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Geneva: World Health Organization."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1179\/2047773213Y.0000000092","article-title":"Efficacy of different albendazole and mebendazole regimens against high-intensity <italic>Trichuris trichiura<\/italic> infections in school children, Jimma, Ethiopia","volume":"107","author":"Z Mekonnen","year":"2013","journal-title":"Pathog Glob Health"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Coducting meta-analyses in R with the metafor package","volume":"36","author":"W Viechtbauer","year":"2010","journal-title":"J Stat Soft"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0169-4758(99)01544-6","article-title":"Reducing intestinal nematode infection: efficacy of albendazole and mebendazole","volume":"16","author":"A Bennett","year":"2000","journal-title":"Parasitol Today"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0035-9203(02)90352-4","article-title":"Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections","volume":"96","author":"M Albonico","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1086\/657310","article-title":"Albendazole and mebendazole administered alone or in combination with ivermectin against <italic>Trichuris trichiura<\/italic>: a randomized controlled trial","volume":"51","author":"S Knopp","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMoa1301956","article-title":"Oxantel pamoate-albendazole for <italic>Trichuris trichiura<\/italic> infection","volume":"370","author":"B Speich","year":"2014","journal-title":"N Engl J Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/1756-3305-7-255","article-title":"Cysteine proteinases from papaya (<italic>Carica papaya<\/italic>) in the treatment of experimental <italic>Trichuris suis<\/italic> infection in pigs: two randomized controlled trials","volume":"7","author":"B Levecke","year":"2014","journal-title":"Parasit Vectors"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpara.2009.11.001","article-title":"Unresolved issues in anthelmintic pharmacology for helminthiases of humans","volume":"40","author":"TG Geary","year":"2010","journal-title":"Int J Parasitol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.trstmh.2006.04.011","article-title":"Control of <italic>Schistosoma mekongi<\/italic> in Cambodia: results of eight years of control activities in the two endemic provinces","volume":"101","author":"M Sinuon","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/jech.2007.066423","article-title":"Using national health weeks to deliver deworming to children: lessons from Mexico","volume":"62","author":"A Flisser","year":"2008","journal-title":"J Epidemiol Community Health"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e1621","DOI":"10.1371\/journal.pntd.0001621","article-title":"Soil-transmitted helminth reinfection after drug treatment: a systematic review and meta-analysis","volume":"6","author":"T-W Jia","year":"2012","journal-title":"PLoS Negl Trop Dis"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T21:59:24Z","timestamp":1565906364000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003204"}},"subtitle":[],"editor":[{"given":"Piero L.","family":"Olliaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,9]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003204","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,9]]}}}