{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:56:53Z","timestamp":1791313013883,"version":"4.3.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002457","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:50:39Z","timestamp":1379638239000},"page":"e2457","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":89,"title":["Cytokine Response Signatures in Disease Progression and Development of Severe Clinical Outcomes for Leptospirosis"],"prefix":"10.1371","volume":"7","author":[{"given":"Eliana A. G.","family":"Reis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 E.","family":"Hagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme S.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Teixeira-Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olindo A.","family":"Martins-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth R.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert I.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitermayer G.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrmicro2208","article-title":"Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen","volume":"7","author":"AI Ko","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.trstmh.2010.07.002","article-title":"Climate change, flooding, urbanisation and leptospirosis: fuelling the fire?","volume":"104","author":"CL Lau","year":"2010","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.qco.0000178824.05715.2c","article-title":"Leptospirosis","volume":"18","author":"AJ McBride","year":"2005","journal-title":"Curr Opin Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/CMR.14.2.296-326.2001","article-title":"Leptospirosis","volume":"14","author":"PN Levett","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/sj.ki.5002393","article-title":"Leptospirosis renal disease: understanding the initiation by Toll-like receptors","volume":"72","author":"CW Yang","year":"2007","journal-title":"Kidney Int"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3201\/eid1403.071064","article-title":"Leptospirosis-associated severe pulmonary hemorrhagic syndrome, Salvador, Brazil","volume":"14","author":"EL Gouveia","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"794","DOI":"10.7326\/0003-4819-125-10-199611150-00002","article-title":"Sporadic urban leptospirosis","volume":"125","author":"JM Vinetz","year":"1996","journal-title":"Ann Intern Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1371\/journal.pntd.0000056","article-title":"A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand","volume":"1","author":"J Thaipadungpanit","year":"2007","journal-title":"PLoS Negl Trop Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1371\/journal.pmed.0030308","article-title":"Determining risk for severe leptospirosis by molecular analysis of environmental surface waters for pathogenic Leptospira","volume":"3","author":"CA Ganoza","year":"2006","journal-title":"PLoS Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e453","DOI":"10.1371\/journal.pntd.0000453","article-title":"Soluble ST2 levels are associated with bleeding in patients with severe Leptospirosis","volume":"3","author":"JF Wagenaar","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jinf.2009.04.004","article-title":"Long pentraxin PTX3 is associated with mortality and disease severity in severe Leptospirosis","volume":"58","author":"JF Wagenaar","year":"2009","journal-title":"J Infect"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e42266","DOI":"10.1371\/journal.pone.0042266","article-title":"Leptospiral Hemolysins Induce Proinflammatory Cytokines through Toll-Like Receptor 2-and 4-Mediated JNK and NF-kappaB Signaling Pathways","volume":"7","author":"H Wang","year":"2012","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e18279","DOI":"10.1371\/journal.pone.0018279","article-title":"Potent innate immune response to pathogenic leptospira in human whole blood","volume":"6","author":"MG Goris","year":"2011","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/clinids\/13.6.1245","article-title":"Tumor necrosis factor in patients with leptospirosis","volume":"13","author":"JM Estavoyer","year":"1991","journal-title":"Rev Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/clinids\/23.5.1177","article-title":"Association of plasma levels of tumor necrosis factor alpha with severity of disease and mortality among patients with leptospirosis","volume":"23","author":"H Tajiki","year":"1996","journal-title":"Clin Infect Dis"},{"key":"ref16","first-page":"138","article-title":"Antimicrobial Susceptibility of Klebsiella pneumoniae Producing Extended-Spectrum beta-lactamase (ESBL) Isolated in Hospitals in Brazil","volume":"1","author":"MH Tajiki","year":"1997","journal-title":"Braz J Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cyto.2011.01.014","article-title":"Serum TNF-alpha, sTNFR1, IL-6, IL-8 and IL-10 levels in Weil's syndrome","volume":"54","author":"I Kyriakidis","year":"2011","journal-title":"Cytokine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0140-6736(99)80012-9","article-title":"Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group","volume":"354","author":"AI Ko","year":"1999","journal-title":"Lancet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1128\/CVI.00217-07","article-title":"Evaluation of four whole-cell Leptospira-based serological tests for diagnosis of urban leptospirosis","volume":"14","author":"AJ McBride","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"673","DOI":"10.4269\/ajtmh.2008.79.673","article-title":"Serum levels of cytokines in two ethnic groups with dengue virus infection","volume":"79","author":"BN Restrepo","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/gerona\/glp198","article-title":"Plasma cytokine levels in a population-based study: relation to age and ethnicity","volume":"65","author":"RP Stowe","year":"2010","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref22","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica (2010) S\u00edntese de indicadores sociais - Uma an\u00e1lise das condi\u00e7\u00f5es de vida da popula\u00e7\u00e3o Brasileira 2010. In: Tabela 8.1 - Popula\u00e7\u00e3o total e respectiva distribui\u00e7\u00e3o percentual, por cor ou ra\u00e7a, segundo as Grandes Regi\u00f5es, Unidades da Federa\u00e7\u00e3o e Regi\u00f5es Metropolitanas - 2009. Rio de Janeiro: Instituto Brasileiro de Geografia e Estat\u00edstica. pp 232."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1186\/cc5783","article-title":"Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis","volume":"11","author":"FA Bozza","year":"2007","journal-title":"Crit Care"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/path.2274","article-title":"The immunology of sepsis","volume":"214","author":"S Sriskandan","year":"2008","journal-title":"J Pathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cimid.2009.05.001","article-title":"Expression of TNF-alpha, TGF-beta, IP-10 and IL-10 mRNA in kidneys of hamsters infected with pathogenic Leptospira","volume":"33","author":"A Lowanitchapat","year":"2010","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2174\/1381612003400533","article-title":"Anti-inflammatory cytokines and cytokine antagonists","volume":"6","author":"TJ Standiford","year":"2000","journal-title":"Curr Pharm Des"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1084\/jem.179.5.1695","article-title":"Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation","volume":"179","author":"MA Cassatella","year":"1994","journal-title":"J Exp Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.iy.11.040193.001121","article-title":"Interleukin-10","volume":"11","author":"KW Moore","year":"1993","journal-title":"Annu Rev Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1165\/ajrcmb.13.3.7544594","article-title":"Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis","volume":"13","author":"TL Bonfield","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"9558","DOI":"10.1074\/jbc.270.16.9558","article-title":"Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms","volume":"270","author":"P Wang","year":"1995","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.CCM.0000149854.61192.DC","article-title":"Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury","volume":"33","author":"PE Parsons","year":"2005","journal-title":"Crit Care Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"F864","DOI":"10.1152\/ajprenal.00025.2012","article-title":"Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice","volume":"303","author":"N Ahuja","year":"2012","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:04:55Z","timestamp":1589007895000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002457"}},"subtitle":[],"editor":[{"given":"Jenifer","family":"Coburn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,19]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002457","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,19]]}}}