{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:18:53Z","timestamp":1791839933641,"version":"4.3.4"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002595","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T21:35:01Z","timestamp":1386279301000},"page":"e2595","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":62,"title":["NLRP3 Inflammasome Activation by Paracoccidioides brasiliensis"],"prefix":"10.1371","volume":"7","author":[{"given":"Aldo Henrique","family":"Tavares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Grace","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Das Neves","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique","family":"Burgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam\u00e9lia Lorenzetti","family":"Bocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s12281-012-0114-x","article-title":"Paracoccidioidomycosis: Latin America&apos;s Own Fungal Disorder","volume":"6","author":"A Restrepo","year":"2012","journal-title":"Current Fungal Infection Reports"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.riam.2010.11.004","article-title":"Experimental medical mycological research in Latin America - a 2000\u20132009 overview","volume":"28","author":"G San-Blas","year":"2011","journal-title":"Rev Iberoam Micol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1590\/S0074-02762009000300019","article-title":"Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: a review from 1996 to 2006","volume":"104","author":"M Prado","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/CMR.6.2.89","article-title":"Paracoccidioidomycosis: an update","volume":"6","author":"E Brummer","year":"1993","journal-title":"Clin Microbiol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/02681219380000121","article-title":"Paracoccidioidomycosis and its etiologic agent <italic>Paracoccidioides brasiliensis<\/italic>","volume":"31","author":"G San-Blas","year":"1993","journal-title":"J Med Vet Mycol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/mmy.40.3.225.242","article-title":"<italic>Paracoccidioides brasiliensis<\/italic> and paracoccidioidomycosis: molecular approaches to morphogenesis, diagnosis, epidemiology, taxonomy and genetics","volume":"40","author":"G San-Blas","year":"2002","journal-title":"Med Mycol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11046-007-9048-1","article-title":"Innate immunity to <italic>Paracoccidioides brasiliensis<\/italic> infection","volume":"165","author":"VLG Calich","year":"2008","journal-title":"Mycopathologia"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.coi.2012.04.007","article-title":"Immunity to fungi","volume":"24","author":"S LeibundGut-Landmann","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-immunol-030409-101229","article-title":"Innate antifungal immunity: the key role of phagocytes","volume":"29","author":"GD Brown","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1189\/jlb.0803371","article-title":"PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages","volume":"75","author":"SN Diniz","year":"2004","journal-title":"J Leukoc Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.4049\/jimmunol.0801599","article-title":"TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection","volume":"183","author":"FV Loures","year":"2009","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1128\/IAI.01198-09","article-title":"Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells","volume":"78","author":"FV Loures","year":"2010","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3109\/13693780802641425","article-title":"TLR-2, TLR-4 and dectin-1 expression in human monocytes and neutrophils stimulated by <italic>Paracoccidioides brasiliensis<\/italic>","volume":"47","author":"CV Bonfim","year":"2009","journal-title":"Med Mycol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e1459","DOI":"10.1371\/journal.pntd.0001459","article-title":"Murine dendritic cells transcriptional modulation upon <italic>Paracoccidioides brasiliensis<\/italic> infection","volume":"6","author":"AH Tavares","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e2317","DOI":"10.1371\/journal.pntd.0002317","article-title":"TLR9 Activation Dampens the Early Inflammatory Response to <italic>Paracoccidioides brasiliensis<\/italic>, Impacting Host Survival","volume":"7","author":"JF Menino","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.mib.2008.06.002","article-title":"Host-microbe interactions: innate pattern recognition of fungal pathogens","volume":"11","author":"FL van de Veerdonk","year":"2008","journal-title":"Curr Opin Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(95)90490-5","article-title":"Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock","volume":"80","author":"P Li","year":"1995","journal-title":"Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"F Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/emmm.201201771","article-title":"Of inflammasomes and pathogens-sensing of microbes by the inflammasome","volume":"5","author":"F Bauernfeind","year":"2013","journal-title":"EMBO Mol Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.it.2011.01.003","article-title":"Inflammasome activation and IL-1beta and IL-18 processing during infection","volume":"32","author":"FL van de Veerdonk","year":"2011","journal-title":"Trends Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature07965","article-title":"Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence","volume":"459","author":"O Gross","year":"2009","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.chom.2009.05.002","article-title":"An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans","volume":"5","author":"AG Hise","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.4049\/jimmunol.0901323","article-title":"Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome","volume":"183","author":"S Joly","year":"2009","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s13238-013-2127-9","article-title":"Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome","volume":"4","author":"H Li","year":"2013","journal-title":"Protein Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/cr.2013.49","article-title":"Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome","volume":"23","author":"G Lei","year":"2013","journal-title":"Cell Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e10008","DOI":"10.1371\/journal.pone.0010008","article-title":"Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase","volume":"5","author":"N Said-Sadier","year":"2010","journal-title":"PloS one"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1286-4579(03)00040-6","article-title":"Production of pro- and anti-inflammatory cytokines by monocytes from patients with paracoccidioidomycosis","volume":"5","author":"M Pera\u00e7oli","year":"2003","journal-title":"Microbes and Infection"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1348-0421.2007.tb03929.x","article-title":"Pro- and anti-inflammatory cytokines produced by human monocytes challenged in vitro with <italic>Paracoccidioides brasiliensis<\/italic>","volume":"51","author":"CS Kurokawa","year":"2007","journal-title":"Microbiol Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1128\/IAI.00375-10","article-title":"MyD88 signaling is required for efficient innate and adaptive immune responses to Paracoccidioides brasiliensis infection","volume":"79","author":"FV Loures","year":"2011","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1128\/IAI.00736-12","article-title":"Myeloid dendritic cells (DCs) of mice susceptible to paracoccidioidomycosis suppress T cell responses whereas myeloid and plasmacytoid DCs from resistant mice induce effector and regulatory T cells","volume":"81","author":"A Pina","year":"2013","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"MB Lutz","year":"1999","journal-title":"Immunol Methods"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"S Mariathasan","year":"2006","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4049\/jimmunol.1202737","article-title":"TLR agonists stimulate Nlrp3-dependent IL-1beta production independently of the purinergic P2X7 receptor in dendritic cells and in vivo","volume":"190","author":"Y He","year":"2013","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ni.2222","article-title":"Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 inflammasome","volume":"13","author":"SI Gringhuis","year":"2012","journal-title":"Nat Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.200903124","article-title":"Glyburide inhibits the Cryopyrin\/Nalp3 inflammasome","volume":"187","author":"M Lamkanfi","year":"2009","journal-title":"J Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4049\/jimmunol.1100613","article-title":"Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome","volume":"187","author":"F Bauernfeind","year":"2011","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.4049\/jimmunol.140.8.2786","article-title":"In vivo and in vitro activation of pulmonary macrophages by IFN-gamma for enhanced killing of <italic>Paracoccidioides brasiliensis<\/italic> or <italic>Blastomyces dermatitidis<\/italic>","volume":"140","author":"E Brummer","year":"1988","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1128\/IAI.68.5.2546-2552.2000","article-title":"Nitric oxide participation in the fungicidal mechanism of gamma interferon-activated murine macrophages against <italic>Paracoccidioides brasiliensis<\/italic> conidia","volume":"68","author":"A Gonzalez","year":"2000","journal-title":"Infect Immun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.4049\/jimmunol.168.9.4593","article-title":"Dual role for nitric oxide in paracoccidioidomycosis: essential for resistance, but overproduction associated with susceptibility","volume":"168","author":"FR Nascimento","year":"2002","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.4049\/jimmunol.1201516","article-title":"NLRP3 inflammasome activity is negatively controlled by miR-223","volume":"189","author":"F Bauernfeind","year":"2012","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.4049\/jimmunol.1002720","article-title":"Differential expression of NLRP3 among hematopoietic cells","volume":"186","author":"G Guarda","year":"2011","journal-title":"J Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1182\/blood-2008-03-146720","article-title":"Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages","volume":"113","author":"MG Netea","year":"2009","journal-title":"Blood"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/emboj.2009.163","article-title":"Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates","volume":"28","author":"P Pelegrin","year":"2009","journal-title":"EMBO J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.4049\/jimmunol.0903019","article-title":"(1,3)-beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages","volume":"184","author":"P Kankkunen","year":"2010","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"FG Bauernfeind","year":"2009","journal-title":"J Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1084\/jem.20021787","article-title":"Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2","volume":"197","author":"BN Gantner","year":"2003","journal-title":"J Exp Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4049\/jimmunol.182.2.1146","article-title":"Differential use of CARD9 by dectin-1 in macrophages and dendritic cells","volume":"182","author":"HS Goodridge","year":"2009","journal-title":"J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2012.09.015","article-title":"Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome","volume":"38","author":"TB Kang","year":"2013","journal-title":"Immunity"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1017\/S1431927604040061","article-title":"A morphological and cytochemical study of the interaction <italic>between Paracoccidiodes brasiliensis<\/italic> and neutrophils","volume":"10","author":"MF Dias","year":"2004","journal-title":"Microsc Microanal"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/13693780701824411","article-title":"Human neutrophils susceptibility to Paracoccidioides brasiliensis: an ultrastructural and cytochemical assay","volume":"46","author":"MF Dias","year":"2008","journal-title":"Med Mycol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.micinf.2007.01.024","article-title":"Early transcriptional response of Paracoccidioides brasiliensis upon internalization by murine macrophages","volume":"9","author":"AH Tavares","year":"2007","journal-title":"Microbes Infect"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"V Hornung","year":"2008","journal-title":"Nat Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1073\/pnas.0804897106","article-title":"Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome","volume":"106","author":"FA Sharp","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-beta","volume":"9","author":"A Halle","year":"2008","journal-title":"Nat Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.4049\/jimmunol.0903937","article-title":"Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3\/ASC inflammasome","volume":"184","author":"X He","year":"2010","journal-title":"J Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1073\/pnas.0803933105","article-title":"The Nalp3 inflammasome is essential for the development of silicosis","volume":"105","author":"SL Cassel","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"L Romani","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.chom.2008.03.003","article-title":"Mycobacterium tuberculosis prevents inflammasome activation","volume":"3","author":"SS Master","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.chom.2008.03.006","article-title":"Linking inflammasome activation and phagosome maturation","volume":"3","author":"V Lazarevic","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.4049\/jimmunol.179.2.1178","article-title":"IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to <italic>Mycobacterium tuberculosis<\/italic> infection","volume":"179","author":"CM Fremond","year":"2007","journal-title":"J Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1128\/IAI.73.2.770-777.2005","article-title":"Enhanced killing of Candida albicans by human macrophages adherent to type 1 collagen matrices via induction of phagolysosomal fusion","volume":"73","author":"SL Newman","year":"2005","journal-title":"Infect Immun"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.4049\/jimmunol.162.10.6148","article-title":"Regulation of the macrophage vacuolar ATPase and phagosome-lysosome fusion by <italic>Histoplasma capsulatum<\/italic>","volume":"162","author":"JE Strasser","year":"1999","journal-title":"J Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.1128\/IAI.73.10.6803-6811.2005","article-title":"Human dendritic cell activity against <italic>Histoplasma capsulatum<\/italic> is mediated via phagolysosomal fusion","volume":"73","author":"LA Gildea","year":"2005","journal-title":"Infect Immun"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"e36292","DOI":"10.1371\/journal.pone.0036292","article-title":"Activation of an NLRP3 inflammasome restricts <italic>Mycobacterium kansasii<\/italic> infection","volume":"7","author":"CC Chen","year":"2012","journal-title":"PloS one"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.4049\/jimmunol.148.5.1486","article-title":"Type I IL-1 receptor blockade exacerbates murine listeriosis","volume":"148","author":"EA Havell","year":"1992","journal-title":"J Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.4049\/jimmunol.172.5.3059","article-title":"The contribution of the Toll-like\/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo","volume":"172","author":"S Bellocchio","year":"2004","journal-title":"J Immunol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T19:08:47Z","timestamp":1688843327000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002595"}},"subtitle":[],"editor":[{"given":"Joseph M.","family":"Vinetz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,5]]},"references-count":66,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002595","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,5]]}}}