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Amsterdam, London, New York: Elsevier."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/oxfordjournals.jhered.a109261","article-title":"Genetics of <italic>Aedes aegypti<\/italic>. Updating the linkage map","volume":"70","author":"LE Munstermann","year":"1979","journal-title":"The Journal of Heredity"},{"key":"ref12","unstructured":"Munstermann L (1990) Linkage map for yellow fever mosquito, <italic>Aedes aegypti<\/italic>; O&apos;Brein S, editor. New York: Cold Spring Harbor Laboratories, Cold Spring Harbor."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/oxfordjournals.jhered.a111333","article-title":"Linkage map for <italic>Aedes aegypti<\/italic> using restriction fragment length polymorphisms","volume":"84","author":"DW Severson","year":"1993","journal-title":"J Hered"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1093\/genetics\/143.4.1727","article-title":"Intensive linkage mapping in a wasp (<italic>Bracon hebetor<\/italic>) and a mosquito (<italic>Aedes aegypti<\/italic>) with single-strand conformation polymorphism analysis of random amplified polymorphic DNA markers","volume":"143","author":"MF Antolin","year":"1996","journal-title":"Genetics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1534\/genetics.105.055178","article-title":"Amplified fragment length polymorphism mapping of quantitative trait loci for malaria parasite 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Exp"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1080\/00034983.1962.11686134","article-title":"Selection of a strain of <italic>Aedes aegypti<\/italic> susceptible to infection with semi-periodic Brugia malayi","volume":"56","author":"WW Macdonald","year":"1962","journal-title":"Ann Trop Med Parasotol"},{"key":"ref39","article-title":"High-resolution mapping of interstitial teleomeric repeats in Syrian hamster metaphase chromosomes","author":"S Demin","year":"2010","journal-title":"Cytogenetic and Genome Research"},{"key":"ref40","unstructured":"NIH website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/rsb.info.nih.gov\/ij\/\" xlink:type=\"simple\">http:\/\/rsb.info.nih.gov\/ij\/<\/ext-link>. Accessed 2011 Mar 10."},{"key":"ref41","unstructured":"Zeiss website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.zeiss.de\" xlink:type=\"simple\">http:\/\/www.zeiss.de<\/ext-link>. Accessed 2010 Dec 5."},{"key":"ref42","unstructured":"R Development Core Team (2008) A language and environment for statistical computing. R Foundation for Statistical Computing Vienna, Austria, ISBN 3-900051-07-0, URL. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.R-project.org\" xlink:type=\"simple\">http:\/\/www.R-project.org<\/ext-link>. Accessed 2012 Oct 26."},{"key":"ref43","unstructured":"Shaffer LG, Slovak ML, Campbell LJ (2009) An international system for human cytogenetic nomenclature. Basel (Switzerland): Karger."},{"key":"ref44","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/gb-2007-8-1-r5","article-title":"Update of the <italic>Anopheles gambiae<\/italic> PEST genome assembly","volume":"8","author":"MV Sharakhova","year":"2007","journal-title":"Genome Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"RESEARCH0085","DOI":"10.1186\/gb-2002-3-12-research0085","article-title":"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly","volume":"3","author":"RA Hoskins","year":"2002","journal-title":"Genome Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00412-003-0241-9","article-title":"FISH analysis of <italic>Drosophila melanogaster<\/italic> heterochromatin using BACs and P elements","volume":"112","author":"N Corradini","year":"2003","journal-title":"Chromosoma"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1022996112742","article-title":"Vital genes in the heterochromatin of chromosomes 2 and 3 of <italic>Drosophila melanogaster<\/italic>","volume":"117","author":"P Dimitri","year":"2003","journal-title":"Genetica"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1534\/genetics.106.065441","article-title":"Cytogenetic and molecular characterization of heterochromatin gene models in <italic>Drosophila melanogaster<\/italic>","volume":"175","author":"F Rossi","year":"2007","journal-title":"Genetics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1046\/j.1365-2583.2002.00347.x","article-title":"Linkage map organization of expressed sequence tags and sequence tagged sites in the mosquito, <italic>Aedes aegypti<\/italic>","volume":"11","author":"DW Severson","year":"2002","journal-title":"Insect Mol Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1365-2583.2010.01025.x","article-title":"High-resolution cytogenetic map for the African malaria vector <italic>Anopheles gambiae<\/italic>","volume":"19","author":"P George","year":"2010","journal-title":"Insect Mol Biol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T19:23:22Z","timestamp":1644348202000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002052"}},"subtitle":[],"editor":[{"given":"Jesus G.","family":"Valenzuela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,14]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002052","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,14]]}}}