{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:09:12Z","timestamp":1791151752638,"version":"4.1.0"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002973","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T19:46:35Z","timestamp":1406835995000},"page":"e2973","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["Auranofin Is Highly Efficacious against Toxoplasma gondii In Vitro and in an In Vivo Experimental Model of Acute Toxoplasmosis"],"prefix":"10.1371","volume":"8","author":[{"given":"Rosa M.","family":"Andrade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan D.","family":"Chaparro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Capparelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3201\/eid1701.P11101","article-title":"Foodborne illness acquired in the United States\u2013major pathogens","volume":"17","author":"E Scallan","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"ref2","unstructured":"CDC (2013) Parasites - Toxoplasmosis (<italic>Toxoplasma<\/italic> infection). Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/parasites\/toxoplasmosis\/\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/parasites\/toxoplasmosis\/<\/ext-link>. Accessed 3 July 2014."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2165\/00002018-200730060-00003","article-title":"Safety and toxicity of sulfadoxine\/pyrimethamine: implications for malaria prevention in pregnancy using intermittent preventive treatment","volume":"30","author":"PJ Peters","year":"2007","journal-title":"Drug Saf"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1136\/bjo.82.11.1306","article-title":"Azithromycin for ocular toxoplasmosis","volume":"82","author":"A Rothova","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.febslet.2008.02.028","article-title":"New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications","volume":"582","author":"AR Sannella","year":"2008","journal-title":"FEBS Lett"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00726-011-0997-9","article-title":"A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition","volume":"42","author":"A Ilari","year":"2012","journal-title":"Amino Acids"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"28977","DOI":"10.1074\/jbc.M109.020701","article-title":"Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects","volume":"284","author":"F Angelucci","year":"2009","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/nm.2758","article-title":"A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target","volume":"18","author":"A Debnath","year":"2012","journal-title":"Nat Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1471-4922(02)02293-6","article-title":"The diversity and evolution of thioredoxin reductase: new perspectives","volume":"18","author":"RP Hirt","year":"2002","journal-title":"Trends Parasitol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/AAC.47.1.309-316.2003","article-title":"High-throughput growth assay for Toxoplasma gondii using yellow fluorescent protein","volume":"47","author":"MJ Gubbels","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1128\/IAI.72.5.2915-2921.2004","article-title":"Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis","volume":"72","author":"X Que","year":"2004","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1128\/AAC.01203-07","article-title":"In vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquone","volume":"52","author":"P Meneceur","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"D553","DOI":"10.1093\/nar\/gkm981","article-title":"ToxoDB: an integrated Toxoplasma gondii database resource","volume":"36","author":"B Gajria","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1600-0773.1985.tb01310.x","article-title":"Auranofin treatment of rats: adaptation to intestinal adverse effects and observations on the cytosolic distribution of gold in the intestines, liver and kidneys","volume":"56","author":"A Glennas","year":"1985","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Gottlieb NL (1986) Pharmacology of auranofin: overview and update. Scand J Rheumatol Suppl 63: 19\u201328.","DOI":"10.1080\/15027732.1986.12461436"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0002-9343(83)90481-3","article-title":"Biologic actions and pharmacokinetic studies of auranofin","volume":"75","author":"DT Walz","year":"1983","journal-title":"Am J Med"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T01:19:10Z","timestamp":1746321550000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002973"}},"subtitle":[],"editor":[{"given":"Michael","family":"P","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,31]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002973","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,31]]}}}