{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:54:00Z","timestamp":1783130040739,"version":"3.54.6"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002972","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T17:44:54Z","timestamp":1405014294000},"page":"e2972","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Predictive Tools for Severe Dengue Conforming to World Health Organization 2009 Criteria"],"prefix":"10.1371","volume":"8","author":[{"given":"Luis R.","family":"Carrasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Sin","family":"Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex R.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun L.","family":"Thein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Jong","family":"Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Lye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Gubler DJ, Meltzer M (1999) Impact of dengue\/dengue hemorrhagic fever on the developing world. In: Karl Margniorosch FAM, Aaron JS, editors. Advances in Virus Research: Academic Press. pp. 35\u201370.","DOI":"10.1016\/S0065-3527(08)60342-5"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0966-842X(01)02288-0","article-title":"Epidemic dengue\/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century","volume":"10","author":"DJ Gubler","year":"2002","journal-title":"Trends in Microbiology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"846","DOI":"10.4269\/ajtmh.2009.80.846","article-title":"Cost of dengue cases in eight countries in the Americas and Asia: a prospective study","volume":"80","author":"JA Suaya","year":"2009","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(07)61687-0","article-title":"Dengue","volume":"370","author":"SB Halstead","year":"2007","journal-title":"The Lancet"},{"key":"ref5","unstructured":"WHO (2002) Weekly epidemiological record. World Health Organization. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/docstore\/wer\/pdf\/2002\/wer7736.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/docstore\/wer\/pdf\/2002\/wer7736.pdf<\/ext-link>. Accessed 2011 Nov 4."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3201\/eid1206.051210","article-title":"Denque prevention and 35 years of vector control in Singapore","volume":"12","author":"EE Ooi","year":"2006","journal-title":"Emerging Infectious Diseases"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0140-6736(95)91771-3","article-title":"Changing epidemiology of dengue in Singapore","volume":"346","author":"K Goh","year":"1995","journal-title":"The Lancet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1426","DOI":"10.1371\/journal.pntd.0001426","article-title":"Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore","volume":"5","author":"LR Carrasco","year":"2011","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jcv.2007.12.017","article-title":"Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults","volume":"42","author":"VJ Lee","year":"2008","journal-title":"Journal of Clinical Virology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4269\/ajtmh.2011.11-0149","article-title":"Validation of probability equation and decision tree in predicting subsequent dengue hemorrhagic fever in adult dengue inpatients in Singapore","volume":"85","author":"TL Thein","year":"2011","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2334-7-22","article-title":"Dengue disease severity in Indonesian children: an evaluation of the World Health Organization classification system","volume":"7","author":"TE Setiati","year":"2007","journal-title":"BMC Infectious Diseases"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1473-3099(06)70465-0","article-title":"Severe dengue: the need for new case definitions","volume":"6","author":"JG Rigau-Perez","year":"2006","journal-title":"Lancet Infectious Diseases"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4269\/ajtmh.2004.70.172","article-title":"Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: Is the world health organization classification system helpful?","volume":"70","author":"CXT Phuong","year":"2004","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"ref14","unstructured":"WHO (2009) Dengue guidelines for diagnosis, treatment, prevention and control. World Health Organization (WHO) and the Special Programme for Research and Training in Tropical Diseases (TDR). Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/whqlibdoc.who.int\/publications\/2009\/9789241547871_eng.pdf\" xlink:type=\"simple\">http:\/\/whqlibdoc.who.int\/publications\/2009\/9789241547871_eng.pdf<\/ext-link>."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1471-2334-11-106","article-title":"Usefulness and applicability of the revised dengue case classification by disease: multi-centre study in 18 countries","volume":"11","author":"J Barniol","year":"2011","journal-title":"BMC Infectious Diseases"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1397","DOI":"10.1371\/journal.pntd.0001397","article-title":"Evaluation of the traditional and revised WHO classifications of dengue disease severity","volume":"5","author":"F Narvaez","year":"2011","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4269\/ajtmh.2012.11-0491","article-title":"Evaluation of the 2009 WHO dengue case classification in an Indonesian pediatric cohort","volume":"86","author":"CAM van de Weg","year":"2012","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1086\/514047","article-title":"Early clinical and laboratory indicators of acute dengue illness","volume":"176","author":"S Kalayanarooj","year":"1997","journal-title":"Journal of Infectious Diseases"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4269\/ajtmh.2005.73.435","article-title":"Comparison of clinical features and hematologic abnormalities between dengue fever and dengue hemorrhagic fever among children in the Philippines","volume":"73","author":"CC Carlos","year":"2005","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1371\/journal.pntd.0000196","article-title":"Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness","volume":"2","author":"L Tanner","year":"2008","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"922","DOI":"10.4269\/ajtmh.2010.09-0552","article-title":"Clinical and laboratory features that differentiate dengue from other febrile illnesses in an endemic area\u2014Puerto Rico, 2007\u20132008","volume":"82","author":"CJ Gregory","year":"2010","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"ref22","first-page":"33","article-title":"Simple prognostic criteria can definitively identify patients who develop severe versus non-severe dengue disease, or have other febrile illnesses","volume":"4","author":"AKI Falconar","year":"2012","journal-title":"Journal of Clinical Medicine Research"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/j.1365-3156.2009.02337.x","article-title":"Decision tree algorithm in deciding hospitalization for adult patients with dengue haemorrhagic fever in Singapore","volume":"14","author":"VJ Lee","year":"2009","journal-title":"Tropical Medicine & International Health"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e769","DOI":"10.1371\/journal.pntd.0000769","article-title":"Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators","volume":"4","author":"JA Potts","year":"2010","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jcv.2010.03.008","article-title":"Predictors of severe manifestations in a cohort of adult dengue patients","volume":"48","author":"L Thomas","year":"2010","journal-title":"Journal of Clinical Virology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jcv.2009.04.004","article-title":"Early clinical and biological features of severe clinical manifestations of dengue in Vietnamese adults","volume":"45","author":"PT Binh","year":"2009","journal-title":"Journal of clinical virology"},{"key":"ref27","unstructured":"Chee YC (2005) Report of the expert panel on dengue. Singapore Ministry of Health. Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.moh.gov.sg\/content\/dam\/moh_web\/Diseases%20and%20Conditions\/Common\/Final_Report-dengue_7_Oct_05.pdf\" xlink:type=\"simple\">http:\/\/www.moh.gov.sg\/content\/dam\/moh_web\/Diseases%20and%20Conditions\/Common\/Final_Report-dengue_7_Oct_05.pdf<\/ext-link>."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.trstmh.2005.05.015","article-title":"The performance of RT-PCR compared with a rapid serological assay for acute dengue fever in a diagnostic laboratory","volume":"100","author":"TM Barkham","year":"2006","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"ref29","unstructured":"Weisberg S, Fox J (2010) An R companion to applied regression. Sage Publications, Incorporated."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2307\/2344614","article-title":"Generalized linear models","volume":"135","author":"JA Nelder","year":"1972","journal-title":"Journal of the Royal Statistical Society Series A"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Venables WN, Ripley BD (2002) Modern Applied Statistics with S. New York: Springer.","DOI":"10.1007\/978-0-387-21706-2"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","article-title":"A new look at the statistical model identification","volume":"19","author":"H Akaike","year":"1974","journal-title":"IEEE Transactions on Automatic Control"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Steyerberg EW (2009) Clinical prediction models: a practical approach to development, validation, and updating. Springer.","DOI":"10.1007\/978-0-387-77244-8"},{"key":"ref34","unstructured":"R Development Core Team (2005) R: A language and environment for statistical computing.; Computing RFfS, editor. Vienna, Austria: R Foundation for Statistical Computing."},{"key":"ref35","unstructured":"Ministry of Health of Singapore (2010) Healthcare financing. Hospital bill size. Singapore Ministry of Health. Dengue age &lt;60. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.moh.gov.sg\/content\/moh_web\/home\/costs_and_financing\/HospitalBillSize\/dengue_age_60_.html\" xlink:type=\"simple\">http:\/\/www.moh.gov.sg\/content\/moh_web\/home\/costs_and_financing\/HospitalBillSize\/dengue_age_60_.html<\/ext-link>. Accessed: 2011 Nov 4."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e2023","DOI":"10.1371\/journal.pntd.0002023","article-title":"Utilities and Limitations of the World Health Organization 2009 Warning Signs for Adult Dengue Severity","volume":"7","author":"T-L Thein","year":"2013","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1186\/1471-2334-13-498","article-title":"Utility of warning signs in guiding admission and predicting severe disease in adult dengue","volume":"13","author":"Y-S Leo","year":"2013","journal-title":"BMC Infectious Diseases"},{"key":"ref38","first-page":"129","article-title":"Dengue virus infection: predictors for severe dengue","volume":"43","author":"JA Pawitan","year":"2011","journal-title":"Acta Medica Indonesiana \u2013 The Indonesian Journal of Internal Medicine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1371\/journal.ppat.0030183","article-title":"Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E","volume":"3","author":"P Avirutnan","year":"2007","journal-title":"PLoS Pathogens"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T06:36:38Z","timestamp":1589006198000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002972"}},"subtitle":[],"editor":[{"given":"Maria G.","family":"Guzman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,10]]},"references-count":39,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002972","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,10]]}}}