{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:37:03Z","timestamp":1789749423025,"version":"4.0.1"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:00:00Z","timestamp":1351123200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001877","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T17:35:05Z","timestamp":1351186505000},"page":"e1877","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":71,"title":["Sensitive and Specific Immunohistochemical Diagnosis of Human Alveolar Echinococcosis with the Monoclonal Antibody Em2G11"],"prefix":"10.1371","volume":"6","author":[{"given":"Thomas F. E.","family":"Barth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias S.","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Tappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Stark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Gr\u00fcner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Buttenschoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hillenbrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Juchems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Henne-Bruns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns M.","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Rausch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Deplazes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","article-title":"Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern","volume":"17","author":"J Eckert","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"ref2","unstructured":"Eckert J, Deplazes P, Kern P (2011) Alveolar echinococcosis <italic>(Echinococcus multilocularis)<\/italic> and other forms of echinococcosis <italic>(Echinococcus vogeli and Echinococcus oligarthrus)<\/italic>. In: Brown D, Palmer S, Torgerson PR, Soulsby E, editors. Zoonoses. Oxford: Oxford University Press: 671\u2013701."},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3201\/eid1310.061161","article-title":"Alveolar echinococcosis, Lithuania","volume":"13","author":"R Bruzinskaite","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1017\/S0031182003003718","article-title":"Perspective on control options for <italic>Echinococcus multilocularis<\/italic> with particular reference to Japan","volume":"127","author":"A Ito","year":"2003","journal-title":"Parasitology"},{"key":"ref5","unstructured":"Marty AM, Johnson LK, Neafie RC (2000) Hydatidosis (echinococcosis). In: Meyers WM, Neafie RC, Marty AM, Wear DJ, editors. Pathology of Infectious Diseases: Volume 1, Helminthiases. Washington,D.C.: Armed Forces Institute of Pathology, American Registry of Pathology. pp145\u2013164."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.parint.2005.11.041","article-title":"WHO classification of alveolar echinococcosis: Principles and application","volume":"55","author":"P Kern","year":"2006","journal-title":"Parasitol Int"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4269\/ajtmh.2010.09-0462","article-title":"Three-dimensional reconstruction of <italic>Echinococcus multilocularis<\/italic> larval growth in human hepatic tissue reveals complex growth patterns","volume":"82","author":"D Tappe","year":"2010","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00001432-200310000-00010","article-title":"Echinococcus multilocularis","volume":"16","author":"P Craig","year":"2003","journal-title":"Curr Opin Infect Dis"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-3024.2006.00836.x","article-title":"Intraperitoneal <italic>Echinococcus multilocularis<\/italic> infection in C57BL\/6 mice affects CD40 and B7 costimulator expression on peritoneal macrophages and impairs peritoneal T cell activation","volume":"28","author":"N Mejri","year":"2006","journal-title":"Parasite Immunol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","article-title":"Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans","volume":"114","author":"E Brunetti","year":"2010","journal-title":"Acta Trop"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1128\/JCM.31.2.373-376.1993","article-title":"Improved primary immunodiagnosis of alveolar echinococcosis in humans by an enzyme-linked immunosorbent assay using the Em2plus antigen","volume":"31","author":"B Gottstein","year":"1993","journal-title":"J Clin Microbiol"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s15010-011-0205-6","article-title":"Serological diagnosis of echinococcosis: The diagnostic potential of native antigens","volume":"40","author":"A Schweiger","year":"2011","journal-title":"Infection"},{"issue":"Pt 11","key":"ref13","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1099\/jmm.0.2008\/002816-0","article-title":"Brain and lung metastasis of alveolar echinococcosis in a refugee from a hyperendemic area","volume":"57","author":"D Tappe","year":"2008","journal-title":"J Med Microbiol"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.pt.2010.12.012","article-title":"Understanding the laminated layer of larval Echinococcus I: Structure","volume":"27","author":"A D\u00edaz","year":"2011","journal-title":"Trends Parasitol"},{"key":"ref15","unstructured":"Thompson RCA (1995) Biology and systematics of Echinococcus. In: Thompson RCA, editor. Echinococcus and Hydatid Disease. Wallingford: CAB International. 50 p."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1017\/S0031182000059278","article-title":"A monoclonal antibody against <italic>Echinococcus multilocularis<\/italic> Em2 antigen","volume":"103 Pt 1","author":"P Deplazes","year":"1991","journal-title":"Parasitology"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.1074\/jbc.M107161200","article-title":"A major <italic>Echinococcus multilocularis<\/italic> antigen is a mucin-type glycoprotein","volume":"277","author":"AJ H\u00fclsmeier","year":"2002","journal-title":"J Biol Chem"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.1128\/IAI.69.10.6074-6083.2001","article-title":"Major carbohydrate antigen of <italic>Echinococcus multilocularis<\/italic> induces an immunoglobulin G response independent of alphabeta+ CD4+ T cells","volume":"69","author":"WJ Dai","year":"2001","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/j.parint.2005.11.006","article-title":"Molecular survival strategies of <italic>Echinococcus multilocularis<\/italic> in the murine host","volume":"55","author":"B Gottstein","year":"2006","journal-title":"Parasitol Int"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00937086","article-title":"<italic>Echinococcus multilocularis<\/italic>: Immunological study on the \u201cEm2-positive\u201d laminated layer during in vitro and in vivo post-oncospheral and larval development","volume":"78","author":"B Gottstein","year":"1992","journal-title":"Parasitol Res"},{"key":"ref21","first-page":"1632","article-title":"Mitteilungen: Die (Weiter-)Verwendung von menschlichen K\u00f6rpermaterialien fuer Zwecke medizinischer Forschung","volume":"2003;100A","journal-title":"Dtsch Arztebl"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/ijc.25663","article-title":"BCL6 gene rearrangement and protein expression are associated with large cell presentation of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue","volume":"129","author":"L Flossbach","year":"2011","journal-title":"Int J Cancer"},{"issue":"3\u20134","key":"ref23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1017\/S0031182000026561","article-title":"Studies on the helminth fauna of Alaska. XXV. The ecology and public health significance of <italic>Echinococcus sibiricensis<\/italic> Rausch &amp; Schiller, 1954, on St. Lawrence Island","volume":"46","author":"R Rausch","year":"1956","journal-title":"Parasitology"},{"issue":"923193","key":"ref24","first-page":"14 pages","article-title":"<italic>Echinococcus multilocularis<\/italic> and its intermediate host: A model of parasite-host interplay","volume":"2010","author":"DA Vuitton","year":"2010","journal-title":"J Biomed Biotechnol"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00423-009-0481-0","article-title":"Hepatic infestation of <italic>Echinococcus multilocularis<\/italic> with extension to regional lymph nodes","volume":"394","author":"K Buttenschoen","year":"2009","journal-title":"Langenbecks Arch Surg"},{"issue":"3\u20134","key":"ref26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.vetpar.2005.03.034","article-title":"Experimental alveolar echinococcosis in pigs, lesion development and serological follow up","volume":"130","author":"P Deplazes","year":"2005","journal-title":"Vet Parasitol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1128\/JCM.01476-08","article-title":"Development of an immunochromatographic test to detect antibodies against recombinant Em18 for diagnosis of alveolar echinococcosis","volume":"47","author":"Y Sako","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"e1516","DOI":"10.1371\/journal.pntd.0001516","article-title":"Excretory\/secretory-products of <italic>Echinococcus multilocularis<\/italic> larvae induce apoptosis and tolerogenic properties in dendritic cells <italic>in vitro<\/italic>","volume":"6","author":"JK Nono","year":"2012","journal-title":"PLoS Negl Trop Dis"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:18:55Z","timestamp":1594772335000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001877"}},"subtitle":[],"editor":[{"given":"Hector H.","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,10,25]]},"references-count":28,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,10,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001877","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,25]]}}}