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Impact of weather on sand fly activity","volume":"48","author":"MG Colacicco-Mayhugh","year":"2011","journal-title":"J Med Entomol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1089\/vbz.2010.0068","article-title":"Leishmaniasis in an era of conflict in the Middle East","volume":"11","author":"RL Jacobson","year":"2011","journal-title":"Vector Borne Zoonotic Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/0974-777X.62881","article-title":"Leishmaniasis Vaccine: Where are We Today?","volume":"2","author":"L Kedzierski","year":"2010","journal-title":"J Glob Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4269\/ajtmh.2010.09-0235","article-title":"Estimation of under-reporting of visceral leishmaniasis cases in Bihar, India","volume":"82","author":"VP Singh","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3855\/jidc.59","article-title":"Cutaneous leishmaniasis in Iraq","volume":"3","author":"AM AlSamarai","year":"2009","journal-title":"J Infect Dev Ctries"},{"key":"ref25","first-page":"464","article-title":"Sero-epidemiological study of visceral leishmaniasis in Basrah, Southern Iraq","volume":"60","author":"ZH Gani","year":"2010","journal-title":"J Pak Med Assoc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1948-7134.2013.12059.x","article-title":"Sand fly surveillance and control on Camp Ramadi, Iraq, as part of a leishmaniasis control program","volume":"38","author":"CA Stoops","year":"2013","journal-title":"J Vector Ecol"},{"key":"ref27","first-page":"1","article-title":"The persisting burden of visceral leishmaniasis in Iraq: data of the National Surveillance System, 1990\u20132009","author":"B Majeed","year":"2012","journal-title":"Epidemiol Infect"},{"key":"ref28","unstructured":"World Health Organization (2014) WHO Leishmaniasis Resource: Iraq. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/leishmaniasis\/resources\/IRAQ.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/leishmaniasis\/resources\/IRAQ.pdf<\/ext-link>. Accessed 29 August 2014."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0035-9203(93)90111-3","article-title":"Evidence for a long-term increase in the incidence of <italic>Leishmania<\/italic> tropica in Aleppo, Syria","volume":"87","author":"RW Ashford","year":"1993","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0035-9203(97)90509-5","article-title":"Twenty years of cutaneous leishmaniasis in Aleppo, Syria","volume":"91","author":"A Tayeh","year":"1997","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref31","unstructured":"World Health Organization (2014) WHO Leishmaniasis Resource: Syrian Arab Republic. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/leishmaniasis\/resources\/SYRIAN_ARAB_REPUBLIC.pdf\" xlink:type=\"simple\">www.who.int\/leishmaniasis\/resources\/SYRIAN_ARAB_REPUBLIC.pdf<\/ext-link>. Accessed 29 August 2014."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijid.2003.10.006","article-title":"Cutaneous leishmaniasis: a 46-year study of the epidemiology and clinical features in Saudi Arabia [1956\u20132002]","volume":"8","author":"JA Al-Tawfiq","year":"2004","journal-title":"Int J Infect Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/j.1468-3083.2011.04339.x","article-title":"Public awareness and attitudes towards cutaneous leishmaniasis in an endemic region in Saudi Arabia","volume":"26","author":"TT Amin","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1016\/j.ijid.2012.11.015","article-title":"Molecular characterization of cutaneous leishmaniasis in Al-Madinah Al-Munawarah province, western Saudi Arabia","volume":"17","author":"HA El-Beshbishy","year":"2013","journal-title":"Int J Infect Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.exppara.2013.02.016","article-title":"Molecular characterization of <italic>Leishmania<\/italic> infection in sand flies from Al-madinah Al-munawarah province, western Saudi Arabia","volume":"134","author":"HA El-Beshbishy","year":"2013","journal-title":"Exp Parasitol"},{"key":"ref36","unstructured":"World Health Organization (2014) WHO Leishmaniasis Resource: Saudi Arabia. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/leishmaniasis\/resources\/SAUDI_ARABIA.pdf\" xlink:type=\"simple\">www.who.int\/leishmaniasis\/resources\/SAUDI_ARABIA.pdf<\/ext-link>. Accessed 29 August 2014."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0035-9203(93)90267-T","article-title":"Cutaneous leishmaniasis due to <italic>Leishmania tropica<\/italic> in Jordan","volume":"87","author":"E Saliba","year":"1993","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4269\/ajtmh.1998.58.160","article-title":"Short report: outbreak of cutaneous leishmaniasis in a nonimmune population of soldiers in Wadi Araba, Jordan","volume":"58","author":"N Jumaian","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4269\/ajtmh.1999.60.4.10348221","article-title":"Short report: outbreak of cutaneous leishmaniasis in a nonimmune population of soldiers in Wadi Araba, Jordan","volume":"60","author":"S Khoury","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1179\/136485909X451735","article-title":"Two recent but temporally distinct outbreaks of cutaneous leishmaniasis among foreign workers in the Dead-Sea area of Jordan","volume":"103","author":"IM Mosleh","year":"2009","journal-title":"Ann Trop Med Parasitol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1365-3156.2008.02063.x","article-title":"Cutaneous leishmaniasis in the Jordanian side of the Jordan Valley: severe under-reporting and consequences on public health management","volume":"13","author":"IM Mosleh","year":"2008","journal-title":"Trop Med Int Health"},{"key":"ref42","first-page":"677","article-title":"Identification of <italic>Leishmania<\/italic> strains from Jordan","volume":"98","author":"EK Saliba","year":"2004","journal-title":"Ann Trop Med Parasitol"},{"key":"ref43","unstructured":"World Health Organization (2014) WHO Leishmaniasis Resource: Jordan. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/leishmaniasis\/resources\/JORDAN.pdf\" xlink:type=\"simple\">www.who.int\/leishmaniasis\/resources\/JORDAN.pdf<\/ext-link>"},{"key":"ref44","first-page":"166","article-title":"A Review on Biology, Epidemiology and Public Health Significance of Leishmaniasis","volume":"4","author":"G Dawit","year":"2013","journal-title":"J Bacteriol Parasitol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/ije\/25.4.862","article-title":"The epidemic of visceral leishmaniasis in western Upper Nile, southern Sudan: course and impact from 1984 to 1994","volume":"25","author":"J Seaman","year":"1996","journal-title":"Int J Epidemiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0140-6736(13)60320-7","article-title":"Health services in Iraq","volume":"381","author":"TK Al Hilfi","year":"2013","journal-title":"Lancet"},{"key":"ref47","unstructured":"World Health Organization (2014) Syrian Arab Republic: Regional Situation Reports. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.emro.who.int\/syr\/information-resources\/regional-situation-reports.html\" xlink:type=\"simple\">http:\/\/www.emro.who.int\/syr\/information-resources\/regional-situation-reports.html<\/ext-link>. Accessed 29 August 2014."},{"key":"ref48","unstructured":"World Health Organization (2014) Global Health Observatory Data Repository: Leishmaniasis. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/gho\/data\/node.main.NTDLEISH?lang=en\" xlink:type=\"simple\">http:\/\/apps.who.int\/gho\/data\/node.main.NTDLEISH?lang=en<\/ext-link>. 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