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Khalid","year":"1998","journal-title":"Phytochemistry"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-8741(99)00117-8","article-title":"In vitro antimalarial activity of limonoids from <italic>Khaya grandifoliola<\/italic> C.D.C. 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Synthesis, DNA-binding and biological studies on a series of 2,6-disubstituted derivatives.","volume":"35","author":"M Agbandje","year":"1992","journal-title":"J Med Chem"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/0031-9422(94)00784-Q","article-title":"Flavonoid <italic>O<\/italic>-glycosides from the leaves of <italic>Morinda morindoides<\/italic>.","volume":"38","author":"K Cimanga","year":"1995","journal-title":"Phytochemistry"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.bmcl.2010.01.095","article-title":"New anti-malarial phenylpropanoid conjugated iridoids from <italic>Morinda morindoides<\/italic>.","volume":"20","author":"S Tamura","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: Food sources and bioavailability.","volume":"79","author":"C Manach","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1248\/cpb.51.58","article-title":"Neucleamides A\u2013E, news monoterpene indole alkaloids from <italic>Nauclea latifolia<\/italic>.","volume":"51","author":"H Shigemori","year":"2003","journal-title":"Chem Pharm Bull"},{"key":"ref81","first-page":"173","article-title":"Neuclefolinine: A new alkaloid from the roots of <italic>Nauclea latifolia<\/italic>.","volume":"17","author":"D Ngnokam","year":"2003","journal-title":"Bull Chem Soc Ethiopia"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/0031-9422(96)00135-5","article-title":"Antifungal and antibacterial naphthoquinones from <italic>Newbouldia laevis<\/italic> roots.","volume":"42","author":"S Gafner","year":"1996","journal-title":"Phytochemistry"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0031-9422(03)00277-2","article-title":"Furanonaphthoquinones, atraric acid and a benzofuran from the stem barks of <italic>Newbouldia laevis<\/italic>.","volume":"64","author":"R Gormann","year":"2003","journal-title":"Phytochemistry"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0031-9422(00)90667-8","article-title":"Pyrazole alkaloids from <italic>Newbouldia laevis<\/italic>.","volume":"35","author":"SA Adesanya","year":"1994","journal-title":"Phytochemistry"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1055\/s-2006-957380","article-title":"New pyrazole alkaloids from the root bark of <italic>Newbouldia laevis<\/italic>.","volume":"64","author":"AJ Aladesanmi","year":"1998","journal-title":"Planta Med"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1248\/bpb.27.193","article-title":"Trypanocidal constituents in plants 4. Withanolides from the aerial parts of <italic>Physalis angulata<\/italic>.","volume":"27","author":"S Nagafuji","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1248\/cpb.54.1226","article-title":"Trypanocidal constituents in plants 6. Minor withanolides from the aerial parts of <italic>Physalis angulata<\/italic>.","volume":"54","author":"F Abe","year":"2006","journal-title":"Chem Pharm Bull"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/cbdv.200790036","article-title":"Cytotoxic withanolides from <italic>Physalis angulata<\/italic> L.","volume":"4","author":"QP He","year":"2007","journal-title":"Chem Biodivers"},{"key":"ref89","first-page":"23","article-title":"Antimicrobial glycosides and derivatives from roots of <italic>Picralima nitida<\/italic>.","volume":"3","author":"J Kouam","year":"2011","journal-title":"Int J Chem"},{"key":"ref90","first-page":"2945","article-title":"[Prosopine and prosopinine alkaloids of <italic>Prosopis africana<\/italic> (Guill and Perr) Taub. (preliminary note)].","volume":"9","author":"G Ratle","year":"1966","journal-title":"Bul Soc Chim Fr"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0031-9422(00)88756-7","article-title":"Stem alkaloids of <italic>Rauwolfia vomitoria<\/italic>.","volume":"17","author":"NN Sabri","year":"1978","journal-title":"Phytochemistry"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0031-9422(00)83823-6","article-title":"Leaf alkaloids of <italic>Rauwolfia vomitoria<\/italic>.","volume":"19","author":"MM Amer","year":"1980","journal-title":"Phytochemistry"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jep.2008.06.018","article-title":"Novel xanthones from <italic>Securidaca longipedunculata<\/italic> with activity against erectile dysfunction.","volume":"119","author":"JJ Marion Meyer","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/jhet.5570310137","article-title":"Structural study of alkaloids from <italic>Securidaca longipedunculata<\/italic> roots. II. Isolation and characterization by supercritical fluid chromatography\/mass spectrometry.","volume":"31","author":"M Scandola","year":"1994","journal-title":"J Heterocycl Chem"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1021\/np058062w","article-title":"Secoiridoid glucosides from <italic>Strychnos spinosa<\/italic>.","volume":"68","author":"A Itoh","year":"2005","journal-title":"J Nat Prod"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1021\/np070038q","article-title":"Antitrypanosomal activity of triterpenoids and sterols from the leaves of <italic>Strychnos spinosa<\/italic> and related compounds.","volume":"70","author":"S Hoet","year":"2007","journal-title":"J Nat Prod"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2174\/138955708783498168","article-title":"Flavonoids and related compounds in parasitic disease control.","volume":"8","author":"D Kerboeuf","year":"2008","journal-title":"Min Rev Med Chem"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1590\/S0102-695X2008000200006","article-title":"Trypanocidal activity of coumarins and styryl-2-pyrones from <italic>Polygala sabulosa<\/italic> A.W. Bennet (Polygalaceae).","volume":"18","author":"MG Pizzolatti","year":"2008","journal-title":"Rev Bras Farmacog"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1021\/jm960280m","article-title":"Structure-cytoprotective activity relationship of simple molecules containing an \u03b1,\u03b2-unsaturated carbonyl system.","volume":"40","author":"AM Rodgriquez","year":"1997","journal-title":"J Med Chem"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2174\/092986711793979779","article-title":"Natural and synthetic naphthoquinones active against <italic>Trypanosoma cruzi<\/italic>: An initial step towards new drugs for Chagas disease.","volume":"18","author":"CO Salas","year":"2011","journal-title":"Curr Med Chem"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1021\/jm001079l","article-title":"2- and 3-Substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from <italic>Trypanosoma cruzi<\/italic>: Synthesis and correlation between redox cycling activities and in vitro cytotoxicity.","volume":"44","author":"L Salmon-Chemin","year":"2001","journal-title":"J Med Chem"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00894-009-0468-3","article-title":"Docking and molecular dynamics simulation of quinone compounds with trypanocidal activity.","volume":"15","author":"FA De Molfetta","year":"2009","journal-title":"J Mol Model"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T16:52:11Z","timestamp":1561999931000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001727"}},"subtitle":[],"editor":[{"given":"Kiyoshi","family":"Kita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,24]]},"references-count":102,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001727","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,24]]}}}