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London, UK: Oxford CAB International. pp. 177\u2013179."},{"key":"ref46","first-page":"99","article-title":"Parasite cysteine proteinases. Perspectives in Drug Discovery and Design","volume":"6","author":"CD Robertson","year":"1996","journal-title":"ESCOM Science Publisher"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-5793(89)81655-2","article-title":"A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C-terminal extension","volume":"258","author":"JC Mottram","year":"1989","journal-title":"FEBS Letters"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"16249","DOI":"10.1074\/jbc.274.23.16249","article-title":"Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif","volume":"274","author":"J Huete-Perez","year":"1999","journal-title":"Journal of Biological Chemistry"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.exppara.2007.10.004","article-title":"Leishmania infantum: prime boost vaccination with C-terminal extension of cysteine proteinase type I displays both type 1 and 2 immune signatures in BALB\/c mice","volume":"118","author":"S Rafati","year":"2008","journal-title":"Exp Parasitol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1016\/j.vaccine.2005.02.009","article-title":"Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum","volume":"23","author":"S Rafati","year":"2005","journal-title":"Vaccine"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.vaccine.2005.11.011","article-title":"Prime-boost vaccination using cysteine proteinases type I and II of Leishmania infantum confers protective immunity in murine visceral leishmaniasis","volume":"24","author":"S Rafati","year":"2006","journal-title":"Vaccine"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1016\/S0264-410X(01)00081-0","article-title":"A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major","volume":"19","author":"S Rafati","year":"2001","journal-title":"Vaccine"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.vaccine.2003.11.014","article-title":"Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis","volume":"22","author":"A Zadeh-Vakili","year":"2004","journal-title":"Vaccine"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e1236","DOI":"10.1371\/journal.pntd.0001236","article-title":"C-terminal domain deletion enhances the protective activity of cpa\/cpb loaded solid lipid nanoparticles against Leishmania major in BALB\/c mice","volume":"5","author":"D Doroud","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1016\/j.vaccine.2007.01.120","article-title":"Chemical adjuvants for plasmid DNA vaccines","volume":"25","author":"JR Greenland","year":"2007","journal-title":"Vaccine"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"320","DOI":"10.18433\/J3R30T","article-title":"Cationic solid lipid nanoparticles loaded by cysteine proteinase genes as a novel anti-leishmaniasis DNA vaccine delivery system: characterization and in vitro evaluations","volume":"13","author":"D Doroud","year":"2010","journal-title":"J Pharm Pharm Sci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1002\/j.1460-2075.1992.tb05444.x","article-title":"A novel antifolate resistance gene on the amplified H circle of Leishmania","volume":"11","author":"B Papadopoulou","year":"1992","journal-title":"EMBO J"},{"key":"ref58","unstructured":"Sambrook J, Fritsch E, Maniatis T (1989) Molecular Cloning: A Laboratory Manual. 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