{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:54:46Z","timestamp":1778028886233,"version":"3.51.4"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T00:00:00Z","timestamp":1414022400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0003275","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T21:09:52Z","timestamp":1414098592000},"page":"e3275","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Chemotherapeutic Potential of 17-AAG against Cutaneous Leishmaniasis Caused by Leishmania (Viannia) braziliensis"],"prefix":"10.1371","volume":"8","author":[{"given":"Diego M.","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio L. O. A.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana S.","family":"Celes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria M.","family":"Borges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia S. T.","family":"Veras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila I.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/j.1469-0691.2011.03635.x","article-title":"Leishmaniasis impact and treatment access","volume":"17","author":"M den Boer","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1590\/S1413-86702003000300009","article-title":"Post-kala-azar dermal leishmaniasis associated with AIDS","volume":"7","author":"A Bittencourt","year":"2003","journal-title":"Braz J Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"824","DOI":"10.4269\/ajtmh.1998.58.824","article-title":"Cutaneous scars in American tegumentary leishmaniasis patients: a site of Leishmania (Viannia) braziliensis persistence and viability eleven years after antimonial therapy and clinical cure","volume":"58","author":"A Schubach","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1086\/382135","article-title":"Persistence of leishmania parasites in scars after clinical cure of American cutaneous leishmaniasis: is there a sterile cure","volume":"189","author":"MG Mendonca","year":"2004","journal-title":"J Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0035-9203(86)90243-9","article-title":"Mucosal leishmaniasis (\u201cespundia\u201d Escomel, 1911)","volume":"80","author":"PD Marsden","year":"1986","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref6","first-page":"319","article-title":"Disseminated cutaneous leishmaniasis in a field clinic in Bahia, Brazil: a report of eight cases","volume":"89","author":"JM Costa","year":"1986","journal-title":"J Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"J Alvar","year":"2012","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.pt.2003.09.008","article-title":"Leishmaniasis\u2013current chemotherapy and recent advances in the search for novel drugs","volume":"19","author":"SL Croft","year":"2003","journal-title":"Trends Parasitol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/clind\/24.4.684","article-title":"Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years","volume":"24","author":"JD Berman","year":"1997","journal-title":"Clin Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1590\/S0037-86821988000400002","article-title":"American cutaneous leishmaniasis: presentation and problems of patient management","volume":"21","author":"JD Chulay","year":"1988","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4269\/ajtmh.2007.77.266","article-title":"Treatment of mucosal leishmaniasis in Latin America: systematic review","volume":"77","author":"VS Amato","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1475-9292-6-3","article-title":"Consultative meeting to develop a strategy for treatment of cutaneous leishmaniasis. Institute Pasteur, Paris. 13\u201315 June, 2006","volume":"6","author":"F Modabber","year":"2007","journal-title":"Kinetoplastid Biol Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1086\/524042","article-title":"Clinical and parasite species risk factors for pentavalent antimonial treatment failure in cutaneous leishmaniasis in Peru","volume":"46","author":"A Llanos-Cuentas","year":"2008","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"E69","DOI":"10.1086\/340526","article-title":"Failure of early treatment of cutaneous leishmaniasis in preventing the development of an ulcer","volume":"34","author":"P Machado","year":"2002","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.actatropica.2011.02.007","article-title":"Systematic review of the adverse effects of cutaneous leishmaniasis treatment in the New World","volume":"118","author":"LF Oliveira","year":"2011","journal-title":"Acta Tropica"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2174\/092986707780362862","article-title":"Chemotherapy of leishmaniasis: past, present and future","volume":"14","author":"J Mishra","year":"2007","journal-title":"Curr Med Chem"},{"key":"ref17","first-page":"17","article-title":"The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones","volume":"32","author":"RI Morimoto","year":"1997","journal-title":"Essays Biochem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1126\/science.1068408","article-title":"Molecular chaperones in the cytosol: from nascent chain to folded protein","volume":"295","author":"FU Hartl","year":"2002","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/annonc\/mdg316","article-title":"The Hsp90 chaperone complex as a novel target for cancer therapy","volume":"14","author":"MP Goetz","year":"2003","journal-title":"Annals of Oncology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1158\/1078-0432.CCR-11-1000","article-title":"Hsp90 molecular chaperone inhibitors: are we there yet","volume":"18","author":"L Neckers","year":"2012","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/138161213804143608","article-title":"Heat shock protein 90 inhibitors as broad spectrum anti-infectives","volume":"19","author":"AK Rochani","year":"2013","journal-title":"Current pharmaceutical design"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s004300100074","article-title":"The heat shock protein 90 of Leishmania donovani","volume":"190","author":"M Wiesgigl","year":"2001","journal-title":"Medical microbiology and immunology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00436-009-1582-y","article-title":"Apoptosis caused by Hsp90 inhibitor geldanamycin in Leishmania donovani during promastigote-to-amastigote transformation stage","volume":"105","author":"Q Li","year":"2009","journal-title":"Parasitology research"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e49496","DOI":"10.1371\/journal.pone.0049496","article-title":"17-AAG kills intracellular Leishmania amazonensis while reducing inflammatory responses in infected macrophages","volume":"7","author":"AL Petersen","year":"2012","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s002800050817","article-title":"The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin","volume":"42","author":"TW Schulte","year":"1998","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1128\/IAI.73.9.5827-5834.2005","article-title":"Toward a novel experimental model of infection to study American cutaneous leishmaniasis caused by Leishmania braziliensis","volume":"73","author":"TR de Moura","year":"2005","journal-title":"Infect Immun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/niox.2000.0319","article-title":"A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite","volume":"5","author":"KM Miranda","year":"2001","journal-title":"Nitric Oxide"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.4049\/jimmunol.0802860","article-title":"IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis","volume":"182","author":"R Khouri","year":"2009","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/0003-2697(76)90488-7","article-title":"Inhibition of nitrite formation from hydroxylammoniumchloride: a simple assay for superoxide dismutase","volume":"70","author":"EF Elstner","year":"1976","journal-title":"Anal Biochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.imbio.2007.12.005","article-title":"The innate immune response against Leishmania parasites","volume":"213","author":"J Liese","year":"2008","journal-title":"Immunobiology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbamcr.2011.12.003","article-title":"Heat shock protein 90 from neglected protozoan parasites","volume":"1823","author":"N Roy","year":"2012","journal-title":"Biochimica et biophysica acta"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1475-2875-11-54","article-title":"Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii","volume":"11","author":"R Mout","year":"2012","journal-title":"Malaria journal"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ijpara.2005.01.007","article-title":"Hsp90 is essential in the filarial nematode Brugia pahangi","volume":"35","author":"E Devaney","year":"2005","journal-title":"International journal for parasitology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"716498","DOI":"10.1155\/2010\/716498","article-title":"In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi","volume":"2010","author":"D Wenkert","year":"2010","journal-title":"Journal of parasitology research"},{"key":"ref35","first-page":"3","article-title":"Epidemiologia das Leishmanioses do Brasil","volume":"75","author":"JML Costa","year":"2005","journal-title":"Gazeta M\u00e9dica da Bahia"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1286-4579(03)00025-X","article-title":"Differential properties of CBA\/J mononuclear phagocytes recovered from an inflammatory site and probed with two different species of Leishmania","volume":"5","author":"IN Gomes","year":"2003","journal-title":"Microbes Infect"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.micinf.2005.07.007","article-title":"Infection-induced respiratory burst in BALB\/c macrophages kills Leishmania guyanensis amastigotes through apoptosis: possible involvement in resistance to cutaneous leishmaniasis","volume":"8","author":"J Sousa-Franco","year":"2006","journal-title":"Microbes Infect"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1645\/GE-2241.1","article-title":"Differences in the antigenic profile and infectivity of murine macrophages of Leishmania (Viannia) parasites","volume":"96","author":"NE Matta","year":"2010","journal-title":"J Parasitol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fimmu.2012.00301","article-title":"Protective and pathologic immune responses in human tegumentary leishmaniasis","volume":"3","author":"LP Carvalho","year":"2012","journal-title":"Frontiers in immunology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"E54","DOI":"10.1086\/340261","article-title":"Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection","volume":"34","author":"I Follador","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00011-012-0442-x","article-title":"HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-\u03baB pathways","volume":"61","author":"SK Shimp","year":"2012","journal-title":"Inflammation research"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"C227","DOI":"10.1152\/ajpcell.00493.2010","article-title":"Obligatory role of heat shock protein 90 in iNOS induction","volume":"301","author":"S Luo","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200702-291OC","article-title":"Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis","volume":"176","author":"A Chatterjee","year":"2007","journal-title":"American journal of respiratory and critical care medicine"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1111\/j.1471-4159.2006.04221.x","article-title":"The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis","volume":"99","author":"C Dello Russo","year":"2006","journal-title":"J Neurochem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/cvr\/cvq046","article-title":"Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis","volume":"86","author":"J Madrigal-Matute","year":"2010","journal-title":"Cardiovascular research"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1096\/fj.06-7637com","article-title":"Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis","volume":"21","author":"V Poulaki","year":"2007","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-3024.2012.01370.x","article-title":"Leishmania (V.) braziliensis and L. (L.) amazonensis promote differential expression of dendritic cells and cellular immune response in murine model","volume":"34","author":"AK Carvalho","year":"2012","journal-title":"Parasite Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"11384","DOI":"10.1074\/jbc.M512307200","article-title":"Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major","volume":"281","author":"S Besteiro","year":"2006","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.ijpara.2012.05.006","article-title":"The presence of Tregs does not preclude immunity to reinfection with Leishmania braziliensis","volume":"42","author":"S Falcao","year":"2012","journal-title":"Int J Parasitol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1084\/jem.194.10.1497","article-title":"The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure","volume":"194","author":"Y Belkaid","year":"2001","journal-title":"J Exp Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature01152","article-title":"CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity","volume":"420","author":"Y Belkaid","year":"2002","journal-title":"Nature"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e1973","DOI":"10.1371\/journal.pntd.0001973","article-title":"Treatment of visceral leishmaniasis: model-based analyses on the spread of antimony-resistant L. donovani in Bihar, India","volume":"6","author":"A Stauch","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-4632.2008.03417.x","article-title":"Treatment of New World cutaneous leishmaniasis\u2013a systematic review with a meta-analysis","volume":"47","author":"FF Tuon","year":"2008","journal-title":"Int J Dermatol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1473-3099(10)70011-6","article-title":"Combination therapy for visceral leishmaniasis","volume":"10","author":"J van Griensven","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"571242","DOI":"10.4061\/2011\/571242","article-title":"Use of antimony in the treatment of leishmaniasis: current status and future directions","volume":"2011","author":"AK Haldar","year":"2011","journal-title":"Molecular biology international"},{"key":"ref56","first-page":"32","article-title":"The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine","volume":"131C","author":"MR Varela","year":"2013","journal-title":"Acta Trop"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/jac\/dkt318","article-title":"In vitro interaction between paromomycin sulphate and four drugs with leishmanicidal activity against three New World Leishmania species","volume":"69","author":"E de Morais-Teixeira","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Trinconi CT, Reimao JQ, Yokoyama-Yasunaka JK, Miguel DC, Uliana SR (2014) Combination therapy with tamoxifen and amphotericin B in experimental cutaneous leishmaniasis. Antimicrob Agents Chemother.","DOI":"10.1128\/AAC.01315-13"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11046-012-9612-1","article-title":"Antifungal activity of geldanamycin alone or in combination with fluconazole against Candida species","volume":"175","author":"J Zhang","year":"2013","journal-title":"Mycopathologia"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s002800000242","article-title":"Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1","volume":"47","author":"MJ Egorin","year":"2001","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref61","first-page":"986","article-title":"17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2\/neu and inhibits the growth of prostate cancer xenografts","volume":"8","author":"DB Solit","year":"2002","journal-title":"Clin Cancer Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2174\/156652409788488757","article-title":"17 AAG for HSP90 inhibition in cancer\u2013from bench to bedside","volume":"9","author":"SZ Usmani","year":"2009","journal-title":"Curr Mol Med"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:09:44Z","timestamp":1589008184000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003275"}},"subtitle":[],"editor":[{"given":"Ben L.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,23]]},"references-count":62,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003275","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,23]]}}}