,"title":["Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease"],"prefix":"10.1371","volume":"6","author":[{"given":"Fabiane L.","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania C.","family":"Ara\u00fajo-Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elen M.","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel M.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim M.","family":"Degrave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Feige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Bailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana C.","family":"Waghabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1590\/S0074-02762007005000106","article-title":"An overview of Chagas disease treatment.","volume":"102","author":"J Jannin","year":"2007","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/clc.4960231205","article-title":"Chagas' heart disease.","volume":"23","author":"A Rassi Jr","year":"2000","journal-title":"Clin Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/S0074-02762002000100001","article-title":"A critical review on Chagas disease chemotherapy.","volume":"97","author":"J Coura","year":"2002","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1590\/S0074-02762009000900042","article-title":"The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease.","volume":"104","author":"JA Marin-Neto","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1098\/rstb.1990.0050","article-title":"Transforming growth factor-beta: multifunctional regulator of differentiation and development.","volume":"327","author":"AB Roberts","year":"1990","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.febslet.2006.04.033","article-title":"The logic of TGFbeta signaling.","volume":"580","author":"J Massague","year":"2006","journal-title":"FEBS Lett"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S1286-4579(99)00252-X","article-title":"TGF-beta in infections and infectious diseases.","volume":"1","author":"SG Reed","year":"1999","journal-title":"Microbes Infect"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cytogfr.2008.08.002","article-title":"Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy.","volume":"19","author":"TC Araujo-Jorge","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1086\/345882","article-title":"Implication Of Transforming Growth Factor-beta1 In Chagas Disease Myocardiopathy.","volume":"186","author":"TC Araujo-Jorge","year":"2002","journal-title":"J Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1590\/S0074-02762009000800004","article-title":"Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection.","volume":"104","author":"MC Waghabi","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1128\/AAC.00022-07","article-title":"SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion.","volume":"51","author":"MC Waghabi","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1128\/AAC.00580-09","article-title":"Pharmacological inhibition of transforming growth factor beta signaling decreases infection and prevents heart damage in acute Chagas' disease.","volume":"53","author":"MC Waghabi","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1021\/jm0509905","article-title":"Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor.","volume":"49","author":"F Gellibert","year":"2006","journal-title":"J Med Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/sj.ki.5002717","article-title":"Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.","volume":"73","author":"M Petersen","year":"2008","journal-title":"Kidney Int"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.exppara.2006.02.020","article-title":"Trypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice.","volume":"114","author":"BP Olivieri","year":"2006","journal-title":"Exp Parasitol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1128\/IAI.70.9.5115-5123.2002","article-title":"Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.","volume":"70","author":"MC Waghabi","year":"2002","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cyto.2009.09.012","article-title":"Tumor necrosis factor alpha induced by Trypanosoma cruzi infection mediates inflammation and cell death in the liver of infected mice.","volume":"49","author":"MT Ronco","year":"2010","journal-title":"Cytokine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1590\/S0074-02762010000600003","article-title":"The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice.","volume":"105","author":"AP Souza","year":"2010","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0092-8674(95)90316-X","article-title":"Trypanosome invasion of mammalian cells requires activation of the TGF beta signaling pathway.","volume":"82","author":"M Ming","year":"1995","journal-title":"Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1128\/IAI.68.4.2077-2081.2000","article-title":"Dual role for transforming growth factor beta-dependent signaling in Trypanosoma cruzi infection of mammalian cells.","volume":"68","author":"BS Hall","year":"2000","journal-title":"Infect Immun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1462-5822.2004.00481.x","article-title":"Activation of transforming growth factor beta by Trypanosoma cruzi.","volume":"7","author":"MC Waghabi","year":"2005","journal-title":"Cell Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0002-9440(10)61189-3","article-title":"Uptake of host cell transforming growth factor-beta by Trypanosoma cruzi amastigotes in cardiomyocytes: potential role in parasite cycle completion.","volume":"167","author":"MC Waghabi","year":"2005","journal-title":"Am J Pathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e1000","DOI":"10.1371\/journal.pntd.0001000","article-title":"Trypanosoma cruzi in the chicken model: Chagas-like heart disease in the absence of parasitism.","volume":"5","author":"AR Teixeira","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/CMR.00063-10","article-title":"Pathogenesis of chagas' disease: parasite persistence and autoimmunity.","volume":"24","author":"AR Teixeira","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1084\/jem.20091975","article-title":"The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands.","volume":"207","author":"M Zhang","year":"2010","journal-title":"J Exp Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1574-6976.2007.00065.x","article-title":"Molecular mechanisms of pathogenicity: how do pathogenic microorganisms develop cross-kingdom host jumps?","volume":"31","author":"P van Baarlen","year":"2007","journal-title":"FEMS Microbiol Rev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1073\/pnas.120055097","article-title":"Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db\/db diabetic mice.","volume":"97","author":"FN Ziyadeh","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"F628","DOI":"10.1152\/ajprenal.2000.278.4.F628","article-title":"Therapy with antisense TGF-beta1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice.","volume":"278","author":"DC Han","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2337\/db06-1018","article-title":"Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor.","volume":"56","author":"LM Russo","year":"2007","journal-title":"Diabetes"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/jm010493y","article-title":"Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).","volume":"45","author":"JF Callahan","year":"2002","journal-title":"J Med Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1124\/mol.62.1.58","article-title":"Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.","volume":"62","author":"NJ Laping","year":"2002","journal-title":"Mol Pharmacol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.3892\/or_00001028","article-title":"Transforming growth factor beta signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity.","volume":"24","author":"H Tanaka","year":"2010","journal-title":"Oncol Rep"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/art.27307","article-title":"Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis.","volume":"62","author":"D Lagares","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"H1415","DOI":"10.1152\/ajpheart.01048.2009","article-title":"Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction.","volume":"298","author":"SM Tan","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1645\/GE-2396.1","article-title":"ECG detection of murine chagasic cardiomyopathy.","volume":"96","author":"CS Eickhoff","year":"2010","journal-title":"J Parasitol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/01.CIR.0000085071.28695.C4","article-title":"Short QT Syndrome: a familial cause of sudden death.","volume":"108","author":"F Gaita","year":"2003","journal-title":"Circulation"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1590\/S0074-02761999000700060","article-title":"Risk of death due to chronic chagasic cardiopathy.","volume":"94","author":"EC Manzullo","year":"1999","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/hrt.2010.210047","article-title":"ECG scar quantification correlates with cardiac magnetic resonance scar size and prognostic factors in Chagas' disease.","volume":"97","author":"DG Strauss","year":"2011","journal-title":"Heart"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1582-4934.2001.tb00170.x","article-title":"Gap junction remodeling and cardiac arrhythmogenesis: cause or coincidence?","volume":"5","author":"NJ Severs","year":"2001","journal-title":"J Cell Mol Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbamem.2004.10.005","article-title":"Gap junctional communication in tissue inflammation and repair.","volume":"1711","author":"M Chanson","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"d1231","DOI":"10.2741\/A836","article-title":"Homeostasis of extracellular matrix by TGF-beta and lefty.","volume":"7","author":"S Tabibzadeh","year":"2002","journal-title":"Front Biosci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1021\/bi048851x","article-title":"Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition.","volume":"44","author":"SB Peng","year":"2005","journal-title":"Biochemistry"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0012360","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"record-id":"55235"},{"DOI":"10.1371\/journal.pntd.0012360","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000}}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:06:56Z","timestamp":1588961216000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001696"}},"subtitle":[],"editor":[{"given":"Mauricio Martins","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,12]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001696","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,12]]}}}