{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:08:09Z","timestamp":1789502889219,"version":"build-2803163510"},"reference-count":113,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0003435","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T14:15:03Z","timestamp":1420726503000},"page":"e3435","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["In Silico Repositioning-Chemogenomics Strategy Identifies New Drugs with Potential Activity against Multiple Life Stages of Schistosoma mansoni"],"prefix":"10.1371","volume":"9","author":[{"given":"Bruno J.","family":"Neves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolpho C.","family":"Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C. B.","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro V. L.","family":"Cravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina H.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"B Gryseels","year":"2006","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)66457-4","article-title":"Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis","volume":"365","author":"CH King","year":"2005","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"DG Colley","year":"2014","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1128\/IAI.00053-13","article-title":"Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity","volume":"81","author":"Z Yang","year":"2013","journal-title":"Infect Immun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e504","DOI":"10.1371\/journal.pntd.0000504","article-title":"Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni","volume":"3","author":"SD Melman","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.actatropica.2012.04.013","article-title":"Time to set the agenda for schistosomiasis elimination","volume":"128","author":"D Rollinson","year":"2013","journal-title":"Acta Trop"},{"key":"ref7","unstructured":"WHO (2014) Schistosomiasis. Fact sheet: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/mediacentre\/factsheets\/fs115\/en\" xlink:type=\"simple\">http:\/\/www.who.int\/mediacentre\/factsheets\/fs115\/en<\/ext-link>."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1017\/S0031182006001648","article-title":"Biology of the schistosome lung-stage schistosomulum","volume":"134","author":"GN Gobert","year":"2007","journal-title":"Parasitology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pt.2005.03.003","article-title":"Comparison of skin invasion among three major species of Schistosoma","volume":"21","author":"Y-X He","year":"2005","journal-title":"Trends Parasitol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-3024.2009.01098.x","article-title":"Immunopathogenesis of human schistosomiasis","volume":"31","author":"ML Burke","year":"2009","journal-title":"Parasite Immunol"},{"key":"ref11","unstructured":"World Health Organization (2012) Progress report 2001\u20132011 and strategic plan 2012\u20132020. Geneva, Switzerland."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e45867","DOI":"10.1371\/journal.pone.0045867","article-title":"Systematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasis","volume":"7","author":"L P\u00e9rez del Villar","year":"2012","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00389899","article-title":"Praziquantel, a new board-spectrum antischistosomal agent","volume":"52","author":"R G\u00f6nnert","year":"1977","journal-title":"Z Parasitenkd"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4269\/ajtmh.1996.55.214","article-title":"Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel","volume":"55","author":"M Ismail","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00436-012-3151-z","article-title":"Susceptibility or resistance of praziquantel in human schistosomiasis: a review","volume":"111","author":"W Wang","year":"2012","journal-title":"Parasitol Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1046\/j.1365-3156.2001.00811.x","article-title":"Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence","volume":"6","author":"B Gryseels","year":"2001","journal-title":"Trop Med Int Heal"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.exppara.2013.06.010","article-title":"Vaccine potential of recombinant cathepsin B against Fasciola gigantica","volume":"135","author":"P Chantree","year":"2013","journal-title":"Exp Parasitol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrd4409","article-title":"FDA approvals for the first 6 months of 2014","volume":"13","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1056\/NEJMoa021556","article-title":"Oral miltefosine for Indian visceral leishmaniasis","volume":"347","author":"S Sundar","year":"2002","journal-title":"N Engl J Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.drudis.2011.02.016","article-title":"In silico repositioning of approved drugs for rare and neglected diseases","volume":"16","author":"S Ekins","year":"2011","journal-title":"Drug Discov Today"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1039\/c2cs35357a","article-title":"Drug repositioning by structure-based virtual screening","volume":"42","author":"D-L Ma","year":"2013","journal-title":"Chem Soc Rev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/gm326","article-title":"Drug repositioning for personalized medicine","volume":"4","author":"YY Li","year":"2012","journal-title":"Genome Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/157018008785777289","article-title":"Three-Dimensional Quantitative Structure-Activity Relationships for a Large Series of Potent Antitubercular Agents","volume":"5","author":"CH Andrade","year":"2008","journal-title":"Lett Drug Des Discov"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1590\/S1516-93322008000200002","article-title":"Abordagem racional no planejamento de novos tuberculost\u00e1ticos: inibidores da InhA, enoil-ACP redutase do M. tuberculosis","volume":"44","author":"CH Andrade","year":"2008","journal-title":"Rev Bras ciencias Farm"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11030-008-9074-z","article-title":"Fragment-based and classical quantitative structure-activity relationships for a series of hydrazides as antituberculosis agents","volume":"12","author":"CH Andrade","year":"2008","journal-title":"Mol Divers"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1021\/ci8004622","article-title":"Rational design and 3D-pharmacophore mapping of 5\u2032-thiourea-substituted alpha-thymidine analogues as mycobacterial TMPK inhibitors","volume":"49","author":"CH Andrade","year":"2009","journal-title":"J Chem Inf Model"},{"key":"ref27","unstructured":"Braga RC, Sabino JR, de Valeria O, Andrade CH (2010) Discovery of novel hit compounds for Trypanosoma cruzi sterol 14\u03b1-demethylase through structure-based virtual screening. Abstracts of Papers, 240th American Chemical Society National Meeting &amp; Exposition, Boston, MA, United States, August 22\u201326. p. MEDI\u2013379."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10822-010-9323-y","article-title":"3D-Pharmacophore mapping of thymidine-based inhibitors of TMPK as potential antituberculosis agents","volume":"24","author":"CH Andrade","year":"2010","journal-title":"J Comput Aided Mol Des"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.3390\/molecules15053281","article-title":"4D-QSAR: perspectives in drug design","volume":"15","author":"CH Andrade","year":"2010","journal-title":"Molecules"},{"key":"ref30","unstructured":"Braga RC, Liao LM, Bezerra JC, Vinaud MC, Andrade CH (2012) Integrated Chemoinformatics approaches to virtual screening in the search of new lead compounds against Leishmania. Abstracts of Papers, 244th American Chemical Society National Meeting &amp; Exposition, Philadelphia, PA, United States, August 19\u201323, 2012. p. CINF\u201346."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1016\/j.bmcl.2013.02.006","article-title":"Discovery of new potential hits of Plasmodium falciparum enoyl-ACP reductase through ligand- and structure-based drug design approaches","volume":"23","author":"BJ Neves","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00894-012-1527-8","article-title":"Structural and chemical basis for enhanced affinity to a series of mycobacterial thymidine monophosphate kinase inhibitors: fragment-based QSAR and QM\/MM docking studies","volume":"19","author":"V Bueno R","year":"2013","journal-title":"J Mol Model"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2174\/1568026611313090010","article-title":"Assessing the Performance of 3D Pharmacophore Models in Virtual Screening: How Good are They?","volume":"13","author":"RC Braga","year":"2013","journal-title":"Curr Top Med Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2174\/1573409910666140410111043","article-title":"3D-QSAR Approaches in Drug Design: Perspectives to Generate Reliable CoMFA Models","volume":"10","author":"CC Melo-Filho","year":"2014","journal-title":"Curr Comput Aided Drug Des"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.2174\/1381612819666131118170238","article-title":"New tuberculostatic agents targeting nucleic acid biosynthesis: drug design using QSAR approaches","volume":"20","author":"V Bueno R","year":"2014","journal-title":"Curr Pharm Des"},{"key":"ref36","volume":"14","unstructured":"Braga RC, Alves VM, Silva AC, Nascimento MN, Silva FC, <etal>et al<\/etal>.. (2014) Virtual Screening Strategies in Medicinal Chemistry: The state of the art and current challenges. Curr Top Med Chem <volume>14<\/volume>.."},{"key":"ref37","unstructured":"Braga RC, Pinto EG, Martins LF, Tempone AG, Liao LM, <etal>et al<\/etal>.. (2014) Multitarget virtual screening approach: Identification of new hit compounds against Leishmania infantum. Abstracts of Papers, 248th ACS National Meeting &amp; Exposition, San Francisco, CA, United States, August 10\u201314, 2014. American Chemical Society. p. COMP\u2013322."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.2174\/1568026614666140506124442","article-title":"Tuning hERG out: Antitarget QSAR Models for Drug Development","volume":"14","author":"RC Braga","year":"2014","journal-title":"Curr Top Med Chem"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Andrade CH, Silva DC, Braga RC (2014) In silico Prediction of Drug Metabolism by P450. Curr Drug Metab.","DOI":"10.2174\/1389200215666140908102530"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2174\/1568026614666140506114019","article-title":"Drug Metabolism, Toxicology Experimental Determination And Theoretical Prediction: Challenges And Perspectives From A Medicinal Chemistry Point Of View","volume":"14","author":"CH Andrade","year":"2014","journal-title":"Curr Top Med Chem"},{"key":"ref41","unstructured":"Alves VM, Braga RC, Silva MB, Muratov E, Fourches D, <etal>et al<\/etal>.. (2014) Pred-hERG: A novel web-accessible computational tool for predicting cardiac toxicity of drug candidates. Abstracts of Papers, 248th ACS National Meeting &amp; Exposition, San Francisco, CA, United States, August 10\u201314, 2014. American Chemical Society. p. CINF\u201340."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1016\/j.bmcl.2010.04.073","article-title":"Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294","volume":"20","author":"EO Carneiro","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2174\/138955712800493807","article-title":"QSAR and QM\/MM approaches applied to drug metabolism prediction","volume":"12","author":"RC Braga","year":"2012","journal-title":"Mini Rev Med Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.4161\/auto.6.8.13551","article-title":"Identification of small molecules enhancing autophagic function from drug network analysis","volume":"6","author":"F Iorio","year":"2010","journal-title":"Autophagy"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/ibd.22958","article-title":"Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases","volume":"18","author":"PM Clark","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e59288","DOI":"10.1371\/journal.pone.0059288","article-title":"A Systematic In Silico Search for Target Similarity Identifies Several Approved Drugs with Potential Activity against the Plasmodium falciparum Apicoplast","volume":"8","author":"NA Bispo","year":"2013","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e4413","DOI":"10.1371\/journal.pone.0004413","article-title":"A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni","volume":"4","author":"CR Caffrey","year":"2009","journal-title":"PLoS One"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"D787","DOI":"10.1093\/nar\/gkp1014","article-title":"Update of TTD: Therapeutic Target Database","volume":"38","author":"F Zhu","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"D668","DOI":"10.1093\/nar\/gkj067","article-title":"DrugBank: a comprehensive resource for in silico drug discovery and exploration","volume":"34","author":"DS Wishart","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"D876","DOI":"10.1093\/nar\/gkr1011","article-title":"STITCH 3: zooming in on protein-chemical interactions","volume":"40","author":"M Kuhn","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nrg1317","article-title":"Chemogenomics: an emerging strategy for rapid target and drug discovery","volume":"5","author":"M Bredel","year":"2004","journal-title":"Nat Rev Genet"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/sj.bjp.0707307","article-title":"Chemogenomic approaches to rational drug design","volume":"152","author":"D Rognan","year":"2007","journal-title":"Br J Pharmacol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e1455","DOI":"10.1371\/journal.pntd.0001455","article-title":"A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni","volume":"6","author":"V Protasio A","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nrd2684","article-title":"Genomic-scale prioritization of drug targets: the TDR Targets database","volume":"7","author":"F Ag\u00fcero","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"D339","DOI":"10.1093\/nar\/gkh007","article-title":"GeneDB: a resource for prokaryotic and eukaryotic organisms","volume":"32","author":"C Hertz-Fowler","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"718491","DOI":"10.1155\/2012\/718491","article-title":"Nutraceutical interventions for promoting healthy aging in invertebrate models","volume":"2012","author":"Y Dong","year":"2012","journal-title":"Oxid Med Cell Longev"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/bioinformatics\/14.1.40","article-title":"Comparative accuracy of methods for protein sequence similarity search","volume":"14","author":"P Agarwal","year":"1998","journal-title":"Bioinformatics"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"W529","DOI":"10.1093\/nar\/gkq399","article-title":"ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids","volume":"38","author":"H Ashkenazy","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"D115","DOI":"10.1093\/nar\/gkh131","article-title":"UniProt: the Universal Protein knowledgebase","volume":"32","author":"R Apweiler","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/bioinformatics\/btl158","article-title":"Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences","volume":"22","author":"W Li","year":"2006","journal-title":"Bioinformatics"},{"key":"ref61","first-page":"22","article-title":"Improvement in the accuracy of multiple sequence alignment program MAFFT","volume":"16","author":"K Katoh","year":"2005","journal-title":"Genome informatics"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1093\/bioinformatics\/18.suppl_1.S71","article-title":"Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues","volume":"18","author":"T Pupko","year":"2002","journal-title":"Bioinformatics"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1093\/molbev\/msh194","article-title":"Comparison of site-specific rate-inference methods for protein sequences: empirical Bayesian methods are superior","volume":"21","author":"I Mayrose","year":"2004","journal-title":"Mol Biol Evol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"D400","DOI":"10.1093\/nar\/gkr1132","article-title":"PubChem&apos;s BioAssay Database","volume":"40","author":"Y Wang","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1021\/ci100176x","article-title":"Trust, but verify: on the importance of chemical structure curation in cheminformatics and QSAR modeling research","volume":"50","author":"D Fourches","year":"2010","journal-title":"J Chem Inf Model"},{"key":"ref66","unstructured":"Landrum G (2014) RDKit: Open-source cheminformatics: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.rdkit.org\/\" xlink:type=\"simple\">http:\/\/www.rdkit.org\/<\/ext-link>."},{"key":"ref67","unstructured":"R Development Core Team (2008) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing."},{"key":"ref68","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrd892","article-title":"The druggable genome","volume":"1","author":"AL Hopkins","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S1359-6446(05)03666-4","article-title":"The druggable genome: an update","volume":"10","author":"AP Russ","year":"2005","journal-title":"Drug Discov Today"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.drudis.2011.02.002","article-title":"Fragment screening to predict druggability (ligandability) and lead discovery success","volume":"16","author":"FNB Edfeldt","year":"2011","journal-title":"Drug Discov Today"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nature03192","article-title":"Chemical space and biology","volume":"432","author":"CM Dobson","year":"2004","journal-title":"Nature"},{"key":"ref72","volume":"432","unstructured":"Lipinski C, Hopkins A (2004) Navigating chemical space for biology and medicine. Nature <volume>432<\/volume>.."},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.ejmech.2010.01.048","article-title":"Assessing the chemical diversity of an hsp90 database","volume":"45","author":"D Audisio","year":"2010","journal-title":"Eur J Med Chem"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1021\/jm300288g","article-title":"Charting, navigating, and populating natural product chemical space for drug discovery","volume":"55","author":"H Lachance","year":"2012","journal-title":"J Med Chem"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1021\/ar100014h","article-title":"Bioactivity-guided navigation of chemical space","volume":"43","author":"RS Bon","year":"2010","journal-title":"Acc Chem Res"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke Schistosoma mansoni","volume":"460","author":"M Berriman","year":"2009","journal-title":"Nature"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.parint.2013.06.003","article-title":"Neurotransmitter transporters in schistosomes: structure, function and prospects for drug discovery","volume":"62","author":"P Ribeiro","year":"2013","journal-title":"Parasitol Int"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/QCO.0b013e328318978f","article-title":"Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis","volume":"21","author":"MJ Doenhoff","year":"2008","journal-title":"Curr Opin Infect Dis"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"e885","DOI":"10.1371\/journal.pntd.0000885","article-title":"A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility","volume":"4","author":"MJ Smout","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1085\/jgp.100.4.703","article-title":"Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists","volume":"100","author":"CJ Cohen","year":"1992","journal-title":"J Gen Physiol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"109S","DOI":"10.1111\/j.1365-2125.1986.tb02860.x","article-title":"The mechanism of action of calcium antagonists relative to their clinical applications","volume":"21","author":"BN Singh","year":"1986","journal-title":"Br J Clin Pharmacol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1590\/0074-0276108052013011","article-title":"Antischistosomal activity of a calcium channel antagonist on schistosomula and adult Schistosoma mansoni worms","volume":"108","author":"V Silva-Moraes","year":"2013","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1042\/bj0330240","article-title":"Studies in the biochemistry of micro-organisms: Griseofulvin, C(17)H(17)O(6)Cl, a metabolic product of Penicillium griseo-fulvum Dierckx","volume":"33","author":"AE Oxford","year":"1939","journal-title":"Biochem J"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1471-2407-10-213","article-title":"Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine","volume":"10","author":"K Rathinasamy","year":"2010","journal-title":"BMC Cancer"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/jcb.21240","article-title":"NF-kappaB pathway is involved in griseofulvin-induced G2\/M arrest and apoptosis in HL-60 cells","volume":"101","author":"Y-H Uen","year":"2007","journal-title":"J Cell Biochem"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ijantimicag.2005.09.006","article-title":"Current state of three-dimensional characterisation of antifungal targets and its use for molecular modelling in drug design","volume":"26","author":"E Ruge","year":"2005","journal-title":"Int J Antimicrob Agents"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/oxfordjournals.aob.a083206","article-title":"Studies on the Biological Activity of Griseofulvin","volume":"13","author":"PW Brian","year":"1949","journal-title":"Ann Bot"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1099\/jmm.0.46542-0","article-title":"Evaluation of susceptibility of Trichophyton mentagrophytes and Trichophyton rubrum clinical isolates to antifungal drugs using a modified CLSI microdilution method (M38-A)","volume":"56","author":"ME Da Silva Barros","year":"2007","journal-title":"J Med Microbiol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0006-2952(95)02406-9","article-title":"Griseofulvin: a novel interaction with bovine brain tubulin","volume":"51","author":"R Chaudhuri a","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00709-004-0081-3","article-title":"Live-cell imaging of tubulin in the filamentous fungus Magnaporthe grisea treated with anti-microtubule and anti-microfilament agents","volume":"225","author":"KJ Czymmek","year":"2005","journal-title":"Protoplasma"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"6342","DOI":"10.1158\/0008-5472.CAN-07-0663","article-title":"Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen","volume":"67","author":"B Rebacz","year":"2007","journal-title":"Cancer Res"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1586\/ern.11.149","article-title":"Tetrabenazine for the treatment of chorea and other hyperkinetic movement disorders","volume":"11","author":"J Jankovic","year":"2011","journal-title":"Expert Rev Neurother"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/med.20187","article-title":"Vesicular monoamine transporters: structure-function, pharmacology, and medicinal chemistry","volume":"31","author":"K Wimalasena","year":"2011","journal-title":"Med Res Rev"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"e478","DOI":"10.1371\/journal.pntd.0000478","article-title":"Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening","volume":"3","author":"M-H Abdulla","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.exppara.2009.12.021","article-title":"The identification of inhibitors of Schistosoma mansoni miracidial transformation by incorporating a medium-throughput small-molecule screen","volume":"125","author":"AS Taft","year":"2010","journal-title":"Exp Parasitol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1172\/JCI116597","article-title":"Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives","volume":"92","author":"C Brugnara","year":"1993","journal-title":"J Clin Invest"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/75737","article-title":"Tracking presynaptic Ca2+ dynamics during neurotransmitter release with Ca2+-activated K+ channels","volume":"3","author":"B Yazejian","year":"2000","journal-title":"Nat Neurosci"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1126\/science.1373909","article-title":"Regulation of arterial tone by activation of calcium-dependent potassium channels","volume":"256","author":"JE Brayden","year":"1992","journal-title":"Science"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"17295","DOI":"10.1074\/jbc.M312217200","article-title":"73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin","volume":"279","author":"T Miyazaki","year":"2004","journal-title":"J Biol Chem"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s12032-013-0575-y","article-title":"The significance of heat shock proteins in breast cancer therapy","volume":"30","author":"S Oskay Halacli","year":"2013","journal-title":"Med Oncol"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1007\/s00436-011-2700-1","article-title":"Molecular cloning and characterization of a HSP70 gene from Schistosoma japonicum","volume":"110","author":"J Yang","year":"2012","journal-title":"Parasitol Res"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00005344-198301000-00023","article-title":"Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities","volume":"5","author":"SN Levine","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1111\/febs.12296","article-title":"Structural diversity of calmodulin binding to its target sites","volume":"280","author":"H Tidow","year":"2013","journal-title":"FEBS J"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF00931079","article-title":"Hatching of Schistosoma mansoni eggs is a Ca2+\/calmodulin-dependent process","volume":"76","author":"T Katsumata","year":"1989","journal-title":"Parasitol Res"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.2307\/3282230","article-title":"Possible involvement of calcium ions in the hatching of Schistosoma mansoni eggs in water","volume":"74","author":"T Katsumata","year":"1988","journal-title":"J Parasitol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4269\/ajtmh.1966.15.314","article-title":"The role of calcium and magnesium ions in invasiveness of schistosome cercariae","volume":"15","author":"RM Lewert","year":"1966","journal-title":"Am J Trop Med Hyg"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2307\/3282693","article-title":"Schistosoma mansoni: the role of calcium in the stimulation of cercarial proteinase release","volume":"77","author":"AC Fusco","year":"1991","journal-title":"J Parasitol"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev.physiol.69.040705.141253","article-title":"Regulation of mammalian ciliary beating","volume":"69","author":"M Salathe","year":"2007","journal-title":"Annu Rev Physiol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0006-2952(72)90064-0","article-title":"Comparative properties of schistosomal and filarial dihydrofolate reductases","volume":"21","author":"JJ Jaffe","year":"1972","journal-title":"Biochem Pharmacol"},{"key":"ref110","first-page":"1129","article-title":"Effect of the broad spectrum anthelmintic drug flubendazole upon Schistosoma mansoni experimentally infected mice","volume":"50","author":"NG Nessim","year":"2000","journal-title":"Arzneimittelforschung"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1747-0285.2012.01354.x","article-title":"Synthesis, biological evaluation, and structure-activity relationship of clonazepam, meclonazepam, and 1,4-benzodiazepine compounds with schistosomicidal activity","volume":"79","author":"CMS Menezes","year":"2012","journal-title":"Chem Biol Drug Des"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"28977","DOI":"10.1074\/jbc.M109.020701","article-title":"Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects","volume":"284","author":"F Angelucci","year":"2009","journal-title":"J Biol Chem"},{"key":"ref113","first-page":"848","article-title":"Studies on prophylactic effect of artesunate on schistosomiasis japonica","volume":"109","author":"S Li","year":"1996","journal-title":"Chin Med J (Engl)"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0003554","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000}}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T16:12:04Z","timestamp":1598631124000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003435"}},"subtitle":[],"editor":[{"given":"Banchob","family":"Sripa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,8]]},"references-count":113,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003435","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,8]]}}}