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(1984) Handbook of endemic Treponematoses: yaws, endemic syphilis, and pinta. Geneva: World Health Organization."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1286-4579(01)01513-1","article-title":"The endemic Treponematoses","volume":"4","author":"GM Antal","year":"2002","journal-title":"Microbes Infect"},{"key":"ref3","unstructured":"World Health Organization (2012) Accelerating work to overcome the global impact of neglected tropical diseases: a roadmap for implementation \u2013 executive summary. Geneva: World Health Organization."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1128\/JCM.00784-06","article-title":"Molecular differentiation of <italic>Treponema pallidum<\/italic> subspecies","volume":"44","author":"A Centurion-Lara","year":"2006","journal-title":"J Clin Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e15713","DOI":"10.1371\/journal.pone.0015713","article-title":"Genome analysis of <italic>Treponema pallidum<\/italic> subsp. <italic>pallidum<\/italic> and subsp. <italic>pertenue<\/italic> strains: most of the genetic differences are localized in six regions","volume":"5","author":"L Mikalov\u00e1","year":"2010","journal-title":"PLoS ONE"},{"key":"ref6","unstructured":"Turner TB, Hollander DH (1957) Biology of the treponematoses. Geneva: World Health Organization."},{"key":"ref7","first-page":"129","article-title":"Extent and nature of the yaws problem in Africa","volume":"8","author":"CJ Hackett","year":"1953","journal-title":"Bull World Health Organ"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"675","DOI":"10.4269\/ajtmh.1938.s1-18.675","article-title":"Bejel: syphilis as a contagious disease of children","volume":"18","author":"H Hudson","year":"1938","journal-title":"Am J Trop Med Hyg"},{"key":"ref9","first-page":"4","article-title":"Eradication of endemic syphilis in Bosnia","volume":"65","author":"N Arslanagic","year":"1989","journal-title":"Genitourin Med"},{"key":"ref10","first-page":"189","article-title":"Eradication of yaws - the Morges Strategy","volume":"87","year":"2012","journal-title":"Wkly Epidemiol Rec"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"s227","DOI":"10.1093\/clinids\/7-Supplement_2.S227","article-title":"Surveillance and control of resurgent yaws in the African region","volume":"7","author":"WR Wirski","year":"1985","journal-title":"Rev Infect Dis"},{"key":"ref12","first-page":"130","article-title":"Yaws in C\u00f4te d&apos;lvoire: health problem forgotten and neglected","volume":"100","author":"B Tour\u00e9","year":"2007","journal-title":"Bull Soc Pathol Exot"},{"key":"ref13","first-page":"206","article-title":"Yaws in the periurban settlements of Port Moresby, Papua New Guinea","volume":"45","author":"LA Manning","year":"2002","journal-title":"P N G Med J"},{"key":"ref14","first-page":"642832","article-title":"Yaws in the Western pacific region: a review of the literature","author":"C Capuano","year":"2011","journal-title":"J Trop Med"},{"key":"ref15","unstructured":"Ministry of Health, Division of Planning and Policy National Health Statistics Office, Solomon Islands (2008) Annual health report 2007. Tech Rep, Solomon Islands."},{"key":"ref16","first-page":"217","article-title":"International Symposium on Yaws and Other Endemic Treponematoses. Washington DC, April 16\u201318, 1984","volume":"7","year":"1985","journal-title":"Rev Infect Dis"},{"key":"ref17","first-page":"827","article-title":"A clinical and serologic survey of bejel in north Burkina Faso","volume":"81","author":"P Gazin","year":"1988","journal-title":"Bull Soc Pathol Exot Filiales"},{"key":"ref18","first-page":"319","article-title":"Serological and clinical studies of endemic <italic>Treponematosis<\/italic> in the Republic of Mali","volume":"69","author":"P Autier","year":"1989","journal-title":"Ann Soc Belg Med Trop"},{"key":"ref19","first-page":"38","article-title":"Serologic studies of non-venereal Treponematoses in infants in Naimey, Niger","volume":"58","author":"J Julvez","year":"1998","journal-title":"Med Trop (Mars)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/clinids\/7-Supplement_2.S260","article-title":"Endemic nonvenereal <italic>Treponematosis<\/italic> (bejel) in Saudi Arabia","volume":"7","author":"G Csonka","year":"1985","journal-title":"Rev Infect Dis"},{"key":"ref21","first-page":"293","article-title":"Endemic non-venereal syphiis (bejel) in Saudi Arabia","volume":"60","author":"Jl Pace","year":"1984","journal-title":"Br J Vener Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/tropej\/41.2.117","article-title":"Bejel in Malatya, Turkey","volume":"41","author":"C Yakinci","year":"1995","journal-title":"J Trop Pediatr"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3201\/eid1901.120756","article-title":"A case of endemic syphilis, Iran [letter]","volume":"19","author":"A Abdolrasouli","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"ref24","first-page":"241","article-title":"Endemic Treponematoses","volume":"56","year":"1981","journal-title":"Wkly Epidemiol Rec"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1086\/429726","article-title":"The clinical appearance of pinta mimics secondary syphilis: another trap of <italic>Treponematosis<\/italic> [letter]","volume":"40","author":"M Giuliani","year":"2005","journal-title":"Clinical Inf Dis"},{"key":"ref26","first-page":"111","article-title":"Immunology of tertiary pinta","volume":"16","author":"SA Pecher","year":"1988","journal-title":"Med Cutan Ibero Lat Am"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/ije\/6.4.349","article-title":"Pinta, yaws, and venereal syphilis in Colombia","volume":"6","author":"DR Hopkins","year":"1977","journal-title":"Int J Epidemiol"},{"key":"ref28","unstructured":"World Health Organization (1987) Programme for the Control of the Endemic Treponematoses. 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In: Goldsmith LA, Katz SI, Gilchrest BA, Paller SA, Lefell DJ, <etal>et al<\/etal>.., editors. Fitzpatrick&apos;s dermatology in general medicine. 8th edition. McGraw Hill, p. 2493."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4269\/ajtmh.2011.11-0062","article-title":"Challenges in recognition and diagnosis of yaws in children in Papua New Guinea","volume":"85","author":"O Mitj\u00e0","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"348","DOI":"10.5694\/j.1326-5377.2010.tb03537.x","article-title":"Chronic cutaneous ulcers secondary to Haemophilus ducreyi infection","volume":"192","author":"TN Peel","year":"2010","journal-title":"Med J Aust"},{"key":"ref37","first-page":"21","article-title":"La lesion inicial del mal de pinta","volume":"6","author":"F Leon y Blanco","year":"1940","journal-title":"Rev Med Trop Parastiol Bacteriol Clin Lab"},{"key":"ref38","first-page":"142","article-title":"Studies on a focus of yaws in the Santiago Basin, province of Esmeraldas, Ecuador","volume":"43","author":"RH Guderian","year":"1991","journal-title":"Trop Geogr Med"},{"key":"ref39","first-page":"95","article-title":"Clinical aspects of Bejel","volume":"29","author":"GW Csonka","year":"1953","journal-title":"Br J Vener Dis"},{"key":"ref40","first-page":"80","article-title":"Aspects de la syphilis endemique des Touareg du Niger","volume":"62","author":"A Basset","year":"1969","journal-title":"Bull Soc Pathol Exot"},{"key":"ref41","first-page":"220","article-title":"Treponemal infections of the head and neck","volume":"27","author":"SA Martinez","year":"1982","journal-title":"Otolaryngol Clin North Am"},{"key":"ref42","first-page":"299","article-title":"Mal de pinto in Mexico","volume":"13","author":"F Marquez","year":"1955","journal-title":"Bull World Health Organ"},{"key":"ref43","first-page":"425","article-title":"Tertiary pinta: case reports and overview","volume":"51","author":"J Fuchs","year":"1993","journal-title":"Cutis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/cid\/ciq246","article-title":"Osteoperiostitis in early yaws: case series and literature review","volume":"52","author":"O Mitj\u00e0","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000252218","article-title":"Late mutilating bejel in the nomadic Bedouins of Kuwait","volume":"143","author":"MW Kanan","year":"1971","journal-title":"Dermatologica"},{"key":"ref46","first-page":"104","article-title":"Mutilating bejel","volume":"29","author":"LGG Jones","year":"1953","journal-title":"Br J Vener Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1258\/td.2009.090249","article-title":"Resurgence of yaws in Tanna, Vanuatu: time for a new approach?","volume":"40","author":"D Fegan","year":"2010","journal-title":"Trop Doct"},{"key":"ref48","unstructured":"Merrit HH, Adams RD, Solomon HC (1946) Neurosyphilis. New York: Oxford University Press."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/clinids\/8.5.760","article-title":"Occurrence of congenital, cardiovascular, visceral, neurologic, and neuro-ophthalmologic complications in late yaws: a theme for future research","volume":"8","author":"GC Roman","year":"1986","journal-title":"Rev Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0161-6420(89)32781-3","article-title":"Ocular manifestations of endemic syphilis (bejel)","volume":"96","author":"KF Tabbara","year":"1989","journal-title":"Ophtalmology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0035-9203(40)90037-2","article-title":"Nervous manifestations of Bejel","volume":"33","author":"H Hoff","year":"1940","journal-title":"Trans Royal Soc Trop Med Hyg"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0035-9203(54)90143-1","article-title":"Cardiovascular disease as a cause of death in the Gold Coast African","volume":"48","author":"GM Edington","year":"1954","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1525-1470.2010.01184.x","article-title":"Secondary yaws: an endemic Treponemal infection","volume":"27","author":"EK Satter","year":"2010","journal-title":"Pediatr Dermatol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.0303-6987.2004.00236.x","article-title":"Secondary syphilis: a histologic and immunohistochemical evaluation","volume":"31","author":"MP Hoang","year":"2004","journal-title":"J Cutan Pathol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1128\/JCM.00720-09","article-title":"Clinical value of <italic>Treponema pallidum<\/italic> real-time PCR for diagnosis of syphilis","volume":"48","author":"R Heymans","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref56","first-page":"102","article-title":"The localisation of treponemes and characterization of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis or early infectious yaws","volume":"69","author":"HJ Engelkens","year":"1993","journal-title":"Genitourin Med"},{"key":"ref57","first-page":"403","article-title":"Ultraestructural aspects of infection with <italic>Treponema pallidum<\/italic> subspecies <italic>pertenue<\/italic> (Pariaman strain)","volume":"67","author":"HJ Engelkens","year":"1991","journal-title":"Genitourin Med"},{"key":"ref58","unstructured":"Lever WF, Schaumburg-Lever G (1992) Treponemal diseases. In: Lever WF, Schaumburg-Lever G, editors. Histopathology of the skin. 7th edition. Philadelphia, PA: J.B. Lippincott. pp. 352\u2013359."},{"key":"ref59","first-page":"5","article-title":"Comparative studies on the histopathology of syphilis, yaws, and pinta","volume":"33","author":"CM Hasselmann","year":"1957","journal-title":"Br J Venereal Dis"},{"key":"ref60","first-page":"239","article-title":"Aspectos histopatologicos da pinta terciaria","volume":"15","author":"SA Pecher","year":"1987","journal-title":"Med Cutan Ibero Lat Am"},{"key":"ref61","first-page":"102","article-title":"Comparison of cardiolipin and Treponemaltests in the serodiagnosis of yaws","volume":"55","author":"HE Menke","year":"1979","journal-title":"Br J Vener Dis"},{"key":"ref62","first-page":"January 13","article-title":"Laboratory diagnostic testing for <italic>Treponema pallidum<\/italic>","year":"2009","journal-title":"Atlanta"},{"key":"ref63","first-page":"479","article-title":"<italic>Treponema pallidum<\/italic> haemagglutination test for yaw; comparison with the TPI and FTA-ABS tests","volume":"48","author":"MF Garner","year":"1972","journal-title":"Br J Vener Dis"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1128\/JCM.33.7.1875-1878.1995","article-title":"Evaluation of immunoglobulin G enzyme immunoassay for serodiagnosis of Yaws","volume":"33","author":"JL Backhouse","year":"1995","journal-title":"J Clin Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e54695","DOI":"10.1371\/journal.pone.0054695","article-title":"Are <italic>Treponema pallidum<\/italic> specific rapid and point-of-care tests for syphilis accurate enough for screening in resource limited settings? 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In: Krieg NR, Holt JG, editors. Bergey&apos;s manual of systematic bacteriology, vol. 1. Baltimore: Williams and Wilkins, pp. 49\u201357."},{"key":"ref74","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1128\/JB.141.1.427-429.1980","article-title":"Genetic relationship between <italic>Treponema pallidum<\/italic> and <italic>Treponema pertenue<\/italic>, two noncultivable human pathogens","volume":"141","author":"RM Miao","year":"1980","journal-title":"J Bacteriol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1128\/IAI.00709-07","article-title":"Genome differences between <italic>Treponema pallidum<\/italic> subsp. <italic>pallidum<\/italic> strain Nichols and T. paraluiscuniculi strain Cuniculi A","volume":"75","author":"M Strouhal","year":"2007","journal-title":"Infect Immun"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"e20415","DOI":"10.1371\/journal.pone.0020415","article-title":"Complete genome sequence of <italic>Treponema paraluiscuniculi<\/italic>, strain Cuniculi A: the loss of infectivity to humans is 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strains","volume":"67","author":"CE Cameron","year":"1999","journal-title":"Infect Immun"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1099\/jmm.0.46943-0","article-title":"Molecular characterization and analysis of a gene encoding the acidic repeat protein (Arp) of <italic>Treponema pallidum<\/italic>","volume":"56","author":"H Liu","year":"2007","journal-title":"J Med Microbiol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1574-695X.2008.00427.x","article-title":"The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal <italic>Treponema pallidum<\/italic> subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis","volume":"53","author":"KN Harper","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"e1832","DOI":"10.1371\/journal.pntd.0001832","article-title":"Whole 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