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Pathol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1743-422X-9-213","article-title":"Deciphering the differential response of two human fibroblast cell lines following Chikungunya virus infection","volume":"9","author":"VG Thon-Hon","year":"2012","journal-title":"Virology J"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.antiviral.2013.06.009","article-title":"Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy","volume":"99","author":"SD Thiberville","year":"2013","journal-title":"Antiviral Res"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.virusres.2011.12.009","article-title":"Characterization of Chikungunya virus infection in human neuroblastoma SH-SY5Y cells: role of apoptosis in neuronal cell death","volume":"163","author":"R Dhanwani","year":"2012","journal-title":"Virus Res"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/vim.2010.0123","article-title":"Role of proinflammatory cytokines and chemokines in chronic arthropathy in CHIKV infection","volume":"24","author":"IK Chaaitanya","year":"2011","journal-title":"Viral Immunol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"e65896","DOI":"10.1371\/journal.pone.0065896","article-title":"Hydrazinocurcumin Encapsuled nanoparticles \u201cre-educate\u201d tumor-associated macrophages and exhibit anti-tumor effects on breast cancer following STAT3 suppression","volume":"8","author":"X Zhang","year":"2013","journal-title":"PLoS One"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bbrc.2012.07.086","article-title":"Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation","volume":"425","author":"D Shiraishi","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.4049\/jimmunol.1201240","article-title":"Genetic ablation of arginase 1 in macrophages and neutrophils enhances clearance of an arthritogenic alphavirus","volume":"189","author":"KA Stoermer","year":"2012","journal-title":"J Immunol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"e1002422","DOI":"10.1371\/journal.ppat.1002422","article-title":"IRGM is a common target of RNA viruses that subvert the autophagy network","volume":"7","author":"IP Gregoire","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref93","first-page":"426","article-title":"IRGM in autophagy and viral infections","volume":"3","author":"DS Petkova","year":"2012","journal-title":"Front Immunol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nri3152","article-title":"Expanding roles for CD4(+) T cells in immunity to viruses","volume":"12","author":"SL Swain","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1016\/j.vaccine.2009.04.015","article-title":"CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus","volume":"27","author":"NE Yun","year":"2009","journal-title":"Vaccine"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/intimm\/12.2.223","article-title":"IFN-gamma-independent IgG2a production in mice infected with viruses and parasites","volume":"12","author":"D Markine-Goriaynoff","year":"2000","journal-title":"Int Immunol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.4049\/jimmunol.172.8.4834","article-title":"Cytokine dysregulation induced by apoptotic cells is a shared characteristic of macrophages from nonobese diabetic and systemic lupus erythematosus-prone mice","volume":"172","author":"H Fan","year":"2004","journal-title":"J Immunol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/JVI.02667-12","article-title":"Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis","volume":"87","author":"M Kumar","year":"2013","journal-title":"J Virol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1440-1711.2004.01238.x","article-title":"Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies","volume":"82","author":"SP Berzins","year":"2004","journal-title":"Immunol Cell Biol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"e1002586","DOI":"10.1371\/journal.ppat.1002586","article-title":"Mannose binding lectin is required for alphavirus-induced arthritis\/myositis","volume":"8","author":"BM Gunn","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.4049\/jimmunol.181.10.7073","article-title":"NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice","volume":"181","author":"LM Maier","year":"2008","journal-title":"J Immunol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1111\/j.1537-2995.2012.03960.x","article-title":"Viremic profiles in asymptomatic and symptomatic chikungunya fever: a blood transfusion threat?","volume":"53","author":"H Appassakij","year":"2013","journal-title":"Transfusion"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1586\/eci.11.48","article-title":"Sidestepping maternal antibody: a lesson from measles virus vaccination","volume":"7","author":"D Kim","year":"2011","journal-title":"Expert Rev Clin Immunol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"8737","DOI":"10.1073\/pnas.1105364108","article-title":"A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice","volume":"108","author":"AM D'Alise","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.4049\/jimmunol.1301600","article-title":"Reduced Regulatory T Cell Diversity in NOD Mice Is Linked to Early Events in the Thymus","volume":"192","author":"C Ferreira","year":"2014","journal-title":"J Immunol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"11263","DOI":"10.1128\/JVI.01352-08","article-title":"Complement receptor 3 promotes severe ross river virus-induced disease","volume":"82","author":"TE Morrison","year":"2008","journal-title":"J Virol"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.molimm.2012.10.024","article-title":"A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity","volume":"55","author":"JF Mohan","year":"2013","journal-title":"Mol Immunol"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1016\/j.vaccine.2008.07.054","article-title":"Chimeric alphavirus vaccine candidates for chikungunya","volume":"26","author":"E Wang","year":"2008","journal-title":"Vaccine"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1099\/vir.0.82858-0","article-title":"Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus","volume":"88","author":"AM Powers","year":"2007","journal-title":"J Gen Virol"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/0028-3886.51289","article-title":"Neurological complications of Chikungunya virus infection","volume":"57","author":"NH Chandak","year":"2009","journal-title":"Neurol India"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.trstmh.2009.07.031","article-title":"Atypical 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