{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:47:48Z","timestamp":1784612868506,"version":"3.55.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002293","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T20:59:15Z","timestamp":1372366755000},"page":"e2293","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["An Adult Mouse Model of Vibrio cholerae-induced Diarrhea for Studying Pathogenesis and Potential Therapy of Cholera"],"prefix":"10.1371","volume":"7","author":[{"given":"Sutthipong","family":"Sawasvirojwong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Potjanee","family":"Srimanote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varanuj","family":"Chatsudthipong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chatchai","family":"Muanprasat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S1473-3099(07)70138-X","article-title":"The true burden and risk of cholera: implications for prevention and control","volume":"7","author":"JN Zuckerman","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1128\/CMR.15.4.757-770.2002","article-title":"Effects of global climate on infectious disease: the cholera model","volume":"15","author":"EK Lipp","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11908-011-0221-9","article-title":"Cholera: lessons from haiti and beyond","volume":"14","author":"AA Weil","year":"2012","journal-title":"Curr Infect Dis Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tips.2005.02.003","article-title":"New drug targets for cholera therapy","volume":"26","author":"JR Thiagarajah","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1053\/j.gastro.2012.01.014","article-title":"Translational approaches for pharmacotherapy development for acute diarrhea","volume":"142","author":"M Donowitz","year":"2012","journal-title":"Gastroenterology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4155\/fmc.13.42","article-title":"Cholera: pathophysiology and emerging therapeutic targets","volume":"5","author":"C Muanprasat","year":"2013","journal-title":"Future Med Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/gmic.1.1.11036","article-title":"Infectious diarrhea: Cellular and molecular mechanisms","volume":"1","author":"K Hodges","year":"2010","journal-title":"Gut Microbes"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"G781","DOI":"10.1152\/ajpgi.2001.280.5.G781","article-title":"Microbes and microbial Toxins: paradigms for microbial-mucosal toxins. V. Cholera: invasion of the intestinal epithelial barrier by a stably folded protein toxin","volume":"280","author":"WI Lencer","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00026.2001","article-title":"Electrolyte transport in the mammalian colon: mechanisms and implications for disease","volume":"82","author":"K Kunzelmann","year":"2002","journal-title":"Physiol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1085\/jgp.200910339","article-title":"Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion","volume":"135","author":"KM Hoque","year":"2010","journal-title":"J Gen Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.4155\/fmc.11.87","article-title":"Developing novel antisecretory drugs to treat infectious diarrhea","volume":"3","author":"EL de Hostos","year":"2011","journal-title":"Future Med Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1074\/jbc.M112.408302","article-title":"<italic>Vibrio cholerae<\/italic> O395 outer membrane vesicles modulate intestinal epithelial Cells in a NOD1 dependent manner and induces dendritic cell-mediated Th2\/Th17 responses","volume":"288","author":"D Chatterjee","year":"2012","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1128\/IAI.00843-08","article-title":"<italic>Vibrio cholerae<\/italic> flagellins induce Toll-like receptor 5-mediated interleukin-8 production through mitogen-activated protein kinase and NF-kappaB activation","volume":"76","author":"LM Harrison","year":"2008","journal-title":"Infect Immun"},{"key":"ref14","first-page":"37","article-title":"<italic>Vibrio cholerae<\/italic> interactions with the gastrointestinal tract: lessons from animal studies","volume":"337","author":"JM Ritchie","year":"2009","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e00047","DOI":"10.1128\/mBio.00047-10","article-title":"Back to the future: studying cholera pathogenesis using infant rabbits","volume":"1","author":"JM Ritchie","year":"2010","journal-title":"MBio"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1084\/jem.168.4.1487","article-title":"Toxin, toxin-coregulated pili, and the toxR regulon are essential for <italic>Vibrio cholerae<\/italic> pathogenesis in humans","volume":"168","author":"DA Herrington","year":"1988","journal-title":"J Exp Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0966-842X(00)01721-2","article-title":"The suckling mouse model of cholera","volume":"8","author":"KE Klose","year":"2000","journal-title":"Trends Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1128\/JB.100.2.1142-1143.1969","article-title":"Reaction of <italic>Vibrio cholerae<\/italic> and choleragenic toxin in ileal loop of laboratory animals","volume":"100","author":"S Basu","year":"1969","journal-title":"J Bacteriol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1254\/jphs.11153FP","article-title":"Novel Action of the Chalcone Isoliquiritigenin as a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Inhibitor: Potential Therapy for Cholera and Polycystic Kidney Disease","volume":"118","author":"C Muanprasat","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.lfs.2012.05.001","article-title":"Hydroxyxanthone as an inhibitor of cAMP-activated apical chloride channel in human intestinal epithelial cell","volume":"90","author":"W Luerang","year":"2012","journal-title":"Life Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e34946","DOI":"10.1371\/journal.pone.0034946","article-title":"Myosin light chain kinase mediates intestinal barrier disruption following burn injury","volume":"7","author":"C Chen","year":"2012","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/clinchem\/24.1.80","article-title":"New automated dye-binding method for serum albumin determination with bromcresol purple","volume":"24","author":"AE Pinnell","year":"1978","journal-title":"Clin Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1053\/j.gastro.2003.11.005","article-title":"Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor","volume":"126","author":"JR Thiagarajah","year":"2004","journal-title":"Gastroenterology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1073\/pnas.052694299","article-title":"Quorum-sensing regulators control virulence gene expression in <italic>Vibrio cholerae<\/italic>","volume":"99","author":"J Zhu","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1128\/IAI.01435-06","article-title":"Effect of fatty acids and cholesterol present in bile on expression of virulence factors and motility of <italic>Vibrio cholerae<\/italic>","volume":"75","author":"A Chatterjee","year":"2007","journal-title":"Infect Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1128\/IAI.00409-09","article-title":"Bicarbonate Induces <italic>Vibrio cholerae<\/italic> virulence gene expression by enhancing ToxT activity","volume":"77","author":"BH Abuaita","year":"2009","journal-title":"Infect Immun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e1001102","DOI":"10.1371\/journal.ppat.1001102","article-title":"A bistable switch and anatomical site control <italic>Vibrio cholerae<\/italic> virulence gene expression in the intestine","volume":"6","author":"AT Nielsen","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/infdis\/119.2.138","article-title":"Experimental canine cholera. I. Development of the model","volume":"119","author":"RB Sack","year":"1969","journal-title":"J Infect Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/clpt.2012.114","article-title":"CFTR inhibitors for treating diarrheal disease","volume":"92","author":"JR Thiagarajah","year":"2012","journal-title":"Clin Pharmacol Ther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1136\/gut.52.10.1419","article-title":"Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial","volume":"52","author":"NH Alam","year":"2003","journal-title":"Gut"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI0216112","article-title":"Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion","volume":"110","author":"T Ma","year":"2002","journal-title":"J Clin Invest"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T07:48:31Z","timestamp":1596008911000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002293"}},"subtitle":[],"editor":[{"given":"Mathieu","family":"Picardeau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002293","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,27]]}}}