{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:25:15Z","timestamp":1791192315336,"version":"4.1.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002430","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T21:20:12Z","timestamp":1379020812000},"page":"e2430","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["A Fusion-Inhibiting Peptide against Rift Valley Fever Virus Inhibits Multiple, Diverse Viruses"],"prefix":"10.1371","volume":"7","author":[{"given":"Jeffrey W.","family":"Koehler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Ripoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin W.","family":"Spik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine V.","family":"Badger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M.","family":"Ogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Wallqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Guttieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Garry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie S.","family":"Schmaljohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1016\/j.ijid.2009.03.029","article-title":"Manifestations of severe Rift Valley fever in Sudan","volume":"14","author":"AA Adam","year":"2009","journal-title":"Int J Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3201\/eid0906.020647","article-title":"Rift Valley fever virus infection among French troops in Chad","volume":"9","author":"JP Durand","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0923-2516(89)80081-0","article-title":"General aspects of the 1987 Rift Valley fever epidemic in Mauritania","volume":"140","author":"JP Digoutte","year":"1989","journal-title":"Res Virol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/vr.105.6.124","article-title":"An epizootic of Rift Valley fever in Egypt in 1977","volume":"105","author":"JM Meegan","year":"1979","journal-title":"Vet Rec"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/path.1700340418","article-title":"Enzootic hepatitis or Rift Valley fever. An undescribed virus disease of sheep, cattle and man from East Africa","volume":"34","author":"R Daubney","year":"1931","journal-title":"J Path Bact"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1086\/378747","article-title":"Rift Valley fever epidemic in Saudi Arabia: epidemiological, clinical, and laboratory characteristics","volume":"37","author":"TA Madani","year":"2003","journal-title":"Clin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.3201\/eid0812.020195","article-title":"Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000\u201301","volume":"8","author":"T Shoemaker","year":"2002","journal-title":"Emerg Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1742-4682-1-10","article-title":"Proteomics computational analyses suggest that the carboxyl terminal glycoproteins of Bunyaviruses are class II viral fusion protein (beta-penetrenes)","volume":"1","author":"CE Garry","year":"2004","journal-title":"Theor Biol Med Model"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1073\/pnas.1217780110","article-title":"Crystal structure of glycoprotein C from Rift Valley fever virus","volume":"110","author":"M Dessau","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.virol.2006.07.035","article-title":"Development and characterization of a Rift Valley fever virus cell-cell fusion assay using alphavirus replicon vectors","volume":"356","author":"CM Filone","year":"2006","journal-title":"Virology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nsmb.1456","article-title":"Viral membrane fusion","volume":"15","author":"SC Harrison","year":"2008","journal-title":"Nat Struct Mol Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/JVI.69.2.695-700.1995","article-title":"Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH","volume":"69","author":"SL Allison","year":"1995","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature02165","article-title":"Structure of the dengue virus envelope protein after membrane fusion","volume":"427","author":"Y Modis","year":"2004","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/sj.emboj.7600064","article-title":"Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation","volume":"23","author":"S Bressanelli","year":"2004","journal-title":"EMBO J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1128\/JVI.75.9.4268-4275.2001","article-title":"Mutational evidence for an internal fusion peptide in flavivirus envelope protein E","volume":"75","author":"SL Allison","year":"2001","journal-title":"J Virol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/375291a0","article-title":"The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution","volume":"375","author":"FA Rey","year":"1995","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1743-422X-2-49","article-title":"Peptide inhibitors of dengue virus and West Nile virus infectivity","volume":"2","author":"YM Hrobowski","year":"2005","journal-title":"Virol J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1000851","DOI":"10.1371\/journal.ppat.1000851","article-title":"Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate","volume":"6","author":"AG Schmidt","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e721","DOI":"10.1371\/journal.pntd.0000721","article-title":"Structural optimization and de novo design of dengue virus entry inhibitory peptides","volume":"4","author":"JM Costin","journal-title":"PLoS Negl Trop Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.virusres.2006.03.001","article-title":"Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein","volume":"120","author":"B Sainz Jr","year":"2006","journal-title":"Virus Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/3293","article-title":"Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry","volume":"4","author":"JM Kilby","year":"1998","journal-title":"Nat Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1089\/aid.1993.9.1051","article-title":"A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion","volume":"9","author":"C Wild","year":"1993","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00249-010-0666-z","article-title":"Insights into the mechanism of HIV-1 envelope induced membrane fusion as revealed by its inhibitory peptides","volume":"40","author":"A Ashkenazi","year":"2011","journal-title":"Eur Biophys J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7669","DOI":"10.1128\/JVI.77.13.7669-7672.2003","article-title":"Direct evidence that C-peptide inhibitors of human immunodeficiency virus type 1 entry bind to the gp41 N-helical domain in receptor-activated viral envelope","volume":"77","author":"NR Kilgore","year":"2003","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1002\/pro.256","article-title":"MPEx: a tool for exploring membrane proteins","volume":"18","author":"C Snider","year":"2009","journal-title":"Protein Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0168-1702(97)00097-X","article-title":"Mapping of the mutations present in the genome of the Rift Valley fever virus attenuated MP12 strain and their putative role in attenuation","volume":"52","author":"P Vialat","year":"1997","journal-title":"Virus Res"},{"issue":"Pt 10","key":"ref27","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1099\/0022-1317-66-10-2271","article-title":"Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development","volume":"66","author":"H Caplen","year":"1985","journal-title":"J Gen Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1016\/j.vaccine.2005.08.034","article-title":"Immunogenicity of combination DNA vaccines for Rift Valley fever virus, tick-borne encephalitis virus, Hantaan virus, and Crimean Congo hemorrhagic fever virus","volume":"24","author":"K Spik","year":"2006","journal-title":"Vaccine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.virol.2007.12.030","article-title":"New and Old World hantaviruses differentially utilize host cytoskeletal components during their life cycles","volume":"374","author":"HN Ramanathan","year":"2008","journal-title":"Virology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.virol.2004.10.048","article-title":"Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening","volume":"332","author":"JS Towner","year":"2005","journal-title":"Virology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.antiviral.2011.10.008","article-title":"Novel plant-derived recombinant human interferons with broad spectrum antiviral activity","volume":"92","author":"JW Koehler","year":"2011","journal-title":"Antiviral Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4269\/ajtmh.1988.39.617","article-title":"Genetic variation among geographic isolates of Rift Valley fever virus","volume":"39","author":"JK Battles","year":"1988","journal-title":"Am J Trop Med Hyg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1128\/JCM.40.7.2323-2330.2002","article-title":"Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR","volume":"40","author":"C Drosten","year":"2002","journal-title":"J Clin Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"954","DOI":"10.4269\/ajtmh.2010.09-0636","article-title":"Comprehensive panel of real-time TaqMan polymerase chain reaction assays for detection and absolute quantification of filoviruses, arenaviruses, and New World hantaviruses","volume":"82","author":"AR Trombley","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e6254","DOI":"10.1371\/journal.pone.0006254","article-title":"PSPP: a protein structure prediction pipeline for computing clusters","volume":"4","author":"MS Lee","year":"2009","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/prot.10550","article-title":"Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling","volume":"53 Suppl 6","author":"D Petrey","year":"2003","journal-title":"Proteins"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1073\/pnas.1217780110","article-title":"Crystal structure of glycoprotein C from Rift Valley fever virus","volume":"110","author":"M Dessau","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nature02239","article-title":"Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus","volume":"427","author":"DL Gibbons","year":"2004","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1038\/emboj.2011.261","article-title":"4.4 A cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus","volume":"30","author":"R Zhang","year":"2011","journal-title":"EMBO J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1126\/science.1127683","article-title":"Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G","volume":"313","author":"S Roche","year":"2006","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1073\/pnas.96.6.2662","article-title":"Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution","volume":"96","author":"VN Malashkevich","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature07082","article-title":"Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor","volume":"454","author":"JE Lee","year":"2008","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"HM Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.1135710","article-title":"Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G","volume":"315","author":"S Roche","year":"2007","journal-title":"Science"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1099\/vir.0.81083-0","article-title":"Hantavirus Gc glycoprotein: evidence for a class II fusion protein","volume":"86","author":"ND Tischler","year":"2005","journal-title":"J Gen Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1097-2765(00)80159-8","article-title":"Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain","volume":"2","author":"W Weissenhorn","year":"1998","journal-title":"Mol Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e721","DOI":"10.1371\/journal.pntd.0000721","article-title":"Structural optimization and de novo design of dengue virus entry inhibitory peptides","volume":"4","author":"JM Costin","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e1002627","DOI":"10.1371\/journal.ppat.1002627","article-title":"Small-molecule inhibitors of dengue-virus entry","volume":"8","author":"AG Schmidt","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e50995","DOI":"10.1371\/journal.pone.0050995","article-title":"Release of dengue virus genome induced by a peptide inhibitor","volume":"7","author":"S-M Lok","year":"2012","journal-title":"PLoS One"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"8495","DOI":"10.1128\/JVI.05129-11","article-title":"Mutational analysis of the zippering reaction during flavivirus membrane fusion","volume":"85","author":"K Pangerl","year":"2011","journal-title":"J Virol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.200507075","article-title":"Domain III from class II fusion proteins functions as a dominant-negative inhibitor of virus membrane fusion","volume":"171","author":"M Liao","year":"2005","journal-title":"J Cell Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"11362","DOI":"10.1128\/JVI.01679-06","article-title":"Functions of the stem region of the Semliki Forest virus fusion protein during virus fusion and assembly","volume":"80","author":"M Liao","year":"2006","journal-title":"J Virol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T23:42:54Z","timestamp":1596498174000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002430"}},"subtitle":[],"editor":[{"given":"Brian","family":"Bird","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,12]]},"references-count":52,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002430","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,12]]}}}