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(2012) Outbreak of Multi-Drug Restistant Salmonella Typhu, Lusaka, Zambia, 2011\u20132012. American Society of Tropical Medicine and Hygiene 61st Annual Meeting. Atlanta, GA."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e29119","DOI":"10.1371\/journal.pone.0029119","article-title":"Population-based incidence of typhoid fever in an urban informal settlement and a rural area in Kenya: implications for typhoid vaccine use in Africa","volume":"7","author":"RF Breiman","year":"2012","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1128\/JCM.42.5.1885-1889.2004","article-title":"Evaluation of rapid diagnostic tests for typhoid fever","volume":"42","author":"SJ Olsen","year":"2004","journal-title":"J Clin Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.diagmicrobio.2008.03.018","article-title":"Clinical value of Tubex and Typhidot rapid diagnostic tests for typhoid fever in an urban community clinic in Bangladesh","volume":"61","author":"A Naheed","year":"2008","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"640","DOI":"10.2471\/BLT.11.087627","article-title":"Sensitivity and specificity of typhoid fever rapid antibody tests for laboratory diagnosis at two sub-Saharan African sites","volume":"89","author":"KH Keddy","year":"2011","journal-title":"Bull World Health Organ"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/infdis\/149.4.652","article-title":"Plasmids mediating resistance to chloramphenicol, trimethoprim, and ampicillin in Salmonella typhi strains isolated in the Southeast Asian region","volume":"149","author":"J Ling","year":"1984","journal-title":"J Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.trstmh.2012.03.006","article-title":"The diagnosis of typhoid fever in the Democratic Republic of the Congo","volume":"106","author":"O Lunguya","year":"2012","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"Suppl 1","key":"ref15","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1093\/infdis\/jit203","article-title":"Cholera Surveillance in Uganda: An Analysis of Notifications for the Years 2007\u20132011","volume":"208","author":"G Bwire","year":"2013","journal-title":"Journal of Infectious Diseases"},{"key":"ref16","unstructured":"Bopp CA, Ries AA, Wells JG (1999) Laboratory methods for the diagnosis of epidemic dysentery and cholera: Centers for Disease Control and Prevention Atlanta, GA."},{"key":"ref17","unstructured":"Mikoleit M (2010) Isolation of Salmonella and Shigella from Faecal Specimens. WHO Global Foodborne Infections Network."},{"key":"ref18","unstructured":"Mikoleit M (2010) Biochemical Identification of Salmonella and Shigella Using an Abbreviated Panel of Tests. WHO Global Foodborne Infections Network."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/fpd.2006.3.59","article-title":"Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet","volume":"3","author":"EM Ribot","year":"2006","journal-title":"Foodborne Pathog Dis"},{"key":"ref20","unstructured":"Institute CaLS (2012) Performance Standards for Antimicrobial Susceptibility Testing; Twenty second Informational Supplement."},{"key":"ref21","unstructured":"CDC (2012) National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS): Human Isolates Final Report, 2010."},{"key":"ref22","first-page":"58","article-title":"Typhoid ileal perforation: analysis of morbidity and mortality in 89 children","volume":"11","author":"SO Ekenze","year":"2008","journal-title":"Niger J Clin Pract"},{"key":"ref23","first-page":"1","article-title":"Typhoid intestinal perforation in north central Nigeria","volume":"24","author":"BT Ugwu","year":"2005","journal-title":"West Afr J Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1086\/421555","article-title":"A Clinical, Microbiological, and Pathological Study of Intestinal Perforation Associated with Typhoid Fever","volume":"39","author":"NQ Chanh","year":"2004","journal-title":"Clinical Infectious Diseases"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1001\/archsurg.1983.01390110027007","article-title":"Typhoid perforation of the intestine","volume":"118","author":"JM Eustache","year":"1983","journal-title":"Arch Surg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1677\/joe.0.0300277","article-title":"Oestrogen: The Natural Stimulant of Body Defence","volume":"30","author":"T Nicol","year":"1964","journal-title":"J Endocrinol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tmaid.2008.12.006","article-title":"An outbreak of peritonitis caused by multidrug-resistant Salmonella Typhi in Kinshasa, Democratic Republic of Congo","volume":"7","author":"JJ Muyembe-Tamfum","year":"2009","journal-title":"Travel Med Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4269\/ajtmh.2008.78.382","article-title":"Difficulties in Bringing Point-of-Use Water Treatment to Scale in Rural Guatemala","volume":"78","author":"SP Luby","year":"2008","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3201\/eid1307.060767","article-title":"Point-of-use water treatment and use among mothers in Malawi","volume":"13","author":"LJ Stockman","year":"2007","journal-title":"Emerging infectious diseases"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(75)92194-7","article-title":"Relative efficacy of blood, urine, rectal swab, bone-marrow, and rose-spot cultures for recovery of Salmonella typhi in typhoid fever","volume":"1","author":"RH Gilman","year":"1975","journal-title":"Lancet"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T05:56:45Z","timestamp":1565243805000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002726"}},"subtitle":[],"editor":[{"given":"Edward T.","family":"Ryan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,6]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002726","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,6]]}}}