{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:21:16Z","timestamp":1792790476442,"version":"4.5.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0003427","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T19:14:08Z","timestamp":1420744448000},"page":"e3427","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Metabolic Responses to Orientia tsutsugamushi Infection in a Mouse Model"],"prefix":"10.1371","volume":"9","author":[{"given":"Jeeyoun","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngae","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoungchul","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Jam","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Ran","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Ja","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geum-Sook","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1286-4579(00)01352-6","article-title":"<italic>Orientia tsutsugamushi<\/italic> infection: overview and immune responses","volume":"3","author":"SY Seong","year":"2001","journal-title":"Microbes Infect"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1128\/JCM.28.4.685-688.1990","article-title":"Serological classification by monoclonal antibodies of <italic>Rickettsia tsutsugamushi<\/italic> isolated in Korea","volume":"28","author":"WH Chang","year":"1990","journal-title":"J Clin Microbiol"},{"key":"ref3","volume":"1","unstructured":"Walker DH (1988) Biology of Rickecttsial disease. Florida: CRC press Inc. Vol. <volume>1<\/volume>.."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1086\/313906","article-title":"Multiple organ failure complicating probable scrub typhus","volume":"31","author":"C Cracco","year":"2000","journal-title":"Clin Infect Dis"},{"key":"ref5","first-page":"193","article-title":"Proliferating sites of <italic>Rickettsia tsutsugamushi<\/italic> in mice by different routes of inoculation evidenced with immunofluorescence","volume":"55","author":"M Murata","year":"1985","journal-title":"Jpn J Exp Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.7883\/yoken1952.38.125","article-title":"A scanning and transmission electron microscopic examination of <italic>Rickettsia tsutsugamushi<\/italic>-infected human endothelial, MRC-5, and L-929 cells","volume":"38","author":"FK Ng","year":"1985","journal-title":"Jpn J Med Sci Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1084\/jem.150.3.703","article-title":"Intracellular localization of <italic>Rickettsia tsutsugamushi<\/italic> in polymorphonuclear leukocytes","volume":"150","author":"Y Rikihisa","year":"1979","journal-title":"J Exp Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7883\/yoken1952.35.9","article-title":"Transmission of scrub typhus to human volunteers by laboratory-reared chiggers","volume":"35","author":"A Shirai","year":"1982","journal-title":"Jpn J Med Sci Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1128\/IAI.05478-11","article-title":"The deubiquitinase activity of the <italic>Salmonella<\/italic> pathogenicity island 2 effector, SseL, prevents accumulation of cellular lipid droplets","volume":"79","author":"ET Arena","year":"2011","journal-title":"Infect Immun"},{"key":"ref10","unstructured":"Kawamura A, Tanaka H, Tamura A (1995) Tsutsugamushi Disease. Tokyo: University of Tokyo Press."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1128\/IAI.01373-10","article-title":"Impact of <italic>salmonella<\/italic> infection on host hormone metabolism revealed by metabolomics","volume":"79","author":"LC Antunes","year":"2011","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.chom.2009.01.004","article-title":"Host-parasite interactions revealed by <italic>Plasmodium falciparum<\/italic> metabolomics","volume":"5","author":"KL Olszewski","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1021\/pr101054m","article-title":"<sup>1<\/sup>H NMR-based metabolomic profiling in mice infected with <italic>Mycobacterium tuberculosis<\/italic>","volume":"10","author":"JH Shin","year":"2011","journal-title":"J Proteome Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e11814","DOI":"10.1371\/journal.pone.0011814","article-title":"A global metabolic shift is linked to <italic>Salmonella<\/italic> multicellular development","volume":"5","author":"AP White","year":"2010","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00216-006-0687-8","article-title":"Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics","volume":"387","author":"Z Pan","year":"2007","journal-title":"Anal Bioanal Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.trac.2007.12.001","article-title":"Quantitative metabolomics using NMR","volume":"27","author":"SW David","year":"2008","journal-title":"Trends Analyt Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1039\/c4mb00090k","article-title":"NMR- and MS-based metabolomics: various organ responses following naphthalene intervention","volume":"10","author":"YS Ling","year":"2014","journal-title":"Mol Biosyst"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1021\/pr2007973","article-title":"Metabolic phenotyping of the Crohn&apos;s disease-like IBD etiopathology in the TNF<sup>\u0394ARE\/WT<\/sup> mouse model","volume":"10","author":"P Baur","year":"2011","journal-title":"J Preteome Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1128\/JCM.31.3.598-605.1993","article-title":"High-level expression of a 56\u2013kilodalton protein gene (bor56) of <italic>Rickettsia tsutsugamushi Boryong<\/italic> and its application to enzyme-linked immunosorbent assays","volume":"31","author":"IS Kim","year":"1993","journal-title":"J Clin Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3412\/jsb.36.783","article-title":"Easy method for infectivity titration of <italic>Rickettsia tsutsugamushi<\/italic> by infected cell counting (author&apos;s transl)","volume":"36","author":"A Tamura","year":"1981","journal-title":"Nihon Saikingaku Zasshi"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s11306-014-0678-2","article-title":"High-throughput, multi-platform metabolomics on very small volumes: <sup>1<\/sup>H NMR metabolite identification in an unadulterated tube-in-tube system","volume":"10","author":"JP Glaves","year":"2014","journal-title":"Metabolomics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/cem.1031","article-title":"Automated alignment of chromatographic data","volume":"20","author":"T Skov","year":"2006","journal-title":"J Chemom"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1366\/0003702011953955","article-title":"Pareto optimal multivariate calibration for spectroscopic data","volume":"55","author":"JH Kalivas","year":"2001","journal-title":"Appl Spectrosc"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s12272-010-0716-1","article-title":"<sup>1<\/sup>H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model","volume":"33","author":"YS Hong","year":"2010","journal-title":"Arch Pharm Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/cem.1187","article-title":"CV-ANOVA for significance testing of PLS and OPLS models","volume":"22","author":"L Eriksson","year":"2008","journal-title":"J Chemometrics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"J Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"ref27","first-page":"623145","article-title":"Genome-based construction of the metabolic pathways of <italic>Orientia tsutsugamushi<\/italic> and comparative analysis within the Rickettsiales order","volume":"2008","author":"CK Min","year":"2008","journal-title":"Comp Funct Genomics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/MMBR.68.4.745-770.2004","article-title":"Metabolic interdependence of obligate intracellular bacteria and their insect hosts","volume":"68","author":"E Zientz","year":"2004","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2169\/internalmedicine.37.429","article-title":"Preferential use of branched-chain amino acids as an energy substrate in patients with liver cirrhosis","volume":"37","author":"M Kato","year":"1998","journal-title":"Intern Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.femsre.2004.09.002","article-title":"Some lessons from Rickettsia genomics","volume":"29","author":"P Renesto","year":"2005","journal-title":"FEMS Microbiol Rev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0026-0495(76)90120-7","article-title":"The effect of bacterial infections on ketone concentrations in rat liver and blood and on free fatty acid concentrations in rat blood","volume":"25","author":"HA Neufeld","year":"1976","journal-title":"Metabolism"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/j.1552-4604.1988.tb05731.x","article-title":"Comparison of excretion of nicotinuric acid after ingestion of two controlled release nicotinic acid preparations in man","volume":"28","author":"HL Figge","year":"1988","journal-title":"J Clin Pharmacol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1124\/jpet.107.120758","article-title":"NAD+ and vitamin B3: from metabolism to therapies","volume":"324","author":"AA Sauve","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1096\/fasebj.5.12.1916088","article-title":"Compartmentation of folate-mediated one-carbon metabolism in eukaryotes","volume":"5","author":"DR Appling","year":"1991","journal-title":"Faseb J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"38381","DOI":"10.1074\/jbc.M205000200","article-title":"Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses","volume":"277","author":"K Herbig","year":"2002","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"E272","DOI":"10.1152\/ajpendo.00351.2003","article-title":"Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor","volume":"286","author":"SR Davis","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000334586","article-title":"Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies","volume":"4","author":"PJ Stover","year":"2011","journal-title":"J Nutrigenet Nutrigenomics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1212\/WNL.45.9.1678","article-title":"Cerebrospinal fluid S-adenosylmethionine (SAMe) and glutathione concentrations in HIV infection: effect of parenteral treatment with SAMe","volume":"45","author":"A Castagna","year":"1995","journal-title":"Neurology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0140-6736(90)90409-X","article-title":"Central-nervous-system methyl-group metabolism in children with neurological complications of HIV infection","volume":"335","author":"R Surtees","year":"1990","journal-title":"Lancet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1089\/apc.1998.12.457","article-title":"AIDS-associated vacuolar myelopathy","volume":"12","author":"A Di Rocco","year":"1998","journal-title":"AIDS Patient Care STDS"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/clinids\/24.3.436","article-title":"Central nervous system involvement in patients with scrub typhus","volume":"24","author":"H Pai","year":"1997","journal-title":"Clin Infect Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1080\/00365540701266755","article-title":"Guillain-Barre syndrome associated with scrub typhus","volume":"39","author":"SH Lee","year":"2007","journal-title":"Scand J Infect Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1099\/jmm.0.034678-0","article-title":"A case of scrub typhus with acalculous cholecystitis, aseptic meningitis and mononeuritis multiplex","volume":"61","author":"K Hayakawa","year":"2012","journal-title":"J Med Microbiol"},{"key":"ref44","first-page":"142","article-title":"Alterations in the Activities of Antioxidant Enzymes of Human Dermal Microvascular Endothelial Cells Infected with Orientia tsutsugamushi","volume":"39","author":"YS Koh","year":"2001","journal-title":"J Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0005-2736(73)90143-0","article-title":"The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy","volume":"323","author":"AJ Verkleij","year":"1973","journal-title":"Biochim Biophys Acta"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0165-022X(84)90013-7","article-title":"<sup>1<\/sup>H NMR methods for the noninvasive study of metabolism and other processes involving small molecules in intact erythrocytes","volume":"9","author":"DL Rabenstein","year":"1984","journal-title":"J Biochem Biophys Methods"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/07315724.1983.10719904","article-title":"Alterations in protein, carbohydrate, and fat metabolism in injured and septic patients","volume":"2","author":"DW Wilmore","year":"1983","journal-title":"J Am Coll Nutr"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"288S","DOI":"10.1093\/jn\/136.1.288S","article-title":"Branched-chain amino acids and immunity","volume":"136","author":"PC Calder","year":"2006","journal-title":"J Nutr"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T11:48:06Z","timestamp":1650973686000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003427"}},"subtitle":[],"editor":[{"given":"Joseph M.","family":"Vinetz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,8]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003427","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,8]]}}}