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WormBook: 1\u201316."},{"key":"ref69","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1007\/s00436-005-1446-z","article-title":"Effects of a combinations of emodepside and praziquantel on parasites of reptiles and rodents","volume":"97","author":"H Mehlhorn","year":"2005","journal-title":"Parasitol Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00436-007-0614-8","article-title":"Efficacy of a combination of emodepside plus praziquantel against larval and adult stages of nematodes (<italic>Trichuris muris<\/italic>, Angiostrongylus cantonensis) in rodents","volume":"101","author":"G Schmahl","year":"2007","journal-title":"Parasitol Res"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e1003586","DOI":"10.1371\/journal.ppat.1003586","article-title":"Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from <italic>Schistosoma mansoni<\/italic>","volume":"9","author":"V Dufour","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1085\/jgp.201210955","article-title":"Lack of negative slope in I-V plots for BK channels at positive potentials in the absence of intracellular blockers","volume":"141","author":"Y Geng","year":"2013","journal-title":"J Gen Physiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.1128\/JB.00296-06","article-title":"The MgtC virulence factor of <italic>Salmonella enterica<\/italic> serovar Typhimurium activates Na<sup>+<\/sup>, K<sup>+<\/sup>-ATPase","volume":"188","author":"D G\u00fcnzel","year":"2006","journal-title":"J Bacteriol"},{"key":"ref74","unstructured":"Chrisford A (2011) An investigation into mode of action and selective toxicity of the novel antiparasitic emodepside. Southhampton, UK: University of Southhampton."},{"key":"ref75","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.ympev.2006.08.025","article-title":"An improved molecular phylogeny of the Nematoda with special emphasis on marine taxa","volume":"42","author":"BH Meldal","year":"2007","journal-title":"Mol Phylogenet Evol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0001-706X(01)00144-9","article-title":"Effects of Bay 44-4400, a new cyclodepsipeptide, on developing stages of filariae (<italic>Acanthochelonema viteae<\/italic>, <italic>Brugia malayi<\/italic>, <italic>Litomosoides sigmodontis<\/italic>) in the rodent <italic>Mastomys coucha<\/italic>","volume":"80","author":"H Zahner","year":"2001","journal-title":"Acta Trop"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/S0020-7519(01)00263-6","article-title":"Filaricidal efficacy of the anthelmintically active cyclodepsipeptides","volume":"31","author":"H Zahner","year":"2001","journal-title":"Int J Parasitol"},{"key":"ref78","first-page":"93","article-title":"Acitivty of the cyclooctadepsipeptide emodepside against <italic>Onchocerca gutturosa<\/italic>, <italic>Onchocerca lienalis<\/italic> and <italic>Brugia pahangi<\/italic>","volume":"73","author":"S Townson","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01199","article-title":"Calcium activation of BK(Ca) potassium channels lacking the calcium bowl and RCK domains","volume":"420","author":"R Piskorowski","year":"2002","journal-title":"Nature"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.pt.2012.04.003","article-title":"Levamisole receptors: a second awakening","volume":"28","author":"RJ Martin","year":"2012","journal-title":"Trends Parasitol"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T16:32:11Z","timestamp":1650817931000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003401"}},"subtitle":[],"editor":[{"given":"David L.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,18]]},"references-count":80,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003401","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,18]]}}}