{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:10:31Z","timestamp":1790205031666,"version":"4.1.0"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002500","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T21:17:11Z","timestamp":1382044631000},"page":"e2500","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Glyburide Reduces Bacterial Dissemination in a Mouse Model of Melioidosis"],"prefix":"10.1371","volume":"7","author":[{"given":"Gavin C. K. W.","family":"Koh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tassili A.","family":"Weehuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Breitbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna K.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth M.","family":"Kager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan J.","family":"Hoogendijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Bast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon J.","family":"Peacock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"van der Poll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Steinmetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Joost","family":"Wiersinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1056\/NEJMra1204699","article-title":"Melioidosis","volume":"367","author":"WJ Wiersinga","year":"2012","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/cid\/ciq192","article-title":"Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis","volume":"52","author":"GCKW Koh","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref3","first-page":"61085","article-title":"Possession, use, and transfer of select agents and toxins: biennial review","volume":"77","year":"2012","journal-title":"Federal Register"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1099\/0022-1317-50-8-657","article-title":"Melioidosis: a clinical model for Gram-negative sepsis","volume":"50","author":"AJ Simpson","year":"2001","journal-title":"J Med Microbiol"},{"key":"ref5","first-page":"379","article-title":"The impact of diabetes on the pathogenesis of sepsis","volume":"31","author":"GCKW Koh","year":"2011","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref6","first-page":"63","article-title":"Reduced interleukin-17 expression of <italic>Burkholderia pseudomallei<\/italic>-infected peripheral blood mononuclear cells of diabetic patients","volume":"26","author":"S Pongcharoen","year":"2008","journal-title":"Asian Pac J Allergy Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1172\/JCI57817","article-title":"Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria","volume":"122","author":"KS Tan","year":"2012","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1365-2567.2011.03544.x","article-title":"Delayed activation of host innate immune pathways in streptozotocin-induced diabetic hosts leads to more severe disease during infection with <italic>Burkholderia pseudomallei<\/italic>","volume":"135","author":"CY Chin","year":"2012","journal-title":"Immunology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.micinf.2011.07.008","article-title":"Altered macrophage function is associated with severe <italic>Burkholderia pseudomallei<\/italic> infection in a murine model of type 2 diabetes","volume":"13","author":"KA Hodgson","year":"2011","journal-title":"Microbes Infect"},{"key":"ref10","unstructured":"WHO Model List of Essential Medicines: 17th list (2011). Geneva, Switzerland: World Health Organization. 41 p."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1182\/blood.V90.8.2911","article-title":"Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1","volume":"90","author":"Y Hamon","year":"1997","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.200903124","article-title":"Glyburide inhibits the Cryopyrin\/Nalp3 inflammasome","volume":"187","author":"M Lamkanfi","year":"2009","journal-title":"J Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00125-005-1680-z","article-title":"A genetic and physiological study of impaired glucose homeostasis control in C57BL\/6J mice","volume":"48","author":"AA Toye","year":"2005","journal-title":"Diabetologia"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.2337\/db06-0358","article-title":"Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL\/6J mice","volume":"55","author":"HC Freeman","year":"2006","journal-title":"Diabetes"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1093\/hmg\/ddl034","article-title":"Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase","volume":"15","author":"T-T Huang","year":"2006","journal-title":"Human Molecular Genetics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/mpat.1997.0179","article-title":"BALB\/c and C57Bl\/6 mice infected with virulent <italic>Burkholderia pseudomallei<\/italic> provide contrasting animal models for the acute and chronic forms of human melioidosis","volume":"24","author":"AK Leakey","year":"1998","journal-title":"Microb Pathog"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1128\/IAI.67.6.2891-2900.1999","article-title":"Characterization of a murine model of melioidosis: comparison of different strains of mice","volume":"67","author":"I Hoppe","year":"1999","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1099\/0022-1317-51-7-539","article-title":"Characterisation of an acapsular mutant of <italic>Burkholderia pseudomallei<\/italic> identified by signature tagged mutagenesis","volume":"51","author":"T Atkins","year":"2002","journal-title":"J Med Microbiol"},{"key":"ref19","first-page":"81","article-title":"Inflammation patterns induced by different Burkholderia species in mice","volume":"10","author":"WJ Wiersinga","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1574-695X.1998.tb01175.x","article-title":"Macrophage-lymphocyte interactions mediate anti-<italic>Burkholderia pseudomallei<\/italic> activity","volume":"21","author":"GC Ulett","year":"1998","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2172-7-19","article-title":"The innate interferon gamma response of BALB\/c and C57BL\/6 mice to in vitro <italic>Burkholderia pseudomallei<\/italic> infection","volume":"7","author":"GC Koo","year":"2006","journal-title":"BMC Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1128\/IAI.00966-06","article-title":"Role of inducible nitric oxide synthase and NADPH oxidase in early control of <italic>Burkholderia pseudomallei<\/italic> infection in mice","volume":"74","author":"K Breitbach","year":"2006","journal-title":"Infect Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jim.2008.11.011","article-title":"Generation of murine bone marow derived macrophages in a standardised serum-free cell culture system","volume":"342","author":"K Eske","year":"2009","journal-title":"J Immunol Methods"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/01.shk.0000142249.08135.e9","article-title":"Innate immune response in Th1- and Th2-dominant mouse strains","volume":"22","author":"H Watanabe","year":"2004","journal-title":"Shock"},{"key":"ref25","unstructured":"Mathews CE, Leiter EH (2005) Chapter 18: Rodent models for the study of diabetes. In: Kahn CR, Weir GC, King GL, Moses AC, Smith RJ, <etal>et al<\/etal>.., editors. Joslin&apos;s Diabetes Mellitus. Philadelphia, Pennsylvania: Lippincott Williams &amp; Wilkins."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/nm1667","article-title":"Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis","volume":"13","author":"B Isermann","year":"2007","journal-title":"Nat Med"},{"key":"ref27","first-page":"91","article-title":"Studies on the diabetogenic action of streptozotocin (NSC-37917)","volume":"29","author":"N Rakieten","year":"1963","journal-title":"Cancer Chemother Rep"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/laban1005-39","article-title":"A rapid, simple, and humane method for submandibular bleeding of mice using a lancet","volume":"34","author":"WT Golde","year":"2005","journal-title":"Lab Anim (NY)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1128\/jb.179.7.2116-2125.1997","article-title":"Mutagenesis of Burkholderia pseudomallei with Tn5-OT182: isolation of motility mutants and molecular characterization of the flagellin structural gene","volume":"179","author":"D DeShazer","year":"1997","journal-title":"J Bacteriol"},{"key":"ref30","first-page":"1388","article-title":"CD14 impairs host defense against Gram-negative sepsis caused by <italic>Burkholderia pseudomallei<\/italic> in mice","volume":"198","author":"WJ Wiersinga","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.1371\/journal.pmed.0040248","article-title":"Toll-like receptor 2 impairs host defense in Gram-negative sepsis caused by <italic>Burkholderia pseudomallei<\/italic> (melioidosis)","volume":"4","author":"WJ Wiersinga","year":"2007","journal-title":"PLoS Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/jac\/dkg011","article-title":"A comparison of antibiotic regimens in the treatment of acute melioidosis in a mouse model","volume":"51","author":"GC Ulett","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"ref33","unstructured":"Clinical and Laboratory Standards Institute (2009) Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard (M07-A8). 8th ed. Wayne, Pennsylvania: Clinical and Laboratory Standards Institute."},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Coppack SW, Lant AF, McIntosh CS, Rodgers AV (1990) Pharmacokinetic and pharmacodynamic studies of glibenclamide in non-insulin dependent diabetes mellitus. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ukpmc.ac.uk\/articlerender.cgi?artid=1230045\" xlink:type=\"simple\">http:\/\/ukpmc.ac.uk\/articlerender.cgi?artid=1230045<\/ext-link>. Accessed 17 May 2009.","DOI":"10.1111\/j.1365-2125.1990.tb03688.x"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1086\/509810","article-title":"A critical role for neutrophils in resistance to experimental infection with <italic>Burkholderia pseudomallei<\/italic>","volume":"195","author":"A Easton","year":"2007","journal-title":"J Infect Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"LB Ware","year":"2000","journal-title":"N Engl J Med"},{"key":"ref37","first-page":"L2","article-title":"Interleukin-1-induced lung neutrophil accumulation and oxygen metabolite-mediated lung leak in rats","volume":"266","author":"JA Leff","year":"1994","journal-title":"Am J Physiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1152\/jappl.1995.79.2.472","article-title":"Cytokine-induced neutrophil chemoattractant is necessary for interleukin-1-induced lung leak in rats","volume":"79","author":"Y Koh","year":"1995","journal-title":"J Appl Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"L Franchi","year":"2009","journal-title":"Nat Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0091-6749(99)70518-X","article-title":"IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family","volume":"103","author":"CA Dinarello","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1128\/IAI.00930-12","article-title":"Impaired early cytokine responses at the site of infection in a murine model of type 2 diabetes and melioidosis comorbidity","volume":"81","author":"KA Hodgson","year":"2012","journal-title":"Infect Immun"},{"key":"ref42","first-page":"C188","article-title":"Role of potassium channels in the regulation of cytokine release from THP-1 cells","volume":"41","author":"AM Deakin","year":"1994","journal-title":"Inflammation Research"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"36944","DOI":"10.1074\/jbc.274.52.36944","article-title":"ATP treatment of human monocytes promotes caspase-1 maturation and externalization","volume":"274","author":"RE Laliberte","year":"1999","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1086\/315155","article-title":"Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis","volume":"180","author":"FN Lauw","year":"1999","journal-title":"J Infect Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1473-3099(07)70265-7","article-title":"Host-pathogen interactions in sepsis","volume":"8","author":"T Van der Poll","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrmicro1385","article-title":"Melioidosis: insights into the pathogenicity of <italic>Burkholderia pseudomallei<\/italic>","volume":"4","author":"WJ Wiersinga","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1128\/IAI.67.7.3593-3600.1999","article-title":"Obligatory role of gamma interferon for host survival in a murine model of infection with <italic>Burkholderia pseudomallei<\/italic>","volume":"67","author":"P Santanirand","year":"1999","journal-title":"Infect Immun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.4049\/jimmunol.166.2.1097","article-title":"Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens","volume":"166","author":"G Lertmemongkolchai","year":"2001","journal-title":"J Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1086\/498983","article-title":"Role of T cells in innate and adaptive immunity against murine <italic>Burkholderia pseudomallei<\/italic> infection","volume":"193","author":"A Haque","year":"2006","journal-title":"J Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1128\/IAI.01257-08","article-title":"Caspase-1 mediates resistance in murine melioidosis","volume":"77","author":"K Breitbach","year":"2009","journal-title":"Infect Immun"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1164\/ajrccm.153.6.8665045","article-title":"Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1","volume":"153","author":"J Pugin","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1128\/IAI.64.3.782-790.1996","article-title":"Intracellular survival of Burkholderia pseudomallei","volume":"64","author":"AL Jones","year":"1996","journal-title":"Infect Immun"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1099\/00222615-31-2-109","article-title":"Survival of <italic>Pseudomonas pseudomallei<\/italic> in human phagocytes","volume":"31","author":"S Pruksachartvuthi","year":"1990","journal-title":"J Med Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"12095","DOI":"10.1073\/pnas.1107183108","article-title":"Dissection of the Burkholderia intracellular life cycle using a photothermal nanoblade","volume":"108","author":"CT French","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1128\/IAI.64.12.4952-4959.1996","article-title":"Burkholderia pseudomallei activates complement and is ingested but not killed by polymorphonuclear leukocytes","volume":"64","author":"AM Egan","year":"1996","journal-title":"Infect Immun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1128\/IAI.00080-07","article-title":"Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis","volume":"75","author":"WJ Wiersinga","year":"2007","journal-title":"Infect Immun"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"e1002452","DOI":"10.1371\/journal.ppat.1002452","article-title":"Inflammasome-dependent pyroptosis and IL-18 protect against <italic>Burkholderia pseudomallei<\/italic> lung infection while IL-1\u03b2 is deleterious","volume":"7","author":"I Ceballos-Olvera","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/j.1523-1755.2005.00276.x","article-title":"The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia\/reperfusion injury in rats","volume":"67","author":"K Pompermayer","year":"2005","journal-title":"Kidney Int"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejphar.2006.10.065","article-title":"Effects of the treatment with glibenclamide, an ATP-sensitive potassium channel blocker, on intestinal ischemia and reperfusion injury","volume":"556","author":"K Pompermayer","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1590\/S0074-02761997000500007","article-title":"Sensitivity of Leishmania spp. to glibenclamide and 4-aminopyridine: a tool for the study of drug resistance development","volume":"92","author":"A Ponte-Sucre","year":"1997","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/cid\/ciq192","article-title":"Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis","volume":"52","author":"GCKW Koh","year":"2011","journal-title":"Clin Infect Dis"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T03:51:22Z","timestamp":1596685882000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002500"}},"subtitle":[],"editor":[{"given":"Gerd","family":"Pluschke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,17]]},"references-count":61,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002500","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,17]]}}}