{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:27:30Z","timestamp":1791196050478,"version":"4.1.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:00:00Z","timestamp":1357776000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0001988","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T21:52:34Z","timestamp":1357854754000},"page":"e1988","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Functional Mapping of Protein Kinase A Reveals Its Importance in Adult Schistosoma mansoni Motor Activity"],"prefix":"10.1371","volume":"7","author":[{"given":"Paulu S. R.","family":"de Saram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Ressurrei\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela J.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rollinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan M.","family":"Emery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"P Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/1756-3305-4-203","article-title":"Insights into the functional biology of schistosomes","volume":"4","author":"AJ Walker","year":"2011","journal-title":"Parasite Vectors"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jez.1402320117","article-title":"Reproductive development of female <italic>Schistosoma mansoni<\/italic> (Digenia: <italic>Schistosomatidae<\/italic>) following bisexual pairing of worms and worm segments","volume":"232","author":"I Popiel","year":"1984","journal-title":"J Exp Zool"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1471-4922(01)01893-1","article-title":"Schistosome male-female interaction: induction of germ-cell differentiation","volume":"17","author":"W Kuntz","year":"2001","journal-title":"Trends Parasitol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e1509","DOI":"10.1371\/journal.pntd.0001509","article-title":"Cell death and reproductive regression in female <italic>Schistosoma mansoni<\/italic>","volume":"6","author":"SE Gelanti","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref6","first-page":"561","article-title":"Reassessment of the cost of chronic helminthic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis","volume":"365","author":"CH King","year":"2005","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"d2651","DOI":"10.1136\/bmj.d2651","article-title":"Diagnosis and management of schistosomiasis","volume":"342","author":"DJ Grey","year":"2011","journal-title":"Brit Med J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke <italic>Schistosoma mansoni<\/italic>","volume":"460","author":"M Berriman","year":"2009","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature08140","article-title":"The <italic>Schistosoma japonicum<\/italic> genome reveals features of host-parasite interplay","volume":"460","year":"2009","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng.1065","article-title":"Whole-genome sequence of <italic>Schistosoma haematobium<\/italic>","volume":"44","author":"ND Young","year":"2012","journal-title":"Nature Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e804","DOI":"10.1371\/journal.pntd.0000804","article-title":"Identification of attractive drug targets in neglected-disease pathogens using an <italic>in silico<\/italic> approach","volume":"4","author":"GJ Crowther","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00021.2003","article-title":"Localized effects of cAMP mediated by distinct routes of protein kinase A","volume":"84","author":"K Task\u00e9n","year":"2004","journal-title":"Physiol Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1677\/JME-10-0010","article-title":"Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins","volume":"44","author":"G Pidoux","year":"2010","journal-title":"J Mol Endocrinol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"8561","DOI":"10.1073\/pnas.0503363102","article-title":"Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A","volume":"102","author":"AC Zambon","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1128\/MCB.19.9.5882","article-title":"Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation","volume":"19","author":"LA Cass","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1128\/MCB.22.12.3981-3993.2002","article-title":"Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation","volume":"22","author":"XW Pan","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"L1309","DOI":"10.1152\/ajplung.2001.280.6.L1309","article-title":"Role of cAMP-dependent protein kinase A activity in endothelial cell cytoskeleton rearrangement","volume":"280","author":"F Liu","year":"2001","journal-title":"Am J Physiol \u2013 Lung Cell Mol Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13483","DOI":"10.1073\/pnas.0405580101","article-title":"Sperm-specific protein kinase A catalytic subunit C alpha(2) orchestrates cAMP signaling for male fertility","volume":"101","author":"MA Nolan","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"8443","DOI":"10.1016\/S0021-9258(18)81805-1","article-title":"cAMP-dependent protein kinase \u2013 model for an enzyme family","volume":"264","author":"SS Taylor","year":"1989","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.cell.2007.07.018","article-title":"PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation","volume":"130","author":"C Kim","year":"2007","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1128\/MCB.18.3.1416","article-title":"Physiological phosphorylation of protein kinase A at Thr-197 is by a protein kinase A kinase","volume":"18","author":"RD Cauthron","year":"1998","journal-title":"Mol Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1084\/jem.20051715","article-title":"Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4","volume":"203","author":"A Nirula","year":"2006","journal-title":"J Exp Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"E1221","DOI":"10.1073\/pnas.1202741109","article-title":"Cotranslational <italic>cis<\/italic>-phosphorylation of the CooH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase","volume":"109","author":"MM Keshwani","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.npep.2005.10.002","article-title":"Protein kinase inhibitor peptide (PKI): A family of endogenous neuropeptides that modulate neuronal cAMP-dependent protein kinase function","volume":"40","author":"GD Dalton","year":"2006","journal-title":"Neuropeptides"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e505","DOI":"10.1371\/journal.pntd.0000505","article-title":"A schistosome cAMP-dependent protein kinase catalytic subunit is essential for parasite viability","volume":"3","author":"BE Swierczewski","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/protein\/10.8.915","article-title":"Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in <italic>Escherichia coli<\/italic>","volume":"10","author":"W Yonemoto","year":"1997","journal-title":"Prot Eng"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"9849","DOI":"10.1073\/pnas.95.17.9849","article-title":"Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase","volume":"95","author":"X Cheng","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1113\/jphysiol.2006.106906","article-title":"Activity-dependent regulation of voltage-gated Na<sup>+<\/sup> channel expression in Mat-LyLu rat prostate cancer cell line","volume":"573","author":"WJ Brackenbury","year":"2006","journal-title":"J Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.biocel.2009.11.021","article-title":"Protein kinase A and regulation of neonatal NaV1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration","volume":"42","author":"AM Chioni","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1471-2164-12-215","article-title":"Eukaryotic protein kinases (ePKs) of the helminth parasite <italic>Schistosoma mansoni<\/italic>","volume":"12","author":"LF Andrade","year":"2011","journal-title":"BMC Genomics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1073\/pnas.0609033103","article-title":"cAMP activation of PKA defines an ancient signalling mechanism","volume":"104","author":"R Das","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1017\/S0031182005008565","article-title":"Classical transmitters and their receptors in flatworms","volume":"131","author":"P Ribeiro","year":"2005","journal-title":"Parasitology"},{"key":"ref33","first-page":"1","article-title":"Neuronal signaling in schistosomes: current status and prospects for post genomics","volume":"88","author":"P Ribeiro","year":"2010","journal-title":"Can J Zool"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1385\/MN:29:1:31","article-title":"Multiple signal transduction pathways mediated by 5-HT receptors","volume":"29","author":"M Noda","year":"2004","journal-title":"Mol Neurobiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","article-title":"Dopamine receptors: from structure to function","volume":"78","author":"C Missale","year":"1998","journal-title":"Physiol Rev"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1983.32.83","article-title":"Neuropharmacology of the parasitic trematode, <italic>Schistosoma mansoni<\/italic>","volume":"32","author":"TN Mellin","year":"1983","journal-title":"Am J Trop Med Hyg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1017\/S0022149X00009949","article-title":"The neural commissural rings of the adult male <italic>Schistosoma mansoni<\/italic>","volume":"61","author":"B Withyachumnarnkul","year":"1987","journal-title":"J Helminthol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1645\/GE-432R","article-title":"Serotonin-induced muscular activity in <italic>Schistosoma mansoni<\/italic> larval stages: importance of 5-HT transport and role in daughter sporocyst production","volume":"91","author":"JP Boyle","year":"2005","journal-title":"J Parasitol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e1523","DOI":"10.1371\/journal.pntd.0001523","article-title":"A novel G protein-coupled receptor of <italic>Schistosoma mansoni<\/italic> (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system","volume":"6","author":"F El Shahabi","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.molbiopara.2009.06.003","article-title":"Investigation of a dopamine receptor in <italic>Schistosoma mansoni<\/italic>: Functional studies and immunolocalization","volume":"168","author":"A Taman","year":"2009","journal-title":"Mol Biochem Parasitol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0014-4894(84)90048-1","article-title":"<italic>Schistosoma mansoni<\/italic>: differences in acetylcholine, dopamine, and serotonin control of circular and longitudinal parasite muscles","volume":"58","author":"RA Pax","year":"1984","journal-title":"Exp Parasitol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1006\/expr.1996.0129","article-title":"<italic>Schistosoma mansoni<\/italic>: L-glutamate-induced contraction in isolated muscle fibres; evidence for a glutamate transporter","volume":"84","author":"CL Miller","year":"1996","journal-title":"Exp Parasitol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.molbiopara.2010.12.001","article-title":"Glutamate-mediated signalling in <italic>Schistosoma mansoni<\/italic>: A novel glutamate receptor is expressed in neurons and the female reproductive tract","volume":"176","author":"A Taman","year":"2011","journal-title":"Mol Biochem Parasitol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0006-2952(02)01358-8","article-title":"Evidence for the presence of glutamatergic receptors in adult <italic>Schistosoma mansoni<\/italic>","volume":"64","author":"DL Mendonca-Silva","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"18505","DOI":"10.1074\/jbc.M802053200","article-title":"AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase","volume":"283","author":"S Horman","year":"2008","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S0031182099006174","article-title":"A confocal microscopical study of the musculature of adult <italic>Schistosoma mansoni<\/italic>","volume":"121","author":"GR Mair","year":"2000","journal-title":"Parasitology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.ijpara.2010.01.001","article-title":"Developmental regulation of protein kinase A expression and activity in <italic>Schistosoma mansoni<\/italic>","volume":"40","author":"BE Swierczewski","year":"2010","journal-title":"Int J Parasitol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0896-6273(00)00129-X","article-title":"Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting","volume":"28","author":"MD Ehlers","year":"2000","journal-title":"Neuron"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.1523\/JNEUROSCI.1951-08.2008","article-title":"Protein kinase A mediates activity-dependent Kv4.2 channel trafficking","volume":"28","author":"RS Hammond","year":"2008","journal-title":"J Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.biochem.68.1.821","article-title":"CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals","volume":"68","author":"AJ Shaywitz","year":"1999","journal-title":"Annu Rev Biochem"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1645\/GE-52R1","article-title":"The involvement of cyclic adenosine monophosphate in the control of schistosome miracidium cilia","volume":"90","author":"H Matsuyama","year":"2004","journal-title":"J Parasitol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1186\/1471-2121-12-6","article-title":"A role for p38 MAPK in the regulation of ciliary motion in a eukaryote","volume":"12","author":"M Ressurreicao","year":"2011","journal-title":"BMC Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.exppara.2009.12.021","article-title":"The identification of inhibitors of <italic>Schistosoma mansoni<\/italic> miracidial transformation by incorporating a medium-throughput small-molecule screen","volume":"125","author":"AS Taft","year":"2010","journal-title":"Exp Parasitol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.ijpara.2009.04.002","article-title":"Protein kinase C signalling during miracidium to mother sporocyst development in the helminth parasite, <italic>Schistosoma mansoni<\/italic>","volume":"39","author":"MHR Ludtmann","year":"2009","journal-title":"Int J Parasitol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.molbiopara.2011.07.002","article-title":"A role for p38 mitogen-activated protein kinase in early post-embryonic development of <italic>Schistosoma mansoni<\/italic>","volume":"180","author":"M Ressurreicao","year":"2011","journal-title":"Mol Biochem Parasitol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0001988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T18:48:15Z","timestamp":1644086895000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0001988"}},"subtitle":[],"editor":[{"given":"Aaron G.","family":"Maule","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,10]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0001988","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,10]]}}}