{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:04:39Z","timestamp":1784034279066,"version":"3.55.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T00:00:00Z","timestamp":1364428800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002149","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T21:00:18Z","timestamp":1364504418000},"page":"e2149","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Rapidly Boosted Plasma IL-5 Induced by Treatment of Human Schistosomiasis haematobium Is Dependent on Antigen Dose, IgE and Eosinophils"],"prefix":"10.1371","volume":"7","author":[{"given":"Shona","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan K. M.","family":"Fofana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissata","family":"Doucour\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aly","family":"Landour\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gachuhi","family":"Kimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Mwatha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Sacko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte J.","family":"Vennervald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,3,28]]},"reference":[{"issue":"(Pt 1)","key":"ref1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1017\/S0031182098003576","article-title":"Adult resistance to schistosomiasis mansoni: age-dependence of reinfection remains constant in communities with diverse exposure patterns","volume":"118","author":"NB Kabatereine","year":"1999","journal-title":"Parasitology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/349243a0","article-title":"Human IgE, IgG4 and resistance to reinfection with <italic>Schistosoma haematobium<\/italic>","volume":"349","author":"P Hagan","year":"1991","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/eji.1830220622","article-title":"Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection","volume":"22","author":"DW Dunne","year":"1992","journal-title":"Eur J Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1128\/IAI.00012-09","article-title":"Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with <italic>Schistosoma japonicum<\/italic> and are attenuated by IgG4","volume":"77","author":"M Jiz","year":"2009","journal-title":"Infect Immun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0035-9203(83)90166-9","article-title":"Observations on possible immunity to reinfection among Kenyan schoolchildren after treatment for <italic>Schistosoma mansoni<\/italic>","volume":"77","author":"RF Sturrock","year":"1983","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1128\/IAI.74.4.2169-2176.2006","article-title":"Correlation between eosinophils and protection against reinfection with <italic>Schistosoma mansoni<\/italic> and the effect of human immunodeficiency virus type 1 coinfection in humans","volume":"74","author":"LM Ganley-Leal","year":"2006","journal-title":"Infect Immun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1365-3024.1985.tb00106.x","article-title":"Eosinophilia and resistance to <italic>Schistosoma haematobium<\/italic> in man","volume":"7","author":"P Hagan","year":"1985","journal-title":"Parasite Immunol"},{"issue":"(Pt 4)","key":"ref8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1017\/S003118209600858X","article-title":"The influence of sex and age on antibody isotype responses to <italic>Schistosoma mansoni<\/italic> and <italic>Schistosoma japonicum<\/italic> in human populations in Kenya and the Philippines","volume":"114","author":"M Webster","year":"1997","journal-title":"Parasitology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-3024.1997.d01-206.x","article-title":"A comparison of humoral responses to <italic>Schistosoma haematobium<\/italic> in areas with low and high levels of infection","volume":"19","author":"F Mutapi","year":"1997","journal-title":"Parasite Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1046\/j.1365-3156.2003.01056.x","article-title":"The relationship between age, sex, egg-count and specific antibody responses against <italic>Schistosoma mansoni<\/italic> antigens in a Ugandan fishing community","volume":"8","author":"CW Naus","year":"2003","journal-title":"Trop Med Int Health"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/eji.1830260628","article-title":"Elevated proliferation and interleukin-4 release from CD4+ cells after chemotherapy in human <italic>Schistosoma haematobium<\/italic> infection","volume":"26","author":"JL Grogan","year":"1996","journal-title":"Eur J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-3156.2006.01805.x","article-title":"Associations between specific antibody responses and resistance to reinfection in a Senegalese population recently exposed to <italic>Schistosoma mansoni<\/italic>","volume":"12","author":"K Vereecken","year":"2007","journal-title":"Trop Med Int Health"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1086\/653828","article-title":"Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with <italic>Schistosoma mansoni<\/italic>","volume":"202","author":"CL Black","year":"2011","journal-title":"J Infect Dis"},{"issue":"(Pt 2)","key":"ref14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1017\/S0031182000053920","article-title":"<italic>Schistosoma mansoni<\/italic>: structural damage and tegumental repair after in vivo treatment with praziquantel","volume":"94","author":"MK Shaw","year":"1987","journal-title":"Parasitology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0140-6736(02)09781-7","article-title":"Resistance to reinfection with <italic>Schistosoma mansoni<\/italic> in occupationally exposed adults and effect of HIV-1 co-infection on susceptibility to schistosomiasis: a longitudinal study","volume":"360","author":"DM Karanja","year":"2002","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0035-9203(91)90231-M","article-title":"Eosinophilia and eosinophil helminthotoxicity in patients treated for <italic>Schistosoma mansoni<\/italic> infections","volume":"85","author":"G Kimani","year":"1991","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1128\/IAI.72.7.4023-4030.2004","article-title":"Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E","volume":"72","author":"CM Fitzsimmons","year":"2004","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1128\/IAI.61.12.4984-4993.1993","article-title":"Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection","volume":"61","author":"M Roberts","year":"1993","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1086\/517832","article-title":"Antigen-specific proliferation and interferon-gamma and interleukin-5 production are down-regulated during <italic>Schistosoma haematobium<\/italic> infection","volume":"177","author":"JL Grogan","year":"1998","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1086\/344352","article-title":"Immune responses induced by repeated treatment do not result in protective immunity to <italic>Schistosoma haematobium<\/italic>: interleukin (IL)-5 and IL-10 responses","volume":"186","author":"AH van den Biggelaar","year":"2002","journal-title":"J Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1128\/IAI.72.2.728-734.2004","article-title":"Cytokine production in whole blood cultures from a fishing community in an area of high endemicity for <italic>Schistosoma mansoni<\/italic> in Uganda: the differential effect of parasite worm and egg antigens","volume":"72","author":"S Joseph","year":"2004","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.4049\/jimmunol.177.8.5490","article-title":"Increased human IgE induced by killing <italic>Schistosoma mansoni<\/italic> in vivo is associated with pretreatment Th2 cytokine responsiveness to worm antigens","volume":"177","author":"K Walter","year":"2006","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1046\/j.1365-2222.2003.01632.x","article-title":"A single nasal allergen challenge increases induced sputum inflammatory markers in non-asthmatic subjects with seasonal allergic rhinitis: correlation with plasma interleukin-5","volume":"33","author":"KM Beeh","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nm0496-449","article-title":"Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia","volume":"2","author":"EA Garcia-Zepeda","year":"1996","journal-title":"Nat Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1084\/jem.179.2.703","article-title":"Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion","volume":"179","author":"S Dubucquoi","year":"1994","journal-title":"J Exp Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.4049\/jimmunol.166.8.4813","article-title":"Cutting edge: eotaxin elicits rapid vesicular transport-mediated release of preformed IL-4 from human eosinophils","volume":"166","author":"C Bandeira-Melo","year":"2001","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1189\/jlb.72.4.769","article-title":"Human eosinophils express and release IL-13 following CD28-dependent activation","volume":"72","author":"G Woerly","year":"2002","journal-title":"J Leukoc Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1172\/JCI118603","article-title":"CD40 expression by human peripheral blood eosinophils","volume":"97","author":"Y Ohkawara","year":"1996","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.4049\/jimmunol.150.6.2554","article-title":"Accessory cell function of human eosinophils. HLA-DR-dependent, MHC-restricted antigen-presentation and IL-1 alpha expression","volume":"150","author":"PF Weller","year":"1993","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/infdis\/167.6.1396","article-title":"Kinetics of serum and cellular interleukin-5 in posttreatment eosinophilia of patients with lymphatic filariasis","volume":"167","author":"AP Limaye","year":"1993","journal-title":"J Infect Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1086\/344318","article-title":"Association of transient dermal mastocytosis and elevated plasma tryptase levels with development of adverse reactions after treatment of onchocerciasis with ivermectin","volume":"186","author":"PJ Cooper","year":"2002","journal-title":"J Infect Dis"},{"key":"ref32","unstructured":"Houghton J (2010) Chemotherapy of human chronic schistosomiasis mansoni: the immediate post-treatment immune response and its biological significance [PhD Thesis]. Cambridge: University of Cambridge."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1126\/science.2787531","article-title":"Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice","volume":"245","author":"RL Coffman","year":"1989","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1172\/JCI115449","article-title":"Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis","volume":"88","author":"AP Limaye","year":"1991","journal-title":"J Clin Invest"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1128\/IAI.68.1.93-99.2000","article-title":"Perturbations in eosinophil homeostasis following treatment of lymphatic filariasis","volume":"68","author":"R Gopinath","year":"2000","journal-title":"Infect Immun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/eji.1830190724","article-title":"Interleukin 4 induces synthesis of IgE and IgG4 in human B cells","volume":"19","author":"M Lundgren","year":"1989","journal-title":"Eur J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1084\/jem.173.3.747","article-title":"Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones","volume":"173","author":"H Gascan","year":"1991","journal-title":"J Exp Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1073\/pnas.90.8.3730","article-title":"Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells","volume":"90","author":"J Punnonen","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1086\/422604","article-title":"Increases in human T helper 2 cytokine responses to <italic>Schistosoma mansoni<\/italic> worm and worm-tegument antigens are induced by treatment with praziquantel","volume":"190","author":"S Joseph","year":"2004","journal-title":"J Infect Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/infdis\/168.4.1000","article-title":"Resistance to <italic>Schistosoma mansoni<\/italic> in humans: influence of the IgE\/IgG4 balance and IgG2 in immunity to reinfection after chemotherapy","volume":"168","author":"CE Demeure","year":"1993","journal-title":"J Infect Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1086\/595792","article-title":"Circulating CD23+ B cell subset correlates with the development of resistance to <italic>Schistosoma mansoni<\/italic> reinfection in occupationally exposed adults who have undergone multiple treatments","volume":"199","author":"PN Mwinzi","year":"2009","journal-title":"J Infect Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.4049\/jimmunol.1002709","article-title":"CD23-bound IgE augments and dominates recall responses through human naive B cells","volume":"186","author":"QK Griffith","year":"2011","journal-title":"J Immunol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T18:44:20Z","timestamp":1688150660000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002149"}},"subtitle":[],"editor":[{"given":"Rodrigo","family":"Correa-Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,28]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002149","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,28]]}}}