{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:23:52Z","timestamp":1791491032409,"version":"4.3.4"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:00:00Z","timestamp":1369872000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002247","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T21:05:09Z","timestamp":1369947909000},"page":"e2247","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":164,"title":["Association between Response to Albendazole Treatment and \u03b2-Tubulin Genotype Frequencies in Soil-transmitted Helminths"],"prefix":"10.1371","volume":"7","author":[{"given":"A\u00efssatou","family":"Diawara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carli M.","family":"Halpenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Churcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Mwandawiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray M.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Streit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Idaghdour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn E.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Gloria","family":"Bas\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger K.","family":"Prichard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,5,30]]},"reference":[{"key":"ref1","first-page":"113","article-title":"Working to overcome the global impact of neglected tropical diseases - First WHO report on neglected tropical diseases. Geneva: World Health Organization","volume":"86","year":"2011","journal-title":"Wkly Epidemiol Rec"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0065-308X(05)62007-6","article-title":"Global epidemiology, ecology and control of soil-transmitted helminth infections","volume":"62","author":"S Brooker","year":"2006","journal-title":"Adv Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1126\/science.1060733","article-title":"Infectious disease. Medical helminthology in the 21st century","volume":"293","author":"DG Colley","year":"2001","journal-title":"Science"},{"key":"ref4","unstructured":"WHO (2002) Prevention and control of schistosomiasis and soil transmitted helminthiasis. Geneva: World Health Organization. 1\u201356 p."},{"key":"ref5","unstructured":"WHO (2006) Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers. Geneva: World Health Organization. 1\u201362 p."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0065-308X(05)61008-1","article-title":"Intervention for the control of soil-transmitted helminthiasis in the community","volume":"61","author":"M Albonico","year":"2006","journal-title":"Adv Parasitol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e1549","DOI":"10.1371\/journal.pntd.0001549","article-title":"A research agenda for helminth diseases of humans: intervention for control and elimination","volume":"6","author":"RK Prichard","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1601","DOI":"10.1371\/journal.pntd.0001601","article-title":"A research agenda for helminth diseases of humans: diagnostics for control and elimination programmes","volume":"6","author":"JS McCarthy","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref9","first-page":"14","article-title":"Is anthelmintic resistance a concern for the control of human soil-transmitted helminths?","volume":"1","author":"J Vercruysse","year":"2011","journal-title":"International Journal for Parasitology: Drugs and Drug Resistance"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/QCO.0b013e328358993a","article-title":"Human soil transmitted helminths: implications of mass drug administration","volume":"25","author":"JLB Vercruysse","year":"2012","journal-title":"Current Opinion in Infectious Diseases"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0166-6851(94)90066-3","article-title":"Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in beta-tubulin isotype 1","volume":"63","author":"MS Kwa","year":"1994","journal-title":"Mol Biochem Parasitol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/FPC.0b013e3282f4711d","article-title":"Genetic analysis of a relationship between macrocyclic lactone and benzimidazole anthelmintic selection on Haemonchus contortus","volume":"18","author":"ML Mottier","year":"2008","journal-title":"Pharmacogenet Genomics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0166-6851(01)00455-8","article-title":"Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzimidazole resistance?","volume":"120","author":"A Silvestre","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.vetpar.2006.10.003","article-title":"Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutation for benzimidazole resistance in nematodes","volume":"144","author":"M Ghisi","year":"2007","journal-title":"Vet Parasitol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.vetpar.2011.11.068","article-title":"Relationship between increased albendazole systemic exposure and changes in single nucleotide polymorphisms on the \u03b2-tubulin isotype 1 encoding gene in Haemonchus contortus","volume":"186","author":"V Barr\u00e8re","year":"2012","journal-title":"Veterinary Parasitology"},{"key":"ref16","article-title":"Molecular and biological diagnostic tests for monitoring benzimidazole resistance in human soil-transmitted helminths","author":"A Diawara","year":"2013","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1371\/journal.pntd.0000397","article-title":"Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides","volume":"3","author":"A Diawara","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4269\/ajtmh.2012.11-0289","article-title":"Prediction of Child Health by Household Density and Asset-Based Indices in Impoverished Indigenous Villages in Rural Panama","volume":"86","author":"CM Halpenny","year":"2012","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e2070","DOI":"10.1371\/journal.pntd.0002070","article-title":"Regional, Household and individual factors that influence soil transmitted helminth reinfection dynamics in preschoolchildren from rural indigenous Panama","volume":"7","author":"CM Halpenny","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref20","unstructured":"Ministry of Agriculture FaF (1977) Manual of veterinary parasotological laboratory techniques 2. ed. Her Majesty's Stationary Office: 129 p."},{"key":"ref21","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni","volume":"14","author":"N Katz","year":"1972","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref22","unstructured":"Montresor ACD, Bundy D, Hall A, Savioli L (1998) Guidelines for the evaluation of soil transmitted helmintiasis and schistosomiasis ai community level. Geneva: WHO. pp 49p."},{"key":"ref23","first-page":"381","article-title":"FLOTAC, a novel apparatus for a multivalent faecal egg count technique","volume":"48","author":"G Cringoli","year":"2006","journal-title":"Parassitologia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1756-3305-2-S2-S6","article-title":"Determination of genomic DNA sequences for beta-tubulin isotype 1 from multiple species of cyathostomin and detection of resistance alleles in third-stage larvae from horses with naturally acquired infections","volume":"2 Suppl 2","author":"SL Lake","year":"2009","journal-title":"Parasit Vectors"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e948","DOI":"10.1371\/journal.pntd.0000948","article-title":"Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic","volume":"5","author":"J Vercruysse","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/117693430500100003","article-title":"Arlequin (version 3.0): an integrated software package for population genetics data analysis","volume":"1","author":"L Excoffier","year":"2005","journal-title":"Evol Bioinform Online"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2307\/2532296","article-title":"Performing the exact test of Hardy-Weinberg proportion for multiple alleles","volume":"48","author":"SW Guo","year":"1992","journal-title":"Biometrics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.2517-6161.1977.tb01600.x","article-title":"Maximun likelihood from Incomplete Data via the EM Algorithm","volume":"39","author":"LN Dempster AP","year":"1977","journal-title":"Journal of the Royal Statistical Society, Serie B (Methodological)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.trstmh.2011.11.006","article-title":"Comparison of the Kato-Katz thick smear and McMaster egg counting techniques for monitoring drug efficacy against soil-transmitted helminths in schoolchildren on Pemba Island, Tanzania","volume":"106","author":"M Albonico","year":"2012","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1371\/journal.pntd.0000754","article-title":"Comparing diagnostic accuracy of Kato-Katz, Koga agar plate, ether-concentration, and FLOTAC for Schistosoma mansoni and soil-transmitted helminths","volume":"4","author":"D Glinz","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4269\/ajtmh.2005.73.234","article-title":"Detection of benzimidazole resistance-associated mutations in the filarial nematode Wuchereria bancrofti and evidence for selection by albendazole and ivermectin combination treatment","volume":"73","author":"AE Schwab","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4269\/ajtmh.2004.71.598","article-title":"Geographic distribution of lymphatic filariasis in Haiti","volume":"71","author":"MV Beau de Rochars","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/jn\/137.6.1455","article-title":"Benefit of vitamin A supplementation on ascaris reinfection is less evident in stunted children","volume":"137","author":"LG Payne","year":"2007","journal-title":"J Nutr"},{"key":"ref34","unstructured":"WHO (2011) National deworming program Kenya's experience. Rio de Janeiro: World Health Organization. 1\u201321 p."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.299.16.1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis","volume":"299","author":"J Keiser","year":"2008","journal-title":"JAMA"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pt.2012.02.004","article-title":"Paradigm lost: how parasite control may alter pattern and process in human helminthiases","volume":"28","author":"MG Basanez","year":"2012","journal-title":"Trends Parasitol"},{"key":"ref37","unstructured":"WHO (1999) Informal consultation on monitoring drug efficacy in the control of schistosomiasis and intestinal nematodes. Geneva: World Health Organization. 1\u201350 p."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1645\/GE3305RN","article-title":"Beta-tubulin complementary DNA sequence variations observed between cyathostomins from benzimidazole-susceptible and -resistant populations","volume":"90","author":"M Drogemuller","year":"2004","journal-title":"J Parasitol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.ijpara.2008.02.001","article-title":"The role of polymorphisms at beta tubulin isotype 1 codons 167 and 200 in benzimidazole resistance in cyathostomins","volume":"38","author":"JE Hodgkinson","year":"2008","journal-title":"Int J Parasitol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.molbiopara.2003.12.008","article-title":"Molecular analysis of the beta-tubulin gene of human hookworms as a basis for possible benzimidazole resistance on Pemba Island","volume":"134","author":"M Albonico","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molbiopara.2007.07.019","article-title":"Characterization of beta-tubulin genes in hookworms and investigation of resistance-associated mutations using real-time PCR","volume":"156","author":"JM Schwenkenbecher","year":"2007","journal-title":"Molecular and Biochemical Parasitology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1590\/S0074-02762009000800021","article-title":"Further evaluation of an updated PCR assay for the detection of Schistosoma mansoni DNA in human stool samples","volume":"104","author":"LI Gomes","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref43","first-page":"35","article-title":"A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp","volume":"81","author":"VY Belizario","year":"2003","journal-title":"Bull World Health Organ"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.vetpar.2010.02.030","article-title":"Anthelmintic efficacy and management practices in sheep farms from the state of Rio de Janeiro, Brazil","volume":"170","author":"DG da Cruz","year":"2010","journal-title":"Vet Parasitol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1080\/10543406.2011.607736","article-title":"The bootstrap and Markov-chain Monte Carlo","volume":"21","author":"B Efron","year":"2011","journal-title":"J Biopharm Stat"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T08:03:56Z","timestamp":1563091436000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002247"}},"subtitle":[],"editor":[{"given":"Jennifer","family":"Keiser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,30]]},"references-count":45,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002247","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,30]]}}}