{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T18:44:09Z","timestamp":1770317049282,"version":"3.49.0"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002314","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T18:51:48Z","timestamp":1374173508000},"page":"e2314","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hemostatic Dysfunction Is Increased in Patients with Hepatosplenic Schistosomiasis Mansoni and Advanced Periportal Fibrosis"],"prefix":"10.1371","volume":"7","author":[{"given":"Luiz Arthur Calheiros","family":"Leite","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adenor Almeida","family":"Pimenta Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ca\u00edque Silveira Martins da","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianka Santana dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita de C\u00e1ssia dos Santos","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Maria Lucena","family":"Montenegro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmundo Pessoa","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L\u00facia Coutinho","family":"Domingues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Stuart","family":"Owen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L\u00facia de Menezes","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.humpath.2010.05.020","article-title":"Severe hepatosplenic schistosomiasis: clinicopathologic study of 102 cases undergoing splenectomy","volume":"42","author":"Li Yuesheng","year":"2011","journal-title":"Hum Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1056\/NEJMra012396","article-title":"Schistosomiasis","volume":"346","author":"AGP Ross","year":"2002","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e1165","DOI":"10.1371\/journal.pntd.0001165","article-title":"A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg\/kg vs. 60 mg\/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil","volume":"2","author":"PL Olliaro","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1590\/S0074-02761997000500027","article-title":"Factors involved in schistosoma infection in rural areas of Northeast Brazil","volume":"92","author":"EM Coutinho","year":"1997","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.trstmh.2008.11.017","article-title":"Platelet function and the von Willebrand factor antigen in the hepatosplenic form of schistosomiasis mansoni","volume":"103","author":"MCB Correia","year":"2009","journal-title":"Roy Soc Trop Med Hyg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-3024.2009.01157.x","article-title":"Schistosomiasis and liver fibrosis","volume":"31","author":"ZA Andrade","year":"2009","journal-title":"Parasite Immunol"},{"key":"ref7","first-page":"183","article-title":"The influence of periportal (Pipestem) fibrosis on long term results of surgical treatment for schistosomotic portal hypertension","volume":"101","author":"AAB Ferraz","year":"2003","journal-title":"Arq Gastroenterol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"B Gryseels","year":"2006","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0168-8278(98)80008-1","article-title":"Early liver dysfuction in schistosomiasis","volume":"29","author":"L Camacho-Lobato","year":"1998","journal-title":"J Hepatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1383-5769(03)00051-5","article-title":"Haemostatic abnormalities in hepatosplenic schistomomiasis mansoni","volume":"52","author":"M Tanabe","year":"2003","journal-title":"Parasitol Int"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1136\/jcp.47.6.502","article-title":"Vitamin K dependent coagulation proteins in endemic hepatosplenomegaly in Egypt","volume":"47","author":"SA Omran","year":"1994","journal-title":"J Clin Pathol"},{"key":"ref12","unstructured":"Niamey Working Group (2000) Ultrasound in schistosomiasis: a practical guide to the standardized use of ultrasonography for the assessment of schistosomiasis-related morbidity. Geneva: World Health Organization. TDR\/STR\/SCH\/00.1."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1590\/S0074-02762001000900023","article-title":"Report of the Second Satellite Symposium on Ultrasound in Schistosomiasis","volume":"96","author":"J Richter","year":"2001","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.dld.2008.01.010","article-title":"High-D-dimer levels predict poor outcome in esophageal variceal bleending","volume":"40","author":"M Primignani","year":"2008","journal-title":"Dig Liver Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0001-706X(02)00136-5","article-title":"Serum hyaronic acid as a comprehensive marker to assess severity of liver disease in schistosomiasis","volume":"84","author":"LA Kopke-Aguiar","year":"2002","journal-title":"Acta Trop"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.actatropica.2008.06.001","article-title":"Anicteric cholangiopathy in schistosomiasis patients","volume":"108","author":"PE Brandt","year":"2008","journal-title":"Acta Trop"},{"key":"ref17","first-page":"1009","article-title":"Splenomegaly, hypersplenism and coagulation abnormalities in liver disease","volume":"14","author":"PA McCormick","year":"2000","journal-title":"Bailli\u00e8re Clin Gastro"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1590\/S1516-84842004000300009","article-title":"\u201cHiperesplenismo\u201d em hipertens\u00e3o porta por esquistossomose mans\u00f4nica","volume":"26","author":"A Petroianu","year":"2004","journal-title":"Rev Bras Hematol Hemoter"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0168-8278(98)80348-6","article-title":"Translocations of platelets into Disse spaces and their entry into hepatocytes in response to lipossaccharides, interleukin-1 and tumour necrosis factor: The role of Kupffer cells","volume":"28","author":"M Nakamura","year":"1998","journal-title":"J Hepatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1751-553X.2007.01005.x","article-title":"Reticulated platelets and thrombopoetin in schistosomiasis patients","volume":"31","author":"LA K\u00f6pke-Aguiar","year":"2009","journal-title":"Int J Lab Hematol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejim.2010.02.001","article-title":"The coagulopathy of chronic liver disease: Is there a causal relationship with bleeding: No","volume":"21","author":"A Tripodi","year":"2010","journal-title":"Eur J Int Med"},{"key":"ref22","first-page":"557","article-title":"Protein C deficient in the compensated form of hepatosplenic schitosomiasis","volume":"20","author":"DR Borges","year":"1987","journal-title":"Braz J Med Biol Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1136\/jcp.49.12.990","article-title":"Hyperfibrinolysis in hepatosplenic schistomiasis","volume":"49","author":"NE El-Bassiouni","year":"1996","journal-title":"J Clin Pathol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T15:27:42Z","timestamp":1539962862000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002314"}},"subtitle":[],"editor":[{"given":"Edgar M.","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,18]]},"references-count":23,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002314","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,18]]}}}