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In: Waller GR, Dermer OC, editors. Biochemical applications of mass spectroscopy. New York: John Wiley and Sons. pp. 1085\u20131127."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2915.1996.tb00742.x","article-title":"Identification of electrophysiologically-active compounds for the malaria mosquito, <italic>Anopheles gambiae<\/italic>, in human sweat","volume":"10","author":"A Cork","year":"1996","journal-title":"Med Vet Entomol"},{"key":"ref31","first-page":"143","article-title":"Evaluation of 1-octen-3-ol and carbon dioxide as black fly attractants in Arkansas","volume":"9","author":"DW Atwood","year":"1993","journal-title":"J Am Mosq Control Assoc"},{"key":"ref32","unstructured":"Crisp G (1956) <italic>Simulium<\/italic> and onchocerciasis in the northern territories of the Gold Coast. London: H.K. Lewis and Co."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/00034983.1987.11812117","article-title":"Studies on the dynamics of transmission of onchocerciasis in a Sudan-savanna area of North Cameroon III. 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Hyg"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1021\/ac060053k","article-title":"Development of a multibed sorption trap, comprehensive two-dimensional gas chromatography, and time-of-flight mass spectrometry system for the analysis of volatile organic compounds in human breath","volume":"78","author":"JM Sanchez","year":"2006","journal-title":"Anal Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.chroma.2003.08.062","article-title":"Sampling and analysis of volatile organic compounds in bovine breath by solid-phase microextraction and gas chromatography-mass spectrometry","volume":"1025","author":"JP Spinhirne","year":"2004","journal-title":"J Chromatogr A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2915.2007.00686.x","article-title":"Sensory and behavioural responses of the stable fly <italic>Stomoxys calcitrans<\/italic> to rumen volatiles","volume":"21","author":"P 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