{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:20:38Z","timestamp":1793413238089,"version":"4.5.0"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T00:00:00Z","timestamp":1380153600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002436","type":"journal-article","created":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T21:13:00Z","timestamp":1380229980000},"page":"e2436","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association between Age and Severity to Leptospirosis in Children"],"prefix":"10.1371","volume":"7","author":[{"given":"Gilles","family":"Guerrier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Hie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Claire","family":"Gourinat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Huguon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Polfrit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Goarant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"D'Ortenzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Missotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1473-3099(03)00830-2","article-title":"Leptospirosis: a zoonotic disease of global importance","volume":"3","author":"AR Bharti","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/CMR.14.2.296-326.2001","article-title":"Leptospirosis","volume":"14","author":"PN Levett","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1590\/S0036-46652004000100004","article-title":"Comparative study of the in-hospital case-fatality rate of leptospirosis between pediatric and adult patients of different age groups","volume":"46","author":"AA Lopes","year":"2004","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref4","first-page":"227","article-title":"[Leptospiral infection and subclinical presentation among children in Salvador, Bahia]","volume":"36","author":"HR Silva","year":"2003","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/BF02723705","article-title":"Leptospirosis in children in Mumbai slums","volume":"69","author":"S Karande","year":"2002","journal-title":"Indian J Pediatr"},{"key":"ref6","first-page":"13","article-title":"[Human leptospirosis outbreak in the district of Ciego de Avila, Cuba]","volume":"32","author":"M Suarez Hernandez","year":"1999","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref7","first-page":"5","article-title":"[Leptospirosis in children in Rio do Janeiro]","volume":"27","author":"ML Cruz","year":"1994","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1991","DOI":"10.1371\/journal.pntd.0001991","article-title":"Risk factors and predictors of severe leptospirosis in New Caledonia","volume":"7","author":"S Tubiana","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref9","unstructured":"Institut de la Statistique et des Etudes Economiques. Recensement de la population. 2009 Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.isee.nc\/population\/population.html\" xlink:type=\"simple\">http:\/\/www.isee.nc\/population\/population.html<\/ext-link>. Accessed 12 May 2013."},{"key":"ref10","first-page":"133","article-title":"[Laboratory based human leptospirosis surveillance in New Caledonia (2001\u20132005)]","volume":"100","author":"A Berlioz-Arthaud","year":"2007","journal-title":"Bull Soc Pathol Exot"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1365-3156.2009.02310.x","article-title":"Outbreak of leptospirosis in New Caledonia: diagnosis issues and burden of disease","volume":"14","author":"C Goarant","year":"2009","journal-title":"Trop Med Int Health"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1365-3156.2006.01619.x","article-title":"Seroepidemiology of leptospirosis in southern Vietnamese children","volume":"11","author":"KT Thai","year":"2006","journal-title":"Trop Med Int Health"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1371\/journal.pntd.0000111","article-title":"A comparative study of leptospirosis and dengue in Thai children","volume":"1","author":"DH Libraty","year":"2007","journal-title":"PLoS Negl Trop Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4269\/ajtmh.1997.56.307","article-title":"Outcome of leptospirosis in children","volume":"56","author":"PC Marotto","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.gene.6364058","article-title":"HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis","volume":"5","author":"J Lingappa","year":"2004","journal-title":"Genes Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.humimm.2009.08.007","article-title":"Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis","volume":"70","author":"RN Fialho","year":"2009","journal-title":"Hum Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1371\/journal.pntd.0000056","article-title":"A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand","volume":"1","author":"J Thaipadungpanit","year":"2007","journal-title":"PLoS Negl Trop Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.vetmic.2011.02.055","article-title":"Pathogenesis of leptospirosis: the influence of genomics","volume":"153","author":"B Adler","year":"2011","journal-title":"Vet Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e59266","DOI":"10.1371\/journal.pone.0059266","article-title":"The jarisch-herxheimer reaction in leptospirosis: a systematic review","volume":"8","author":"G Guerrier","year":"2013","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.qco.0000178824.05715.2c","article-title":"Leptospirosis","volume":"18","author":"AJ McBride","year":"2005","journal-title":"Curr Opin Infect Dis"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T19:33:37Z","timestamp":1539977617000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002436"}},"subtitle":[],"editor":[{"given":"Jessica N.","family":"Ricaldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,26]]},"references-count":20,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002436","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,26]]}}}