{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:35Z","timestamp":1791174695423,"version":"4.1.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T00:00:00Z","timestamp":1341273600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001704","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T21:03:12Z","timestamp":1341349392000},"page":"e1704","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":118,"title":["Safety and Immunogenicity of rSh28GST Antigen in Humans: Phase 1 Randomized Clinical Study of a Vaccine Candidate against Urinary Schistosomiasis"],"prefix":"10.1371","volume":"6","author":[{"given":"Gilles","family":"Riveau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Deplanque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Remou\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Schacht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Vodougnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Capron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Thiry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Martial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Libersa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Capron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0169-4758(96)80640-5","article-title":"Praziquantel: An urgent and exciting challenge.","volume":"12","author":"CA Redman","year":"1996","journal-title":"Parasitology Today"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4269\/ajtmh.1995.53.167","article-title":"Efficacy and Side Effects of Praziquantel in an Epidemic Focus of Schistosoma mansoni.","volume":"53","author":"FF Stelma","year":"1995","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0169-4758(97)01207-6","article-title":"Schistosomiasis Vaccine:Research to Development.","volume":"14","author":"NR Bergquist","year":"1998","journal-title":"Parasitology Today"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4269\/ajtmh.1995.53.61","article-title":"Short Report: Diminished Susceptibility to Praziquantel in a Senegal Isolate of Schistosoma mansoni.","volume":"53","author":"PG Fallon","year":"1995","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1645\/GE-1297.1","article-title":"Response of Schistosoma mansoni isolates having different drug sensitivity to praziquantel over several life cycle passages with and without therapeutic pressure.","volume":"94","author":"AN Sabra","year":"2008","journal-title":"Journal of Parasitology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1568008023340587","article-title":"Prospects for a schistosome vaccine.","volume":"2","author":"A Capron","year":"2002","journal-title":"Current Drug Targets Immune, Endocrine and Metabolic Disorders"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/326149a0","article-title":"Molecular cloning of a protective antigen of schistosomes.","volume":"326","author":"JM Balloul","year":"1987","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0022-2836(92)91013-F","article-title":"Crystallization and preliminary X-ray diffraction studies of a protective cloned 28 kDa glutathione S-transferase from Schistosoma mansoni.","volume":"224","author":"F Trottein","year":"1992","journal-title":"Journal of Molecular Biology"},{"key":"ref9","first-page":"940","article-title":"Schistosoma mansoni 28-kDa glutathione S-transferase and immunity against parasite fecundity and egg viability. Role of the amino- and carboxyl-terminal domains.","volume":"150","author":"CB Xu","year":"1993","journal-title":"Journal of Immunology (Baltimore, Md: 1950)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1086\/314875","article-title":"Control of schistosomiasis pathology by combination of Sm28GST DNA immunization and praziquantel treatment.","volume":"180","author":"L Dupr\u00e9","year":"1999","journal-title":"The Journal of Infectious Diseases"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1365-3024.1991.tb00545.x","article-title":"Immunization of mice and baboons with the recombinant Sm28GST affects both worm viability and fecundity after experimental infection with Schistosoma mansoni.","volume":"13","author":"D Boulanger","year":"1991","journal-title":"Parasite Immunology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1365-3024.1995.tb00903.x","article-title":"Vaccination of patas monkeys experimentally infected with Schistosoma haematobium using a recombinant glutathione S-transferase cloned from S. mansoni.","volume":"17","author":"D Boulanger","year":"1995","journal-title":"Parasite Immunology"},{"issue":"Pt 3","key":"ref13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1017\/S0031182097001352","article-title":"Potential of a recombinant Schistosoma bovis-derived glutathione S-transferase to protect cattle against experimental and natural S. mattheei infection.","volume":"115","author":"J De Bont","year":"1997","journal-title":"Parasitology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1128\/IAI.66.3.1142-1148.1998","article-title":"Relationship of impairment of schistosome 28-kilodalton glutathione S-transferase (GST) activity to expression of immunity to Schistosoma mattheei in calves vaccinated with recombinant Schistosoma bovis 28-kilodalton GST.","volume":"66","author":"JM Grzych","year":"1998","journal-title":"Infection and Immunity"},{"key":"ref15","article-title":"Vaccination against schistosomiasis: concepts and strategies. Concepts in Vaccine Design","author":"G Riveau","year":"1996"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pt.2005.01.003","article-title":"Schistosomes: the road from host-parasite interactions to vaccines in clinical trials.","volume":"21","author":"A Capron","year":"2005","journal-title":"Trends in Parasitology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4049\/jimmunol.150.2.527","article-title":"IgA antibodies to a protective antigen in human Schistosomiasis mansoni.","volume":"150","author":"JM Grzych","year":"1993","journal-title":"Journal of Immunology (Baltimore, Md: 1950)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1086\/315454","article-title":"Sex-dependent neutralizing humoral response to Schistosoma mansoni 28GST antigen in infected human populations.","volume":"181","author":"F Remou\u00e9","year":"2000","journal-title":"The Journal of Infectious Diseases"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/S0140-6736(95)91041-7","article-title":"Prospects for immunological control of schistosomiasis.","volume":"345","author":"DW Dunne","year":"1995","journal-title":"Lancet"},{"key":"ref20","first-page":"97","article-title":"Guidelines for Good Clinical Practice (GCP) for Trials on Pharmaceutical Products - Sixth Report.","year":"1995"},{"key":"ref21","article-title":"Guidelines for Good Clinical Practice (3 errata post step 4 included).","year":"1996"},{"key":"ref22","article-title":"Guidance for Industry: Toxicity grading scale for healthy adult and adolescent volunteers enrolled in preventive vaccine clinical trials.","year":"2007"},{"key":"ref23","first-page":"1548","article-title":"Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Laboratory reference values.","volume":"351","author":"A Kratz","year":"2004","journal-title":"The New England Journal of Medicine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1600-0773.1996.tb00192.x","article-title":"Effect of aluminium hydroxide administration on normal mice: tissue distribution and ultrastructural localization of aluminium in liver.","volume":"78","author":"M Fiejka","year":"1996","journal-title":"Pharmacology & Toxicology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF02592350","article-title":"Development of Th 1- or Th 2-dominated immune responses: what about the polarizing signals?","volume":"26","author":"S Romagnani","year":"1996","journal-title":"International Journal of Clinical & Laboratory Research"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4615-1823-5_8","article-title":"Adjuvant properties of aluminum and calcium compounds.","volume":"6","author":"RK Gupta","year":"1995","journal-title":"Pharmaceutical Biotechnology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000237532","article-title":"An update on human Th1 and Th2 cells.","volume":"113","author":"S Romagnani","year":"1997","journal-title":"International Archives of Allergy and Immunology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0169-4758(98)01322-2","article-title":"Schistosomiasis: forty years' war on the worm.","volume":"14","author":"A Capron","year":"1998","journal-title":"Parasitology Today (Personal Ed)"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T01:45:30Z","timestamp":1687571130000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001704"}},"subtitle":[],"editor":[{"given":"David Joseph","family":"Diemert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,3]]},"references-count":28,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001704","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,3]]}}}